112-24-3

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[The effect of cyclin kinase inhibitor p27 on tumor necrosis factor-alpha induced mesangial cell proliferation].

Xiaobin Mei et al.

Zhonghua nei ke za zhi, 41(9), 599-601 (2002-11-08)

To investigate the role of cyclin kinase inhibitor p27 on proliferation of mesangial cell (MC) induced by tumor necrosis factor-alpha (TNF-alpha). p27 protein of MC lysate was detected with Western blotting analysis. The degree of MC proliferation was estimated through

Direct interaction and cooperative role of tumor suppressor p16 with band 3 (AE1).

Guo-Hui Fu et al.

FEBS letters, 579(10), 2105-2110 (2005-04-07)

By using the C-terminal 112-residue of band 3 to screen the K562 cDNA library, we find that the p16 interacts with band 3, which was confirmed both in yeast and in mammalian cells. Functional experiments show that p16 facilitates the

The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder.

Bradley N Smith et al.

European journal of human genetics : EJHG, 21(1), 102-108 (2012-06-14)

A massive hexanucleotide repeat expansion mutation (HREM) in C9ORF72 has recently been linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we describe the frequency, origin and stability of this mutation in ALS+/-FTD from five European cohorts (total

Alternative antiandrogen therapy in patients with castration-resistant prostate cancer: a single-center experience.

Takatsugu Okegawa et al.

International journal of urology : official journal of the Japanese Urological Association, 17(11), 950-955 (2010-09-03)

Outcomes of alternative (second-line) antiandrogen therapy in 112 patients with relapsing prostate cancer after first-line hormonal therapy were analyzed. A good response (prostate-specific antigen [PSA] decrease 50%) and a partial response (PSA decrease of 0–50%) by switching from bicalutamide (BCL)

Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1.

Meghan L Rudd et al.

BMC cancer, 14, 884-884 (2014-11-28)

Endometrial cancer (EC) is the 8th leading cause of cancer death amongst American women. Most ECs are endometrioid, serous, or clear cell carcinomas, or an admixture of histologies. Serous and clear ECs are clinically aggressive tumors for which alternative therapeutic

Polymorphism of angiotensin converting enzyme, angiotensinogen, and angiotensin II type 1 receptor genes and end-stage renal failure in IgA nephropathy: IGARAS--a study of 274 Men.

L Frimat et al.

Journal of the American Society of Nephrology : JASN, 11(11), 2062-2067 (2000-10-29)

The impact of renin-angiotensin system (RAS) gene polymorphism on the prognosis of IgA nephropathy (IgAN) is still debated. A longitudinal study of renal prognosis in patients with IgAN was conducted to search retrospectively for a genotype-phenotype association between RAS polymorphisms

Human platelet antigens polymorphisms and susceptibility of thrombosis in hemodialysis patients.

Yousr Gorgi et al.

Hemodialysis international. International Symposium on Home Hemodialysis, 12(3), 331-335 (2008-07-22)

To investigate the association between the polymorphisms of human platelet antigen (HPA)-1,2,3,4,5 and susceptibility to develop thrombosis accident in arteriovenous fistula (AVF), genomic DNA of 112 hemodialysis (HD) patients and 100 healthy blood donors were genotyped by PCR-SSP. The patients

Conventional (clear cell) renal carcinoma metastases have greater bcl-2 expression than high-risk primary tumors.

Cheryl T Lee et al.

Urologic oncology, 21(3), 179-184 (2003-06-18)

Bcl-2 antagonizes p53-induced apoptosis and may contribute to chemoresistance. In renal cell carcinoma (RCC), the role of bcl-2 is not well-defined, though its expression is reportedly low in primary tumors and lacks prognostic value. This study evaluates patterns of bcl-2

Endothelin-1 attenuates apoptosis in cultured trophoblasts from term human placentas.

M Cervar-Zivkovic et al.

Reproductive sciences (Thousand Oaks, Calif.), 14(5), 430-439 (2007-10-05)

The authors test the hypothesis that endothelin-1 (ET-1) modulates apoptosis in human term trophoblasts. Primary cultures of cytotrophoblasts from term human placentas (n = 5) were cultured for 16 hours total or 24 hours prior to harvest at 72 hours

Mechanical ventilation induces brainstem inflammation in preterm fetal sheep.

Kayla Vidinopoulos et al.

Frontiers in pediatrics, 11, 1225294-1225294 (2023-11-08)

Preterm infants have immature respiratory drive and often require prolonged periods of mechanical ventilation. Prolonged mechanical ventilation induces systemic inflammation resulting in ventilation-induced brain injury, however its effect on brainstem respiratory centers is unknown. We aimed to determine the effects

C-reactive protein is a negative independent factor in patients with stage IV colorectal cancer undergoing oxaliplatin-based chemotherapy.

