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Mahmood Khan et al.
PloS one, 10(5), e0126338-e0126338 (2015-05-21)
Dilated cardiomyopathy is a major cause of progressive heart failure. Utilization of stem cell therapy offers a potential means of regenerating viable cardiac tissue. However, a major obstacle to stem cell therapy is the delivery and survival of implanted stem
Akon Higuchi et al.
Journal of biomedical materials research. Part A, 79(2), 380-392 (2006-08-03)
The Pluronic F68 and F127, a triblock copolymer of ethylene oxide and propylene oxide, was activated using carbonyldiimidazole (CDI), and CDI-activated Pluronic F68 and F127 was subsequently immobilized on the surface of a poly-L-lysine-coated polystyrene tissue culture flask. Cell culture
Jian-Bin Li et al.
Journal of adolescence, 43, 159-170 (2015-07-02)
The current study investigated the relationship between parental attachment and depressive symptoms as well as the mediating effect of self-control in two different cultures. Samples were 1305 Chinese and 1327 Italian adolescents. They completed the Inventory of Parental and Peer
Aqueous synthesis of peptide thioesters from amino acids and a thiol using 1,1'-carbonyldiimidazole.
Arthur L Weber
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 35(5), 421-427 (2005-10-19)
A new method was developed for the synthesis of peptide thioesters from free amino acids and thiols in water. This one-pot simple method involves two steps: (1) activation in water of an amino acid presumably as its N-carboxyanhydride (NCA) using
J M Aguado et al.
The Journal of hospital infection, 90(2), 117-125 (2015-04-07)
Clostridium difficile infection (CDI) is the leading cause of infectious nosocomial diarrhoea in Europe. Despite increased focus, its incidence and severity are increasing in many European countries. We developed a series of consensus statements to identify unmet clinical needs in
N Eliakim-Raz et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 34(6), 1201-1205 (2015-02-18)
Data on risk factors for Clostridium difficile infection (CDI) in diabetic patients are scarce. Recently, it has been shown that metformin increases the Bacteroidetes/Firmicutes ratio; therefore, it may yield a protective effect against CDI. We aimed to assess risk factors
Ibrahim H A Badr et al.
Carbohydrate polymers, 134, 687-694 (2015-10-03)
Bacterial cellulose (BC) and heparin-modified bacterial cellulose (HBC) were utilized to enhance the biocompatibility of highly thrombogenic PVC-based potassium and calcium membrane electrodes. Three types of membrane electrodes were prepared: (1) conventional PVC electrode (control), (2) PVC-based electrode sandwiched with
Gennara Cavallaro et al.
International journal of pharmaceutics, 495(2), 719-727 (2015-09-28)
Nanocarriers of amphiphilic polymeric materials represent versatile delivery systems for poorly water soluble drugs. In this work the technique of solvent evaporation from multiple emulsions was applied to produce nanovectors based on new amphiphilic copolymer, the α,β-poly(N-2-hydroxyethyl)-DL-aspartamide-polylactic acid (PHEA-PLA), purposely
Pankaj Omprakash Pathak et al.
Carbohydrate research, 408, 33-43 (2015-04-05)
Asialoglycoprotein receptors (ASGPR) are hepatocyte bound receptors, which exhibit receptor mediated endocytosis (RME) for galactose specific moieties. Arabinogalactan (AG), a liver specific high galactose containing branched polysaccharide was hydrophobized using cholesterol (CHOL) as a lipid anchor via a two step
Kim H Chuong et al.
Qualitative health research, 25(10), 1359-1371 (2015-01-18)
Advances in human microbiome research have generated considerable interest in elucidating the role of bacteria in health and the application of microbial ecosystem therapies and probiotics. Fecal transplants involve the introduction of gut microbes from a healthy donor's stool to
Frank Münch et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 48(2), 236-243 (2014-11-22)
Experience regarding warm blood cardioplegia according to Calafiore results from its broad use in adult patients. In this experimental study, tepid (28°C) modified full blood cardioplegia (MBC) was adopted for paediatric use and compared with cold crystalloid cardioplegia (CCC). Twenty
Julia Stolarow et al.
BMC biotechnology, 15, 77-77 (2015-08-20)
Immobilization of enzymes onto different carriers increases enzyme's stability and reusability within biotechnological and pharmaceutical applications. However, some immobilization techniques are associated with loss of enzymatic specificity and/or activity. Possible reasons for this loss are mass transport limitations or structural
Brenton R Ware et al.
Toxicological sciences : an official journal of the Society of Toxicology, 145(2), 252-262 (2015-02-27)
Primary human hepatocytes (PHHs) are a limited resource for drug screening, their quality for in vitro use can vary considerably across different lots, and a lack of available donor diversity restricts our understanding of how human genetics affect drug-induced liver
Haoyu Liu et al.
Carbohydrate polymers, 113, 480-489 (2014-09-27)
Polymer design and selection are crucial to the development of amorphous solid dispersions (ASD) for solubilization of otherwise poorly water-soluble drugs. The matrix polymer is required to interact strongly at the molecular level with the drug to prevent recrystallization, but
Monideepa B Becerra et al.
BMC infectious diseases, 15, 254-254 (2015-07-02)
Clostridium difficile infection (CDI) remains one of the major hospital acquired infections in the nation, often attributable to increased antibiotic use. Little research, however, exists on the prevalence and impact of CDI on patient and hospital outcomes among populations requiring
Yossi Shemesh et al.
