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显示 1-30 共 37 条结果 关于 "126-13-6" 范围 论文
J Kwiatkowska et al.
Annals of human genetics, 62(Pt 4), 277-285 (1999-01-30)
We performed a comprehensive analysis for mutations in the TSC1 gene using Southern blot analysis, and SSCP and heteroduplex analysis of amplified exons in 13 families with genetic linkage to the TSC1 region, 22 small families without linkage information, and
Natan D da Silva et al.
Genes, 14(1) (2023-01-22)
Patients with peripheral artery disease (PAD) have reduced muscle capillary density. Walking training (WT) is recommended for PAD patients. The goal of the study was to verify whether WT promotes angiogenesis in PAD-affected muscle and to investigate the possible role
Whitney A Qualls et al.
Journal of the American Mosquito Control Association, 28(3), 219-224 (2013-07-10)
In order to better understand the role a barrier application plays in an integrated mosquito management program, we applied a bifenthrin barrier application to a large golf course community and evaluated the mosquito population, service requests, and money spent for
J Prosser et al.
Oncogene, 5(10), 1573-1579 (1990-10-01)
Using the polymerase chain reaction, we have amplified exons 5 and 6 of the human p53 gene from paired samples of tumour and blood DNA of 60 patients with sporadic breast tumours and from placental or tonsil DNA of 30
R S Camilleri et al.
Journal of thrombosis and haemostasis : JTH, 6(2), 331-338 (2007-11-23)
Thrombotic thrombocytopenic purpura (TTP) is most commonly associated with deficiency or inhibition of von Willebrand factor-cleaving protease (ADAMTS-13) activity. ADAMTS-13 mutations and polymorphisms have been reported in childhood congenital TTP, but their significance in adult onset TTP remains unclear. We
Chad Vickers et al.
The Journal of biological chemistry, 277(17), 14838-14843 (2002-01-30)
Human angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a zinc metalloprotease whose closest homolog is angiotensin I-converting enzyme. To begin to elucidate the physiological role of ACE2, ACE2 was purified, and its catalytic activity was characterized. ACE2 proteolytic activity has a pH
M L Santiago et al.
European journal of immunology, 28(12), 4257-4267 (1998-12-23)
In the present study, we mapped the major quantitative trait loci (QTL) differing between the NZW and C57BL/6 inbred strains of mice by making use of (NZW x C57BL/6.Yaa)F1 mice, a model in which the lupus-like autoimmune syndrome observed in
Irene Lurkin et al.
PloS one, 5(1), e8802-e8802 (2010-01-26)
Recently a number of randomized trials have shown that patients with advanced colorectal cancer do not benefit from therapies targeting the epidermal growth factor receptor when their tumors harbor mutations in the KRAS, BRAF and PIK3CA genes. We developed two
Nicholas M Ruel et al.
Molecular pharmacology, 95(6), 584-596 (2019-03-27)
6-Mercaptopurine (6-MP) is a nucleobase analog used in the treatment of acute lymphoblastic leukemia and inflammatory bowel disorders. However, the mechanisms underlying its transport into target cells have remained elusive. The protein encoded by SLC43A3_1 [equilibrative nucleobase transporter 1 (ENBT1)]
T Gohda et al.
Clinical nephrology, 57(5), 365-370 (2002-05-31)
Genetic factors may play an important role in the pathogenesis of reduced bone mineral density (BMD). IL-6 is a multifunctional cytokine and a candidate gene for regulation of bone mineral density (BMD). The relationship between a microsatellite polymorphism of the
Helen O Leung et al.
The Journal of chemical physics, 128(6), 064315-064315 (2008-02-20)
Guided by ab initio calculations, Fourier transform microwave rotational spectra in the 6-22 GHz region are obtained for the complex formed between 1,1,2-trifluoroethylene and acetylene, including the normal isotopomer, three of four singly substituted (13)C species obtained in natural abundance
Jong-Shiaw Jin et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 25(2), 140-146 (2006-04-25)
Ovary cancer invasion is responsible for both local tissue destruction and distant metastasis. Invasion is largely mediated by matrix metalloproteases that are thought to be induced by tumor cell-derived extracellular matrix metalloprotease inducer (EMMPRIN) in surrounding fibroblasts. We hypothesized that
Xiao-li Zhu et al.
Zhonghua bing li xue za zhi = Chinese journal of pathology, 41(9), 584-589 (2012-11-20)
To retrospectively analyze KRAS and BRAF gene mutation features in Chinese colorectal cancer (CRC) and their clinicopathologic relationship. 557 colorectal cancer cases were collected, including 325 colon cancer and 232 rectal cancer. PCR amplification and DNA sequencing were used to
S A Cohen et al.
The Journal of membrane biology, 128(3), 219-226 (1992-06-01)
We previously characterized two monoclonal antibodies, A/B2 and L/D3, that bind to the amino-terminus of the sodium channel but produce distinct immunocytochemical patterns in innervated adult skeletal muscle. Because these findings suggested the presence of several channel isoforms, we sought
Sarah Edkins et al.
Cancer biology & therapy, 5(8), 928-932 (2006-09-14)
An activating point mutation in codon 12 of the HRAS gene was the first somatic point mutation identified in a human cancer and established the role of somatic mutations as the common driver of oncogenesis. Since then, there have been
P Krenek et al.
