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Nguyen Duc Hanh et al.
Drug development and industrial pharmacy, 40(6), 793-802 (2013-04-19)
Phyllanthin is a major bioactive lignan component of Phyllanthus amarus, with several known biological activities. This study dealt with the isolation and physicochemical characterization of phyllanthin. Phyllanthin was isolated from P. amarus leaves by column chromatography and purified by recrystallization
Pegah Zahedi et al.
Journal of pharmaceutical and biomedical analysis, 117, 485-491 (2015-10-16)
In this work, a simple and efficient surfactant assisted pulsed two-phase electromembrane extraction (SA-PEME) procedure combined with gas chromatography (GC) has been developed for the determination of alfentanil, sufentanil and methadone in various samples. It has been found that the
Catarina Florindo et al.
International journal of pharmaceutics, 469(1), 179-189 (2014-04-22)
In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), novel organic salts containing fluoroquinolones (e.g. ciprofloxacin and norfloxacin) were prepared, using an optimized synthetic procedure based on direct protonation
J Hadgraft et al.
Skin pharmacology and applied skin physiology, 16(2), 123-129 (2003-03-15)
Concern has been expressed about the ability of simple algorithms to predict skin permeability and hence skin flux. For a series of thalidomide analogues, a number of software packages have been used to predict octanol water partition coefficients. These, in
Ysaías J Alvarado et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 103, 361-367 (2012-12-25)
The preferential solvation of thiophene- and furan-2-carboxaldehyde phenylhydrazone derivatives in DMSO-water and DMSO-n-octanol mixtures has been studied using visible absorption spectroscopy with a previous characterization of the electronic transitions by Time-Dependent Density Functional Theory (TDDFT) and solvatochromic study in several
Evgeni Eltzov et al.
Analytical chemistry, 87(7), 3655-3661 (2015-03-17)
Indoor air pollution became a recent concern found to be oftentimes worse than outdoor air quality. We developed a tool that is cheap and simple and enables continuous monitoring of air toxicity. It is a biosensor with both a nondisposable
In-Hwan Baek et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(11), 975-987 (2014-05-31)
1. JHL45, a novel immune modulator against atopic dermatitis (AD), was synthesized from decursin isolated from Angelica gigas. The goal is to evaluate the lead compound using quantitative modeling approaches to novel anti-AD drug development. 2. We tested the anti-inflammatory effect of
Elian-Simplice Yaganza et al.
Applied and environmental microbiology, 75(5), 1465-1469 (2008-12-31)
Twenty-one salts were tested for their effects on the growth of Pectobacterium carotovorum subsp. carotovorum and Pectobacterium atrosepticum. In liquid medium, 11 salts (0.2 M) exhibited strong inhibition of bacterial growth. The inhibitory action of salts relates to the water-ionizing
Amin M D Shakhawat et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(41), 14070-14075 (2015-10-16)
Arc ensembles in adult rat olfactory bulb (OB) and anterior piriform cortex (PC) were assessed after discrimination training on highly similar odor pairs. Nonselective α- and β-adrenergic antagonists or saline were infused in the OB or anterior PC during training.
K S Arias et al.
ChemSusChem, 6(1), 123-131 (2013-01-11)
The selective acetalization of 5-hydroxymethylfurfural (HMF) with long-chain alkyl alcohols has been performed to obtain precursors of molecules with surfactant properties. If direct acetalization of HMF with n-octanol is performed in the presence of strong acids (homogeneous and heterogeneous catalysts)
Maya Emmons-Bell et al.
International journal of molecular sciences, 16(11), 27865-27896 (2015-11-28)
The shape of an animal body plan is constructed from protein components encoded by the genome. However, bioelectric networks composed of many cell types have their own intrinsic dynamics, and can drive distinct morphological outcomes during embryogenesis and regeneration. Planarian
Stanisław Popiel et al.
Analytica chimica acta, 837, 52-63 (2014-07-09)
Novel solid-phase microextraction (SPME) fibres containing methyl, ethyl, butyl acrylate and methacrylate were first prepared by a sol-gel technique and investigated for determination of selected organoarsenic compounds (lewisite, methyldichloroarsine, phenyldichloroarsine, diphenylchloroarsine and triphenylarsine) from water samples. The influence of sorption
Wendell Ho-Tin Law et al.
ChemMedChem, 9(6), 1316-1329 (2014-03-20)
We present a new class of phosphorescent cyclometalated iridium(III) bipyridyl-phenylenediamine complexes [Ir(N^C)2 (bpy-DA)](PF6 ) (bpy-DA=4-(N-(2-amino-5-methoxyphenyl)aminomethyl)-4'-methyl-2,2'-bipyridine; HN^C=2-(2,4-difluorophenyl)pyridine (Hdfppy) (1 a), 2-phenylpyridine (Hppy) (2 a), 2-phenylquinoline (Hpq) (3 a), 2-phenylcinchoninic acid methyl ester (Hpqe) (4 a)) and their triazole counterparts [Ir(N^C)2 (bpy-T)](PF6
Dan Liu et al.
Journal of chromatography. A, 1356, 157-162 (2014-07-08)
Hydrophilic organic/salt-containing aqueous two-phase system composing of ethanol, water and ammonium sulfate for separation polar compounds was investigated on multilayer coil associated with J-type HSCCC devices. Compared to the classical polar solvent system based on 1-butanol-water or PEG1000-ammonium sulfate-water, the
Maya George et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 142-152 (2012-10-23)
Wet media milling by top down method has proved to be an effective method to prepare nanosuspension of poorly soluble drugs/APIs. Few or no attempts have been made so far to understand the feasibility of nanosuspension formulation in terms of
Susruta Samanta et al.