Nucleosides, nucleotides & nucleic acids, 34(11), 753-762 (2015-10-01)
Carboxylates and dicarboxylates are important phosphate mimics. Herein, we present a simple synthetic route for the preparation of RNA carboxylate/dicarboxylate conjugates, starting from suitably protected NH2- and COOH-containing molecules that are coupled to the RNA on the solid support. The
Ayele H Negussie et al.
Journal of materials science. Materials in medicine, 26(6), 198-198 (2015-06-25)
Therapeutic embolization of blood vessels is a minimally invasive, catheter-based procedure performed with solid or liquid emboli to treat bleeding, vascular malformations, and vascular tumors. Hepatocellular carcinoma (HCC) affects about half a million people per year. When unresectable, HCC is
Kihong Lim et al.
Journal of immunological methods, 426, 120-127 (2015-09-08)
β2 integrins play critical roles in migration of immune cells and in the interaction with other cells, pathogens, and the extracellular matrix. Among the β2 integrins, Mac-1 (Macrophage antigen-1), composed of CD11b and CD18, is mainly expressed in innate immune
Nobuaki Mori et al.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 21(10), 718-722 (2015-08-05)
Physicians often fail to suspect Clostridium difficile infection (CDI) and many microbiology laboratories use suboptimal diagnostic techniques. To estimate the extent of and reasons for incorrect diagnosis of CDI in Japan, we investigated toxigenic C. difficile isolated from all stool
Hye-Mi So et al.
Methods in molecular biology (Clifton, N.J.), 625, 239-249 (2010-04-28)
In this chapter, we discuss in detail the fabrication of carbon nanotube biosensors that use a single-walled carbon nanotube field-effect transistor (SWNT-FET) as a transducer, and aptamers as molecular recognition elements. We use a patterned growth technique to grow SWNTs
S J Ruiz et al.
Annals of diagnostic pathology, 19(4), 187-192 (2015-04-29)
Follicular helper T-cell lymphoma is a recently described variant of T-cell lymphoma sharing the cell of origin with angioimmunoblastic T-cell lymphoma and with primary cutaneous CD4-positive small/medium T-cell lymphoma. To better characterize the morphologic and immunophenotypic features of follicular helper
Kelsey T Laird et al.
Journal of pediatric psychology, 40(5), 517-525 (2015-01-27)
Evaluate the psychometric properties of child- and parent-report versions of the four-item Abdominal Pain Index (API) in children with functional abdominal pain (FAP) and healthy controls, using a revised scoring method that facilitates comparisons of scores across samples and time.
Emiel Cracco et al.
PloS one, 10(9), e0137080-e0137080 (2015-09-04)
Although the field of emotion regulation in children and adolescents is growing, there is need for age-adjusted measures that assess a large variety of strategies. An interesting instrument in this respect is the FEEL-KJ because it measures 7 adaptive and
Hiroyuki Shimizu et al.
Internal medicine (Tokyo, Japan), 54(17), 2155-2159 (2015-09-04)
Clostridium difficile infection (CDI) is the major cause of antibiotic-associated diarrhea in hospital inpatients. Rapid testing for the toxins in stool specimens is inconclusive due to its low sensitivity. Therefore, a two-step method is recommended as the most appropriate approach.
Roberta Cavalli et al.
International journal of pharmaceutics, 402(1-2), 254-257 (2010-10-05)
Three types of cyclodextrin nanosponges were synthetized cross-linking α, β or γ cyclodextrin with carbonyldiimidazole as cross-linker. Nanosponges are solid nanoparticles previously used as drug carriers. In this studies cyclodextrin nanosponges were developed as oxygen delivery system. For this purpose
Polym. Mater. Sci. Eng., 61, 936-936 (1989)
Danny Lafrance et al.
Organic letters, 13(9), 2322-2325 (2011-04-15)
Malonic acid derivatives undergo unusually mild decarboxylation when treated with N,N'-carbonyldiimidazole (CDI) at room temperature to generate the carbonyl imidazole moiety in high yield, which can be reacted further with a variety of nucleophiles in an efficient one-pot process.
Wei Chen et al.
Molecular medicine reports, 12(5), 7712-7720 (2015-10-16)
A previous nationwide Chinese epidemiological study revealed through isolation of A‑B+ Clostridium difficile strains, which produce toxin B (TcdB), but not toxin A TcdA, that the strains are widespread and more frequent in east Asian countries,. The development of a
N V Roik et al.
Journal of colloid and interface science, 362(1), 172-179 (2011-07-16)
Surface grafting of β-cyclodextrin onto aminopropylsilica has been carried out under mild conditions using 1,1'-carbonyldiimidazole as an activator. The obtained β-cyclodextrin-silica has been characterized by means of chemical and IR spectral analysis. Adsorption of para-aminobenzoic and para-aminosalicylic acids onto the
Rohan P Choraghe et al.
Life (Basel, Switzerland), 11(2) (2021-02-13)
At host-pathogen contact sites with Candida albicans, Dectin-1 activates pro-inflammatory signaling, while DC-SIGN promotes adhesion to the fungal surface. We observed that Dectin-1 and DC-SIGN collaborate to enhance capture/retention of C. albicans under fluid shear culture conditions. Therefore, we devised
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