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Chandrashekhara Manithody et al.
Biochemistry, 44(30), 10063-10070 (2005-07-27)
It has been hypothesized that two antiparallel structures comprised of residues 82-91 and 102-116 in factor Xa (fXa) may harbor a factor Va- (fVa-) dependent prothrombin recognition site in the prothrombinase complex. There are 11 charged residues in the 82-116
Hiromi Sasaki et al.
The Journal of biological chemistry, 277(47), 44765-44771 (2002-09-18)
In mammalian cultured cells, the cystine/glutamate exchange transport mediated by system x(c)- is important to maintain intracellular GSH levels. System x(c)- consists of two protein components, xCT and the heavy chain of 4F2 antigen. The activity of system x(c)- is
F Pouresmaeili et al.
Biology of reproduction, 57(3), 655-659 (1997-09-01)
We have cloned the PERF 15 gene, which encodes the most abundant protein of the perinuclear theca of rat spermatozoa. PERF 15 is related to the superfamily of lipophilic transport proteins. It has a molecular weight of 15,060 and is
Yong-Yeon Cho et al.
Cancer research, 69(10), 4398-4406 (2009-05-14)
Our previous findings indicated that RSK2 plays a critical role in proliferation and cell transformation induced by tumor promoters, such as epidermal growth factor or 12-O-tetradecanoylphorbol-13-acetate, and that kaempferol, a natural compound found in edible plants, selectively inhibits RSK2 activity.
Daniela Lixandru et al.
Annals of nutrition & metabolism, 56(4), 294-301 (2010-05-11)
The antiatherosclerotic enzyme paraoxonase (PON1) is affected by disease and lifestyle. We investigated the impact of diet in diabetic foot patients from 2 European countries. Dietary intake and serum PON1 activity, using as substrate paraoxon (paraoxonase) or phenylacetate (arylesterase), were
B Ebert et al.
Neurochemistry international, 34(5), 427-434 (1999-07-09)
The equilibrium binding characteristics of the tritiated GABAA agonist, 5-aminomethyl-3-isothiazolol (thiomuscimol) are described. Using the filtration technique to separate bound- from free-ligand, [3H]thiomuscimol was shown to bind to the GABA(A) receptor site(s) in a saturable manner with a Kd value
V Narayanan et al.
Journal of neurochemistry, 57(1), 75-80 (1991-07-01)
Myelin P2 protein is a small (14,800 Da) protein found in peripheral and central nervous system myelin. To investigate the regulation of expression of this myelin protein, a mouse genomic library was screened with a rabbit P2 cDNA (pSN2.2-2), and
George Z Rassidakis et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 8(2), 488-493 (2002-02-13)
BAX, a proapoptotic member of the BCL-2 family of proteins, has been detected in Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin's disease (HD), but its clinical significance is unknown. Therefore, we correlated BAX expression with presenting features and clinical outcome
Tuula K Outinen et al.
Nephron, 130(3), 182-190 (2015-07-04)
Puumala hantavirus (PUUV) induces an acute tubulointerstitial nephritis and acute kidney injury (AKI). Our aim was to evaluate the prognosis of severe AKI associated with PUUV infection. We examined 556 patients who were treated at Tampere University Hospital during 1982-2013
Inés Racamonde et al.
Analytica chimica acta, 865, 22-30 (2015-03-04)
Fabric phase sorptive extraction (FPSE) is a new, yet very promising member of the sorbent-based sorptive microextraction family. It has simultaneously improved both the extraction sensitivity and the speed of the extraction by incorporating high volume of sol-gel hybrid inorganic-organic
A Battezzati et al.
Diabetes, 49(9), 1543-1551 (2000-09-02)
In response to hypoglycemia, healthy individuals rapidly antagonize insulin action on glucose and lipid metabolism, but the effects on protein metabolism are unclear. Because amino acids are an important substrate for gluconeogenesis and a fuel alternative to glucose for oxidation
Guro E Lind et al.
