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Chemopreventive and therapeutic potentials of thymoquinone in HepG2 cells: mechanistic perspectives.
Abeer ElKhoely et al.
Journal of natural medicines, 69(3), 313-323 (2015-03-23)
Liver cancer is the fifth commonest malignancy worldwide and the third leading cause of death. Identifying novel curative and preventive therapy may improve its prognosis. In this study, thymoquinone (TQ), the most active biological ingredient of Nigella sativa Linn, was
Doo-San Park et al.
Environmental toxicology and pharmacology, 39(2), 635-642 (2015-02-16)
The repeated use of pesticides, and their subsequent residues, has contributed to severe adverse effects on the environment, including risks to human health. Therefore, it is important to assess the quality of the environment to ensure it remains free from
M Argun et al.
Eye (London, England), 28(6), 752-760 (2014-03-08)
Under conditions of oxidative stress, cell apoptosis is triggered through the mitochondrial intrinsic pathway. Increased levels of reactive oxygen species (ROS) are linked to excess cell loss and mediate the initiation of apoptosis in a diverse range of cell types.
Subburayan Karthikeyan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 274-282 (2015-03-18)
Previously, we reported that the prepared resveratrol (RSV) loaded gelatin nanoparticles (GNPs) possessed enhanced anticancer effect than free RSV in non-small cell lung carcinoma cells and Swiss albino mice. The present study aims to explore the relevant mechanism of cell
Mohammad Waseem et al.
Archives of medical research, 45(6), 462-468 (2014-08-01)
Cisplatin (CP) is regarded as a major anticancer drug against a wide spectrum of leukemia and other malignancies. The mode of action of CP on cancer cells is attributed to its property of releasing free radicals which, at the same
Da Xiao et al.
PloS one, 10(6), e0128936-e0128936 (2015-06-30)
The wheat aphids, Rhopalosiphum padi (Linnaeus) and Sitobion avenae (Fabricius), are key pests on wheat crops worldwide. Management practices rely primarily on insecticides. The pirimicarb (carbamate) is used extensively as an effective insecticide to control these two aphids. In addition
K M Sadek
Andrologia, 46(9), 1047-1054 (2013-11-13)
This study was conducted to determine the mechanism underlying the chemotherapeutic efficacy of an ethanolic Moringa oleifera leaf extract (MOLEE) against chromium-induced impairments of rat testes using biochemical methods. Twenty male Wistar rats were divided into four groups of five
R B K Carteri et al.
The Journal of sports medicine and physical fitness, 55(7-8), 735-741 (2015-09-12)
Since studies on resistance exercise and oxidative stress markers show contradictory results, it is not clear whether different intensities of exercise are the determinant of changes in such markers. The objective of this study was to investigate the acute effects
Murat Ozmen et al.
Aquatic toxicology (Amsterdam, Netherlands), 165, 144-153 (2015-06-04)
The toxic effects of two selected xenobiotics, bisphenol A (BPA) and atrazine (ATZ), were evaluated after photocatalytic degradation using nano-sized, Mn-doped TiO2. Undoped and Mn-doped TiO2 nanoparticles were synthesized. The samples were characterized by X-ray diffractometry (XRD), scanning electron microscopy
Ismail Isik et al.
Toxicology and industrial health, 31(12), 1095-1105 (2013-05-03)
The present study was aimed to investigate the effects of subacute and subchronic treatment of some plant growth regulators (PGRs), such as abscisic acid (ABA) and gibberellic acid (GA3), on neurological and immunological biomarkers in various tissues of rats. The
Jia-Ning Yin et al.
International journal of clinical and experimental medicine, 8(8), 12374-12381 (2015-11-10)
Pulmonary fibrosis (PF) leads to chronic inflammation and accumulation of macrophages, neutrophils, and lymphocytes in the alveoli. The factors involved in the development of PF include reactive oxygen species and tissue remodelling regulators. The present study demonstrates the effect of
Amal Al-Aboudi et al.
Acta pharmacologica Sinica, 36(7), 879-886 (2015-05-06)
To investigate the binding mode of synthesized adamantly derivatives inside of cholinesterase enzymes using molecular docking simulations. A series of hybrid compounds containing adamantane and hydrazide moieties was designed and synthesized. Their inhibitory activities against acetylcholinesterase (AChE) and (butyrylcholinesterase) BChE
Sun-Joo Oh et al.
Pharmacology, 96(1-2), 32-40 (2015-06-06)
The antiphotoaging activities of ginsenoside Rb2 on the skin, one of the predominant protopanaxadiol-type ginsenosides, were evaluated in cultured human dermal fibroblasts. The antiphotoaging activity was examined by analyzing the levels of reactive oxygen species (ROS), matrix metalloproteinase-2 (MMP-2), total
Yungao Li et al.
International journal of biological macromolecules, 74, 171-178 (2014-12-30)
The thermal stability of inulin fructotransferase (IFTase) subjected to high hydrostatic pressure (HHP) was studied. The value of inactivation rate of IFTase in the range of 70-80°C decreased under the pressure of 100 or 200 MPa, indicating that the thermostability
Hamidreza Akrami et al.
Archiv der Pharmazie, 348(5), 366-374 (2015-03-31)
A series of triazole-containing carbazole derivatives were designed as new anti-acetylcholinesterase (AChE) agents. The target compounds 6a-q were simply prepared via a one-pot three-component click reaction of N-propargyl-9H-carbazole, sodium azide, and an appropriate benzyl halide. The in vitro anti-cholinesterase assay
Yan Zhang et al.
