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Tatiana V Abramova et al.
Nucleosides, nucleotides & nucleic acids, 24(9), 1333-1343 (2005-10-29)
We detail the design, synthesis, and characterization of an o-nitrobenzyl-based photolabile linker containing amine and carboxyl anchor groups. A model nucleoside monomer modified with an imidazole residue and a precursor unit linked to a heterocyclic base through a photolabile tether
A Yamamoto et al.
Journal of pharmaceutical sciences, 80(11), 1067-1071 (1991-11-01)
Absorption and metabolic characteristics of p-aminobenzoic acid (PABA) and m-aminobenzoic acid (MABA) from the rat small intestine were examined by means of in situ recirculation and in vitro everted sac experiments. p-Aminobenzoic acid was extremely rapidly absorbed from the rat
Robert Y North et al.
Electrophoresis, 32(20), 2797-2804 (2011-10-14)
The performance of the current preparative-scale isoelectric trapping systems is limited by the serial arrangement of the separation compartments. A new system has been developed that achieves trapping by recursive electrophoresis in a compartmentalized system (T-RECS). T-RECS features (i) parallel-connected
Paride Mantecca et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(1), 16-30 (2015-03-31)
The increased resistances to conventional antibiotics determine a strong need for new antibacterials, and specific syntheses at the nanoscale promise to be helpful in this field. A novel Zinc-doped Copper oxide nanocomposite (nZn-CuO) has been recently sonochemically synthesized and successfully
Seok Min Yoon et al.
Langmuir : the ACS journal of surfaces and colloids, 23(23), 11875-11882 (2007-10-09)
One-dimensional (1D) helical organic nanostructures were synthesized by a modified vapor-solid (VS) process, called the vaporization-condensation-recrystallization (VCR) process. The conventional solution-phase synthetic methods generally mediate self-assemblies of repeating unit molecules. To provide enough intermolecular interaction forces among the unit molecules
Satoru Kamoda et al.
Journal of chromatography. A, 1050(2), 211-216 (2004-10-29)
Carbohydrate chains in glycoprotein pharmaceuticals have important roles for the expression of their biological activities. Therefore, development of an assessment method for the carbohydrate chains is an important parameter for quality control of glycoprotein pharmaceuticals such as newly developed therapeutic
M Nagao et al.
Environmental health perspectives, 93, 169-174 (1991-06-01)
A poly(ADP-ribose) polymerase inhibitor, benzamide (BA), was found to induce flat revertants of NIH 3T3 cells that had been transformed by human Ha-ras, rat Ki-ras, rat c-raf, and human ret-II. These genes had been amplified in original transformants, but they
U Altenschmidt et al.
European journal of biochemistry, 194(2), 647-653 (1990-12-12)
A new pathway for aerobic metabolism of 2-aminobenzoate which proceeds via anthranoyl-CoA has recently been revealed in a Pseudomonas strain KB740. This bacterial strain was found to contain a small 8.1-kbp plasmid pKB740 which appears to harbour the genes encoding
Mark Eisenberg et al.
Science (New York, N.Y.), 301(5636), 1102-1104 (2003-08-23)
In memory consolidation, the memory trace stabilizes and becomes resistant to certain amnesic agents. The textbook account is that for any memorized item, consolidation starts and ends just once. However, evidence has accumulated that upon activation in retrieval, the trace
P E Devaraj et al.
Molecular and cellular biochemistry, 124(2), 175-181 (1993-07-21)
In mouse fibroblasts stimulated from quiescence into proliferation by serum the induction of expression of the c-myc proto-oncogene is strongly stimulated by 3-methoxybenzamide. Similar superinduction effects are seen with related compounds such as 3-aminobenzamide and the acid analogues, 3-anisic acid
Lowell J Brady et al.
mAbs, 7(3), 562-570 (2015-04-22)
Accurate measurement and functional characterization of antibody Fc domain N-linked glycans is critical to successful biosimilar development. Here, we describe the application of methods to accurately quantify and characterize the N-linked glycans of 2 IgG1 biosimilars with effector function activity
J D Beckmann et al.
Journal of cellular physiology, 152(2), 274-280 (1992-08-01)
Transforming growth factor-beta (TGF-beta) exerts several effects on cultured airway epithelial cells including inhibition of proliferation and stimulation of fibronectin gene expression. ADP-ribosylation is one potential regulatory mechanism of gene expression by TGF-beta. We tested this possibility by exposing cultured
D Shiokawa et al.
FEBS letters, 413(1), 99-103 (1997-08-11)
The effects of 3-aminobenzamide (3ABm) and benzamide (BAm), known specific inhibitors of poly(ADP-ribose) polymerase (PARP), on actinomycin D (Act D)-induced apoptosis in HL-60 cells were examined. These inhibitors had no appreciable effect on apoptotic DNA fragmentation, chromatin condensation or PARP
Andreas Puyskens et al.
Cell host & microbe, 27(2), 238-248 (2020-01-07)
Antimicrobial resistance in tuberculosis (TB) is a public health threat of global dimension, worsened by increasing drug resistance. Host-directed therapy (HDT) is an emerging concept currently explored as an adjunct therapeutic strategy for TB. One potential host target is the
M Wakselman et al.
