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Matthew Stroh et al.
Biochemical pharmacology, 88(4), 573-583 (2013-12-24)
A popular, if not centric, approach to the study of an event is to first consider that of the simplest cause. When dissecting the underlying mechanisms governing idiopathic diseases, this generally takes the form of an ab initio genetic approach.
Eunna Choi et al.
Infection and immunity, 82(6), 2203-2210 (2014-03-20)
In order to survive inside macrophages, Salmonella produces a series of proteins encoded by genes within Salmonella pathogenicity island 2 (SPI-2). In the present study, we report that Fur, a central regulator of iron utilization, negatively controls the expression of
Magnus Steigedal et al.
Journal of immunology (Baltimore, Md. : 1950), 193(12), 6081-6089 (2014-11-16)
Competition for iron is a critical component of successful bacterial infections, but the underlying in vivo mechanisms are poorly understood. We have previously demonstrated that lipocalin 2 (LCN2) is an innate immunity protein that binds to bacterial siderophores and starves
William E Winter et al.
Laboratory medicine, 45(2), 92-102 (2014-05-30)
Iron is one of the most important nonorganic substances that make life possible. Iron plays major roles in oxygen transport (eg, hemoglobin; -67% of total body iron [TBI]), short-term oxygen storage (eg, myoglobin; -3.5% of TBI), and energy generation (eg
L Iu Milovanova et al.
Terapevticheskii arkhiv, 85(6), 17-24 (2013-07-23)
To study the clinical significance of determining the serum concentration of phosphorus and calcium metabolism regulators--the morphogenetic proteins FGF-23 and Klotho in patients with different stages of chronic kidney disease (CKD). The serum levels of FGF-23 (a human FGF-23 ELISA
Shee Chien Yong et al.
Science (New York, N.Y.), 345(6201), 1170-1173 (2014-09-06)
Alkaline phosphatases play a crucial role in phosphate acquisition by microorganisms. To expand our understanding of catalysis by this class of enzymes, we have determined the structure of the widely occurring microbial alkaline phosphatase PhoX. The enzyme contains a complex
Don-Kyu Kim et al.
Nature medicine, 20(4), 419-424 (2014-03-25)
In response to microbial infection, expression of the defensin-like peptide hepcidin (encoded by Hamp) is induced in hepatocytes to decrease iron release from macrophages. To elucidate the mechanism by which Salmonella enterica var. Typhimurium (S. typhimurium), an intramacrophage bacterium, alters
Robert F Anderson et al.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 372(2019), 20130054-20130054 (2014-06-04)
Fluxes of lithogenic material and fluxes of three palaeo-productivity proxies (organic carbon, biogenic opal and alkenones) over the past 100,000 years were determined using the (230)Th-normalization method in three sediment cores from the Subantarctic South Atlantic Ocean. Features in the
Microcytic anemia.
Shraga Aviner et al.
The New England journal of medicine, 371(26), 2536-2536 (2014-12-30)
Ocean Science. Microbial proteins and oceanic nutrient cycles.
C Mark Moore
Science (New York, N.Y.), 345(6201), 1120-1121 (2014-09-06)
Femkje A M Jonker et al.
Journal of clinical pathology, 67(8), 717-723 (2014-06-12)
Iron deficiency is an important child health problem. Its diagnosis in areas of high infection exposure remains complicated as inflammation may interfere with the accuracy of peripheral iron markers. With this study, we aimed to validate the conventional iron markers
Yu Wang et al.
Biochimica et biophysica acta, 1840(10), 3022-3033 (2014-07-06)
The neurodegenerative disease Friedreich's ataxia is the result of frataxin deficiency. Frataxin is a mitochondrial protein involved in iron-sulfur cluster (Fe-S) cofactor biogenesis, but its functional role in this pathway is debated. This is due to the interconnectivity of iron
Hypoferremia of infection: a double-edged sword?
Kristen L Lokken et al.
Nature medicine, 20(4), 335-337 (2014-04-09)
Ocean chemistry: Fingerprints of a trace nutrient.
Joseph A Resing et al.
Nature, 511(7508), 164-165 (2014-07-11)
Donglei Wu et al.
Environmental technology, 34(17-20), 2663-2669 (2014-02-18)
In this study, nanoscale zero-valent iron (NZVI) was synthesized by conventional liquid-phase chemical reduction methods without a support material and then characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The effect of NZVI particles
Joseph Marie Sieliechi et al.
Environmental technology, 35(13-16), 1831-1839 (2014-06-25)
In this study, spatial and seasonal variations of phosphorus fractions in Lake Bini sediments were evaluated using a sequential extraction method. The sampling of water and sediments (surface and coring) was carried out at seven sites around the lake during
Tim M Conway et al.
