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National Toxicology Program technical report series, (557)(557), 1-163 (2011-03-19)
Beta-myrcene, an acyclic unsubstituted monoterpene, and the essential oils which contain it are used as intermediates in the production of terpene alcohols (geraniol, nerol, and linalool), which, in turn, serve as intermediates in the production of aroma and flavor chemicals.
Manuel Weinheimer et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 108, 13-22 (2016-09-04)
The efflux transporter P-glycoprotein (P-gp) significantly modulates drug transport across the intestinal mucosa, strongly reducing the systemic absorption of various active pharmaceutical ingredients. P-gp inhibitors could serve as helpful tools to enhance the oral bioavailability of those substances. As a
J S Coon et al.
Cancer research, 51(3), 897-902 (1991-02-01)
A recently developed non-ionic surfactant called Solutol HS 15 (poly-oxyethylene esters of 12-hydroxystearic acid), with low toxicity in vivo, was shown to reverse completely the multidrug resistance of KB 8-5 and KB 8-5-11 human epidermoid carcinoma cells in vitro but
Matthias Folwaczny et al.
Journal of clinical periodontology, 32(5), 530-534 (2005-04-22)
Interleukin (IL)-18 regulates the expression of the proinflammatory cytokine interferon (IFN)-gamma. The present study sought to test the putative involvement of six different IL-18 gene polymorphisms in pre-disposition to destructive periodontal disease. A total of 123 patients with periodontitis and
Jong-Min Kim et al.
Archives of neurology, 64(10), 1510-1518 (2007-10-10)
To examine the presence of an ATXN2 mutation in patients with parkinsonism in the Korean population and to find the difference in the ATXN2 mutation between ataxic and parkinsonian phenotypes. Survey. Seoul National University Hospital (a referral center). Patients Patients
Viralam S Kiran et al.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 13(18), e2124-e2129 (2017-07-26)
The aims of this study were to determine the incidence and correlates of left ventricular (LV) dysfunction amongst percutaneous patent ductus arteriosus (PDA) device closure patients, and to propose an indexed parameter for predicting LV dysfunction. In a retrospective cross-sectional
F Ivy Carroll et al.
Journal of medicinal chemistry, 48(4), 1221-1228 (2005-02-18)
A series of 3'-substituted deschloroepibatidine analogues (3a-g and 4) showed high affinity for alpha4beta2 binding and relatively weak affinity for alpha7 nAChRs. The 3'-ethynyl (3g) and 3'-fluoro (3a) analogues with K(i) values of 0.02 and 0.037 nM, respectively, were the
K Kurachi et al.
Biochemistry, 24(20), 5494-5499 (1985-09-24)
Human cDNAs coding for angiogenin, a human tumor derived angiogenesis factor, were isolated from a cDNA library prepared from human liver poly(A) mRNA employing a synthetic oligonucleotide as a hybridization probe. The largest cDNA insert (697 base pairs) contained a
M Kohnle et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 6(1), 205-208 (2006-01-26)
We investigated prospectively the efficacy of ezetimibe in addition to statin therapy in stable renal transplant patients in whom hypercholesterolemia was not sufficiently treated. Eighteen renal transplant patients received 10 mg ezetimibe once daily in addition to high-dose statin therapy
Frank Bergmann et al.
Oncology reports, 24(4), 909-915 (2010-09-03)
The promigratory molecule L1CAM is overexpressed in various tumors, often representing an unfavorable prognostic marker. Recently, we identified L1CAM expression in pancreatic ductal adenocarcinoma (PDAC) cells accounting for chemoresistance and increased cell migration. Thus, the present study aims at further
Larissa A Balabanova et al.
Marine biotechnology (New York, N.Y.), 14(1), 87-95 (2011-06-08)
An extracellular nuclease was purified 165-fold with a specific activity of 41,250 U/mg poly(U) by chromatography with modified chitosan from the culture of marine fungus Penicillium melinii isolated from colonial ascidium collected near Shikotan Island, Sea of Okhotsk, at a
H-L Liu et al.
Bone marrow transplantation, 49(8), 1063-1069 (2014-05-21)
This study included data from 185 consecutively treated patients, 16 years of age or older, who underwent myeloablative transplantation using unrelated umbilical cord blood (UCB) (UCB transplantation (UCBT), n=70) or HLA-identical sibling donor peripheral blood stem cells alone or combined
B J Curry et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 16(5), 1760-1769 (1998-05-20)
The detection of melanoma cells in the circulation by polymerase chain reaction (PCR) assays has been shown by several investigators to correlate with the stage of the disease and possibly with prognosis. We performed prospective studies on 276 patients with
V Polanská et al.
Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti, 64(2), 77-80 (2008-04-19)
The aim of this study was to evaluate the presence of the dry eye syndrome and corneal complications in patients with rheumatoid arthritis and to assess its association with the -174 gene polymorphism for interleukin 6. The group consisted of
Sayon Roy et al.
Diabetes, 52(5), 1229-1234 (2003-04-30)
Overexpression of extracellular matrix (ECM) components is closely associated with the development of vascular basement membrane (BM) thickening, a histological hallmark of diabetic microangiopathy. To determine whether BM thickening of retinal capillaries could be prevented by down regulating synthesis of
Sergey Zaichik et al.