Canadian journal of physiology and pharmacology, 84(12), 1245-1250 (2007-05-10)
Isoproterenol-induced cardiac hypertrophy is associated with increased expression of endothelial nitric oxide synthase in the aorta but without signs of improved endothelial function. The aim was to examine the hypothesis that increased expression of eNOS allosteric inhibitor caveolin-1 could be
D Vaiman et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 5(5), 288-297 (1994-05-01)
Cattle microsatellite clones (136) were isolated from cosmid (10) and plasmid (126) libraries and sequenced. The dinucleotide repeats were studied in each of these sequences and compared with dinucleotide repeats found in other vertebrate species where information was available. The
J R Meinertz et al.
Journal of aquatic animal health, 26(4), 243-250 (2014-10-17)
Aquaflor is a feed premix for fish containing the broad spectrum antibacterial agent florfenicol (FFC) incorporated at a ratio of 50% (w/w). To enhance the effectiveness of FFC for salmonids infected with certain isolates of Flavobacterium psychrophilum causing cold water
Matthew L Lyons et al.
Journal of shoulder and elbow surgery, 24(7), 1098-1105 (2015-05-11)
Osteochondritis dissecans (OCD) of the capitellum is a condition most commonly seen in adolescents involved in repetitive overhead sports and can profoundly affect ability to return to play and long-term elbow function. Treatment of large, unstable defects in the elbow
Sabine Stachowski-Haberkorn et al.
Ecotoxicology (London, England), 17(4), 235-245 (2008-02-01)
Effects of the herbicide Basamaïs (bentazon) and the fungicide Opus (epoxiconazole) on oyster spat (Crassostrea gigas) were assessed using in-situ microcosms in a field experiment lasting 13 days. Six-week-old hatchery spat (mean size 1.1 mm), previously collected on PVC plates
Karl Gertow et al.
Circulation. Cardiovascular genetics, 5(6), 656-665 (2012-11-16)
Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted
Yasodha Natkunam et al.
Haematologica, 92(2), 176-183 (2007-02-14)
VICKZ family members are RNA-binding regulatory proteins expressed during embryogenesis but not usually found in normal adult tissue. The presence of VICKZ in normal germinal centers (GC) prompted us to characterize the expression pattern of this protein in lymphoid and
Chiara Francesca Magistrali et al.
Anaerobe, 33, 42-47 (2015-02-02)
The aim of this study is to describe the prevalence and risk factors of Clostridium difficile shedding in six farms belonging to two companies in Northern Italy. Four hundred and twenty veal calves, randomly selected and individually identified, were sampled
Bryan M H Keng et al.
Journal of the American Geriatrics Society, 67(12), 2568-2573 (2019-08-17)
The link between skeletal muscle and heart disease remains intriguing. It is unknown how skeletal muscle may be associated with aspects of myocardial structure and function, particularly in the presence of aging-related sarcopenia. We hypothesize that among aging adults with
Peter Daley et al.
The Lancet. Infectious diseases, 15(5), 528-534 (2015-04-13)
Vitamin D has immunomodulatory effects that might aid clearance of mycobacterial infection. We aimed to assess whether vitamin D supplementation would reduce time to sputum culture conversion in patients with active tuberculosis. We did this randomised, double-blind, placebo-controlled, superiority trial
M Danciger et al.
Investigative ophthalmology & visual science, 42(11), 2458-2465 (2001-10-03)
To determine the locus of the mutant gene causing autosomal recessive cone-rod dystrophy (arCRD) in a consanguineous pedigree, to evaluate a candidate gene expressed in retina that maps to this locus, and to estimate the percentage of arCRD cases caused
Won Ho Kim et al.
Platelets, 26(1), 38-42 (2014-01-18)
Previous laboratory and clinical data have shown evidence for the concept of rebalanced hemostasis in liver disease. We evaluate whether this concept of rebalanced hemostasis can be applied in patients with idiopathic thrombocytopenic purpura (ITP). Twenty patients with ITP (platelet
Camila de Moraes et al.
BMC physiology, 8, 12-12 (2008-05-31)
Obesity has been associated with a variety of disease such as type II diabetes mellitus, arterial hypertension and atherosclerosis. Evidences have shown that exercise training promotes beneficial effects on these disorders, but the underlying mechanisms are not fully understood. The
E K Walsh et al.
American journal of physiology. Heart and circulatory physiology, 287(5), H2115-H2121 (2004-07-31)
Our objective was to investigate the potential role of selective endothelial nitric oxide (NO) synthase (eNOS) overexpression in coronary blood vessels in the control of myocardial oxygen consumption (MVO2). Transgenic (Tg) eNOS-overexpressing mice (eNOS Tg) (n=22) and wild-type (WT) mice
Md Munir Hossain et al.
BMC genomics, 10, 443-443 (2009-09-22)
MicroRNAs are the major class of gene-regulating molecules playing diverse roles through sequence complementarity to target mRNAs at post-transcriptional level. Tightly regulated expression and interaction of a multitude of genes for ovarian folliculogenesis could be regulated by these miRNAs. Identification
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