Claudia Trenkwalder et al.
The Lancet. Neurology, 12(12), 1141-1150 (2013-10-22)
Opioids are a potential new treatment for severe restless legs syndrome. We investigated the efficacy and safety of a fixed-dose combination of prolonged release oxycodone-naloxone for patients with severe restless legs syndrome inadequately controlled by previous, mainly dopaminergic, treatment. This