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Sheri L Pollock et al.
Leukemia & lymphoma, 55(6), 1383-1387 (2013-08-10)
The t(5;17) variant of acute promyelocytic leukemia (APL) fuses the nucleophosmin (NPM) gene at 5q35 with the retinoic acid receptor alpha (RARA) at 17q12-22. We have previously shown that leukemic cells express both NPM-RAR and RAR- NPM reciprocal translocation products.
Janna Nissen et al.
The American journal of clinical nutrition, 101(1), 218-227 (2014-12-21)
Little is known about how the genetic variation in vitamin D modulating genes influences ultraviolet (UV)B-induced 25-hydroxyvitamin D [25(OH)D] concentrations. In the Food with vitamin D (VitmaD) study, we showed that common genetic variants rs10741657 and rs10766197 in 25-hydroxylase (CYP2R1)
G E Lester
Federation proceedings, 45(10), 2524-2527 (1986-09-01)
Transplacental movement of calcium from mother to fetus is essential for normal fetal development. In most species, fetal plasma calcium levels are higher than maternal levels at term. The role of cholecalciferol metabolites, with specific emphasis on 1,25-dihydroxycholecalciferol (1,25(OH)2D), in
M Rauner et al.
Bone, 64, 281-287 (2014-05-02)
Cathepsin S is a cysteine protease that controls adipocyte differentiation and has been implicated in vascular and metabolic complications of obesity. Considering the inverse relation of osteoblasts and adipocytes and their mutual precursor cell, we hypothesized that cathepsin S may
Michael Haas et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(4), 2631-2640 (2014-12-05)
The present prospective single-center study investigated the prognostic role of novel serum biomarkers in advanced pancreatic cancer (PC). Patients (pts) with locally advanced or metastatic PC treated with first-line palliative chemotherapy were included. Among others, the serum markers CYFRA 21-1
Minyong Kang et al.
PloS one, 9(4), e94888-e94888 (2014-04-15)
Kidney disease is emerging as a critical medical problem worldwide. Because of limited treatment options for the damaged kidney, stem cell treatment is becoming an alternative therapeutic approach. Of many possible human stem cell sources, pluripotent stem cells are most
Li-Shu Guo et al.
Die Pharmazie, 70(2), 117-122 (2015-05-23)
Metformin is usually used for the treatment of type 2 diabetes. Recently, many studies suggest that metformin and vitamin D have broad-spectrum antitumor activities. Our aim in this research was to study the effects of vitamin D3 combined with metformin
Sudhindra M Bhattacharya et al.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 128(2), 174-176 (2014-12-09)
To assess the effects of tibolone on serum calcium and vitamin D3 levels, the effects on health-related quality of life (HRQOL), and the relationship between these variables. An open-label, prospective, parallel-arm study was conducted at S.C. Das Memorial Medical and
M D Witham et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 25(3), 287-294 (2014-12-03)
Low 25-hydroxyvitamin D levels are common in patients with chronic fatigue syndrome; such patients also manifest impaired vascular health. We tested whether high-dose intermittent oral vitamin D therapy improved markers of vascular health and fatigue in patients with chronic fatigue
The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implications for all healthcare providers.
Alex Vasquez et al.
Alternative therapies in health and medicine, 10(5), 28-36 (2004-10-14)
Negar Tabatabaei et al.
The Journal of nutrition, 144(12), 1985-1993 (2014-10-17)
The effects of vitamin D during pregnancy on maternal and neonatal bone health remain unclear. This study was designed to test whether dietary vitamin D dose-dependently affects maternal and neonatal bone health. Female guinea pigs (n = 45; 4 mo
Verónica González-Pardo et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt A, 197-200 (2013-12-10)
We have previously shown that 1α,25(OH)2-Vitamin D3 [1α,25(OH)2D3] and its less calcemic analog TX 527 inhibit the proliferation of endothelial cells transformed by the viral G protein-coupled receptor associated to Kaposi sarcoma (vGPCR) and this could be partially explained by
Basavraj Sooragonda et al.
Acta haematologica, 133(1), 31-35 (2014-07-12)
The effect of vitamin D replacement on hemoglobin (Hb) concentration in subjects with concurrent deficiencies of vitamin D and iron is not known. We report on an investigator-initiated, randomized, single-blinded, placebo-controlled, 12-week interventional trial. Thirty subjects with iron-deficiency anemia (serum
Robert Scragg et al.
Hypertension (Dallas, Tex. : 1979), 64(4), 725-730 (2014-07-02)
Previous randomized controlled trials of vitamin D supplementation and blood pressure (BP) mainly have given vitamin D for short periods (<6 months) or at low doses (400 IU per day). This study aims to determine whether long-term high-dose vitamin D
S Lopa et al.
European cells & materials, 27, 298-311 (2014-04-25)
Cell-based therapies have recently been proposed for the treatment of degenerative articular pathologies, such as early osteoarthritis, with an emphasis on autologous mesenchymal stem cells (MSCs), as an alternative to terminally differentiated cells. In this study, we performed a donor-matched
Miles D Witham et al.
