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Liting Guo et al.
International journal of nanomedicine, 10, 4535-4547 (2015-07-28)
The study investigated the reversal of multidrug resistance (MDR) and the biodistribution of nanoparticles (NPs) that target leukemia cells in a nude mice model via a surface-bound transferrin (Tf). The cytotoxic cargo of daunorubicin (DNR) and tetrandrine (Tet) was protected
Wei Chen et al.
Molecular medicine reports, 12(5), 7712-7720 (2015-10-16)
A previous nationwide Chinese epidemiological study revealed through isolation of A‑B+ Clostridium difficile strains, which produce toxin B (TcdB), but not toxin A TcdA, that the strains are widespread and more frequent in east Asian countries,. The development of a
Danny Lafrance et al.
Organic letters, 13(9), 2322-2325 (2011-04-15)
Malonic acid derivatives undergo unusually mild decarboxylation when treated with N,N'-carbonyldiimidazole (CDI) at room temperature to generate the carbonyl imidazole moiety in high yield, which can be reacted further with a variety of nucleophiles in an efficient one-pot process.
N V Roik et al.
Journal of colloid and interface science, 362(1), 172-179 (2011-07-16)
Surface grafting of β-cyclodextrin onto aminopropylsilica has been carried out under mild conditions using 1,1'-carbonyldiimidazole as an activator. The obtained β-cyclodextrin-silica has been characterized by means of chemical and IR spectral analysis. Adsorption of para-aminobenzoic and para-aminosalicylic acids onto the
Lei Zheng et al.
Talanta, 146, 483-489 (2015-12-24)
In this study, we prepared polyclonal antibodies against anti-diabetic drug nateglinide (NTG), and established a sensitive chemiluminescent immunoassay (CLIA) to detect NTG in tablets and serum. Two kinds of immunogens were synthesized using ethylcarbodiimide (EDC)/hydroxysuccinimide (NHS) and carbonyldiimidazole (CDI)/4-dimethylaminopyridine (DMAP)
Rohan P Choraghe et al.
Life (Basel, Switzerland), 11(2) (2021-02-13)
At host-pathogen contact sites with Candida albicans, Dectin-1 activates pro-inflammatory signaling, while DC-SIGN promotes adhesion to the fungal surface. We observed that Dectin-1 and DC-SIGN collaborate to enhance capture/retention of C. albicans under fluid shear culture conditions. Therefore, we devised
Nobuaki Mori et al.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 21(10), 718-722 (2015-08-05)
Physicians often fail to suspect Clostridium difficile infection (CDI) and many microbiology laboratories use suboptimal diagnostic techniques. To estimate the extent of and reasons for incorrect diagnosis of CDI in Japan, we investigated toxigenic C. difficile isolated from all stool
Renata Marcia de Figueiredo et al.
The Journal of organic chemistry, 71(11), 4147-4154 (2006-05-20)
Amino alcohols are important synthons for N-heterocycles. We have developed an efficient method to activate hydroxyl groups, which avoids the use of toxic reagents and tolerates a wide variety of functional groups. Our strategy has been applied to the synthesis
Laura Faiella et al.
Molecular bioSystems, 8(10), 2637-2644 (2012-07-18)
Clerodane diterpenoids are a class of naturally occurring molecules widely distributed in the Lamiaceae family. Neo-clerodane diterpenoids from Salvia ssp were recently described as compounds inhibiting the proliferation of human cancer cell lines. To gain new insights into molecular mechanism(s)
Hye-Mi So et al.
Methods in molecular biology (Clifton, N.J.), 625, 239-249 (2010-04-28)
In this chapter, we discuss in detail the fabrication of carbon nanotube biosensors that use a single-walled carbon nanotube field-effect transistor (SWNT-FET) as a transducer, and aptamers as molecular recognition elements. We use a patterned growth technique to grow SWNTs
Mei Yan et al.
The Analyst, 137(12), 2834-2839 (2012-05-05)
A novel, simple and highly sensitive amplified fluorescence label-free immunosensor by using p-acid-encapsulated silica nanomaterials has been developed for the first time. 4,4'-(2,5-Dimethoxy-1,4-phenylene)bis(ethyne-2,1-diyl)dibenzoic acid (p-acid) and p-acid-encapsulated silica were prepared, and characterized by Fourier transform infrared spectroscopy, nuclear magnetic resonance
Jui-Hsin Huang et al.
Journal of biomedical science, 22, 65-65 (2015-08-08)
Opportunistically nosocomial infections in hospitalized patients are often related to Clostridium difficile infections (CDI) due to disruption of the intestinal micro-flora by antibiotic therapies during hospitalization. Clostridial exotoxins A and B (TcdA and TcdB) specifically bind to unknown glycoprotein(s) in
Samad Esmaeilzadeh
Environmental health and preventive medicine, 20(6), 434-440 (2015-08-13)
The aims of the study were to explore the association between depressive symptoms (DS), physical activity (PA), aerobic and muscular fitness in a sample of children. Four hundred and fifty-six schoolboys aged 7-11-year-old underwent standard anthropometry and various physical fitness
Haruko Nakamura et al.
Journal of pharmacological sciences, 128(4), 170-178 (2015-08-04)
Induced pluripotent stem (iPS) cells are promising tools to investigate disease mechanism and develop new drugs. Intraneuronal transport, which is fundamental for neuronal survival and function, is vulnerable to various pharmacological and chemical agents and is disrupted in some neurodegenerative
Virgil Percec et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 14(3), 909-918 (2007-11-21)
Twin-dendritic organogelators have been prepared through selective functionalization of N-(3-aminopropyl)-1,3-propanediamine (APPDA) with self-assembling dendrons by using 1,1'-carbonyldiimidazole (CDI). Subsequent modification of the APPDA linker provided an additional degree of structural diversity by which to tailor the gelator self-assembly in bulk
Hussein N Yassine et al.
