111-34-2

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Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed.

Aida Oliván-Viguera et al.

Basic & clinical pharmacology & toxicology, 119(2), 184-192 (2016-01-29)

Opening of intermediate-conductance calcium-activated potassium channels (KC a 3.1) produces membrane hyperpolarization in the vascular endothelium. Here, we studied the ability of two new KC a 3.1-selective positive-gating modulators, SKA-111 and SKA-121, to (1) evoke porcine endothelial cell KC a

Indium 111-labeled J591 anti-PSMA antibody for vascular targeted imaging in progressive solid tumors.

Neeta Pandit-Taskar et al.

EJNMMI research, 5, 28-28 (2015-05-20)

J591 is a monoclonal antibody that targets the external domain of the prostate-specific membrane antigen (PSMA). Besides prostate cancer cells, it also targets the neovasculature of non-prostate solid tumors. We provide an analysis of the antibody mass-dose dependency of lesion

Probing the role of crystallographically defined/predicted hinge-bending regions in the substrate-induced global conformational transition and catalytic activation of human phenylalanine hydroxylase by single-site mutagenesis.

Anne Jorunn Stokka et al.

The Journal of biological chemistry, 279(25), 26571-26580 (2004-04-03)

Phenylalanine hydroxylase (PAH) is generally considered to undergo a large and reversible conformational transition upon l-Phe binding, which is closely linked to the substrate-induced catalytic activation of this hysteretic enzyme. Recently, several crystallographically solvent-exposed hinge-bending regions including residues 31-34, 111-117

Porcine aorta smooth-muscle myosin contains three species made of different combinations of two 17-kDa essential light-chain isoforms.

T Katoh et al.

European journal of biochemistry, 227(1-2), 459-465 (1995-01-15)

Porcine aorta myosin was reacted with a bifunctional cross-linking reagent, N,N'-o-phenylenedimaleimide. The 17-kDa essential light chain (LC17) in each myosin head was intramolecularly cross-linked within a single myosin molecule. The 34-kDa cross-linked LC17 dimer was isolated and its peptide map

Fabiola Olivieri et al.

Mechanisms of ageing and development, 133(11-12), 675-685 (2012-10-09)

Circulating microRNAs (miRs) have been investigated as diagnostic/prognostic biomarkers in human diseases. However, little is known about their expression throughout the aging process. Eleven healthy individuals aged 20, 80 and 100 years underwent miR plasma profiling. The validation cohort consisted

ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours.

S Vicent et al.

British journal of cancer, 90(5), 1047-1052 (2004-03-05)

Activation of the ERK1/2 pathway is involved in malignant transformation both in vitro and in vivo. Little is known about the role of activated ERK1/2 in non-small cell lung cancer (NSCLC). The purpose of this study was to characterise the

Six novel mutations in the proopiomelanocortin and melanocortin receptor 4 genes in severely obese adults living in southern Italy.

Pasqualina Buono et al.

Clinical chemistry, 51(8), 1358-1364 (2005-06-14)

The genetic characterization of obese individuals could clarify the molecular mechanisms underlying body weight regulation and lead to targeted therapy. Here we report variants of the proopiomelanocortin (POMC) and melanocortin receptor 4 (MC4R) genes detected in severely obese adults living

Melatonin attenuates the skin sympathetic nerve response to mental stress.

Matthew D Muller et al.

American journal of physiology. Heart and circulatory physiology, 305(9), H1382-H1386 (2013-09-03)

Melatonin attenuates muscle sympathetic nerve responses to sympathoexcitatory stimuli, but it is unknown whether melatonin similarly attenuates reflex changes in skin sympathetic nerve activity (SSNA). In this double-blind, placebo-controlled, crossover study, we tested the hypothesis that melatonin (3 mg) would

Ferrocenyl-modified DNA: synthesis, characterization and integration with semiconductor electrodes.

Andrew R Pike et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 11(1), 344-353 (2004-11-20)

The ferrocenyl-nucleoside, 5-ethynylferrocenyl-2'-deoxycytidine (1) has been prepared by Pd-catalyzed cross-coupling between ethynylferrocene and 5-iodo-2'-deoxycytidine and incorporated into oligonucleotides by using automated solid-phase synthesis at both silica supports (CPG) and modified single-crystal silicon electrodes. Analysis of DNA oligonucleotides prepared and cleaved

[Study of the role of nuclear factor-kappa B in preterm birth with subclinical chorioamnionitis].

Sui Yao et al.

Zhonghua fu chan ke za zhi, 43(9), 670-674 (2008-12-18)

To investigate the role of nuclear factor-kappa B (NF-kappaB) in preterm birth with subclinical chorioamnionitis. From October 2005 to October 2006, 111 cases including 36 cases of preterm birth in labor, 37 cases of full term gravida with spontaneous labor

Polymorphism C1114G of gene encoding the cardiac regulator of G-protein signaling 2 may be associated with number of episodes of neurally mediated syncope.

Malgorzata Lelonek et al.

Archives of medical research, 40(3), 191-195 (2009-05-12)

The cardiac regulator of G-protein signaling 2 (RGS2) negatively regulates G-protein-coupled receptor signaling. The C1114G polymorphism reduces RGS2 gene expression. This molecular disorder may be one of the important factors influencing progress of neurally mediated syncope. The aim of the

CASK aberrations in male patients with Ohtahara syndrome and cerebellar hypoplasia.