Journal of hypertension, 32(8), 1693-1699 (2014-06-01)
Orthostatic hypotension commonly accompanies supine hypertension, and is associated with low 25-hydroxyvitamin D levels. We tested whether high-dose intermittent oral vitamin D therapy could ameliorate orthostatic hypotension in older patients with isolated systolic hypertension. We conducted a subgroup analysis of
Omar Z Ameer et al.
American journal of physiology. Heart and circulatory physiology, 307(2), H143-H151 (2014-05-20)
This study investigated the effects of hypertension on regional aortic biomechanical and structural properties in three rat models of vascular calcification: the hypertensive Lewis polycystic kidney (LPK; n = 13) model of chronic kidney disease, spontaneously hypertensive rats (SHRs; n
Veena L Venkat et al.
Journal of pediatric gastroenterology and nutrition, 59(6), 702-707 (2014-11-25)
Fat-soluble vitamin (FSV) deficiency is a well-recognized consequence of cholestatic liver disease and reduced intestinal intraluminal bile acid. We hypothesized that serum bile acid (SBA) would predict biochemical FSV deficiency better than serum total bilirubin (TB) level in infants with
Rodney D Britt et al.
Journal of cellular physiology, 230(6), 1189-1198 (2014-09-11)
Asthma in the pediatric population remains a significant contributor to morbidity and increasing healthcare costs. Vitamin D3 insufficiency and deficiency have been associated with development of asthma. Recent studies in models of adult airway diseases suggest that the bioactive Vitamin
Luca De Toni et al.
Endocrinology, 155(11), 4266-4274 (2014-08-06)
Recent studies disclosed a cross talk between testis and bone. By the action of LH, Leydig cells are able to modulate bone metabolism through testosterone and insulin-like factor 3. Moreover, LH modulates the Leydig expression of CYP2R1, the key enzyme
Cholecalciferol Solution
United States Pharmacopeia, 987-987 (2013)
Pankaj Arora et al.
Circulation, 131(3), 254-262 (2014-11-02)
A large body of epidemiological and experimental evidence suggests that vitamin D deficiency may promote hypertension. This raises the possibility that vitamin D supplementation could be a simple intervention to reduce blood pressure, but data from prospective, randomized trials are
D Hamam et al.
Cell death & disease, 5, e1499-e1499 (2014-10-31)
The molecular mechanisms promoting lineage-specific commitment of human mesenchymal (skeletal or stromal) stem cells (hMSCs) into adipocytes (ADs) are not fully understood. Thus, we performed global microRNA (miRNA) and gene expression profiling during adipocytic differentiation of hMSC, and utilized bioinformatics
Tatiane Vilaça et al.
European journal of endocrinology, 170(4), 469-475 (2014-01-08)
Strontium ranelate is used to treat osteoporosis. Calcium (Ca) and strontium (Sr) have common chemical features and are absorbed by the same pathways. Vitamin D has a main role in calcium intestinal absorption. The aim of this study was to
Andy Rorie et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 112(4), 376-382 (2014-02-11)
Observational reports have linked vitamin D with chronic urticaria, yet no randomized controlled trial has been conducted. To determine whether high-dose vitamin D supplementation would decrease Urticaria Symptom Severity (USS) scores and medication burden in patients with chronic urticaria. In
Xiaocang Cao et al.
The international journal of biochemistry & cell biology, 53, 372-379 (2014-06-11)
Alleviation of hyperglycemia in chemical-induced diabetic mice has been reported after bone marrow transplantation. Nevertheless, the underlying mechanism remains elusive. In the present study, we transplanted genetically labeled primary mouse mesenchymal stem cells into the pancreas of the streptozotocin-treated hyperglycemic
Xin Xu et al.
Molecular carcinogenesis, 54(2), 134-147 (2013-09-07)
Rat mammary carcinoma susceptibility 5a1 (Mcs5a1), which is concordant to human MCS5A1 breast cancer risk locus, mediates susceptibility by a non-mammary cell-autonomous mechanism associated with T cell differential expression of F-box protein 10 (Fbxo10). Human FBXO10, an evolutionarily conserved ubiquitin
Sunil K Halder et al.
Reproductive sciences (Thousand Oaks, Calif.), 21(9), 1108-1119 (2014-06-14)
We examined the antitumor and therapeutic potentials of paricalcitol, an analog of 1,25-dihydroxyvitamin D3 with lower calcemic activity, against uterine fibroids using in vitro and in vivo evaluations in appropriate uterine fibroid cells and animal models. We found that paricalcitol
Christopher C Gibson et al.
Circulation, 131(3), 289-299 (2014-12-10)
Cerebral cavernous malformation (CCM) is a hemorrhagic stroke disease affecting up to 0.5% of North Americans that has no approved nonsurgical treatment. A subset of patients have a hereditary form of the disease due primarily to loss-of-function mutations in KRIT1
Kevin D Cashman et al.
The Journal of nutrition, 144(7), 1050-1057 (2014-05-16)
Fundamental knowledge gaps in relation to the 3 epimer of 25-hydroxycholecalciferol [3-epi-25(OH)D₃] limit our understanding of its relevance for vitamin D nutrition and health. The aims of this study were to characterize the 3-epi-25(OH)D₃ concentrations in a nationally representative sample
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