Minoru Fukuchi et al.

Anticancer research, 33(11), 5051-5055 (2013-11-14)

To determine the clinical significance of C-reactive protein (CRP) concentration in patients with stage IV colorectal cancer (CRC) undergoing oxaliplatin-based chemotherapy. We retrospectively reviewed the medical charts of 112 patients with stage IV CRC who had received modified FOLFOX6 (5-fluorouracil

Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats.

Ruth M Barrientos et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(42), 14641-14648 (2012-10-19)

To investigate the role of the pro-inflammatory cytokine interleukin-1β (IL-1β) in postoperative cognitive dysfunction (POCD) in aged rats, we used laparotomy to mimic human abdominal surgery in adult (3 months) and aged (24 months) F344/BN rats. We demonstrated that memory

Identification of novel functional sequence variants in the gene for peptidase inhibitor 3.

Mahboob A Chowdhury et al.

BMC medical genetics, 7, 49-49 (2006-05-25)

Peptidase inhibitor 3 (PI3) inhibits neutrophil elastase and proteinase-3, and has a potential role in skin and lung diseases as well as in cancer. Genome-wide expression profiling of chorioamniotic membranes revealed decreased expression of PI3 in women with preterm premature

Cleavage speed and implantation potential of early-cleavage embryos in IVF or ICSI cycles.

Meng-Ju Lee et al.

Journal of assisted reproduction and genetics, 29(8), 745-750 (2012-07-25)

We examined whether there is a correlation among early embryo cleavage, speed of cleavage, and implantation potential for in-vitro fertilization (IVF) treatment and intracytoplasmic sperm injection (ICSI). This retrospective study examined 112 cycles of IVF and 82 cycles of ICSI

Optimising cell temperature and dispersion field strength for the screening for putrescine and cadaverine with thermal desorption-gas chromatography-differential mobility spectrometry.

M Ali Awan et al.

Analytica chimica acta, 611(2), 226-232 (2008-03-11)

Biogenic amines, and putrescine and cadaverine in particular, have significant importance in the area of food quality monitoring, and are also potentially important markers of infection, for cancer, diabetes, arthritis and cystic fibrosis. A thermal desorption-gas chromatograph-heated differential mobility spectrometer

Long-term azithromycin for Indigenous children with non-cystic-fibrosis bronchiectasis or chronic suppurative lung disease (Bronchiectasis Intervention Study): a multicentre, double-blind, randomised controlled trial.

Patricia C Valery et al.

The Lancet. Respiratory medicine, 1(8), 610-620 (2014-01-28)

Indigenous children in high-income countries have a heavy burden of bronchiectasis unrelated to cystic fibrosis. We aimed to establish whether long-term azithromycin reduced pulmonary exacerbations in Indigenous children with non-cystic-fibrosis bronchiectasis or chronic suppurative lung disease. Between Nov 12, 2008

An insertion/deletion TEX28 polymorphism and its application to analysis of red/green visual pigment gene arrays.

Hisao Ueyama et al.

Journal of human genetics, 49(10), 548-557 (2004-09-21)

TEX28 gene (fTEX) is present immediately downstream of the red/green visual pigment gene array on the human X chromosome. Its pseudogene (pTEX) that lacks exon 1 is present within the array between pigment genes. We found that both fTEX and

Kinetic analysis shows that iron deficiency decreases liver vitamin A mobilization in rats.

J T Jang et al.

The Journal of nutrition, 130(5), 1291-1296 (2000-05-10)

In view of evidence that nutritional status of iron and vitamin A may affect the other nutrient's metabolism, we used model-based compartmental analysis to examine effects of iron deficiency on whole-body vitamin A dynamics in rats. Weanling male Sprague-Dawley rats

Penetration and cytotoxicity of a bleaching gel activated by LED/laser in restored teeth.

Sibelli Parreiras et al.

American journal of dentistry, 27(6), 301-306 (2015-02-25)

To evaluate the amount of hydrogen peroxide (HP) in the pulp chamber of teeth restored with composite resin and its cytotoxic effect on fibroblast cell line 3T3/NIH. 112 human premolars were randomized into groups according to the combination of factors:

Few associations of candidate genes with nonsyndromic orofacial clefts in the population of Lithuania.

Ausra Morkūniené et al.

