112003

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Hippuric acid test using 13C-labelling and NMR spectroscopy.

K Akira et al.

Clinical chemistry and laboratory medicine, 39(3), 215-217 (2001-05-15)

This article describes a 13C-labelling and nuclear magnetic resonance approach for hippuric acid test which is potentially useful for evaluating liver reserve. In this approach, urine samples collected after ingestion of 13C-labelled benzoic acid were directly analysed by 13C nuclear

A wide-targeted urinary and serum metabolomics strategy reveals the effective substance of the Wu-tou decoction.

Xiaoxu Cheng et al.

Journal of separation science, 43(4), 727-735 (2019-11-26)

As an important Chinese medicine decoction, Wu-tou decoction has been used to treat rheumatic arthritis for more than a thousand years. We previously reported that the Wu-tou decoction could change the urinary and serum metabolites in adjuvant-induced arthritis rats significantly.

Hippuric acid nanocomposite enhances doxorubicin and oxaliplatin-induced cytotoxicity in MDA-MB231, MCF-7 and Caco2 cell lines.

Samer Hasan Hussein Al Ali et al.

Drug design, development and therapy, 7, 25-31 (2013-01-25)

The aim of the current study is to design a new nanocomposite for inducing cytotoxicity of doxorubicin and oxaliplatin toward MDA-MB231, MCF-7, and Caco2 cell lines. A hippuric acid (HA) zinc layered hydroxide (ZLH) nanocomposite was synthesized under an aqueous

Midostaurin, a Novel Protein Kinase Inhibitor for the Treatment of Acute Myelogenous Leukemia: Insights from Human Absorption, Metabolism, and Excretion Studies of a BDDCS II Drug.

Handan He et al.

Drug metabolism and disposition: the biological fate of chemicals, 45(5), 540-555 (2017-03-09)

The absorption, metabolism, and excretion of midostaurin, a potent class III tyrosine protein kinase inhibitor for acute myelogenous leukemia, were evaluated in healthy subjects. A microemulsion formulation was chosen to optimize absorption. After a 50-mg [

Retention and effective diffusion of model metabolites on porous graphitic carbon.

Daniel B Lunn et al.

Journal of chromatography. A, 1530, 112-119 (2017-11-22)

The study of metabolites in biological samples is of high interest for a wide range of biological and pharmaceutical applications. Reversed phase liquid chromatography is a common technique used for the separation of metabolites, but it provides little retention for

Ammonium Fluoride as Suitable Additive for HILIC-Based LC-HRMS Metabolomics.

Luca Narduzzi et al.

Metabolites, 9(12) (2019-12-01)

Hydrophilic Interaction Liquid Chromatography (HILIC) chromatography is widely applied in metabolomics as a complementary strategy to reverse phase chromatography. Nevertheless, it still faces several issues in terms of peak shape and compounds ionization, limiting the automatic de-convolution and data semi-quantification

Dietary supplementation with cocoa flavanols does not alter colon tissue profiles of native flavanols and their microbial metabolites established during habitual dietary exposure in C57BL/6J mice.

Katheryn M Goodrich et al.

Journal of agricultural and food chemistry, 62(46), 11190-11199 (2014-10-23)

Metabolism of flavanols (catechins, procyanidins) by gut microbiota has been extensively characterized. Comparatively little is known about accumulation of flavanols and their metabolites in the colon tissues, particularly during chronic exposure to low doses. Mice were fed low doses of

Application of novel solid phase extraction-NMR protocols for metabolic profiling of human urine.

Daniel McGill et al.

Faraday discussions, 218(0), 395-416 (2019-05-23)

Metabolite identification and annotation procedures are necessary for the discovery of biomarkers indicative of phenotypes or disease states, but these processes can be bottlenecked by the sheer complexity of biofluids containing thousands of different compounds. Here we describe low-cost novel

Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis.

Lindsey E Romick-Rosendale et al.

Arthritis research & therapy, 13(6), R199-R199 (2011-12-14)

Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease, and kidney involvement with SLE, a.k.a. lupus nephritis (LN), is a frequent and severe complication of SLE that increases patient morbidity and mortality. About 50% of patients with SLE

Quantitative analysis for organic acids in biological samples: batch isolation followed by gas chromatographic-mass spectrometric analysis.

G Hoffmann et al.

Clinical chemistry, 35(4), 587-595 (1989-04-01)

This new method for qualitative and quantitative determination of organic acids, aldehydes, and ketones in biological samples is effective for use with urine, plasma, and amniotic fluid, and it requires no deproteinization. Isolation by batch-wise liquid partition chromatography on silicic

A method using angiotensin converting enzyme immobilized on magnetic beads for inhibitor screening.

