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Alex Iranzo et al.
The Lancet. Neurology, 10(9), 797-805 (2011-08-02)
Serial dopamine transporter (DAT) imaging in patients with Parkinson's disease (PD) and other synucleinopathies shows progressive nigrostriatal dopaminergic dysfunction. Because idiopathic rapid-eye-movement (REM) sleep behaviour disorder (IRBD) can precede the classic symptoms of PD and other synucleinopathies, we postulated that
Megha Barot et al.
Experimental eye research, 106, 47-54 (2012-11-03)
This study was designed to investigate functional localization of both efflux (P-glycoprotein, P-gp) and influx (peptide) transporters in the mitochondrial membrane of cultured rabbit primary corneal epithelial cells (rPCECs). Isolation and purification of mitochondria was performed by optimized cell fractionation
Chintan Patel et al.
The American journal of pathology, 184(11), 3040-3051 (2014-09-10)
Retinopathy of prematurity adversely affects premature infants because of oxygen-induced damage of the immature retinal vasculature, resulting in pathological neovascularization (NV). Our pilot studies using the mouse model of oxygen-induced retinopathy (OIR) showed marked increases in angiogenic mediators, including endothelins
Chibing Tan et al.
Journal of the American Chemical Society, 124(39), 11827-11832 (2002-09-26)
We have recently reported phospholipid bicelles (bilayered micelles) that have positive anisotropy of the magnetic susceptibility and align with their normals parallel to an external magnetic field [J. Am. Chem. Soc. 2001, 123, 1537]. Improvements have been made via the
Huiyong Wang et al.
Analytica chimica acta, 721, 147-153 (2012-03-13)
We present a comparison of two sensitive methods, HPLC with fluorescence detector (HPLC/FLD) and UPLC with electrospray tandem mass spectrometry (UPLC/MS/MS), for the determination of indoleamine neurotransmitters (NTs) and their metabolites in sea lamprey plasma samples. Liquid-liquid extraction (LLE) and
G Kevin Chen et al.
Molecular pharmacology, 65(4), 906-916 (2004-03-27)
We investigated the mechanisms of MDR1 gene activation by CCAAT/enhancer binding protein beta (C/EBPbeta, or nuclear factor for interleukin 6) in human cancer cells. Transfection of the breast cancer cell line MCF-7 and its doxorubicin-selected variant MCF-7/ADR by either C/EBPbeta
Ze-long Zhong et al.
Experimental diabetes research, 2012, 350852-350852 (2013-01-11)
To identify predictors of end-stage proliferative diabetic retinopathy (PDR) in a cohort of individuals with type 2 diabetes mellitus (T2DM) from the Northern Chinese Han population. We investigated characteristics of 153 consecutive diabetic patients with end-stage PDR (62 males, 91
Matthew J Delmonico et al.
Journal of the American Geriatrics Society, 53(2), 204-210 (2005-01-28)
To determine the influence of angiotensinogen (AGT) A-20C, M235 T, and angiotensin II type 1 receptor (AGTR1) A1166C genotypes on resting blood pressure (BP) response to strength training (ST) in older men and women. Prospective intervention study with retrospective genotyping.
Larissa A Balabanova et al.
Marine biotechnology (New York, N.Y.), 14(1), 87-95 (2011-06-08)
An extracellular nuclease was purified 165-fold with a specific activity of 41,250 U/mg poly(U) by chromatography with modified chitosan from the culture of marine fungus Penicillium melinii isolated from colonial ascidium collected near Shikotan Island, Sea of Okhotsk, at a
Ming Ma et al.
Oncology letters, 15(4), 4649-4656 (2018-03-16)
Celecoxib is a newly-identified nonsteroidal anti-inflammatory drug, which has been used to treat fever in clinical practice. Celecoxib has been demonstrated to suppress the viability of various human tumor cells. However, the effect of celecoxib on response of T-cell lymphoma
Anna Yemelyanova et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(2), 268-274 (2012-09-22)
While cervical cancer screening relies on cervical cytology and high-risk human papillomavirus (HPV) detection, the histologic diagnosis, and specifically lesion grade, is the main parameter that drives clinical management of screen-positive women. Morphologically diagnosed squamous intraepithelial lesions (SIL/CIN) regress spontaneously
Y Ramamoorthy et al.
Pharmacogenetics, 11(6), 477-487 (2001-08-16)
CYP2D6 is involved in the metabolism of several classes of drugs, including tricyclic antidepressants, selective serotonin reuptake inhibitors and various amphetamines. CYP2D6*10 is an allelic variant, producing an enzyme with Pro34Ser and Ser486Thr amino acid substitutions. Approximately 75% of Asians
Francesca Spinella et al.
The Journal of biological chemistry, 278(42), 41294-41301 (2003-08-09)
Endothelin-1 (ET-1) is overexpressed in ovarian carcinoma and acts as an autocrine factor selectively through the ETA receptor (ETAR) to promote tumor cell proliferation, survival, neovascularization, and invasiveness. Loss of gap junctional intercellular communication (GJIC) is critical for tumor progression
Mathieu Manassero et al.
Journal of feline medicine and surgery, 16(8), 623-630 (2013-12-07)
Ureteral obstruction secondary to ureterolithiasis in cats is a challenging situation. Ureteral stenting has recently been introduced to prevent complications that often occurred after ureterotomy or other invasive surgeries. The purpose of this study is to describe the stenting technique
Monica C Toffoli et al.
Inflammation, 30(1-2), 28-37 (2007-01-16)
Neutrophils isolated from human peripheral blood added to a monolayer of human endothelial cells (ECV-304 cell line) stimulated with LPS (100 ng ml(-1)) resulted in: (a) neutrophil activation, measured by spreading and release of leukotriene B(4) (LTB(4)); (b) neutrophil degranulation
Bénédicte Fontaine-Bisson et al.
