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Shingo Kariya et al.
Amyotrophic lateral sclerosis & frontotemporal degeneration, 15(7-8), 581-587 (2014-05-09)
Abstract Sporadic amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no established biological marker. Recent observation of a reduced number of gems (survival motor neuron protein (SMN)-positive nuclear bodies) in cells from patients with familial ALS and the
Juliano Alves Pereira et al.
Clinical and experimental pharmacology & physiology, 42(7), 788-794 (2015-05-12)
The standard therapy used in the treatment of Duchenne muscle dystrophy (DMD) is corticoids, such as deflazacort and prednisone. However, they have limited therapeutic value, and their combination with drugs already in use to treat other human diseases could potentially
Suganthi Chittaranjan et al.
Oncotarget, 5(17), 7960-7979 (2014-10-04)
The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K). Approximately 70% of ODGs with 1p19q co-deletions harbor somatic mutations in the Capicua Transcriptional Repressor (CIC) gene on chromosome
Kathryn Bartley et al.
International journal for parasitology, 45(13), 819-830 (2015-08-25)
An aqueous extract of the haematophagous poultry ectoparasite, Dermanyssus gallinae, was subfractionated using anion exchange chromatography. Six of these subfractions were used to immunise hens and the blood from these hens was fed, in vitro, to poultry red mites. Mite
Laila C Schenkel et al.
The Journal of nutritional biochemistry, 26(11), 1221-1234 (2015-08-06)
Choline plays a critical role in systemic lipid metabolism and hepatic function. Here we conducted a series of experiments to investigate the effect of choline supplementation on metabolically altered Pcyt2(+/-) mice. In Pcyt2(+/-) mice, the membrane phosphatidylethanolamine (PE) turnover is
Mariana Carneiro et al.
Ecotoxicology and environmental safety, 120, 93-101 (2015-06-06)
Anatoxin-a is a potent neurotoxin produced by several genera of cyanobacteria. Deaths of wild and domestic animals due to anatoxin-a exposure have been reported following a toxic response that is driven by the inhibition of the acetylcholine receptors at neuromuscular
Gabriela de Almeida Leonardi et al.
Genetics and molecular biology, 38(2), 191-198 (2015-08-15)
Eucalyptus urograndis is a hybrid eucalyptus of major economic importance to the Brazilian pulp and paper industry. Although widely used in forest nurseries around the country, little is known about the biochemical changes imposed by environmental stress in this species.
Chiaki Takahata et al.
Carcinogenesis, 36(8), 841-851 (2015-05-31)
Topoisomerase 1 (Top1) is the intercellular target of camptothecins (CPTs). CPT blocks DNA religation in the Top1-DNA complex and induces Top1-attached nick DNA lesions. In this study, we demonstrate that excision repair cross complementing 1 protein-xeroderma pigmentosum group F (ERCC1-XPF)
Hua Gong et al.
SpringerPlus, 3, 528-528 (2014-10-04)
The keratin-associated proteins (KAPs) are fundamental components of hair and wool fibres, and are believed to in part be responsible for some of the properties of these fibres. KAPs can be divided into three groups: the high sulphur (HS) KAPs
Fernanda Ludolf et al.
PLoS neglected tropical diseases, 8(3), e2745-e2745 (2014-03-22)
New interventions tools are a priority for schistosomiasis control and elimination, as the disease is still highly prevalent. The identification of proteins associated with active infection and protective immune response may constitute the basis for the development of a successful
Zhenhua Zhang et al.
Journal of virological methods, 213, 57-64 (2014-11-30)
Hepatitis B virus (HBV) genotypes vary in their geographical distribution and virological features. Previous investigations have shown that HBV genotype B is a predominant HBV genotype in China. Studies on HBV concerning different isolates frequently meet the question about the
Susanna Trapp et al.
Journal of virology, 83(2), 884-895 (2008-11-14)
Human immunodeficiency virus (HIV) is taken up by and replicates in immature dendritic cells (imDCs), which can then transfer virus to T cells, amplifying the infection. Strategies known to boost DC function were tested for their ability to overcome this
Mohammad Mahdi Ahmadian-Attari et al.
Neurotoxicity research, 28(2), 95-107 (2015-03-19)
Alzheimer's disease (AD) is a primary neurodegenerative disorder associated with progressive memory impairment. Recent studies suggest that hypothermia may contribute to the development and exacerbation of AD. The aim of this study was to investigate the role of chronic hypothermia
Daniele Maggioni et al.
Nutrition and cancer, 66(7), 1257-1267 (2014-09-27)
In this study the potential anticancer effect of 2 flavonoids, myiricetin (MYR) and naringenin (NAR) has been evaluated on an oral squamous cell carcinoma (OSCC) cell line, SCC-25, and HaCaT cells. Both the flavonoids inhibited SCC-25 cell growth, although NAR
Shasha Su et al.
PloS one, 10(11), e0143513-e0143513 (2015-11-26)
Leucine-rich-repeat-containing G-protein-coupled receptor 5 (lgr5) is a candidate marker for colorectal cancer stem cells (CSC). In the current study, we investigated the methylation status within thelgr5 promoter and evaluated its relationship with CSC differentiation, prognosis for colorectal cancer, and its
Michelle L Van Sinderen et al.