Macromolecular bioscience, 14(6), 842-852 (2014-04-18)
This work deals with the synthesis of insulin loaded nanoparticles (NPs) composed of thiolated Eudragit L100 (Eul-cys) and reduced glutathione (GSH) as potential nanocarriers for oral delivery of insulin. Perfectly spherical NPs with an average particle size of nearly 200-300 nm
Lei Wang et al.
Bioconjugate chemistry, 25(7), 1252-1260 (2014-06-28)
A new strategy for accurate and reversible modulation of protein activity via simple conjugation of the sulfhydryl modifier and polymer with the introduced Cys residue in protein was developed in this study. With Escherichia coli inorganic pyrophosphatase (PPase) as a
Fouzia Amamou et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 78, 177-184 (2015-01-27)
Cadmium (Cd) is one of the most common heavy metal pollutants. It is accumulated particularly in liver and kidney. The present study examined the possible protective effect of olive oil and colocynth oil consumption against Cd-induced damage on plasma lipids
Dongxu Wang et al.
Toxicology and applied pharmacology, 283(1), 65-74 (2015-01-15)
(-)-Epigallocatechin-3-gallate (EGCG), a constituent of green tea, has been suggested to have numerous health-promoting effects. On the other hand, high-dose EGCG is able to evoke hepatotoxicity. In the present study, we elucidated the responses of hepatic major antioxidant enzymes and
Isaac A Adedara et al.
Renal failure, 37(3), 497-504 (2015-01-24)
Benzo(a)pyrene (B[a]P), a polycyclic aromatic hydrocarbon generally formed from incomplete combustion of organic matter, reportedly causes renal injury and elicits a nephropathic response. The present study investigated the modulatory effect of Kolaviron, an isolated bioflavonoid from the seed of Garcinia
Franz Worek et al.
Toxicology letters, 231(1), 92-98 (2014-09-23)
Highly toxic organophosphorus (OP) nerve agents are well characterized regarding chemical, biological and toxicological properties and the effectiveness of standard atropine and oxime therapy. Open literature data on the key nerve agent precursor methylphosphonic difluoride (DF) are scarce. To fill
Mohammad Haaris Ajmal Khan et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 31, 53-60 (2015-05-26)
Cadmium (Cd) induces neurotoxicity owing to its highly deleterious capacity to cross the blood brain barrier (BBB). Recent studies have provided insights on antioxidant properties of bioflavonoids which have emerged as potential therapeutic and nutraceutical agents. The aim of our
Yi Li et al.
Bioorganic & medicinal chemistry, 17(10), 3536-3542 (2009-04-28)
A series of mechanism-based inhibitors designed to interact with the S' subsites of serine proteases was synthesized and their inhibitory activity toward the closely-related serine proteases human neutrophil elastase (HNE) and proteinase 3 (PR 3) was investigated. The compounds were
Maria Luiza Zeraik et al.
PloS one, 9(10), e110277-e110277 (2014-10-24)
Pro-oxidant effects of phenolic compounds are usually correlated to the one-electron redox potential of the phenoxyl radicals. Here we demonstrated that, besides their oxidizability, hydrophobicity can also be a decisive factor. We found that esterification of protocatechuic acid (P0) provoked
Tian Wang et al.
Journal of pharmaceutical and biomedical analysis, 102, 519-528 (2014-12-03)
Disulfide reduction in therapeutic monoclonal antibodies can occur during cell harvest operations as a result of cell breakage. Understanding these product quality changes and manufacturers' ability to control them would likely be of concern to regulatory bodies. To study the
Hyun Ah Jung et al.
Archives of pharmacal research, 38(6), 1178-1187 (2014-10-11)
The aim of the present study was to evaluate the comparative anti-Alzheimer's disease (AD) activities of different parts of Nelumbo nucifera (leaves, de-embryo seeds, embryos, rhizomes, and stamens) in order to determine the selectivity and efficient use of its individual
Ademola Adetokunbo Oyagbemi et al.
Environmental toxicology, 30(11), 1235-1243 (2014-04-08)
Removal of lead from the environment of man or otherwise, the movement of man from lead-contaminated areas has been employed as a means of abatement of the toxic effects of lead. Whether toxic effects in already-exposed individuals subside after lead
Omar Mezghrani et al.
International journal of pharmaceutics, 478(2), 553-568 (2014-12-03)
Hepatocellular carcinoma (HCC) dual targeted stimuli responsive nanoparticles (NPs) for intracellular delivery of doxorubicin (DOX) were developed based on a reduction cleavable hyaluronic acid-glycyrrhetinic acid conjugate (HA-Cyst-GA). HA-Cyst-GA conjugate readily formed NPs in aqueous milieu and exhibited a high drug
E O Farombi et al.
Human & experimental toxicology, 37(4), 358-372 (2017-04-20)
The persistent inflammation and oxidative stress at the local site in ulcerative colitis reportedly extend to the testes via systemic circulation resulting in testicular dysfunction. The influence of 6-gingerol (6G), a phenolic compound isolated from Zingiber officinale, on colitis-mediated testicular
Israr Ahmad et al.
Molecular and cellular biochemistry, 393(1-2), 209-222 (2014-04-29)
Cytochrome P4502E1 (CYP2E1), glutathione-S-transferase A4-4 (GSTA4-4), and inducible nitric oxide synthase (iNOS) are implicated in maneb- and paraquat-induced toxicity leading to various pathological conditions. The study aimed to investigate the role of CYP2E1 in maneb- and paraquat-induced oxidative stress in
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