124 898-13-1

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Thrombospondin-1 mimetic peptide ABT-898 affects neovascularization and survival of human endometriotic lesions in a mouse model.

Diane S Nakamura et al.

The American journal of pathology, 181(2), 570-582 (2012-06-26)

Endometriosis is a common cause of pelvic pain and infertility in women, and a common indication for hysterectomy, yet the disease remains poorly diagnosed and ineffectively treated. Because endometriotic lesions require new blood supply for survival, inhibiting angiogenesis could provide

Compatibility of a novel thrombospondin-1 analog with fertility and pregnancy in a xenograft mouse model of endometriosis.

Diane S Nakamura et al.

PloS one, 10(3), e0121545-e0121545 (2015-03-27)

Endometriosis is a gynecological disease defined by the growth of endometrium outside of the uterus. Although endometriosis contributes to 50% of female infertility cases, medical treatments are incompatible with pregnancy. Angiogenesis, the growth of blood vessels from existing vasculature, plays

EGFR and HER2 expression in advanced biliary tract cancer.

Jan Harder et al.

World journal of gastroenterology, 15(36), 4511-4517 (2009-09-25)

To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2) in patients with advanced biliary tract cancer (BTC). EGFR and HER2 expression was studied in

Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain.

S Attaphitaya et al.

The Journal of biological chemistry, 274(7), 4383-4388 (1999-02-06)

We report here the cloning, primary structure, heterologous expression, tissue distribution, and localization of a cDNA encoding rat NHE5, a fifth member of the mammalian plasma membrane Na+/H+ exchanger (NHE) gene family. The full-length open reading frame as well as

Temperature-dependent electron capture detector response to common alternative fluorocarbons.

S R Sousa et al.

Analytical chemistry, 69(19), 3871-3878 (1997-10-01)

The relative electron capture detector (ECD) response to alternative fluorocarbons (AFCs) using gas chromatography are found to be at least 1 order of magnitude lower than that for CFC-12. Detection limits for the chlorofluorocarbons CFC-12, HCFC-22, HCFC-123, and HCFC-124 are

Refractive error and visual impairment in Ireland schoolchildren.

Siofra Christine Harrington et al.

The British journal of ophthalmology, 103(8), 1112-1118 (2018-10-14)

To report refractive error prevalence and visual impairment in Republic of Ireland (henceforth 'Ireland') schoolchildren. The Ireland Eye Study examined 1626 participants (881 boys, 745 girls) in two age groups, 6-7 years (728) and 12-13 years (898), in Ireland between

Association between HER2 status in gastric cancer and clinicopathological features: a retrospective study using whole-tissue sections.

Renato Santos Laboissiere et al.

BMC gastroenterology, 15, 157-157 (2015-11-05)

Gastric cancer is usually diagnosed in an advanced stage of disease and treatment options are sparse. Trastuzumab was recently approved for metastatic or locally advanced carcinomas arising in the stomach or in the gastroesophageal junction in patients with HER2-positive tumors.

Imaging hNET reporter gene expression with 124I-MIBG.

Maxim A Moroz et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 48(5), 827-836 (2007-05-04)

The norepinephrine transporter (NET) has recently been suggested as a useful reporter gene. We have extended this effort by constructing an internal ribosomal entry site (IRES)-linked hNET-green fluorescent protein (GFP) hybrid reporter gene for both nuclear and optical imaging. A

The herpes simplex virus type 1 UL3 transcript starts within the UL3 open reading frame and encodes a 224-amino-acid protein.

Nancy S Markovitz

Journal of virology, 81(19), 10524-10531 (2007-07-13)

Several different herpes simplex viruses (HSVs) and vectors are being explored as therapeutic products for use in the treatment of cancer and neurological disorders. The viral strain and the combination of mutant viral genes that ultimately may serve as a

Chemical investigations of disperse dyes in patch test preparations.

Kristina Ryberg et al.

Contact dermatitis, 58(4), 199-209 (2008-03-21)

Contact allergy to textile dyes is not uncommon. The allergy is detected by patch testing patients with commercial patch test preparations. To investigate 8 disperse dyes (DDs) used for patch testing in the departments in Malmö and in Leuven and

Fragile X syndrome screening of families with consanguineous and non-consanguineous parents in the Iranian population.

Ali Reza Pouya et al.

European journal of medical genetics, 52(4), 170-173 (2009-04-14)

Fragile X syndrome is the most common form of inherited mental retardation (MR). It is caused by the expansion of CGG triplet repeats in the fragile X mental retardation 1 (FMR1) gene. In mentally retarded males, the frequency of fragile

Disulphide bond assignment in human tissue inhibitor of metalloproteinases (TIMP).

R A Williamson et al.