The journal of physical chemistry. B, 117(11), 3250-3257 (2013-02-28)
Curcumin, a naturally occurring drug molecule, has been extensively investigated for its various potential usages in medicine. Its water insolubility and high metabolism rate require the use of drug delivery systems to make it effective in the human body. Among
Kasim Ocakoglu et al.
Journal of drug targeting, 23(1), 89-95 (2014-09-19)
The biological potential of a synthetic copper chlorophyll derivative was investigated via in vivo and in vitro experiments. The Cu-chlorophyll derivative photosensitizer (Cu-PH-A) was labeled with (131)I with high efficiency (92.9 ± 4.2%) using the iodogen method. Cell culture studies
Samuel Vidal Mussi et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 282-290 (2012-11-28)
This work aimed to develop solid lipid nanoparticles (SLNs) loaded with doxorubicin evaluating the influence of docosahexaenoic acid (DHA), a polyunsaturated fatty acid that enhances the activity of anticancer drugs, on drug encapsulation efficiency (EE). The SLN were characterized for
J Marcus et al.
Physical chemistry chemical physics : PCCP, 17(48), 32528-32538 (2015-11-26)
We study the addition of electrolytes to surfactant-free microemulsions in the domain where polydisperse pre-Ouzo aggregates are present. As in previous studies, the microemulsion is the ternary system water/ethanol/1-octanol, where ethanol acts as co-solvent. Addition of electrolytes modifies the static
Navendu Bhatnagar et al.
Physical chemistry chemical physics : PCCP, 15(17), 6467-6474 (2013-03-27)
United-atom force fields, based on the Transferable Potentials for Phase Equilibria (TraPPE), are developed for twelve nitro-aromatic compounds, which include 2,4-dinitrotoluene (2,4-DNT), 2,6-dinitrotoluene (2,6-DNT), 3-nitrotoluene (3-NT), 4-nitrotoluene (4-NT), 1,3-dinitrobenzene (1,3-DNB), 1,4-dinitrobenzene (1,4-DNB), 2,4-dinitroanisole (DNAN), 1,3,5-trinitrobenzene (TNB), 2,4,6-trinitrotoluene (TNT), 2-nitroanisole (2-NAN)
Xiaoqing Zhou et al.
The Analyst, 140(5), 1662-1671 (2015-01-27)
An effective dual preconcentration method involving off-line hollow fiber liquid-liquid-liquid microextraction (HF-LLLME) and on-line sweeping micellar electrokinetic chromatography (sweeping-MEKC) was proposed for the determination of five second-generation antidepressants, including fluoxetine, sertraline, paroxetine, fluvoxamine and citalopram. In HF-LLLME, the analytes were
Irene Sargiannidou et al.
Neurobiology of disease, 30(2), 221-233 (2008-03-21)
Murine oligodendrocytes express the gap junction (GJ) proteins connexin32 (Cx32), Cx47, and Cx29. CNS phenotypes in patients with X-linked Charcot-Marie-Tooth disease may be caused by dominant effects of Cx32 mutations on other connexins. Here we examined the expression of Cx31.3
John A Arnott et al.
Expert opinion on drug discovery, 7(10), 863-875 (2012-09-21)
The role of lipophilicity in drug discovery and design is a critical one. Lipophilicity is a key physicochemical property that plays a crucial role in determining ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties and the overall suitability of drug
Maria José Nunes de Paiva et al.
Journal of chromatography. A, 1388, 102-109 (2015-02-28)
Bile acids (BAs) are derived from cholesterol and produced in the liver. The most abundant bile acids in humans are usually conjugated with glycine and taurine and are divided into primary BAs such as cholic acid (CA) and chenodeoxycholic acid
Dean G Brown et al.
Journal of medicinal chemistry, 57(23), 10144-10161 (2014-11-18)
To better understand the difficulties surrounding the identification of novel antibacterial compounds from corporate screening collections, physical properties of ∼3200 antibacterial project compounds with whole cell activity against Gram-negative or Gram-positive pathogens were profiled and compared to actives found from
Yvonne Lange et al.
The Journal of biological chemistry, 280(43), 36126-36131 (2005-09-01)
We tested the hypothesis that certain membrane-intercalating agents increase the chemical activity of cholesterol by displacing it from its low activity association with phospholipids. Octanol, 1,2-dioctanoyl-sn-glycerol (a diglyceride), and N-hexanoyl-D-erythrosphingosine (a ceramide) were shown to increase both the rate of
H Fujioka et al.
Nuclear medicine communications, 19(6), 561-566 (1999-05-11)
We have developed a new method to replace the conventional method of quantitatively measuring cerebral blood flow (CBF), in which octanol-extracted radioactivity counts are measured in continuous arterial blood samples. With the new method, the whole-brain time-activity curves early after
María Ramos-Payán et al.
Analytica chimica acta, 849, 7-11 (2014-10-11)
A novel approach based on the use of nanometallic-decorated hollow fibers to assist electromembrane extraction is proposed. Microporous polypropylene hollow fibers, on which nanometallic silver was deposited, have been used for the first time as liquid membrane support in electromembrane
B W Barry et al.
The Journal of pharmacy and pharmacology, 39(7), 535-546 (1987-07-01)
Mannitol, hydrocortisone and progesterone were selected as model penetrants to assess the mode of action of eight potential penetration enhancers in human skin. Their partition coefficients, octanol: water and stratum corneum: water were measured and correlated with their postulated routes
Nunzio Denora et al.
International journal of pharmaceutics, 437(1-2), 221-231 (2012-09-04)
This study investigates the use of codrugs of the GABAergic agent 2-phenyl-imidazo[1,2-a]pyridinacetamide and dopamine (DA) or ethyl ester L-Dopa (LD) as a strategy to deliver DA and simultaneously activate GABA-receptors in the brain. For this purpose, both DA and LD
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