124230

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Tianyi Jiang et al.

Microorganisms, 8(8) (2020-08-19)

Supplementation of probiotics is a promising gut microbiota-targeted therapeutic method for hyperlipidemia and atherosclerosis. However, the selection of probiotic candidate strains is still empirical. Here, we obtained a human-derived strain, Lactobacillus mucosae A1, which was shown by metagenomic analysis to

Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual-Modality MRI and NIR Nanoprobe.

Chunyan Li et al.

Small (Weinheim an der Bergstrasse, Germany), 11(35), 4517-4525 (2015-06-11)

In clinical practice, it is difficult to identify tumor margins during brain surgery due to its inherent infiltrative character. Herein, a unique dual-modality nanoprobe (Gd-DOTA-Ag2S QDs, referred as Gd-Ag2S nanoprobe) is reported, which integrates advantages of the deep tissue penetration

NCα-gem-dimethylated peptoid side chains: A novel approach for structural control and peptide sequence mimetics.

Radhe Shyam et al.

Biopolymers, 110(6), e23273-e23273 (2019-03-22)

The design of linear peptoid oligomers adopting well-defined secondary structures while mimicking defined peptide primary sequences is a major challenge in the context of drug discovery. To this end, chemists have developed cis-inducing peptoid side chains to build robust polyproline

Synthesis and Cytotoxicity Evaluation of DOTA-Conjugates of Ursolic Acid.

Michael Kahnt et al.

Molecules (Basel, Switzerland), 24(12) (2019-06-20)

In this study, we report the synthesis of several amine-spacered conjugates of ursolic acid (UA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). Thus, a total of 11 UA-DOTA conjugates were prepared holding various oligo-methylene diamine spacers as well as different substituents at the

Journal of the Chemical Society. Perkin Transactions 1, 459-459 (1993)

SYNTHESIS OF (NITRILOTRIACETIC ACID)-END-FUNCTIONALIZED POLYSTYRENE USING ATOM TRANSFER RADICAL POLYMERIZATION.

Cho HY, et al.

Synthesis, 1000, 4H-4H (2006)

Synthesis of new glycopeptidomimetics based on N-substituted oligoglycine bearing an N-linked lactoside side-chain.

Saha UK and Roy R.

Journal of the Chemical Society. Chemical Communications, 24, 2571-2573 (1995)

Synthesis of fused heteroarylprolines and pyrrolopyrroles.

Guillaume Jeannotte et al.

The Journal of organic chemistry, 69(14), 4656-4662 (2004-07-03)

Fused heteroarylprolines were prepared starting from 4-oxo-N-(PhF)proline benzyl ester (6, PhF = 9-(9-phenylfluorenyl)) following two approaches. First, allylation of oxoproline 6 followed by Wacker oxidation gave 1,4-dione 8 that was selectively converted to pyrroloproline 10b, pyrrolopyrrole 12, and pyridazinoproline 9.

A (99m)Tc-labeled misonidazole analogue: step toward a (99m)Tc-alternative to [18F]fluromisonidazole for detecting tumor hypoxia.

Madhava B Mallia et al.

Cancer biotherapy & radiopharmaceuticals, 30(2), 79-86 (2015-01-09)

The PET radiopharmaceutical [(18)F]Fluromisonidazole ([(18)F]FMISO) is presently the agent of choice for the clinical imaging of tumor hypoxia. Considering the logistic advantages of (99m)Tc and wider availability of SPECT machines, a (99m)Tc-radiopharmaceutical for this purpose constitutes an attractive choice. In

Gas chromatography with parallel hard and soft ionization mass spectrometry.

Leila Hejazi et al.

Rapid communications in mass spectrometry : RCM, 29(1), 91-99 (2014-12-03)

Mass spectrometric identification of compounds in chromatography can be obtained from molecular masses from soft ionization mass spectrometry techniques such as field ionization (FI) and fragmentation patterns from hard ionization techniques such as electron ionization (EI). Simultaneous detection by EI

Efficient polymer-assisted strategy for the deprotection of protected oligosaccharides.

Hiroshi Tanaka et al.

Angewandte Chemie (International ed. in English), 45(38), 6349-6352 (2006-08-19)

Liposome-like nanocapsules of dual drug-tailed betaine for cancer therapy.

Shuo Fang et al.

International journal of pharmaceutics, 493(1-2), 460-465 (2015-08-11)

A novel dual drug-tailed betaine conjugate amphiphile has been firstly synthesized in which the polar headgroup is derived from glycine betaine and the hydrophobic tails are chlorambucil molecules. The newly prepared conjugate undergoes self-assembly to form stable liposome-like nanocapsules as

Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.

Shohei Hamada et al.

Bioorganic & medicinal chemistry letters, 19(10), 2852-2855 (2009-04-11)

N-Oxalylglycine (NOG) derivatives were synthesized, and their inhibitory effect on histone lysine demethylase activity was evaluated. NOG and compound 1 inhibited histone lysine demethylases JMJD2A, 2C and 2D in enzyme assays, and their dimethyl ester prodrugs DMOG and 21 exerted

Nanoparticle-supported temperature responsive polymer brushes for affinity separation of histidine-tagged recombinant proteins.

Lingdong Jiang et al.

Acta biomaterialia, 94, 447-458 (2019-05-06)

We developed a modular approach for the preparation of nanoparticle-supported polymer brushes carrying repeating iminodiacetate units for affinity separation of histidine-tagged recombinant proteins. The nanoparticle-supported polymer brushes were prepared via the combination of surface-initiated atom transfer radical polymerization with Cu(I)-catalyzed

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