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Ying Liu et al.
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 33(6), 427-431 (2010-10-29)
To investigate the expression and role of O(6)-methylguanine DNA methyltransferase (MGMT) and p53 in non-small cell lung cancer (NSCLC) and the association with prognosis. Immunohistochemical method was used to investigate the expression of MGMT and p53 in NSCLC specimens from
Larissa Martins de Brito Moraes et al.
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, 20(4), 312-317 (2011-12-15)
Neosporosis and toxoplasmosis are parasitic diseases which can cause reproductive problems in goats and sheep. The current study aimed to determine the occurrence of anti-Neospora caninum and anti-Toxoplasma gondii IgG antibodies in goats and sheep from the districts of Amarante
X Zhang et al.
Genomics, 33(3), 473-479 (1996-05-01)
Basement membrane (type IV) collagen, a subfamily of the collagen protein family, is encoded by six distinct genes in mammals. Three of those, COL4A3, COL4A4, and COL4A5, are linked with Alport syndrome (hereditary nephritis). Patients with leimoyomatosis associated with Alport
M M M Abd-Elnaeim et al.
Reproduction in domestic animals = Zuchthygiene, 44(2), 312-319 (2008-11-11)
The functions of placental oestrogens during equine pregnancy are still unclear. Yet, they may act predominantly as local regulators of growth and differentiation in the microplacentomes. Thus, expression patterns of oestrogen receptors (ERs) alpha and beta were investigated in the
Justin D La Favor et al.
Journal of proteome research, 17(3), 1031-1040 (2018-02-03)
Priapism is a disorder in which prolonged penile erection persists uncontrollably, potentially leading to tissue damage. Priapism commonly afflicts patient populations with severely low nitric oxide (NO) bioavailability. Because NO is a primary mediator of erection, the molecular mechanisms involved
R A Maurer et al.
DNA (Mary Ann Liebert, Inc.), 5(5), 363-369 (1986-10-01)
Two different cDNAs containing sequences coding for the beta-subunit of bovine follicle stimulating hormone (FSH-beta) have been isolated from a phage lambda gt11 bovine pituitary cDNA library. The complete nucleotide sequence of both clones was determined, and the combined sequence
Issa F Khouri et al.
Blood, 124(14), 2306-2312 (2014-08-26)
Myelosuppression, graft-versus-host disease (GVHD), and relapse remain major causes of morbidity after stem cell transplantation for relapsed lymphoma. In this phase 1/2 study, we tested the safety and efficacy of escalating doses of bendamustine (70, 90, 110, and 130 mg/m2
I Keser et al.
Acta haematologica, 111(4), 205-210 (2004-05-22)
We have studied 918 chromosomes for mutations leading to beta-thalassemia and sickle cell anemia, which are the two most frequently found monogenic disorders in Antalya, Turkey. Three hundred and seventy-seven postnatal and 82 prenatal cases were studied between 2000 and
Michael T Lerch et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(19), E2437-E2446 (2015-04-29)
Application of hydrostatic pressure shifts protein conformational equilibria in a direction to reduce the volume of the system. A current view is that the volume reduction is dominated by elimination of voids or cavities in the protein interior via cavity
S W Hennessy et al.
The Journal of cell biology, 108(2), 729-736 (1989-02-01)
The nucleotide sequence of human thrombospondin (TS) mRNA has been determined from human fibroblast and endothelial cDNAs. The sequence of 5802 bp begins 110 bp upstream from the initiator codon and includes the entire 3' untranslated region (UTR) of the
Timothy D Howard et al.
Stroke, 36(9), 1848-1851 (2005-08-16)
Endothelial nitric oxide exerts a variety of protective effects on endothelial cells and blood vessels, and therefore the nitric oxide synthase 3 gene (NOS3) is a logical candidate gene for stroke susceptibility. We used the population-based Stroke Prevention in Young
J Chander et al.
Mycopathologia, 135(1), 9-12 (1996-01-01)
A total of 110 patients of symptomatic otomycosis was investigated, prospectively. Aural swabs were collected on 1st, 7th and 14th day and examined by direct microscopy and culture for fungi. Of these, 80 patients found to be having pure fungal
H J Klier et al.
European journal of biochemistry, 197(1), 23-28 (1991-04-10)
From a genomic library in EMBL 3, two overlapping clones for the human 46-kDa mannose 6-phosphate receptor (MPR46) were isolated, which span the entire coding sequence. The human MPR46 gene is distributed over 12 kb and is divided into seven
J Harsfalvi et al.
Biochimica et biophysica acta, 1073(2), 268-274 (1991-03-04)
Exhaustive extraction of human platelets with 6 M guanidine-HCl, and 5% beta-mercaptoethanol, followed by 5% SDS resulted in a sedimentable material which showed fibrous structure by transmission electron microscopy. When platelets treated with 8 M urea, 50 mM DTT and
Brittany L Kmush et al.
The American journal of tropical medicine and hygiene, 94(1), 203-211 (2015-12-02)
Hepatitis E virus (HEV) infection is severe during pregnancy, with a pregnant case fatality rate around 30%. In Bangladesh, plasma samples from 1,100 women during the first trimester (TM) and third TM of pregnancy and 3 months postpartum (PP) were
Shin-Yi Lin et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 118(7), 1154-1160 (2018-12-26)
Dabigatran is effective in preventing ischemic stroke and systemic embolism in patients with atrial fibrillation. Although the therapeutic window for dabigatran is wide, its pharmacokinetic properties can differ between specific populations. This study aimed to establish a real-life plasma dabigatran
D Nolte et al.