PloS one, 10(8), e0136143-e0136143 (2015-09-01)
The maintenance of glucose homeostasis within the body is crucial for constant and precise performance of energy balance and is sustained by a number of peripheral organs. Estrogens are known to play a role in the maintenance of glucose homeostasis.
Vijayashankar Suganya et al.
Clinica chimica acta; international journal of clinical chemistry, 450, 210-219 (2015-08-25)
Autism is a complex developmental disability for which no specific diagnostic markers have been identified so far. The present study aimed to evaluate whether there is any abnormal protein(s) excreted in the urine of autistic children by proteome analysis which
Kennon S Deal et al.
Analytical chemistry, 84(3), 1510-1516 (2011-12-24)
Akin to optical beam chopping, we demonstrate that formation and routing of aqueous droplets in oil can chop a fluidic sample to permit phase sensitive detection. This hand-operated microfluidic sample chopper (μChopper) greatly reduces the detection limit of molecular absorbance
Bernice Wright et al.
Journal of biomaterials applications, 30(2), 147-159 (2015-03-21)
Poly (lactic-co-glycolic) acid microspheres are amenable to a number of biomedical procedures that support delivery of cells, drugs, peptides or genes. Hydrophilisation or wetting of poly (lactic-co-glycolic) acid are an important pre-requisites for attachment of cells and can be achieved
Fabrizio Anella et al.
Life (Basel, Switzerland), 4(4), 929-943 (2014-12-17)
The "RNA world" and the "Lipid world" theories for the origin of cellular life are often considered incompatible due to the differences in the environmental conditions at which they can emerge. One obstacle resides in the conflicting requirements for divalent
Prashant S Wani et al.
Nature communications, 6, 6384-6384 (2015-03-31)
Proteasome assembly is a complex process, requiring 66 subunits distributed over several subcomplexes to associate in a coordinated fashion. Ten proteasome-specific chaperones have been identified that assist in this process. For two of these, the Pba1-Pba2 dimer, it is well
S Iyer et al.
Cell death and differentiation, 22(10), 1665-1675 (2015-03-07)
Bak and Bax mediate apoptotic cell death by oligomerizing and forming a pore in the mitochondrial outer membrane. Both proteins anchor to the outer membrane via a C-terminal transmembrane domain, although its topology within the apoptotic pore is not known.
P Y Lee et al.
Journal of applied microbiology, 117(3), 854-865 (2014-06-10)
This study was conducted to identify antigenic proteins of Candida tropicalis that are targeted by the host immune system. An immunoproteomic approach was used to discover antigens from cell wall of C. tropicalis that were recognized by sera from experimentally
Xiangyang Hu et al.
The Plant cell, 26(12), 4763-4781 (2014-12-30)
Winter-annual accessions of Arabidopsis thaliana require either exposure to cold stress or vernalization to initiate flowering via FRIGIDA (FRI). FRI acts as a scaffold protein to recruit several chromatin modifiers that epigenetically modify flowering genes. Here, we report that proteasome-mediated
Elisabetta Moratti et al.
PloS one, 10(3), e0119110-e0119110 (2015-03-17)
PTPRG is a widely expressed protein tyrosine phosphatase present in various isoforms. Peptides from its extracellular domain have been detected in plasma by proteomic techniques. We aim at characterizing the plasmatic PTPRG (sPTPRG) form and to identify its source. The
Jeffrey C Chandler et al.
Journal of proteome research, 14(2), 664-675 (2014-12-17)
Francisella tularensis causes disease (tularemia) in a large number of mammals, including man. We previously demonstrated enhanced efficacy of conventional antibiotic therapy for tularemia by postexposure passive transfer of immune sera developed against a F. tularensis LVS membrane protein fraction
Hongwei Liu et al.
Molecular medicine reports, 12(2), 2495-2502 (2015-05-09)
Overactivation of poly (ADP-ribose) polymerase 1 (PARP-1), as a result of sustained DNA oxidation in ischemia-reperfusion injury, triggers programmed cell necrosis and apoptosis. The present study was conducted to demonstrate whether hydrogen-rich saline (HRS) has a neuroprotective effect on retinal
Songyuan Bao et al.
Molecular biology reports, 40(2), 1927-1936 (2012-10-19)
Two new laccase genes, named lac1 and lac2, were cloned from the edible basidiomycete Coprinus comatus. Comparison of the deduced amino acid sequences revealed two laccases showed 66.12 % identity and clustered with lac2 and lac3 from Coprinopsis cinerea in same
Z Huang et al.
Thrombosis and haemostasis, 112(1), 142-150 (2014-03-19)
ATP released by activated platelets can serve as a positive feedback machinery to amplify platelet responses by activating P2X1 receptors. It has, however, not been defined how P2X1 activities influence thromboxane A2 (TXA2)-stimulated platelet functional responses. Our aim was to
Omar Jaure et al.
Oncology letters, 9(2), 845-850 (2015-01-28)
Breast cancer is the most common type of cancer in females in Argentina, with an incidence rate similar to that in the USA. However, the contribution of the BRCA1 or BRCA2 mutation in breast cancer incidence has not yet been
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