International journal of pharmaceutics, 581, 119299-119299 (2020-04-07)
The aim of this study was to evaluate the impact of a PEG-corona on oily droplets of a nanoemulsion on phosphate cleavage on their surface. A PEG-free nanoemulsion composed of 60% oleic acid, 30% Capmul MCM EP and 10% Span
Eva Kolwijck et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 19(8), 1335-1338 (2009-12-17)
We studied preoperative CA-125 levels of 123 patients with borderline ovarian tumors (BOTs) and performed an analysis with data of earlier published studies. CA-125 levels were compared according to histology and stage of disease. Preoperative serum CA-125 levels were significantly
E Meller et al.
The Journal of pharmacology and experimental therapeutics, 292(2), 684-691 (2000-01-20)
In hippocampal membranes, the selective 5-hydroxytryptamine (5-HT(1A)) receptor agonists 8-hydroxy-dipropylaminotetralin (8-OH-DPAT) and N,N-dipropyl-5-carboxamidotryptamine (N,N-DP-5-CT) stimulated guanosine-5'-O-(3-thio)triphosphate ([(35)S]GTPgammaS) binding by 130 to 140%; binding stimulated by nonselective agonists (5-HT and 5-CT) was approximately 30% greater. However, the selective 5-HT(1A) receptor antagonist
J H Xia et al.
Yi chuan xue bao = Acta genetica Sinica, 26(6), 591-597 (2000-07-06)
Through the analysis of EST database, we obtained one human EST (GenBank: H28856) which showed significant similarity with the partial coding sequence of rat dimethylglycine dehydrogenase gene. This EST was mapped to 9q34 due to 95.6% identity with one genomic
A J Bilski et al.
Journal of cardiovascular pharmacology, 5(3), 430-437 (1983-05-01)
While specific antagonists of the beta 1-adrenoceptor, such as atenolol and betaxolol, are widely available, a potent specific antagonist selective for the beta 2-adrenoceptor has yet to be described. Previously described beta 2-selective antagonists such as butoxamine, H 35/25, and
Naohide Oue et al.
International journal of cancer, 125(10), 2383-2392 (2009-08-12)
Gastric cancer (GC) is 1 of the most common human cancers. Early detection remains the most promising approach to improving long-term survival of patients with GC. We previously performed Serial Analysis of Gene Expression (SAGE) on 4 primary GCs and
Kristi L Bennett et al.
JAMA, 304(24), 2724-2731 (2010-12-24)
Germline loss-of-function phosphatase and tensin homolog gene (PTEN) mutations cause 80% of Cowden syndrome, a rare autosomal-dominant disorder (1 in 200,000 live births), characterized by high risks of breast, thyroid, and other cancers. A large heterogeneous group of individuals with
Shun Wang et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 31(4), 623-632 (2008-07-18)
Abnormal fatty acid metabolism may play an important role in the pathogenesis of essential hypertension (EH). We compared fasting serum free fatty acid (FFA) composition between EH patients and nonhypertensive (NH) subjects, and examined the relationships between fasting serum FFA
Nicolette van Duinen et al.
Clinical endocrinology, 74(2), 160-165 (2010-11-04)
The majority of patients with head and neck paragangliomas (HNPGL) have biochemically silent tumours. Chromogranin A (CgA) is a tumour marker for neuroendocrine tumours. To assess the role of CgA as a tumour marker in patients with hereditary HNPGL. We
Catherine D Sanders et al.
Pediatric pulmonology, 53(11), 1565-1573 (2018-09-22)
Primary ciliary dyskinesia (PCD) and cri du chat syndrome (CdCS) are distinct disorders that can co-occur due to a common genetic locus on chromosome 5p. Chronic respiratory symptoms associated with PCD can occur in CdCS and are typically attributed to
S Tsuruoka et al.
Pflugers Archiv : European journal of physiology, 442(3), 321-328 (2001-08-04)
We have recently reported that the apical membrane of the proximal tubule S2 segment from wild-type mice (WT mice) has the capacity for P-glycoprotein- (P-gp-) mediated drug efflux, whereas mice in which both mdr1a and mdr1b genes are disrupted (KO
Kayo Nishimatsu et al.
Annals of nuclear medicine, 29(9), 766-771 (2015-07-15)
In positron emission tomography (PET) with F-18-fluorodeoxyglucose (FDG), non-tumorous focal uptake is often observed around the lumbar spinous processes (LSPs). Close approximation of LSPs with sclerosis is often seen, which is called Baastrup disease. The aim of this study was
Dirk Hellwig et al.
European journal of nuclear medicine and molecular imaging, 32(9), 1041-1049 (2005-05-20)
The aims of this prospective study were to validate single-photon emission computed tomography (SPECT) with p-[(123)I]iodo-L-phenylalanine (IPA) in brain tumours and to evaluate its potential for the characterisation of indeterminate brain lesions. In 45 patients with indeterminate brain lesions or
Peter K Stricklett et al.
American journal of physiology. Renal physiology, 290(6), F1315-F1319 (2005-12-29)
Endothelin-1 (ET-1) inhibition of vasopressin (AVP)-stimulated cAMP accumulation in the collecting duct has been hypothesized to be mediated, at least in part, by nitric oxide (NO). To examine this, the effect of ET-1 on NO production by acutely isolated rat
P Heffeter et al.
The Journal of pharmacology and experimental therapeutics, 312(1), 281-289 (2004-08-28)
KP1019 [indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A) is a metal complex with promising anticancer activity. Since chemoresistance is a major obstacle in chemotherapy, this study investigated the influence of several drug resistance mechanisms on the anticancer activity of KP1019. Here we demonstrate
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