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 36(6), 331-337 (2004-12-14)
Molecular mechanisms regulating leukocyte sequestration into the tissue during endotoxemia and/or sepsis are still poorly understood. This in vivo study investigates the biological role of murine PECAM-1 and VCAM-1 for leukocyte sequestration into the lung, liver and striated skin muscle.
Kristina M Brooks et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67(2), 193-201 (2018-02-08)
Once-weekly isoniazid and rifapentine for 3 months is a treatment option in persons with human immunodeficiency virus and latent tuberculosis infection. This study aimed to examine pharmacokinetic drug-drug interactions between this regimen and dolutegravir, a first-line antiretroviral medication. This was
C H Pullin et al.
Journal of the American College of Cardiology, 38(7), 1799-1805 (2001-12-12)
We sought to study the effect of low-dose folic acid supplementation or optimization of dietary folate intake on plasma homocysteine and endothelial function in healthy adults. Elevated homocysteine is associated with cardiovascular disease, but it is not known whether this
W Tian et al.
Immunogenetics, 53(9), 724-728 (2002-02-28)
The human major histocompatibility complex (MHC) class I chain-related gene A ( MICA) is located 46 kb upstream of HLA-B and encodes a stress-inducible protein which displays a restricted pattern of tissue expression. MICA molecules interact with NKG2D, augmenting the
L Wang et al.
American journal of physiology. Cell physiology, 278(1), C73-C80 (2000-01-25)
Developmental changes in electrocardiogram (ECG) and response to selective K(+) channel blockers were assessed in conscious, unsedated neonatal (days 1, 7, 14) and adult male mice (>60 days of age). Mean sinus R-R interval decreased from 120 +/- 3 ms
Lene O Reuther et al.
European journal of clinical pharmacology, 59(11), 797-801 (2003-11-25)
To study the distribution of the thiopurine methyltransferase (TPMT) genotype among azathioprine (Aza)-tolerant and -intolerant patients with various disorders, and to investigate a possible relationship with the Aza metabolite levels. Forty-six Aza-tolerant and six Aza-intolerant patients had the TPMT genotype
Dominick J Angiolillo et al.
Journal of the American College of Cardiology, 63(15), 1500-1509 (2013-12-18)
The goal of this study was to evaluate the pharmacodynamic effects of switching patients from ticagrelor to prasugrel. Clinicians may need to switch between more potent P2Y12 inhibitors because of adverse effects or switch to the use of a once-daily
Anna Jouppila-Mättö et al.
Histology and histopathology, 26(4), 443-449 (2011-03-02)
Snail1, a key regulator of epithelial-mesenchymal transition (EMT), plays an important role in tumour progression. Previous studies of snail1 have mainly focused on the epithelial tumour cells. The objective of this study was to evaluate the expression of snail1 protein
Wojciech Rokita et al.
Ginekologia polska, 83(11), 822-826 (2013-02-06)
The aim of the study was to assess the diagnostic value of pap smears and detection of the p16 and Ki67 proteins in women with cervical intraepithelial neoplasia (CIN). 630 women, aged between 25 and 65, with abnormal pap smears
Andrew M Bellizzi
Histopathology, 76(2), 251-264 (2019-06-25)
Special AT-rich sequence-binding protein 2 (SATB2) is a transcriptional regulator with critical roles in brain, craniofacial and skeletal development. It has emerged as a key marker of lower gastrointestinal (GI) tract columnar epithelial and osteoblastic differentiation. Transcription factor immunohistochemistry is
Ophir Bar-On et al.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 14(1), 53-62 (2014-06-12)
Nontuberculous mycobacteria (NTM) are emerging infections in the CF population. To assess NTM infection prevalence and associated features in our CF clinic population. Patient records, 2002-2011, were reviewed for NTM infection. FEV1, pancreatic function, sputum microbiology, and serum cytokines were
U Roll et al.
Diabetologia, 37(11), 1132-1141 (1994-11-01)
To investigate the impact of diabetic mothers on the maturation of the immune system in their offspring, immunophenotypic markers of major lymphocyte subpopulations were evaluated by two-colour flow cytometric analysis in 160 healthy children of diabetic mothers (100 with insulin-dependent
E Meller et al.
The Journal of pharmacology and experimental therapeutics, 292(2), 684-691 (2000-01-20)
In hippocampal membranes, the selective 5-hydroxytryptamine (5-HT(1A)) receptor agonists 8-hydroxy-dipropylaminotetralin (8-OH-DPAT) and N,N-dipropyl-5-carboxamidotryptamine (N,N-DP-5-CT) stimulated guanosine-5'-O-(3-thio)triphosphate ([(35)S]GTPgammaS) binding by 130 to 140%; binding stimulated by nonselective agonists (5-HT and 5-CT) was approximately 30% greater. However, the selective 5-HT(1A) receptor antagonist
K Rajender Reddy et al.
The Lancet. Infectious diseases, 15(1), 27-35 (2014-12-09)
We did a phase 3 study in previous non-responders with chronic hepatitis C virus (HCV) genotype 1 infection and compensated liver disease that related to the standard of care for these patients at the time this study was initiated. We
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