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Matthew L Herman et al.
Human mutation, 30(4), 537-547 (2009-02-26)
Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of rare cornification diseases. Germline mutations in TGM1 are the most common cause of ARCI in the United States. TGM1 encodes for the TGase-1 enzyme that functions in the formation of
E A Iyayi et al.
Poultry science, 92(6), 1595-1603 (2013-05-21)
Two studies were conducted to determine the true P digestibility (TPD) of black-eyed pea (BEP) and peanut flour (PNF) and the TPD response to phytase supplementation using the regression method. Sequential diets containing 115, 230, or 345 g of BEP/kg
H Kobayashi et al.
Bioscience, biotechnology, and biochemistry, 64(5), 948-957 (2000-07-06)
The fruit bodies of Lentinus edodes produce two acid nucleases, nucleases Le1 and Le3, both of which are thought to be candidates for the enzymes producing a tasty substance, 5'-GMP. To obtain the basic information on the mechanism of production
Z Su et al.
International journal of obesity (2005), 32(7), 1180-1189 (2008-04-17)
To identify the genes controlling body fat, we carried out a quantitative trait locus (QTL) analysis using C57BL/6J (B6) and 129S1/SvImJ (129) mice, which differ in obesity susceptibility after consuming an atherogenic diet. Mice were fed chow until 8 weeks
Rolf Symons et al.
Radiology, 274(1), 93-102 (2014-09-11)
To evaluate the relationship between myocardial infarction ( MI myocardial infarction ) severity at magnetic resonance (MR) imaging and regional and global postinfarction left ventricular ( LV left ventricular ) remodeling. This HIPAA-compliant study was institutional review board approved. In
Vincent Probst et al.
Circulation. Cardiovascular genetics, 2(6), 552-557 (2009-12-25)
Mutations in SCN5A are identified in approximately 20% to 30% of probands affected by Brugada syndrome (BrS). However, in familial studies, the relationship between SCN5A mutations and BrS remains poorly understood. The aim of this study was to investigate the
A H Schmaier et al.
The Journal of clinical investigation, 75(1), 242-250 (1985-01-01)
In order to characterize which proteins of the contact phase of coagulation interact with platelets, human platelets were studied immunochemically and functionally to determine if they contain C1- inhibitor. By means of monospecific antibody to C1- inhibitor, a competitive enzyme-linked
Mauricio Tohen et al.
Archives of general psychiatry, 60(11), 1079-1088 (2003-11-12)
Despite the longer duration of the depressive phase in bipolar disorder and the frequent clinical use of antidepressants combined with antipsychotics or mood stabilizers, relatively few controlled studies have examined treatment strategies for bipolar depression. To examine the use of
L Feliciano et al.
Cardiovascular research, 40(1), 45-55 (1999-01-07)
To determine the effects of vasoactive intestinal peptide (VIP), released endogenously from cardiac vagal nerves, on coronary artery blood flow (CBF). We determined the effects of vagal nerve stimulation (VNS) at frequencies of 10, 15, 20, and 30 Hz on
M Obana et al.
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 69(9), 991-1006 (1995-09-01)
The efficacy, safety and usefulness of balofloxacin (BLFX) for patients with acute infectious enteritis and the carriers mainly shigellosis, were investigated. The drug was administered at a daily dose of 200 mg twice a day for 3 days to patients
William R Mundy et al.
Toxicology, 270(2-3), 121-130 (2010-02-13)
In vitro test methods can provide a rapid approach for the screening of large numbers of chemicals for their potential to produce toxicity (hazard identification). In order to identify potential developmental neurotoxicants, a battery of in vitro tests for neurodevelopmental
Patricia Alvarez-Muñoz et al.
Journal of diabetes and its complications, 24(4), 242-249 (2009-04-28)
Endoglin is an accessory receptor molecule that, in association with transforming growth factor beta (TGF-beta) family receptors Types I and II, binds TGF-beta1, TGF-beta3, activin A, bone morphogenetic protein (BMP)-2 and BMP-7, regulating TGF-beta dependent cellular responses. Relevant to diabetic
Yoshimasa Nobeyama et al.
International journal of cancer, 121(2), 301-307 (2007-03-21)
To identify tumor-suppressor genes inactivated by aberrant methylation of promoter CpG islands (CGIs) in human malignant melanomas, genes upregulated by treatment of cells with a demethylating agent, 5-aza-2'-deoxycytidine (5-aza-dC), were searched for using oligonucleotide microarrays in melanoma cell lines, HMV-I
T Fuentes et al.
Experimental physiology, 95(1), 160-171 (2009-09-01)
To examine whether obesity-associated leptin resistance could be due to down-regulation of leptin receptors (OB-Rs) and/or up-regulation of suppressor of cytokine signalling 3 (SOCS3) and protein tyrosine phosphatase 1B (PTP1B) in skeletal muscle, which blunt janus kinase 2-dependent leptin signalling
Xiang Kong et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 15(3), 259-270 (2013-05-17)
This study was designed to investigate the underlying mechanisms of synergistic antihypertensive effect produced by combination therapy of losartan and pioglitazone in metabolic syndrome (MS) rats. An MS model was induced by feeding rats a high-fat, high-sodium diet and 20%
Hanna Barchanska et al.