PloS one, 10(12), e0144138-e0144138 (2015-12-04)
Apolipoprotein C-III (apoC-III) regulates triglyceride (TG) metabolism. In plasma, apoC-III exists in non-sialylated (apoC-III0a without glycosylation and apoC-III0b with glycosylation), monosialylated (apoC-III1) or disialylated (apoC-III2) proteoforms. Our aim was to clarify the relationship between apoC-III sialylation proteoforms with fasting plasma
Joana Carvalho et al.
Journal of biomedical materials research. Part A, 93(1), 389-399 (2009-07-02)
A new class of degradable dextrin-based hydrogels (dextrin-HEMA) was developed. The hydroxyethyl methacrylate ester (HEMA) hydroxyl groups were activated with N,N'-carbonyldiimidazole (CDI), followed by their coupling to dextrin, yielding a derivatized material that can be polymerized in aqueous solution to
J M Aguado et al.
The Journal of hospital infection, 90(2), 117-125 (2015-04-07)
Clostridium difficile infection (CDI) is the leading cause of infectious nosocomial diarrhoea in Europe. Despite increased focus, its incidence and severity are increasing in many European countries. We developed a series of consensus statements to identify unmet clinical needs in
Kim H Chuong et al.
Qualitative health research, 25(10), 1359-1371 (2015-01-18)
Advances in human microbiome research have generated considerable interest in elucidating the role of bacteria in health and the application of microbial ecosystem therapies and probiotics. Fecal transplants involve the introduction of gut microbes from a healthy donor's stool to
Gennara Cavallaro et al.
International journal of pharmaceutics, 495(2), 719-727 (2015-09-28)
Nanocarriers of amphiphilic polymeric materials represent versatile delivery systems for poorly water soluble drugs. In this work the technique of solvent evaporation from multiple emulsions was applied to produce nanovectors based on new amphiphilic copolymer, the α,β-poly(N-2-hydroxyethyl)-DL-aspartamide-polylactic acid (PHEA-PLA), purposely
Mahmood Khan et al.
PloS one, 10(5), e0126338-e0126338 (2015-05-21)
Dilated cardiomyopathy is a major cause of progressive heart failure. Utilization of stem cell therapy offers a potential means of regenerating viable cardiac tissue. However, a major obstacle to stem cell therapy is the delivery and survival of implanted stem
Aqueous synthesis of peptide thioesters from amino acids and a thiol using 1,1'-carbonyldiimidazole.
Arthur L Weber
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 35(5), 421-427 (2005-10-19)
A new method was developed for the synthesis of peptide thioesters from free amino acids and thiols in water. This one-pot simple method involves two steps: (1) activation in water of an amino acid presumably as its N-carboxyanhydride (NCA) using
Julia Stolarow et al.
BMC biotechnology, 15, 77-77 (2015-08-20)
Immobilization of enzymes onto different carriers increases enzyme's stability and reusability within biotechnological and pharmaceutical applications. However, some immobilization techniques are associated with loss of enzymatic specificity and/or activity. Possible reasons for this loss are mass transport limitations or structural
Frank Münch et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 48(2), 236-243 (2014-11-22)
Experience regarding warm blood cardioplegia according to Calafiore results from its broad use in adult patients. In this experimental study, tepid (28°C) modified full blood cardioplegia (MBC) was adopted for paediatric use and compared with cold crystalloid cardioplegia (CCC). Twenty
Haoyu Liu et al.
Carbohydrate polymers, 113, 480-489 (2014-09-27)
Polymer design and selection are crucial to the development of amorphous solid dispersions (ASD) for solubilization of otherwise poorly water-soluble drugs. The matrix polymer is required to interact strongly at the molecular level with the drug to prevent recrystallization, but
Ayele H Negussie et al.
Journal of materials science. Materials in medicine, 26(6), 198-198 (2015-06-25)
Therapeutic embolization of blood vessels is a minimally invasive, catheter-based procedure performed with solid or liquid emboli to treat bleeding, vascular malformations, and vascular tumors. Hepatocellular carcinoma (HCC) affects about half a million people per year. When unresectable, HCC is
S J Ruiz et al.
Annals of diagnostic pathology, 19(4), 187-192 (2015-04-29)
Follicular helper T-cell lymphoma is a recently described variant of T-cell lymphoma sharing the cell of origin with angioimmunoblastic T-cell lymphoma and with primary cutaneous CD4-positive small/medium T-cell lymphoma. To better characterize the morphologic and immunophenotypic features of follicular helper
Hiroyuki Shimizu et al.
Internal medicine (Tokyo, Japan), 54(17), 2155-2159 (2015-09-04)
Clostridium difficile infection (CDI) is the major cause of antibiotic-associated diarrhea in hospital inpatients. Rapid testing for the toxins in stool specimens is inconclusive due to its low sensitivity. Therefore, a two-step method is recommended as the most appropriate approach.
Monideepa B Becerra et al.
BMC infectious diseases, 15, 254-254 (2015-07-02)
Clostridium difficile infection (CDI) remains one of the major hospital acquired infections in the nation, often attributable to increased antibiotic use. Little research, however, exists on the prevalence and impact of CDI on patient and hospital outcomes among populations requiring
Kihong Lim et al.
Journal of immunological methods, 426, 120-127 (2015-09-08)
β2 integrins play critical roles in migration of immune cells and in the interaction with other cells, pathogens, and the extracellular matrix. Among the β2 integrins, Mac-1 (Macrophage antigen-1), composed of CD11b and CD18, is mainly expressed in innate immune
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