Journal of medicinal chemistry, 36(11), 1539-1547 (1993-05-28)
In order to obtain selective suicide substrates of trypsin-like proteases including plasminogen activators, plasmin, and thrombin, a series of cyclopeptides cyclo[Arg or Lys-aB(CH2X)-Gly4], in which a substituted o- or m-aminobenzoyl group constitutes a latent electrophile, have been prepared. Treatment of
R Russ et al.
FEMS microbiology letters, 122(1-2), 137-143 (1994-09-15)
The aerobic metabolism of 3-aminobenzoate by bacteria was studied. Bacterial strains degrading 3-aminobenzoate were obtained by enrichment with 3-aminobenzoate (strain Ia3) or 5-aminosalicylate (strains BN9 and 5AS1). During growth with 3-aminobenzoate, strain Ia3 and strain 5AS1 transiently accumulated 5-aminosalicylate in
Evan Shave et al.
Electrophoresis, 28(13), 2291-2299 (2007-06-09)
The Biflow, a new isoelectric trapping instrument was designed to obtain a narrow DeltapI fraction from a complex feed in one step. The Biflow contains two identical separation units, each unit houses: an anode and cathode compartment, an anodic and
Paola Scarcia et al.
Environmental toxicology, 29(8), 950-960 (2012-11-06)
Punta Lara is located in the Río de la Plata estuary near industrial areas contaminated mainly by organic pollutants. In this work, the responses and status of hepatic biomarkers were studied in juvenile carp (Cyprinus carpio) by means of a
Michael D Clift et al.
Bioorganic & medicinal chemistry letters, 18(10), 3122-3125 (2007-11-09)
The design, synthesis, and evaluation of novel gamma-aminobutyric acid aminotransferase (GABA-AT) inhibitors and inactivators can lead to the discovery of new GABA-related therapeutics. To this end, a series of aromatic amino acid compounds was synthesized to aid in the design
Wen-Chang Li
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(27), 9799-9810 (2015-07-15)
Many neural circuits show fast reconfiguration following altered sensory or modulatory inputs to generate stereotyped outputs. In the motor circuit of Xenopus tadpoles, I study how certain voltage-dependent ionic currents affect firing thresholds and contribute to circuit reconfiguration to generate
Kevin Guo et al.
Analytical chemistry, 81(10), 3919-3932 (2009-03-25)
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be
Iris Thondorf et al.
Bioorganic & medicinal chemistry, 19(21), 6409-6418 (2011-10-01)
The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been performed on its natural and synthetic
Julia Cuers et al.
Carbohydrate research, 348, 55-63 (2011-12-17)
Substituent patterns in oligosaccharide derivatives obtained from methyl cellulose were determined up to DP10 by electrospray ionization mass spectrometry employing separation of the oligomer fractions by HPLC. Oligosaccharides were labeled with meta-aminobenzoic acid after perdeuteromethylation and partial hydrolysis of methyl
Qiliang Deng et al.
Chemical communications (Cambridge, England), 48(24), 3009-3011 (2012-02-14)
Fluorescent conjugated polymer, poly(3-aminobenzoic acid), as a new class of fluorescence sensor for detection of trace amounts of water in organic solvents was developed. This sensor exhibits extraordinarily high sensitivity with a detection limit as low as 0.008 wt% for
A Syahrani et al.
Journal of Asian natural products research, 2(4), 305-309 (2001-03-16)
Two new biotransformation products, N-acetyl-m-aminobenzoic acid and N-formyl-m-aminobenzoic acid were isolated from cell suspension cultures of Solanum laciniatum following administration of m-aminobenzoic acid, and their structures were elucidated using one- and two-dimensional 1H- and 13C-NMR data.
K Kakehi et al.
Journal of chromatography. A, 863(2), 205-218 (1999-12-11)
The efficiencies in derivatization of reducing carbohydrates were compared by capillary electrophoresis using maltose as a model with nine monoaminobenzene derivatives by reductive amination in the presence of sodium cyanoborohydride. We found that aminobenzene derivatives substituted at the 3-position showed
Sung-Gil Hong et al.
Environmental science & technology, 49(7), 4466-4472 (2015-03-31)
We developed a process for one-pot CO2 conversion and utilization based on simple conversion of CO2 to bicarbonate at ambient temperature with no energy input, by using the cross-linking-based composites of carboxylated polyaniline nanofibers (cPANFs) and carbonic anhydrase. Carbonic anhydrase
Mark D Kaji et al.
British journal of pharmacology, 172(15), 3737-3747 (2015-04-09)
Cys-loop GABA receptors represent important targets for human chemotherapeutics and insecticides and are potential targets for novel anthelmintics (nematicides). However, compared with insect and mammalian receptors, little is known regarding the pharmacological characteristics of nematode Cys-loop GABA receptors. Here we
Lari Lehtiö et al.
Journal of medicinal chemistry, 52(9), 3108-3111 (2009-04-10)
Poly(ADP-ribose) polymerases (PARPs) activate DNA repair mechanisms upon stress- and cytotoxin-induced DNA damage, and inhibition of PARP activity is a lead in cancer drug therapy. We present a structural and functional analysis of the PARP domain of human PARP-3 in
A J Watson et al.
Gastroenterology, 109(2), 472-482 (1995-08-01)
H2O2 causes DNA damage, which activates poly(adenosine diphosphate ribose) polymerase (PARP), a nuclear enzyme that uses nicotinamide adenine dinucleotide (NAD) as a substrate. When DNA strand breaks are extensive, consumption of NAD by PARP can cause adenosine triphosphate depletion. The
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