Environmental science and pollution research international, 21(6), 4751-4758 (2013-12-24)
Simple and effective extraction methods based on matrix solid-phase dispersion (MSPD), dispersive liquid-liquid microextraction (DLLME), and solid-phase extraction (SPE) coupled with high-performance liquid chromatography with diode array detector (HPLC-DAD) were developed to determine triketone herbicides-sulcotrione (SUL), mesotrione (MES), tembotrione (TEMB)
Ko-Tung Chang et al.
Electrophoresis, 36(3), 413-419 (2014-09-17)
A low-cost platform is proposed for the growth and real-time monitoring of biological cells. The main components of the platform include a PMMA cell culture microchip and a multichannel lens-free CMOS (complementary metal-oxide-semiconductor) / LED imaging system. The PMMA microchip
P V T Vidigal et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 41(8), 643-647 (2008-09-18)
Cystic fibrosis (CF) is the most common autosomal recessive disease of the Caucasian population. Among the various CF mutations, p.F508del is the most frequent, accounting for two-thirds of the global CF chromosomes, although showing great variability among populations. We have
Alexandra A Smith et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 58(3), 356-361 (2019-04-24)
Opioids are widely used in veterinary and human medicine to manage pain. However, there is a paucity of information in the literature regarding the pharmacokinetics of opioid transdermal patches (TDP) in NHP. Therefore, to determine whether opioid TDP attain therapeutic
Fan Lin et al.
Applied immunohistochemistry & molecular morphology : AIMM, 12(2), 153-159 (2004-09-10)
P504S/alpha-methylacryl CoA racemase has been shown to be a relatively sensitive and specific positive marker for prostatic adenocarcinoma. The potential utility of P504S in renal cell neoplasms has not been explored in a large series. We assessed the diagnostic value
Marco A Riojas et al.
Cancer biology & therapy, 6(11), 1710-1716 (2007-11-08)
The hypermethylation of tumor-suppressor gene promoter regions has been shown to result in the epigenetic inactivation of many genes. ASC/TMS1 is a pro-apoptotic gene that has been shown to be methylated in many different human neoplasms. The methylation status of
N Negreira et al.
Analytica chimica acta, 638(1), 36-44 (2009-03-21)
A sensitive procedure for the determination of three UV filters: ethylhexyl salicylate (EHS), 3,3,5-trimethylcyclohexyl salicylate (Homosalate, HMS), 2-hydroxy-4-methoxybenzophenone (BP-3) and two related hydroxylated benzophenones (2,4-dihydroxybenzophenone, BP-1 and 2,2'-dihydroxy-4-methoxybenzophenone, BP-8) in water samples is presented. Analytes were first concentrated on the
Bo Yang et al.
Zhongguo shi yan xue ye xue za zhi, 17(4), 857-860 (2009-08-25)
This study was purposed to investigate lrp16 gene expression in leukemia cell lines and bone marrow cells of leukemia patients and explore the relationship between lrp16 gene expression and development of leukemia. Reverse transcriptase-polymerase chain reaction (RT-PCR) was employed to
Zahoor Qadir Samra et al.
Clinical laboratory, 57(9-10), 741-747 (2011-10-28)
Cancer is a major cause of death throughout the world. Xanthine oxidase (XO) is considered an oxygen derived free radicals producer and paraoxonasel (PON1) is known as a free radicals scavenger. This study was undertaken to determine the activity of
Bin Tang et al.
Chemosphere, 262, 127807-127807 (2020-08-09)
Human hair has been identified as a non-invasive alternative matrix for assessing the human exposure to specific organic contaminants. In the present study, a solvent-saving analytical method for the simultaneous determination of 8 polybrominated diphenyl ethers (PBDEs), 3 hexabromocyclododecanes (HBCDDs)
Rongfang Liu et al.
Experimental biology and medicine (Maywood, N.J.), 240(9), 1214-1222 (2015-02-11)
Hydrogen has antioxidant and anti-inflammatory effects on lung ischemia-reperfusion injury when it is inhaled by donor or/and recipient. This study examined the effects of lung inflation with 3% hydrogen during the cold ischemia phase on lung graft function in rats.
Antonio Cuadrado-Lavín et al.
The Journal of antimicrobial chemotherapy, 70(8), 2376-2381 (2015-04-10)
Helicobacter pylori eradication remains a challenge. Non-bismuth-based quadruple regimens (NBQR) have shown high eradication rates (ER) elsewhere that need to be locally confirmed. The objective of this study was to compare the first-line ER of a hybrid therapy (20 mg
Daniel Hernandez-Baltazar et al.
PloS one, 7(12), e51341-e51341 (2013-01-10)
The study of signal transduction in dopamine (DA)-containing neurons as well as the development of new therapeutic approaches for Parkinson's disease requires the selective expression of transgenes in such neurons. Here we describe optimization of the use of the NTS-polyplex
Talin Ebrahimian et al.
American journal of physiology. Heart and circulatory physiology, 295(4), H1481-H1488 (2008-08-05)
Oxidative stress is implicated in menopause-associated hypertension and cardiovascular disease. The role of antioxidants in this process is unclear. We questioned whether the downregulation of thioredoxin (TRX) is associated with oxidative stress and the development of hypertension and target-organ damage
Miguel F Sanmamed et al.
Clinical chemistry, 61(1), 297-304 (2014-11-21)
Around 50% of cutaneous melanomas harbor the BRAF(V600E) mutation and can be treated with BRAF inhibitors. DNA carrying this mutation can be released into circulation as cell-free BRAF(V600E) (cfBRAF(V600E)). Droplet digital PCR (ddPCR) is an analytically sensitive technique for quantifying
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