The Biochemical journal, 268(2), 267-274 (1990-06-01)

Disulphide bonds in human recombinant tissue inhibitor of metalloproteinases (TIMP) were assigned by resolving proteolytic digests of TIMP on reverse-phase h.p.l.c. and sequencing those peaks judged to contain disulphide bonds by virtue of a change in retention time on reduction.

Site-directed mutagenesis and structure-function analysis of the human apolipoprotein A-I. Relation between lecithin-cholesterol acyltransferase activation and lipid binding.

A Minnich et al.

The Journal of biological chemistry, 267(23), 16553-16560 (1992-08-15)

We have mutagenized the human apoA-I gene and have generated cell lines which express normal and mutant apoA-I forms. Point mutations were introduced which changed Gln-1, Gln-2 to Arg,Arg, Pro99 to His, and Pro121 to His. In addition, the following

Comparative analysis and clinical value of the expression of metalloproteases and their inhibitors by intratumor stromal fibroblasts and those at the invasive front of breast carcinomas.

J M Del Casar et al.

Breast cancer research and treatment, 116(1), 39-52 (2009-02-26)

An immunohistochemical study was performed using tissue arrays and specific antibodies against MMPs -1, -2, -7, -9, -11, -13, -14, and TIMPs -1, -2 and -3. More than 5,000 determinations on cancer specimens from 124 patients with invasive breast cancer

Hepatic de novo synthesis of glucose 6-phosphate is not affected in peroxisome proliferator-activated receptor alpha-deficient mice but is preferentially directed toward hepatic glycogen stores after a short term fast.

Robert H J Bandsma et al.

The Journal of biological chemistry, 279(10), 8930-8937 (2003-12-23)

Apart from impaired beta-oxidation, Pparalpha-deficient (Pparalpha(-/-)) mice suffer from hypoglycemia during prolonged fasting, suggesting alterations in hepatic glucose metabolism. We compared hepatic glucose metabolism in vivo in wild type (WT) and Pparalpha(-/-) mice after a short term fast, applying novel

Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro.

Lalji K Gediya et al.

Journal of medicinal chemistry, 51(13), 3895-3904 (2008-06-12)

Novel mutual prodrugs (MPs) of ATRA (all- trans-retinoic acid) and HDIs (histone deacetylase inhibitors) ( 10, 13, 17- 19) connected via glycine acyloxyalkyl carbamate linker (AC linker) or through a benzyl ester linker (1,6-elimination linker) were rationally designed and synthesized.

Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes.

Gerard A J Morris et al.

BMC genetics, 7, 12-12 (2006-03-01)

The aetiology of the autoimmune disease type 1 diabetes (T1D) involves many genetic and environmental factors. Evidence suggests that innate immune responses, including the action of interferons, may also play a role in the initiation and/or pathogenic process of autoimmunity.

Textile dye dermatitis.

K L Hatch et al.

Journal of the American Academy of Dermatology, 32(4), 631-639 (1995-04-01)

The literature concerning textile dye dermatitis published during the last decade was reviewed. Sixty-one cases of dye-allergic contact dermatitis in which the presentation or course of the dermatitis was unusual or the dye allergen was one not previously reported have

Permeation through phospholipid bilayers, skin-cell penetration, plasma stability, and CD spectra of α- and β-oligoproline derivatives.

Beata Kolesinska et al.

Chemistry & biodiversity, 10(1), 1-38 (2013-01-24)

After a survey of the special role, which the amino acid proline plays in the chemistry of life, the cell-penetrating properties of polycationic proline-containing peptides are discussed, and the widely unknown discovery by the Giralt group (J. Am. Chem. Soc.

Enterovirus A71 Oncolysis of Malignant Gliomas.

Xiaowei Zhang et al.

Molecular therapy : the journal of the American Society of Gene Therapy, 28(6), 1533-1546 (2020-04-19)

Malignant gliomas, the most lethal type of primary brain tumor, continue to be a major therapeutic challenge. Here, we found that enterovirus A71 (EV-A71) can be developed as a novel oncolytic agent against malignant gliomas. EV-A71 preferentially infected and killed

Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element.

H Inoue et al.

The Journal of biological chemistry, 270(42), 24965-24971 (1995-10-20)

There exist two distinct isozymes of prostaglandin-endoperoxide synthase (PES). PES-2 mRNA is synergistically induced by lipopolysaccharide (LPS) and 12-O-tetradecanoylphorbol-13-acetate (TPA) in bovine arterial endothelial cells. On the other hand, PES-1 mRNA is constitutively expressed under these conditions. Therefore, the promoter

[KRAS and BRAF gene mutations in correlation with clinicopathologic features of colorectal carcinoma in Chinese].