Nature, 511(7508), 212-215 (2014-07-11)
Dissolved iron is an essential micronutrient for marine phytoplankton, and its availability controls patterns of primary productivity and carbon cycling throughout the oceans. The relative importance of different sources of iron to the oceans is not well known, however, and
Parenteral iron as a cause of hypophosphataemia.
Francisco J Fernández-Fernández et al.
BMJ (Clinical research ed.), 349, g4616-g4616 (2014-07-17)
Joseph E Kiss et al.
JAMA, 313(6), 575-583 (2015-02-11)
Although blood donation is allowed every 8 weeks in the United States, recovery of hemoglobin to the currently accepted standard (12.5 g/dL) is frequently delayed, and some donors become anemic. To determine the effect of oral iron supplementation on hemoglobin
Jungho Ryu et al.
Journal of nanoscience and nanotechnology, 13(5), 3422-3426 (2013-07-19)
Spinel structured highly dense NiMn2O4-based (NMO) negative temperature coefficient (NTC) thermistor thick films were fabricated by aerosol-deposition at room temperature. To enhance the thermistor B constant, which represents the temperature sensitivity of the NMO thermistor material, Co and Co-Fe doping
Isabelle R Miousse et al.
Radiation research, 182(1), 92-101 (2014-06-25)
There is an increasing need to better understand the long-term health effects of high-linear energy transfer (LET) radiation due to exposure during space missions, as well as its increasing use in clinical treatments. Previous studies have indicated that exposure to
[R. J. Ulvik replies].
Rune J Ulvik
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 133(12-13), 1285-1285 (2013-07-03)
Carmen S D Rodrigues et al.
Environmental technology, 35(9-12), 1307-1319 (2014-04-08)
This study aims to investigate the efficiency of individual and integrated processes applied to organic matter abatement and biodegradability improvement of a polyester dyeing wastewater, namely coagulation/flocculation combined with Fenton's reagent (Approach 1), Fenton oxidation alone (Approach 2) and its
Sandro Silva-Gomes et al.
Frontiers in cellular and infection microbiology, 3, 96-96 (2013-12-25)
Due to their chemical versatility, transition metals were incorporated as cofactors for several basic metabolic pathways in living organisms. This same characteristic makes them potentially harmful, since they can be engaged in deleterious reactions like Fenton chemistry. As such, organisms
Microbial reduction in wastewater treatment using Fe(3+) and Al(3+) coagulants and PAA disinfectant.
Surendra K Pradhan et al.
Journal of water and health, 11(4), 581-589 (2013-12-18)
Wastewater is an important source of pathogenic enteric microorganisms in surface water and a major contaminating agent of drinking water. Although primary and secondary wastewater treatments reduce the numbers of microorganisms in wastewater, significant numbers of microbes can still be
Hong-Seok Kim et al.
Chemosphere, 113, 93-100 (2014-07-30)
Effects of anions (NO3(-), HCO3(-), Cl(-), SO4(2-)) and humic acid on the reactivity and core/shell chemistries of polyacrylic acid-coated nanoscale zero-valent iron (PAA-NZVI) and inorganically modified NZVI (INORG-NZVI) particles were investigated. The reactivity tests under various ion concentrations (0.2-30mN) revealed
Microcytic anemia.
Thomas G DeLoughery
The New England journal of medicine, 371(26), 2537-2537 (2014-12-30)
Nosratola D Vaziri
Nephrology news & issues, 28(2), 4-5 (2014-03-22)
Loss of blood associated with hemodialysis procedures and laboratory testing, together with impaired iron absorption due to elevation of hepcidin, invariably cause iron deficiency in end-stage renal disease patients. For this reason, nearly all ESRD patients require intravenous iron to
Tian Tian et al.
Biochemical and biophysical research communications, 443(2), 376-381 (2013-12-18)
Iron-sulfur (Fe-S) clusters are the oldest and most versatile inorganic cofactors that are required to sustain fundamental life processes. Bacteria have three systems of [Fe-S] cluster biogenesis, designated ISC, NIF, and SUF. In contrast, the Thermus thermophiles HB8 has only
Judith Ernst et al.
Food and nutrition bulletin, 35(4 Suppl), S198-S204 (2015-02-03)
Preliminary evidence suggests that improved nutrition early in HIV infection may delay progression to AIDS and delay the initiation or improve the effectiveness of antiretroviral drug therapy. There are few studies that evaluate food-based interventions in drug-naïve, HIV-infected women and
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