127-51-5

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Imprinted gene Zinc finger protein 127 is a novel regulator of master pluripotency transcription factor, Oct4.

Yoo-Wook Kwon et al.

BMB reports, 51(5), 242-248 (2018-01-18)

Induced pluripotent stem cells (iPSCs) show great promise for replacing current stem cell therapies in the field of regenerative medicine. However, the original method for cellular reprogramming, involving four exogenous transcription factors, is characterized by low efficiency. Here, we focused

Plasma concentrations of tafenoquine, a new long-acting antimalarial agent, in thai soldiers receiving monthly prophylaxis.

Michael D Edstein et al.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 37(12), 1654-1658 (2003-12-23)

We measured plasma tafenoquine concentrations in Thai soldiers given a monthly regimen of tafenoquine to determine whether these concentrations adequately suppressed malarial infections on the Thai-Cambodian border. After receiving a treatment course of artesunate and doxycycline, 104 male soldiers were

Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas.

Dunfa Peng et al.

PloS one, 6(7), e22009-e22009 (2011-08-06)

Metallothionein 3 (MT3) maintains intracellular metal homeostasis and protects against reactive oxygen species (ROS)-induced DNA damage. In this study, we investigated the epigenetic alterations and gene expression of the MT3 gene in esophageal adenocarcinomas (EACs). Using quantitative bisulfite pyrosequencing, we

Headspace solid-phase microextraction with gas chromatography-mass spectrometry determination of naphthalene in the composite food samples from the 2011 Canadian total diet study in Ottawa.

Xu-Liang Cao et al.

Journal of food protection, 75(12), 2163-2171 (2012-12-06)

A method based on isotope dilution headspace solid-phase microextraction, followed by gas chromatography and mass spectrometry, was developed for the determination of naphthalene in foods. Optimum method sensitivity was achieved by the addition of NaCl in water at saturation and

[Relationship of epidermal growth factor receptor gene mutations, clinicopathologic features and prognosis in patients with non-small cell lung cancer].

Miao-jing Fan et al.

Zhonghua bing li xue za zhi = Chinese journal of pathology, 40(10), 679-682 (2012-02-11)

To investigate epidermal growth factor receptor (EGFR) gene mutations in exons 19 and 21 of patients with non-small cell lung cancer (NSCLC) and to analyze the relationship of EGFR mutations with clinicopathological features and prognosis. The EGFR gene exons 19

The mouse plasma membrane Ca2+ pump isoform 1 promoter: cloning and characterization.

Y Du et al.

Archives of biochemistry and biophysics, 316(1), 302-310 (1995-01-10)

The expression of plasma membrane Ca2+ pump (PMCA) is regulated by various hormones or agonists via multiple second messenger pathways. Two different 5' segments of the PMCA1 gene (isoform 1) were cloned from a mouse genomic library. While one segment

Sutureless 3F Enable Valve Replacement for Pure Aortic Regurgitation.

Marco Vola et al.

Journal of cardiac surgery, 30(11), 796-800 (2015-10-06)

We present our experience in the use of the sutureless valve in patients undergoing aortic valve replacement for pure aortic regurgitation. Out of 167 patients who underwent sutureless aortic valve implantation with a Medtronic 3f Enable prosthesis in our unit

Fragile-X carrier screening and the prevalence of premutation and full-mutation carriers in Israel.

H Toledano-Alhadef et al.

American journal of human genetics, 69(2), 351-360 (2001-07-10)

Fragile-X syndrome is caused by an unstable CGG trinucleotide repeat in the FMR1 gene at Xq27. Intermediate alleles (51-200 repeats) can undergo expansion to the full mutation on transmission from mother to offspring. To evaluate the effectiveness of a fragile-X

Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones.

Tran Thuy Chau et al.

Antimicrobial agents and chemotherapy, 51(12), 4315-4323 (2007-10-03)

This study describes the pattern and extent of drug resistance in 1,774 strains of Salmonella enterica serovar Typhi isolated across Asia between 1993 and 2005 and characterizes the molecular mechanisms underlying the reduced susceptibilities to fluoroquinolones of these strains. For

Autoantibodies against C-reactive protein: clinical associations in systemic lupus erythematosus and primary antiphospholipid syndrome.

Maria A Figueredo et al.

The Journal of rheumatology, 33(10), 1980-1986 (2006-10-03)

To investigate the prevalence of anti-C-reactive protein (CRP) autoantibodies in patients with systemic lupus erythematosus (SLE) and non-SLE patients with persistent antiphospholipid antibodies (aPL) and their association with clinical manifestations. Sera of 137 patients with SLE, 127 with persistent aPL

Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia.

Masaya Tanno et al.

Circulation research, 93(3), 254-261 (2003-06-28)

The ischemic activation of p38alpha mitogen-activated protein kinase (p38alpha-MAPK) is thought to contribute to myocardial injury. Under other circumstances, activation is through dual phosphorylation by MAPK kinase 3 (MKK3). Therefore, the mkk3-/- murine heart should be protected during ischemia. In

Excellent Accuracy of Glucose Level in Cystic Fluid for Diagnosis of Pancreatic Mucinous Cysts.

Sandra Faias et al.

Digestive diseases and sciences, 65(7), 2071-2078 (2019-11-11)

CEA in pancreatic cystic fluid (PCF) is standard for mucinous cysts diagnosis. Glucose is an alternative, but its accuracy remains poorly described. To evaluate PCF glucose using a glucometer and compare its accuracy with CEA for mucinous cysts diagnosis. In

Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension.

Carlo J Milani et al.

The American journal of the medical sciences, 340(5), 389-394 (2010-08-21)

Previous studies have demonstrated that the urinary excretion of angiotensinogen is significantly increased in ANG II-infused hypertensive rats, which is associated with an augmentation of intrarenal ANG II levels. These findings suggest that urinary angiotensinogen excretion rates provide an index

Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial.

Bardia Nourbakhsh et al.

The Lancet. Neurology, 20(1), 38-48 (2020-11-27)

Methylphenidate, modafinil, and amantadine are commonly prescribed medications for alleviating fatigue in multiple sclerosis; however, the evidence supporting their efficacy is sparse and conflicting. Our goal was to compare the efficacy of these three medications with each other and placebo

Necitumumab plus pemetrexed and cisplatin as first-line therapy in patients with stage IV non-squamous non-small-cell lung cancer (INSPIRE): an open-label, randomised, controlled phase 3 study.

Luis Paz-Ares et al.

The Lancet. Oncology, 16(3), 328-337 (2015-02-24)

Necitumumab is a second-generation recombinant human immunoglobulin G1 EGFR monoclonal antibody that competitively inhibits ligand binding. We aimed to compare necitumumab plus pemetrexed and cisplatin with pemetrexed and cisplatin alone in patients with previously untreated, stage IV, non-squamous non-small-cell lung

Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis.

Antje Timmer et al.

The Cochrane database of systematic reviews, 9(9), CD000478-CD000478 (2012-09-14)

Maintenance of remission is a major issue in inflammatory bowel disease. In ulcerative colitis, the evidence for the effectiveness of azathioprine and 6-mercaptopurine for the maintenance of remission is still controversial. To assess the effectiveness and safety of azathioprine and

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