111-76-2

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关键词:'111-76-2'

显示 1-17 共 17 条结果关于 "111-76-2" 范围论文

In the search for new anticancer drugs. XXIV: Synthesis and anticancer activity of amino acids and dipeptides containing the 2-chloroethyl- and [N'-(2-chloroethyl)-N'-nitroso]-aminocarbonyl groups.

G Sosnovsky et al.

Journal of pharmaceutical sciences, 82(1), 1-10 (1993-01-01)

A series of L,L- (42, 44, 46, and 60) and D,D- (43, 45, 47, and 61) dipeptide derivatives composed of phenylglycine, phenylalanine, homophenylalanine, and valine and containing a 2-chloroethylamino group at the C-terminus and an N'-(2-chloroethyl)-N'-nitroso-aminocarbonyl group at the N-terminus

Calsequestrin 2 deletion shortens the refractoriness of Ca²⁺ release and reduces rate-dependent Ca²⁺-alternans in intact mouse hearts.

Dmytro Kornyeyev et al.

Journal of molecular and cellular cardiology, 52(1), 21-31 (2011-10-11)

Calsequestrin (Casq2) is a low affinity Ca(2+)-binding protein located in sarcoplasmic reticulum (SR) of cardiac myocytes. Casq2 acts as a Ca(2+) buffer regulating free Ca(2+) concentration in the SR lumen and plays a significant role in the regulation of Ca(2+)

Longitudinal CSF proteomics identifies NPTX2 as a prognostic biomarker of Alzheimer's disease.

Ondrej Libiger et al.

Alzheimer's & dementia : the journal of the Alzheimer's Association, 17(12), 1976-1987 (2021-05-14)

Biomarkers that reflect pathologic processes affecting neuronal function during preclinical and early stages of Alzheimer's disease (AD) are needed to aid drug development. A targeted, stable isotope, quantitative mass spectrometry-based investigation of longitudinal changes in concentrations of previously identified candidate

Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.

L M Obeid et al.

The Journal of biological chemistry, 267(29), 20804-20810 (1992-10-15)

The expression of the beta isoenzyme for protein kinase C is regulated developmentally and in response to inducers of cell differentiation (such as phorbol esters and 1 alpha,25-dihydroxyvitamin D3). The 5' segment of the gene for protein kinase C beta

[The risk of hemorrhage in long-term use of aspirin and triflusal].

J Alvarez Sabín et al.

Revista de neurologia, 27(160), 951-955 (1999-02-10)

Different studies have shown that aspirin (AAS), in low doses, may lead to a considerable frequency of hemorrhagic complications when used in the long term. We compare the long-term occurrence of hemorrhagic complications with low doses of AAS and high

Association of CYP2A6 deletion polymorphism with smoking habit and development of pulmonary emphysema.

N Minematsu et al.

Thorax, 58(7), 623-628 (2003-07-02)

Nicotine is responsible for smoking dependence and is mainly metabolised by CYP2A6. Several types of genetic polymorphism of CYP2A6 have been reported, but their relation to smoking habit and chronic obstructive pulmonary disease (COPD) phenotypes has not been fully clarified.

The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families.

Rogier A Oldenburg et al.

Cancer research, 63(23), 8153-8157 (2003-12-18)

The frame-shifting mutation 1100delC in the cell-cycle-checkpoint kinase 2 gene (CHEK2) has been reported to be associated with familial breast cancer in families in which mutations in BRCA1 and BRCA2 were excluded. To investigate the role of this variant as

Performance of cystatin C-based equations in a pediatric cohort at high risk of kidney injury.

Edward J Nehus et al.

Pediatric nephrology (Berlin, Germany), 28(3), 453-461 (2012-11-13)

Limited data exist on the performance of cystatin C-based glomerular filtration rate (GFR) equations in pediatric transplant recipients and other high-risk patients. The aim of our study was therefore to evaluate the performance of current cystatin C-based equations in this

Clinical evaluation of pediatric ethylene glycol monobutyl ether poisonings.

B S Dean et al.