Journal of applied genetics, 48(1), 89-91 (2007-02-03)

Nonsyndromic orofacial clefting (NS-OFC) is a common complex multifactorial trait with a considerable genetic component and a number of candidate genes suggested by various approaches. Twenty biallelic and microsatellite DNA markers in the strong candidate loci TGFA, TGFB3, GABRB3, RARA

Electrospun core-shell nanofibers as an adsorbent for on-line micro-solid phase extraction of monohydroxy derivatives of polycyclic aromatic hydrocarbons from human urine, and their quantitation by LC-MS.

Dan Chen et al.

Mikrochimica acta, 187(1), 57-57 (2019-12-19)

A method is described for automatted on-line micro-solid phase extraction using polydopamine-modified polystyrene/silica electrospun nanofibers as an adsorbent for monohydroxy metabolites of polycyclic aromatic hydrocarbons (OH-PAHs). They were then quantified by liquid chromatography-mass spectrometry. The sorbent has a network structure

Repeated intravenous doxapram induces phrenic motor facilitation.

M S Sandhu et al.

Experimental neurology, 250, 108-115 (2013-09-10)

Doxapram is a respiratory stimulant used to treat hypoventilation. Here we investigated whether doxapram could also trigger respiratory neuroplasticity. Specifically, we hypothesized that intermittent delivery of doxapram at low doses would lead to long-lasting increases (i.e., facilitation) of phrenic motor

MAP0004, orally inhaled dihydroergotamine for acute treatment of migraine: efficacy of early and late treatments.

Stewart J Tepper et al.

Mayo Clinic proceedings, 86(10), 948-955 (2011-10-04)

To evaluate the efficacy of MAP0004, an orally inhaled dihydroergotamine, for acute treatment of migraine when administered at various time points from within 1 hour to more than 8 hours after migraine onset. This post hoc subanalysis was conducted using

Altrenogest treatment during late pregnancy did not reduce colostrum yield in primiparous sows.

A Foisnet et al.

Journal of animal science, 88(5), 1684-1693 (2010-02-02)

The decrease in circulating concentrations of progesterone is the lactogenic trigger in many species. The aim of the present study was to determine the effect of an orally active progestogen, altrenogest, administered in late gestation, on lactogenesis in sows. Gilts

Chronic Intermittent Mild Whole-Body Hypothermia Is Therapeutic in a Mouse Model of ALS.

Lee J Martin et al.

Cells, 10(2) (2021-02-10)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes motor neuron degeneration. There are no cures or effective treatments for ALS. Therapeutic hypothermia is effectively used clinically to mitigate mortality in patients with acute acquired brain injury and

MALDI-TOF mass spectrometry screening of cholelithiasis risk markers in the gene of HNF1alpha.

Dominique Richter et al.

Journal of proteomics, 75(12), 3386-3399 (2012-05-10)

In recent years MALDI-TOF MS gained importance for high-throughput DNA analysis. In the present study this technique was used for the pathogenetic analysis of gallstone disease. The intestinal apical sodium-dependent bile acid transporter (ASBT) shows a genetic association with gallstone

The functional role of hemojuvelin in acute ischemic stroke.

Guang-Huar Young et al.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 40(6), 1316-1327 (2019-07-17)

Our study aimed to establish the role of hemojuvelin (HJV) in acute ischemic stroke (AIS). We performed immunohistochemistry for HJV expression in human brain tissues from 10 AIS and 2 non-stroke autopsy subjects. Plasma HJV was measured in 112 AIS

Characterization of unique DNA-binding and transcriptional-activation functions in the carboxyl-terminal extension of the zinc finger region in the human vitamin D receptor.

J C Hsieh et al.

Biochemistry, 38(49), 16347-16358 (1999-12-10)

The vitamin D receptor (VDR) binds 1,25-dihydroxyvitamin D(3) and mediates its actions on gene transcription by heterodimerizing with retinoid X receptors (RXRs) on direct repeat (DR+3) vitamin D responsive elements (VDREs) located in target genes. The VDRE binding function of

Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma.

Ute Gabriel et al.

Oncology reports, 20(6), 1419-1423 (2008-11-21)

We report on cytotoxic effects of bcl-2 and bcl-xL antisense-oligodeoxynucleotides (AS-ODNs) in benign urothelial and transitional cell carcinoma (TCC) cell lines. The benign urothelial cell line (UROtsa) and four TCC cell lines (UM-UC-3, RT 112 , HT 1197 and T

Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells.

Linlong Wang et al.

Journal of applied toxicology : JAT, 34(8), 870-877 (2013-07-03)

Quinolones have been reported to induce adverse effects on articular cartilage, tendons and ligaments. However, the effects of quinolones on menisci have not been revealed. The present study was to test the effects of levofloxacin on meniscus cells in vitro.

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