Weiwei Tang et al.

Journal of pharmaceutical and biomedical analysis, 164, 223-230 (2018-11-06)

Angiotensin converting enzyme (ACE), fusing with FLAG tag, was overexpressed in human embryonic kidney 293T cells. This recombinant FLAG-tagged ACE was immobilized on anti-FLAG antibody coated magnetic beads by affinity method in crude cell lysate for the first time. The

Isolation, purification and molecular mechanism of a peanut protein-derived ACE-inhibitory peptide.

Aimin Shi et al.

PloS one, 9(10), e111188-e111188 (2014-10-28)

Although a number of bioactive peptides are capable of angiotensin I-converting enzyme (ACE) inhibitory effects, little is known regarding the mechanism of peanut peptides using molecular simulation. The aim of this study was to obtain ACE inhibiting peptide from peanut

Edible nuts deliver polyphenols and their transformation products to the large intestine: An in vitro fermentation model combining targeted/untargeted metabolomics.

Gabriele Rocchetti et al.

Food research international (Ottawa, Ont.), 116, 786-794 (2019-02-06)

The fate of polyphenols from edible tree nuts was investigated using a simulated in vitro intestinal fermentation system. The digested food matrix was fermented for 48 h and the changes in the phenolic profiles were evaluated by both untargeted UHPLC-QTOF and

Pharmacokinetic study of multiple active constituents after oral gavage of Guizhi decoction in rats using a LC-MS/MS method.

Yingrong Chen et al.

European journal of drug metabolism and pharmacokinetics, 38(4), 283-293 (2013-02-23)

Guizhi decoction (GZD) is a classic traditional Chinese medicine formula, clinically used for the treatment of influenza, common cold, and other pyretic conditions. A sensitive, specific, and validated liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed to investigate the pharmacokinetic

Sinapic acid prevents hypertension and cardiovascular remodeling in pharmacological model of nitric oxide inhibited rats.

Thangarasu Silambarasan et al.

PloS one, 9(12), e115682-e115682 (2014-12-23)

Hypertensive heart disease is a constellation of abnormalities that includes cardiac fibrosis in response to elevated blood pressure, systolic and diastolic dysfunction. The present study was undertaken to examine the effect of sinapic acid on high blood pressure and cardiovascular

Comparative study of Mg/Al- and Zn/Al-layered double hydroxide-perindopril erbumine nanocomposites for inhibition of angiotensin-converting enzyme.

Samer Hasan Hussein Al Ali et al.

International journal of nanomedicine, 7, 4251-4262 (2012-08-21)

The intercalation of a drug active, perindopril, into Mg/Al-layered double hydroxide for the formation of a new nanocomposite, PMAE, was accomplished using a simple ion exchange technique. A relatively high loading percentage of perindopril of about 36.5% (w/w) indicates that

Urinary metabolomics study on the anti-inflammation effects of flavonoids obtained from Glycyrrhiza.

Mengying Wei et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1086, 1-10 (2018-04-15)

Rheumatoid arthritis (RA) is a chronic disease with pain, swelling, and limitation in the motion and function of multiple joints thus leading to high disability. Previous studies have shown that flavonoids and saponins are the most abundant and active constituents

Influence of Food Matrix on the Bioaccessibility of Fruit Polyphenolic Compounds.

Tomasz Tarko et al.

Journal of agricultural and food chemistry, 68(5), 1315-1325 (2020-01-09)

This study examined the bioaccessibility of polyphenolic compounds originating directly from fruits or from fruit extracts during their digestion conducted in a simulated human digestive tract. The results demonstrated that polyphenols bound to the food matrix are less bioavailable, but

Identification of new urinary gamma-hydroxybutyric acid markers applying untargeted metabolomics analysis following placebo-controlled administration to humans.

Andrea E Steuer et al.

Drug testing and analysis, 11(6), 813-823 (2018-12-15)

Gamma-hydroxybutyrate (GHB) is a short-chain fatty acid that occurs naturally in the mammalian brain and is prescribed as a medication against narcolepsy or used as a drug of abuse. Particularly, its use as a knock-out drug in cases of drug-facilitated

Mechanisms of Metabolism Interaction Between p-Cresol and Mycophenolic Acid.

Yan Rong et al.

Toxicological sciences : an official journal of the Society of Toxicology, 173(2), 267-279 (2019-11-20)

Mycophenolic acid (MPA) is commonly prescribed for preventing graft rejection after kidney transplantation. The primary metabolic pathways of MPA are hepatic glucuronidation through UDP-glucuronosyltransferase (UGT) enzymes in the formation of MPA-glucuronide (MPAG, major pathway) and MPA-acyl glucuronide (AcMPAG). p-Cresol, a

A comparative study on the bioavailability of phenolic compounds from organic and nonorganic red grapes.