Journal of toxicology. Clinical toxicology, 30(4), 557-563 (1992-01-01)

Ethylene glycol butyl ether, CAS 111-76-2, an ingredient in many popular commercial window/glass cleaners, is known to produce equal if not greater toxicity than ethylene glycol when administered to animals. Treatment recommendations for human poisonings are based upon animal data

Pretargeted Radioimmunotherapy of Prostate Cancer with an Anti-TROP-2×Anti-HSG Bispecific Antibody and a (177)Lu-Labeled Peptide.

Catharina M van Rij et al.

Cancer biotherapy & radiopharmaceuticals, 29(8), 323-329 (2014-09-17)

TROP-2 is a pancarcinoma marker that is expressed at high levels in many epithelial cancers, including prostate cancer (PC). The trivalent bispecific antibody TF12 (anti-TROP2 × anti-HSG [histamine-succinyl-glycine]) has shown to effectively target PC. In this study, the efficacy of

[A probe for evaluating the role of HLA class II antigens coded with the DRB gene in etiopathogenesis of familial sarcoidosis in Poland using the K-nearest neighbor experimental statistical method].

A Goljan et al.

Pneumonologia i alergologia polska, 68(11-12), 545-556 (2001-04-26)

The aim of this study was evaluation of the significance of HLA-DRB1,-DRB3,-DRB4,-DRB5 associated alleles in the genetic susceptibility to sarcoidosis. We investigated 17 Polish 'families with' familial occurrence of the disease. Thirty three affected family members and 78 healthy relatives

Lipocalin 2 expression is associated with aggressive features of endometrial cancer.

Monica Mannelqvist et al.

BMC cancer, 12, 169-169 (2012-05-09)

Increased expression of lipocalin 2 (LCN2) has been observed in several cancers. The aim of the present study was to investigate LCN2 in endometrial cancer in relation to clinico-pathologic phenotype, angiogenesis, markers of epithelial-mesenchymal transition (EMT), and patient survival. Immunohistochemical

Oral vanoxerine prevents reinduction of atrial tachyarrhythmias: preliminary results.

Ivan Cakulev et al.

Journal of cardiovascular electrophysiology, 22(11), 1266-1273 (2011-05-28)

Vanoxerine is a promising, new, investigational antiarrhythmic drug. The purpose of this study was to test the hypothesis that oral dosing of vanoxerine would first terminate induced atrial flutter (AFL) and atrial fibrillation (AF), and then prevent their reinduction. In

Site-specific radiometal labeling and improved biodistribution using ABY-027, a novel HER2-targeting affibody molecule-albumin-binding domain fusion protein.

Anna Orlova et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(6), 961-968 (2013-03-27)

Because of their better penetration, smaller targeting proteins may be superior to antibodies for radioimmunotherapy of solid tumors. Therefore, Affibody molecules (6.5 kDa) have a potential for being suitable as targeted moiety for radiolabeled therapeutic proteins. Previous studies have demonstrated

[The androgen receptor gene polymorphism and clinical picture of androgen deficiency syndrome during aging male of men's population in Wroclaw].

Anna Trzmiel-Bira et al.

Endokrynologia Polska, 60(5), 370-378 (2009-11-04)

One of the changes observed in the ageing process is the progressive reduction in androgen levels, which may be associated with the development of the clinical syndrome of androgen deficiency. The androgen receptor gene polymorphism may also contribute to the

Calcium-channel blocker-clarithromycin drug interactions and acute kidney injury.

Sonja Gandhi et al.

JAMA, 310(23), 2544-2553 (2013-12-19)

Calcium-channel blockers are metabolized by the cytochrome P450 3A4 (CYP3A4; EC 1.14.13.97) enzyme. Blood concentrations of these drugs may rise to harmful levels when CYP3A4 activity is inhibited. Clarithromycin is an inhibitor of CYP3A4 and azithromycin is not, which makes

Everolimus for subependymal giant cell astrocytoma in patients with tuberous sclerosis complex: 2-year open-label extension of the randomised EXIST-1 study.

David Neal Franz et al.

The Lancet. Oncology, 15(13), 1513-1520 (2014-12-03)

In the EXIST-1 trial, initiated on Aug 10, 2009, more than 35% of patients with subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex had at least 50% reduction in SEGA volume after 9·6 months of treatment with everolimus.

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