Xiao-li Zhu et al.

Zhonghua bing li xue za zhi = Chinese journal of pathology, 41(9), 584-589 (2012-11-20)

To retrospectively analyze KRAS and BRAF gene mutation features in Chinese colorectal cancer (CRC) and their clinicopathologic relationship. 557 colorectal cancer cases were collected, including 325 colon cancer and 232 rectal cancer. PCR amplification and DNA sequencing were used to

Distribution and differential induction of CYP2E1 by ethanol and acetone in the mesocorticolimbic system of rat.

M José Sánchez-Catalán et al.

Alcohol and alcoholism (Oxford, Oxfordshire), 43(4), 401-407 (2008-03-11)

The expression of cytochrome P4502E1 (CYP2E1) in the brain has been demonstrated in several regions, nevertheless there is a lack of specific studies on the constitutive expression and induction at the mesocorticolimbic system, the most relevant brain pathway in the

Added value of diffusion-weighted MRI for nodal radiotherapy planning in pelvic malignancies.

N Sushentsev et al.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 21(10), 1383-1389 (2019-03-15)

To evaluate the added value of diffusion-weighted imaging (DWI) to T2-weighted imaging (T2WI) for improved identification of pelvic lymph nodes (LN) by radiation oncologists. This retrospective study included 20 patients with histopathologically proven node-negative prostate cancer. All patients underwent 3T-MRI

Standardized centile curves and reference intervals of serum insulin-like growth factor-I (IGF-I) levels in a normal Japanese population using the LMS method.

Tsuyoshi Isojima et al.

Endocrine journal, 59(9), 771-780 (2012-06-08)

Measurements of insulin-like growth factor-I (IGF-I) are useful not only for diagnosis and management of patients with growth hormone (GH)-related disorders but also for assessing nutritional status. We reported population-based references of serum IGF-I in 1996. However, they did not

HLA class II alleles and haplotypes in Lithuanian children with type 1 diabetes and healthy children (HLA and type 1 diabetes).

Erika Skrodenienė et al.

Medicina (Kaunas, Lithuania), 46(8), 505-510 (2010-10-23)

Type 1 diabetes mellitus is a slowly progressive autoimmune disease. The genetic background of type 1 diabetes mellitus is polygenic with the major disease locus located in the human leukocytes antigen (HLA) region. High risk and protective alleles, haplotypes, and

Multi-mycotoxin analysis in wheat semolina using an acetonitrile-based extraction procedure and gas chromatography-tandem mass spectrometry.

Yelko Rodríguez-Carrasco et al.

Journal of chromatography. A, 1270, 28-40 (2012-11-28)

A new analytical method for the rapid and simultaneous determination of ten mycotoxins including patulin, zearalenone and eight trichothecenes (nivalenol, fusarenon-X, diacetoxyscirpenol, 3-acetyl-deoxynivalenol, neosolaniol, deoxynivalenol, T-2 and HT-2) in wheat semolina has been developed and optimized. Sample extraction and purification

Significance of Bcl-2 and Bax proteins in cervical carcinogenesis: an immunohistochemical study in squamous cell carcinoma and squamous intraepithelial lesions.

Phaik-Leng Cheah et al.

The Malaysian journal of pathology, 28(1), 1-5 (2007-08-19)

Sixteen low grade (LSIL), 22 high grade (HSIL) squamous intraepithelial lesions, 28 invasive (13 stage I and 15 stage II-IV) squamous cell carcinoma (SCC) and 15 benign cervices were immunohistochemically studied for involvement of Bcl-2 and Bax proteins in cervical

cDNA sequence and chromosomal localization of the remaining three human nuclear encoded iron sulphur protein (IP) subunits of complex I: the human IP fraction is completed.

J Loeffen et al.

Biochemical and biophysical research communications, 247(3), 751-758 (1998-07-02)

NADH:ubiquinone oxidoreductase (complex I) of the mitochondrial respiratory chain can be fragmented in a flavoprotein (FP), iron-sulfur protein (IP), and hydrophobic protein (HP) subfraction. The IP subfraction is hypothesized to be significant, since it contains important prosthetic groups highly conserved

ISL1 expression is not restricted to pancreatic well-differentiated neuroendocrine neoplasms, but is also commonly found in well and poorly differentiated neuroendocrine neoplasms of extrapancreatic origin.

Abbas Agaimy et al.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(7), 995-1003 (2013-03-19)

The human insulin gene enhancer-binding protein islet-1 (ISL1) is a transcription factor involved in the differentiation of the neuroendocrine pancreatic cells. Recent studies identified ISL1 as a marker for pancreatic well-differentiated neuroendocrine neoplasms. However, little is known about ISL1 expression

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