Cellular oncology : the official journal of the International Society for Cellular Oncology, 28(5-6), 259-272 (2006-12-15)
Gene silencing through CpG island hypermethylation is a major mechanism in cancer development. In the present study, we aimed to identify and validate novel target genes inactivated through promoter hypermethylation in colorectal tumor development. With the use of microarrays, the
P Burman et al.
Clinical endocrinology, 44(3), 319-324 (1996-03-01)
Binding sites specific for growth hormone have been identified in the brain, but the action of GH on the central nervous system is still poorly understood. In a double-blind, placebo-controlled 21-month trial with a cross-over design, with each treatment period
R H Kim et al.
Matrix biology : journal of the International Society for Matrix Biology, 14(1), 31-40 (1994-01-01)
Bone sialoprotein (BSP) is a major structural protein of the bone matrix that is specifically expressed by fully-differentiated osteoblasts. To characterize the gene and to study the tissue-and differentiation stage-specific regulation of BSP gene transcription we have isolated and partially
M Manning et al.
Journal of peptide science : an official publication of the European Peptide Society, 7(9), 449-465 (2001-10-06)
We report the solid phase synthesis of four pairs of L- and D-thienylalanine (Thi/D-Thi) position two modified analogues of the following four oxytocin (OT) antagonists: des-9-glycinamide [1-(beta-mercapto-beta,beta-pentamethylene propionic acid), 2-O-methyltyrosine, 4-threonine]ornithine-vasotocin (desGly(NH2)9,d (CH2)5[Tyr(Me)2,Thr4]OVT) (A); the Tyr-(NH2)9 analogue of (A), d(CH2)5[Tyr(Me)2,Thr4,Tyr-(NH2)9]OVT
Carola Reindl et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 15(7), 2238-2247 (2009-03-12)
CBL is a negative regulator of activated receptor tyrosine kinases (RTK). In this study, we determined the frequency of CBL mutations in acute leukemias and evaluated the oncogenic potential of mutant CBL. The cDNA of 300 acute myeloid leukemia (AML)/myelodysplastic
D S Kim et al.
Plant cell reports, 23(1-2), 71-80 (2004-04-06)
To increase the specific free amino acid content in the japonica rice (Oryza sativa L.) cultivar Donganbyeo, mutant cell lines resistant to growth inhibition by 5-methyltryptophan (5MT) were selected from embryo-cultured callus irradiated with 50 Gy gamma-rays. Four 5MT-resistant homozygous
Nan Wang et al.
Experimental and therapeutic medicine, 20(5), 21-21 (2020-09-17)
Storage mites, such as Tyrophagus putrescentiae, are an important source of allergens that cause allergic diseases in humans. It has previously been indicated that T. putrescentiae has a high sensitization rate as an allergen in some Asian and European countries.
Kenneth V I Rolston et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 22(1), 7-14 (2013-08-27)
The goal of this study was to describe the outcomes associated with daptomycin treatment of documented gram-positive infections in patients with neutropenia. All patients with neutropenia (≤500 cells/m(3)) and at least one documented gram-positive culture from 2006-2009 were identified from
A Ramos-Miguel et al.
Neuroscience, 215, 17-30 (2012-04-28)
Cyclin-dependent kinase 5 (cdk5) participates in opioid receptor signalling through complex molecular mechanisms. The acute effects of selective μ-(fentanyl) and δ-(SNC-80) opioid receptor agonists, as well as the chronic effects of morphine (the prototypic opiate agonist mainly acting at μ-receptors)
Michael Manns et al.
Lancet (London, England), 384(9954), 1597-1605 (2014-08-01)
An unmet need exists for interferon-free and ribavirin-free treatments for chronic hepatitis C virus (HCV) infection. In this study, we assessed all-oral therapy with daclatasvir (NS5A replication complex inhibitor) plus asunaprevir (NS3 protease inhibitor) in patients with genotype 1b infection
Hyo-Soo Kim et al.
Lancet (London, England), 396(10257), 1079-1089 (2020-09-04)
A potent P2Y12 inhibitor-based dual antiplatelet therapy is recommended for up to 1 year in patients with acute coronary syndrome receiving percutaneous coronary intervention (PCI). The greatest benefit of the potent agent is during the early phase, whereas the risk
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