Hirotomo Saitsu et al.

Epilepsia, 53(8), 1441-1449 (2012-06-20)

Ohtahara syndrome (OS) is one of the most severe and earliest forms of epilepsy. STXBP1 and ARX mutations have been reported in patients with OS. In this study, we aimed to identify new genes involved in OS by copy number

Hypoxia inducible factor-1 alpha and carbonic anhydrase IX overexpression are associated with poor survival in breast cancer patients.

A O Kaya et al.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 17(4), 663-668 (2013-01-22)

Hypoxia is common in many solid tumors such as breast, head-neck, and soft tissue malignancies. Hypoxia causes overexpression of hypoxia inducible factor-1 alpha (HIF-1α) and carbonic anhydrase IX (CA IX) which are associated with unfavorable prognosis in breast cancer. In

Correlation between serum prostate-specific antigen and alpha-1-antitrypsin in men without and with prostate cancer.

Solo Kuvibidila et al.

The Journal of laboratory and clinical medicine, 147(4), 174-181 (2006-04-04)

Prostate specific antigen (PSA) is frequently used for prostate cancer (PCa) screening, but serum levels are also increased by prostate inflammation. Elevations in serum levels of alpha1-antitrypsin (ATT), a marker of inflammation, in cancer patients are well documented. However, an

Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene.

P Madeddu et al.

Circulation, 96(10), 3570-3578 (1997-12-13)

To evaluate the role of kinins in the regulation of cardiovascular function, we studied the phenotype of a mouse strain with disruption of the bradykinin B2-receptor gene (Bk 2r-/-). Under basal conditions, tail-cuff blood pressure was higher in Bk2r-/- than

Cardioprotective effect of an endothelin receptor antagonist during ischaemia/reperfusion in the severely atherosclerotic mouse heart.

Adrian T Gonon et al.

British journal of pharmacology, 144(6), 860-866 (2005-02-03)

1. Endothelin (ET) receptor antagonists are cardioprotective during myocardial ischaemia and reperfusion through a nitric oxide (NO)-dependent mechanism. The aim of the present study was to investigate whether the ET receptor antagonist, bosentan, is cardioprotective in atherosclerotic mice. 2. Buffer-perfused

Optimization and validation of a fast digestion method for the determination of major and trace elements in breast milk by ICP-MS.

Maria Luisa Astolfi et al.

Analytica chimica acta, 1040, 49-62 (2018-10-18)

Breast milk guarantees all the nutrients required by infants during their first few months of life and remains the most important food source for their health and growth. However, the mother may transfer potentially toxic chemicals to the suckling infant

Influence of the IL-1Ra gene polymorphism on in vivo synthesis of IL-1Ra and IL-1beta after live yellow fever vaccination.

U T Hacker et al.

Clinical and experimental immunology, 125(3), 465-469 (2001-09-05)

The inflammatory response in infectious and autoimmune diseases is regulated by the balance between pro- and anti-inflammatory cytokines. The IL-1 complex contains polymorphic genes coding for IL-1alpha, IL-1beta and IL-1Ra. The IL-1Ra (variable number of tanden repeat) VNTR polymorphism has

Paediatric autoimmune encephalopathies: clinical features, laboratory investigations and outcomes in patients with or without antibodies to known central nervous system autoantigens.

Yael Hacohen et al.

Journal of neurology, neurosurgery, and psychiatry, 84(7), 748-755 (2012-11-24)

To report the clinical and investigative features of children with a clinical diagnosis of probable autoimmune encephalopathy, both with and without antibodies to central nervous system antigens. Patients with encephalopathy plus one or more of neuropsychiatric symptoms, seizures, movement disorder

The effects of particulate matter on inflammation of respiratory system: Differences between male and female.

Kelly Yoshizaki et al.

The Science of the total environment, 586, 284-295 (2017-02-09)

Air pollution is known to exacerbate respiratory diseases and epidemiological studies have shown that women present more chronic respiratory symptoms than man exposed to traffic pollution, however, the reason why is unclear. This study evaluated the inflammatory differences in BALB/c

Immunohistochemical expression of SPARC is correlated with recurrence, survival and malignant potential in meningiomas.

Suheyla Uyar Bozkurt et al.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 117(9), 651-659 (2009-08-26)

Meningioma is a common neoplasm that constitutes almost 30% of all primary central nervous system tumors and is associated with inconsistent clinical outcomes. The extracellular matrix proteins play a crucial role in meningioma cell biology and are important in tumor

Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group.

Louis Guillou et al.

The American journal of surgical pathology, 31(9), 1387-1402 (2007-08-28)

Low-grade fibromyxoid sarcomas (LGFMS) bear either the t(7,16) (q32-34;p11) or t(11,16) (p11;p11) translocations, resulting in FUS-CREB3L2 or FUS-CREB3L1 fusions, respectively. Heretofore, fusion transcripts were mainly detected in frozen tissues, using reverse transcription-polymerase chain reaction. In this study, we aimed to

Network pharmacology, molecular docking integrated surface plasmon resonance technology reveals the mechanism of Toujie Quwen Granules against coronavirus disease 2019 pneumonia.

Miaobo Ye et al.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 85, 153401-153401 (2020-11-17)

The Coronavirus disease 2019 pneumonia broke out in 2019 (COVID-19) and spread rapidly, which causes serious harm to the health of people and a huge economic burden around the world. In this study, the network pharmacology, molecular docking and surface

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