Metabolism: clinical and experimental, 56(5), 649-655 (2007-04-21)
Tumor necrosis factor alpha (TNF-alpha) is a proinflammatory cytokine that impairs insulin action and alters lipid metabolism. We investigated the effects of genetic polymorphisms of TNF-alpha on circulating biomarkers of insulin resistance and lipid metabolism during an 8-hour metabolic profile
Alfredo J Lucendo et al.
Digestive diseases and sciences, 56(4), 1107-1111 (2010-08-21)
Recent articles have described patients that share eosinophilic esophagitis (EoE) and celiac disease (CD) suggesting a true relationship between both diseases. The purpose of this study was to investigate whether HLA DQ2 and DQ8 predisposing to CD are increased in
Christiane Auray-Blais et al.
Molecular genetics and metabolism, 102(1), 49-56 (2010-10-12)
Mucopolysaccharidoses (MPSs) are complex storage disorders caused by specific lysosomal enzyme deficiencies, resulting in the accumulation of glycosaminoglycans (GAGs) in urine, plasma, as well as in various tissues. We devised and validated a straightforward, but accurate and precise tandem mass
Yoshinao Muro et al.
Arthritis research & therapy, 17, 57-57 (2015-04-18)
Anti-PM/Scl antibodies are associated with polymyositis (PM)/systemic scleroderma (SSc) overlap syndromes and are also found in other systemic autoimmune diseases. Although anti-PM/Scl reactivity is found in 3-11% of PM or SSc patients and in approximately 25% of PM/SSc overlap patients
Christos Bantis et al.
Kidney international, 66(1), 288-294 (2004-06-18)
Interleukin-10 (IL-10) is a cytokine with immunosuppressive properties. We evaluated the influence of G-1082A polymorphism in the IL-10 gene promoter, which has been associated with modified IL-10 production, on the two most common forms of primary glomerulonephritis: IgA nephropathy (IgAN)
Zachary DeLoughery et al.
Chemical research in toxicology, 27(5), 843-851 (2014-03-22)
Cr(VI) genotoxicity is caused by products of its reductive metabolism inside the cells. Reactive oxygen species (ROS) and Cr(V,IV) intermediates are potential sources of oxidative damage by Cr(VI). Here, we investigated seven fluorescent probes for the detection of ROS and
Pedro Rodríguez-López et al.
International journal of food microbiology, 206, 84-95 (2015-05-24)
In order to find out how real Listeria monocytogenes-carrying biofilms are in industrial settings, a total of 270 environmental samples belonging to work surfaces from fish (n = 123), meat (n = 75) and dairy industries (n = 72) were
C G Garlisi et al.
American journal of respiratory cell and molecular biology, 24(1), 90-98 (2001-01-12)
Human interleukin (IL)-5 gene transcription is regulated by several transcription factor binding sites, including CLE 0, GATA, and a region from position -123 to -92 known as response element (RE)-II. By expression cloning, a partial protein was identified that bound
Hyeon-Kyu Go et al.
Nutrients, 7(10), 8532-8544 (2015-10-27)
The objective of this study was to investigate the therapeutic efficacies of crude yam (Dioscorea batatas) powder (PY), water extract of yam (EY), and allantoin (the active constituent of yam) in streptozotocin (STZ)-induced diabetic rats with respect to glucose, insulin
L G Altman et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 32(11), 1217-1223 (1984-11-01)
Lowicryl K4M (K4M) was recently introduced as an embedding medium for immunocytochemistry at the electron microscope level (BL Armbruster, E Carlemalm, R Chiovetti, RM Garavito, JA Hobot, E Kellenberger, W Villiger (1982):J Microsc 126:77 and E Carlemalm, M Garavito, W
J Jane et al.
Carbohydrate research, 132(1), 105-118 (1984-09-01)
Human-salivary, porcine-pancreatic, and Bacillus subtilis alpha amylases were used to study the structure of amylose-V complexes with butyl alcohol, tert-butyl alcohol, 1,1,2,2-tetrachloroethane, and 1-naphthol, and of retrograded amylose. Alpha amylase hydrolyzes the amorphous, folding areas on the surfaces of the
Jay R Thiagarajah et al.
The Journal of biological chemistry, 277(21), 19139-19144 (2002-03-14)
Two aquaporin (AQP)-type water channels are expressed in mammalian cornea, AQP1 in endothelial cells and AQP5 in epithelial cells. To test whether these aquaporins are involved in corneal fluid transport and transparency, we compared corneal thickness, water permeability, and response
Hakan Guvenir et al.
Allergy and asthma proceedings, 36(5), 386-393 (2015-09-01)
Nonsteroidal anti-inflammatory drugs (NSAID) are the second-most frequent drugs that cause hypersensitivity reactions among children. Studies related to NSAIDs hypersensitivity in children are limited. In this study, we aimed to evaluate children admitted with suspicion of NSAIDs reaction. Between January
Zhiqiang Pan et al.
Anesthesiology, 127(1), 147-163 (2017-04-25)
Ten-eleven translocation methylcytosine dioxygenase converts 5-methylcytosine in DNA to 5-hydroxymethylcytosine, which plays an important role in gene transcription. Although 5-hydroxymethylcytosine is enriched in mammalian neurons, its regulatory function in nociceptive information processing is unknown. The global levels of 5-hydroxymethylcytosine and
L Pang et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 26(6), 781-781 (2019-11-02)
In invasive aspergillosis (IA), monitoring response to antifungal treatment is challenging. We aimed to explore if routine blood parameters help to anticipate outcomes following IA. Post hoc secondary analysis of two multicenter randomized trials was performed. The Global Comparative Aspergillosis
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