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Rui Zhang et al.
The New phytologist, 227(5), 1392-1405 (2020-05-02)
The petal spur of the basal eudicot Aquilegia is a key innovation associated with the adaptive radiation of the genus. Previous studies have shown that diversification of Aquilegia spur length can be predominantly attributed to variation in cell elongation. However
Mandy Otto et al.
The Journal of clinical investigation, 130(9), 4999-5010 (2020-06-26)
Patients with diabetes develop endothelial dysfunction shortly after diabetes onset that progresses to vascular disease underlying the majority of diabetes-associated comorbidities. Increased lipid peroxidation, mitochondrial calcium overload, and mitochondrial dysfunction are characteristics of dysfunctional endothelial cells in diabetic patients. We
Martin Heil et al.
Nature, 430(6996), 205-208 (2004-07-09)
Induced plant resistance traits are expressed in response to attack and occur throughout the plant kingdom. Despite their general occurrence, the evolution of such resistances has rarely been investigated. Here we report that extrafloral nectar, a usually inducible trait, is
G P Rossi et al.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 48(5), 343-350 (2000-09-09)
The mechanisms and factors leading to enhanced aldosterone secretion and ultimately to neoplastic transformation of the adrenal cortex are poorly defined. Angiotensin-II (Ang-II) and endothelin-1 (ET-1) have emerged as likely candidates among potential aldosterone secretagogues and adrenocortical growth-promoting factors. We
Wan Mohd Nuzul Hakimi Salleh et al.
Natural product communications, 10(11), 2005-2008 (2016-01-12)
The chemical composition of the essential oil and antioxidant and anti-inflammatory activities of the extracts from Piper miniatum were determined. GC and GC-MS analysis of the essential oil resulted in the identification of 64 components, accounting for 89.2% of the
Ivana Holková et al.
Plant physiology and biochemistry : PPB, 48(10-11), 887-892 (2010-09-11)
The involvement of lipoxygenase (LOX, EC 1.13.11.12) in elicitor-induced opium poppy defense response was investigated. Papaver somniferum L. suspension cultures were treated with abiotic elicitor methyl jasmonate (MJ), fungal elicitor (Botrytis cinerea homogenate) and phenidone (specific inhibitor of LOX) to
Sumner H Burstein et al.
Bioorganic & medicinal chemistry, 15(10), 3345-3355 (2007-03-27)
A library of amino acid-fatty acid conjugates (elmiric acids) was synthesized and evaluated for activity as potential anti-inflammatory agents. The compounds were tested in vitro for their effects on cell proliferation and prostaglandin production, and compared with their effects on
Jun-Hyung Kim et al.
Neurochemistry international, 90, 204-214 (2015-09-15)
Zinc oxide nanoparticles (ZnO NPs) are known to induce oxidative stress and modulate an inflammatory process in various cell types. Although the cytotoxic effects of ZnO NPs in various cell types have been evaluated, few neurotoxic surveys on ZnO NPs
Woo-Ju Song et al.
Nanomaterials (Basel, Switzerland), 9(7) (2019-07-25)
The present study examined the potential toxic concentrations of zinc oxide nanoparticles (ZnO NPs) and associated autophagy and apoptosis-related injuries in primary neocortical astrocyte cultures. Concentrations of ZnO NPs ≥3 μg/mL induced significant toxicity in the astrocytes. At 24 h
The Oxidation of 1-Phenyl-4, 4-dimethyl-3-pyrazolidinone in Alkaline Solution.
The Journal of Organic Chemistry, 30(8), 2571-2575 (1965)
Monika Frey et al.
Phytochemistry, 65(8), 1047-1055 (2004-04-28)
The indole-3-glycerol phosphate lyase Igl is the structural gene of volatile indole biosynthesis in the tritrophic interaction in maize. The gene is activated on transcriptional level with the same kinetics and to the same level by the fatty acid-amino acid
J Peng et al.
Plant biology (Stuttgart, Germany), 13(2), 276-284 (2011-02-12)
When attacked by herbivores, plants release herbivore-induced plant volatiles (HIPV) that may function in direct defence by repelling herbivores or reducing their growth. Emission of HIPV may also contribute to indirect defence by attracting natural enemies of the herbivore. Here
J C Bedick et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 130(1), 107-117 (2001-09-07)
Nodulation is the first, and qualitatively predominant, cellular defense reaction to bacterial infections in insects. We tested the hypothesis that eicosanoids also mediate nodulation reactions to bacterial challenge in adults of a social insect, the honey bee, Apis mellifera. Treating
Venkatesan Radhika et al.
PloS one, 5(2), e9265-e9265 (2010-02-23)
Plants produce nectar in their flowers as a reward for their pollinators and most of our crops depend on insect pollination, but little is known on the physiological control of nectar secretion. Jasmonates are well-known for their effects on senescence
Eun-Seon Kim et al.
Plant molecular biology, 52(6), 1203-1213 (2003-12-20)
Lipoxygenases (LOXs) catalyze the formation of fatty acid hydroperoxides involved in responses to stresses. This study examines the expression of a non-traditional dual positional specific maize LOX in response to wounding or methyl jasmonate (MeJA). Full-length maize LOX cDNA was
John Meshki et al.
