109-61-5

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Highly sensitive detection of melanoma at an early stage based on the increased serum secreted protein acidic and rich in cysteine and glypican-3 levels.

Yoshiaki Ikuta et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 11(22), 8079-8088 (2005-11-22)

There are no available tumor markers detecting primary melanoma at an early stage. The identification of such serum markers would be of significant benefit for an early diagnosis of melanoma. We recently identified glypican-3 (GPC3) as a novel tumor marker

An improved HPLC method for therapeutic drug monitoring of daunorubicin, idarubicin, doxorubicin, epirubicin, and their 13-dihydro metabolites in human plasma.

S Fogli et al.

Therapeutic drug monitoring, 21(3), 367-375 (1999-06-12)

A single high-performance liquid chromatography (HPLC) method, suitable for the analysis of daunorubicin, idarubicin, doxorubicin, epirubicin, and their 13-dihydro metabolites is validated in the present study. Preparation of plasma samples was performed by a first extraction of analytes with a

Identification of AHNAK as a novel autoantigen in systemic lupus erythematosus.

Filip Sköldberg et al.

Biochemical and biophysical research communications, 291(4), 951-958 (2002-02-28)

To identify candidate autoantigens associated with arthritis, a rat chondrocyte cDNA library was immunoscreened with serum from a patient with rheumatoid arthritis. One isolated cDNA encoded part of AHNAK, a 700-kDa phosphoprotein with DNA binding properties, that appears to be

Drug-coated balloons vs. drug-eluting stents for treatment of long femoropopliteal lesions.

Thomas Zeller et al.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 21(3), 359-368 (2014-06-11)

To compare the performance of drug-coated balloons (DCB) and drug-eluting stents (DES) in long femoropopliteal lesions. A retrospective dual center study included 228 patients (139 men; median age 69 years) with femoropopliteal lesions ≥10 cm suffering from peripheral artery disease

Effect of valacyclovir on EHV-5 viral kinetics in horses with equine multinodular pulmonary fibrosis.

Charlotte A Easton-Jones et al.

Journal of veterinary internal medicine, 32(5), 1763-1767 (2018-09-18)

Equine herpesvirus-5 is commonly isolated from the lungs of horses with EMPF, suggesting an etiological link. Valacyclovir is used empirically to treat EMPF; however, no data is available concerning its impact on EHV-5 viral kinetics. To determine the effect of

Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines.

Ja-Lok Ku et al.

Oncogene, 23(40), 6736-6742 (2004-07-27)

It was recently reported that RUNX3 gene expression is significantly downregulated in human gastric cancer cells due to hypermethylation of its promoter region or hemizygous deletion (Cell, 109, 2002). To verify the genetic alterations and methylation status of the RUNX3

Claudin-18 is an early-stage marker of pancreatic carcinogenesis.

Mariko Tanaka et al.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 59(10), 942-952 (2011-08-13)

Pancreatic ductal neoplasms exhibit gastric epithelium-like characteristics. In this study, we evaluated the expression of claudin-18 (CLDN18), a gastric epithelium-associated claudin, in pancreatic intraepithelial neoplasias (PanINs), intraductal papillary mucinous neoplasms (IPMNs), mucinous cystic neoplasms (MCNs), and pancreatic ductal adenocarcinomas (PDACs)

Determination of the disulfide structure and N-glycosylation sites of the extracellular domain of the human signal transducer gp130.

R L Moritz et al.

The Journal of biological chemistry, 276(11), 8244-8253 (2000-12-01)

gp130 is the common signal transducing receptor subunit for the interleukin-6-type family of cytokines. Its extracellular region (sgp130) is predicted to consist of five fibronectin type III-like domains and an NH2-terminal Ig-like domain. Domains 2 and 3 constitute the cytokine-binding

Quantification of Polyfunctional Thiols in Wine by HS-SPME-GC-MS Following Extractive Alkylation.

Lauren E Musumeci et al.

Molecules (Basel, Switzerland), 20(7), 12280-12299 (2015-07-15)

Analyses of key odorous polyfunctional volatile thiols in wines (3-mercaptohexanol (3-MH), 3-mercaptohexylacetate (3-MHA), and 4-mercapto-4-methyl-2-pentanone (4-MMP)) are challenging due to their high reactivity and ultra-trace concentrations, especially when using conventional gas-chromatography electron impact mass spectrometry (GC-EI-MS). We describe a method

Concordance of a point mutation 5' to the G gamma globin gene with G gamma beta +. Hereditary persistence of fetal hemoglobin in the black population.

F S Collins et al.

Blood, 64(6), 1292-1296 (1984-12-01)

Hereditary persistence of fetal hemoglobin (HPFH) is a genetically heterogeneous and clinically benign condition characterized by persistent expression of fetal hemoglobin (Hb F) into adulthood. In the G gamma beta + type, no major deletions in the globin gene cluster

Ca2+ levels in myotubes grown from the skeletal muscle of dystrophic (mdx) and normal mice.

A J Bakker et al.

The Journal of physiology, 460, 1-13 (1993-01-01)

1. Myotubes were grown in culture from normal (C57BL/ScSn) and mdx mice and the cytosolic [Ca2+] was monitored through development (5-21 days in culture) using fura-2 loaded via ionophoresis. Simultaneous measurements of the membrane potential and cytosolic [Ca2+] were made

Impact of leptin deficiency compared with neuronal-specific leptin receptor deletion on cardiometabolic regulation.

Jussara M do Carmo et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 317(4), R552-R562 (2019-08-15)

The main goal of this study was to compare the impact of total body leptin deficiency with neuronal-specific leptin receptor (LR) deletion on metabolic and cardiovascular regulation. Liver fat, diacylglycerol acyltransferase-2 (DGTA2), and CD36 protein content were measured in wild-type

Measurement of cytosolic free Ca2+ concentrations in human and rat osteosarcoma cells: actions of bone resorption-stimulating hormones.

C J Boland et al.

Endocrinology, 118(3), 980-989 (1986-03-01)

Influx of extracellular Ca++ into bone cells has been postulated as an early action of PTH and other bone resorption-stimulating factors. To test this hypothesis directly, we measured the cytosolic free Ca2+ concentration ([Ca2+]i) in two hormone-responsive human (SaOS-2 and

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