Lisard Iglesias-Carres et al.

Food chemistry, 299, 125092-125092 (2019-07-08)

The health-promoting functions of fruit phenolic compounds are mainly attributed to their metabolites. The organic cultivation of fruits is becoming increasingly popular. Thus, this study evaluates whether the differences in red Grenache grapes derived from organic culture conditions influence the

A metabonomic study of biochemical changes characteristic of genetically hypertensive rats based on (1)H NMR spectroscopic urinalysis.

Kazuki Akira et al.

Hypertension research : official journal of the Japanese Society of Hypertension, 35(4), 404-412 (2011-11-18)

Spontaneously hypertensive rats (SHR) provide a simple model for studying essential hypertension. Their genetic and metabolic features are of great interest because they may provide insights into the pathophysiological processes underlying essential hypertension. We have thus investigated the metabolic characteristics

Occupational exposure to solvent mixtures: effects on health and metabolism.

H Ukai et al.

Occupational and environmental medicine, 51(8), 523-529 (1994-08-01)

Exposure monitoring by personal diffusive samplers, biological monitoring of toluene exposure by urinary hippuric acid determination, haematology, serum biochemistry for liver function, and a subjective symptom survey by questionnaire were conducted on 303 male solvent workers. They were exposed to

Selective determination of mandelic acid in urine using molecularly imprinted polymer in microextraction by packed sorbent.

Esmaeel Soleimani et al.

Archives of toxicology, 92(1), 213-222 (2017-09-06)

Mandelic acid (MA) is a major metabolite of ethylbenzene and styrene. For the first time, a selective, fast, and easy-to-use procedure was developed for the determination of MA in urine samples. The new procedure is based on MIMEPS, the combination

Electrical monitoring of photoisomerization of block copolymers intercalated into graphene sheets.

Semin Kim et al.

Nature communications, 11(1), 1324-1324 (2020-03-14)

Insulating polymers have received little attention in electronic applications. Here, we synthesize a photoresponsive, amphiphilic block copolymer (PEO-b-PVBO) and further control the chain growth of the block segment (PVBO) to obtain different degrees of polymerization (DPs). The benzylidene oxazolone moiety

Comparison of capillary electrophoresis-mass spectrometry and hydrophilic interaction chromatography-mass spectrometry for anionic metabolic profiling of urine.

Miranda G M Kok et al.

Talanta, 132, 1-7 (2014-12-06)

In order to assess the utility of a recently developed capillary electrophoresis-mass spectrometry (CE-MS) method for the study of anionic metabolites in urine, a comparison was made with hydrophilic interaction chromatography-MS (HILIC-MS) using negative electrospray ionization. After optimization of the

A possible new oxidation marker for hair adulteration: Detection of PTeCA (1H-pyrrole-2,3,4,5-tetracarboxylic acid) in bleached hair.

Lisa Eisenbeiss et al.

Drug testing and analysis, 12(2), 230-238 (2019-10-28)

Hair analysis has become a valuable tool in forensic toxicology to assess drug or alcohol abstinence. Yet, hair adulteration by cosmetic products presents a major challenge for forensic hair analysis. Oxidative treatments, e.g. bleaching, may lead to analyte loss and

Nikolaos G Psihogios et al.

NMR in biomedicine, 21(3), 195-207 (2007-05-03)

NMR-based metabonomic analysis is a well-established approach to characterizing healthy and diseased states. The aim of this study was to investigate inter-individual variability in the metabolic urinary profile of a healthy Greek population, not subjected to strict dietary limitations, by

Blueberry metabolites restore cell surface glycosaminoglycans and attenuate endothelial inflammation in diabetic human aortic endothelial cells.

Brett Ronald Cutler et al.

International journal of cardiology, 261, 155-158 (2018-03-17)

Glycosaminoglycan (GAG), a major component of the endothelial glycocalyx, is severely perturbed in diabetic vasculature leading to endothelial inflammation and vascular disease in diabetes. We tested the hypothesis that blueberry metabolites (BBM) ameliorate endothelial inflammation in diabetic endothelial cells (ECs)

Effects of Various Drying Methods on Some Physico-Chemical Properties and the Antioxidant Profile and ACE Inhibition Activity of Oyster Mushrooms (Pleurotus Ostreatus).

Sergey Piskov et al.

Foods (Basel, Switzerland), 9(2) (2020-02-13)

In food biotechnology, Pleurotus ostreatus is of great interest as a source of natural antioxidants and angiotensin-converting enzyme (ACE) inhibitors. However, research in this area has not yet been completed. The effect of various drying methods on the structural properties

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