111-39-7

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Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer.

Francesca Molinari et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 17(14), 4901-4914 (2011-06-03)

KRAS mutations represent the main cause of resistance to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MoAbs) in metastatic colorectal cancer (mCRC). We evaluated whether highly sensitive methods for KRAS investigation improve the accuracy of predictions of anti-EGFR MoAbs efficacy.

Observation of Clinicopathologic Features of Pituitary Adenoma With Neuronal Differentiation.

Limei Zheng et al.

Frontiers in endocrinology, 13, 848762-848762 (2022-04-05)

To investigate the clinicopathologic features of pituitary adenoma with neuronal differentiation. Four patients with mixed gangliocytoma-pituitary adenomas between January 2011 and January 2021 and 111 new-onset patients with adenomas between January 2019 and June 2021 who attended the First Affiliated

Imaging findings of hepatic focal nodular hyperplasia in men and women: are they really different?

Tommaso Vincenzo Bartolotta et al.

La Radiologia medica, 119(4), 222-230 (2013-12-04)

This study was undertaken to compare the imaging findings of focal nodular hyperplasia (FNH) in men and women, as seen on multidetector computed tomography (MDCT), magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS). Two radiologists reviewed 195 imaging studies (17

Phylogeny, Prevalence, and Shiga Toxin (Stx) Production of Clinical Escherichia coli O157 Clade 2 Strains Isolated in Shimane Prefecture, Japan.

Jun Kawase et al.

Current microbiology, 78(1), 265-273 (2020-10-24)

This study investigated the genetic and pathogenic variation of the subgroups of clade 2 strains of Shiga toxin (Stx)-producing Escherichia coli (STEC) O157. A total of 111 strains of STEC O157 isolated in Shimane prefecture, Japan, were classified in clade

Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer.

Mohammad Obaidul Hoque et al.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 5(12), 1887-1893 (2010-11-26)

Prognosis for patients with non-small cell lung cancer (NSCLC) is poor. The potential value of modulating epidermal growth factor receptor (EGFR) for treatment is reflected by the recent approval of specific drugs that inhibit its activity. Mutations in EGFR were

Study of the use of antidepressants for depression in dementia: the HTA-SADD trial--a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine.

S Banerjee et al.

Health technology assessment (Winchester, England), 17(7), 1-166 (2013-02-27)

Depression is common in dementia, causing considerable distress and other negative impacts. Treating it is a clinical priority, but the evidence base is sparse and equivocal. This trial aimed to determine clinical effectiveness of sertraline and mirtazapine in reducing depression

Structure of the gene for the F allele of complement receptor type 1 and sequence of the coding region unique to the S allele.

D P Vik et al.

Journal of immunology (Baltimore, Md. : 1950), 151(11), 6214-6224 (1993-12-01)

The genes for human complement receptor type 1 (CR1) F and S alleles have been cloned and span a region of 133-160 kb on chromosome 1. The F allele was found to comprise 39 exons and the S allele contains

Paraoxonase 1 (PON1) 55 polymorphism, lipid profiles and psoriasis.

M Asefi et al.

The British journal of dermatology, 167(6), 1279-1286 (2012-07-28)

Paraoxonase 1 (PON1) is a serum high-density lipoprotein-bound enzyme with antioxidant function. It hydrolyses lipid peroxides, protecting low-density lipoproteins from oxidative modifications. Patients with psoriasis are at greater risk of oxidative stress, which is associated with abnormal plasma lipid metabolism.

PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial.

Frederick J Raal et al.

Lancet (London, England), 385(9965), 331-340 (2014-10-06)

Heterozygous familial hypercholesterolaemia is characterised by low cellular uptake of LDL cholesterol, increased plasma LDL cholesterol concentrations, and premature cardiovascular disease. Despite intensive statin therapy, with or without ezetimibe, many patients are unable to achieve recommended target levels of LDL

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