Tianxiang Kevin Han et al.
The Journal of pharmacology and experimental therapeutics, 352(3), 519-528 (2015-01-08)
Metformin is the frontline therapy for type II diabetes mellitus. The oral bioavailability of metformin is unexpectedly high, between 40 and 60%, given its hydrophilicity and positive charge at all physiologic pH values. Previous studies in Caco-2 cell monolayers, a