American journal of physiology. Cell physiology, 286(2), C264-C271 (2003-11-14)
Nucleotides are released during vascular injury from activated platelets and broken cells, which could stimulate human neutrophils. In this study, we characterized the P2Y receptors and investigated the functional effects of extracellular nucleotides on human neutrophils. Pharmacological characterization using selective
Torsten Hans Schroeder et al.
Biologics : targets & therapy, 2(1), 151-160 (2008-03-01)
Leukocyte adhesion contributes to perfusion abnormalities and tissue damage during trauma, shock or overwhelming inflammation. This study was performed to determine whether the lipoxygenase inhibitor phenidone and derivatives decrease the expression of adhesion molecules on tumor necrosis factor-alpha (TNF-alpha) stimulated
Changjong Moon et al.
Brain research, 1035(2), 206-210 (2005-02-22)
This study examined whether phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), affects the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in the rat, and the expression of both COX-1/-2 and 5-LOX in EAE spinal cords. Oral phenidone
Hasan Tunaz
Archives of insect biochemistry and physiology, 63(3), 93-100 (2006-10-19)
Influence of fungal species (conidia spores) on mortality of Pieris brassicae larvae differed when injected into the larvae. The effects of B. bassiana (ARSEF-1151) were expressed in a conidial dose-dependent manner on mortality of the larvae. An increased and faster
M B Wie et al.
Neuroscience letters, 272(2), 91-94 (1999-10-03)
The abrupt elevation in the levels of cyclooxygenase or lipoxygenase metabolites of arachidonic acid during cerebral ischemia contributes to neuronal injury. Recently, evidence has accumulated that both excitotoxic and apoptotic features can coexist in ischemia models in vitro and in
T Sen et al.
Phytotherapy research : PTR, 16(4), 331-335 (2002-07-12)
Studies were carried out to evaluate the influence of the methanol fraction of Pluchea indica Less root extract (PIRE), the dual inhibitors (BW 755C and phenidone) and vitamin on both in vivo and in vitro free radical-scavenging activities, CCl(4)-induced lipid
A Wakatsuki et al.
Biology of the neonate, 76(2), 84-91 (1999-07-08)
To determine whether ischemia followed by subsequent reperfusion can induce fetal cerebral oxidative damage, we created a model of fetal ischemia/reperfusion using rats at day 19 of pregnancy. Fetal ischemia was induced by unilateral occlusion of the utero-ovarian artery for
H C Kim et al.
Brain research, 874(1), 15-23 (2000-08-11)
Acculmulating evidence indicates that a marked generation of oxygen free radicals derived from the metabolism of arachidonic acid causes neurodegeneration. Recently, we have demonstrated that the novel antioxidant actions mediated by phenidone, a dual inhibitor of cyclooxygenase/lipoxygenase pathways, may play
C Audouin et al.
Bioorganic & medicinal chemistry letters, 11(6), 845-848 (2001-03-30)
N-Aminoindoline derivatives were prepared and their 5-lipoxygenase inhibitory activities were evaluated in vitro and compared with those of phenidone and NDGA. Compound 4 presents the most effective 5-LO inhibition.
Maaike Bruinsma et al.
Oecologia, 162(2), 393-404 (2009-10-07)
Herbivore-induced plant defences influence the behaviour of insects associated with the plant. For biting-chewing herbivores the octadecanoid signal-transduction pathway has been suggested to play a key role in induced plant defence. To test this hypothesis in our plant-herbivore-parasitoid tritrophic system
Dong Duan et al.
Journal of experimental botany, 67(6), 1795-1804 (2016-02-05)
Stilbene synthase is a key enzyme for the production of the phytoalexin resveratrol. Some clones of Vitis sylvestris, a wild European grapevine species which is almost extinct, have been shown to accumulate more resveratrol in response to different forms of
Zhengyi Li et al.
Neuroscience letters, 445(1), 1-6 (2008-09-02)
Anti-inflammatory drugs such as ibuprofen appear to prevent the development of Parkinson's disease (PD); however, long-term use has undesirable side-effects. A new strategy for anti-inflammatory drug therapy is using a dual inhibitor of COX and lipooxygenase (LOX). Here, we compared
Joonyup Kim et al.
FEBS letters, 587(2), 226-230 (2012-12-12)
It has previously been shown that jasmonic acid affects the ethylene signaling pathway. EIN2 is a central component of ethylene signaling that is downstream of the receptors. EIN2 has previously been shown to be required for ethylene responses. We found
P Rebuffat et al.
International journal of molecular medicine, 7(3), 301-305 (2001-02-17)
Endothelins (ETs) are a family of 21-amino acid hypertensive peptides, which together with their receptors ETA and ETB are expressed in human adrenal cortex. Evidence has been provided that ETs exert a potent secretagogue effect on human adrenocortical cells, acting
H Fujita et al.
Atherosclerosis, 147(1), 69-75 (1999-10-19)
Our aim was to assess the potential role of lipoxygenase (LO) products in neointimal formation following vascular injury. We investigated the effect of LO pathway inhibition, by phenidone, on the concentration of 12- and 5-hydroxyeicosatetraenoic acid (12- and 5-HETE) in
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