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John Meshki et al.
American journal of physiology. Cell physiology, 286(2), C264-C271 (2003-11-14)
Nucleotides are released during vascular injury from activated platelets and broken cells, which could stimulate human neutrophils. In this study, we characterized the P2Y receptors and investigated the functional effects of extracellular nucleotides on human neutrophils. Pharmacological characterization using selective
Jun-Hyung Kim et al.
Neurochemistry international, 90, 204-214 (2015-09-15)
Zinc oxide nanoparticles (ZnO NPs) are known to induce oxidative stress and modulate an inflammatory process in various cell types. Although the cytotoxic effects of ZnO NPs in various cell types have been evaluated, few neurotoxic surveys on ZnO NPs
Woo-Ju Song et al.
Nanomaterials (Basel, Switzerland), 9(7) (2019-07-25)
The present study examined the potential toxic concentrations of zinc oxide nanoparticles (ZnO NPs) and associated autophagy and apoptosis-related injuries in primary neocortical astrocyte cultures. Concentrations of ZnO NPs ≥3 μg/mL induced significant toxicity in the astrocytes. At 24 h
Sumner H Burstein et al.
Bioorganic & medicinal chemistry, 15(10), 3345-3355 (2007-03-27)
A library of amino acid-fatty acid conjugates (elmiric acids) was synthesized and evaluated for activity as potential anti-inflammatory agents. The compounds were tested in vitro for their effects on cell proliferation and prostaglandin production, and compared with their effects on
Ivana Holková et al.
Plant physiology and biochemistry : PPB, 48(10-11), 887-892 (2010-09-11)
The involvement of lipoxygenase (LOX, EC 1.13.11.12) in elicitor-induced opium poppy defense response was investigated. Papaver somniferum L. suspension cultures were treated with abiotic elicitor methyl jasmonate (MJ), fungal elicitor (Botrytis cinerea homogenate) and phenidone (specific inhibitor of LOX) to
Rui Zhang et al.
The New phytologist, 227(5), 1392-1405 (2020-05-02)
The petal spur of the basal eudicot Aquilegia is a key innovation associated with the adaptive radiation of the genus. Previous studies have shown that diversification of Aquilegia spur length can be predominantly attributed to variation in cell elongation. However
Mandy Otto et al.
The Journal of clinical investigation, 130(9), 4999-5010 (2020-06-26)
Patients with diabetes develop endothelial dysfunction shortly after diabetes onset that progresses to vascular disease underlying the majority of diabetes-associated comorbidities. Increased lipid peroxidation, mitochondrial calcium overload, and mitochondrial dysfunction are characteristics of dysfunctional endothelial cells in diabetic patients. We
Martin Heil et al.
Nature, 430(6996), 205-208 (2004-07-09)
Induced plant resistance traits are expressed in response to attack and occur throughout the plant kingdom. Despite their general occurrence, the evolution of such resistances has rarely been investigated. Here we report that extrafloral nectar, a usually inducible trait, is
Wan Mohd Nuzul Hakimi Salleh et al.
Natural product communications, 10(11), 2005-2008 (2016-01-12)
The chemical composition of the essential oil and antioxidant and anti-inflammatory activities of the extracts from Piper miniatum were determined. GC and GC-MS analysis of the essential oil resulted in the identification of 64 components, accounting for 89.2% of the
G P Rossi et al.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 48(5), 343-350 (2000-09-09)
The mechanisms and factors leading to enhanced aldosterone secretion and ultimately to neoplastic transformation of the adrenal cortex are poorly defined. Angiotensin-II (Ang-II) and endothelin-1 (ET-1) have emerged as likely candidates among potential aldosterone secretagogues and adrenocortical growth-promoting factors. We
The Oxidation of 1-Phenyl-4, 4-dimethyl-3-pyrazolidinone in Alkaline Solution.
The Journal of Organic Chemistry, 30(8), 2571-2575 (1965)
Venkatesan Radhika et al.
PloS one, 5(2), e9265-e9265 (2010-02-23)
Plants produce nectar in their flowers as a reward for their pollinators and most of our crops depend on insect pollination, but little is known on the physiological control of nectar secretion. Jasmonates are well-known for their effects on senescence
Eun-Seon Kim et al.
Plant molecular biology, 52(6), 1203-1213 (2003-12-20)
Lipoxygenases (LOXs) catalyze the formation of fatty acid hydroperoxides involved in responses to stresses. This study examines the expression of a non-traditional dual positional specific maize LOX in response to wounding or methyl jasmonate (MeJA). Full-length maize LOX cDNA was
J Peng et al.
Plant biology (Stuttgart, Germany), 13(2), 276-284 (2011-02-12)
When attacked by herbivores, plants release herbivore-induced plant volatiles (HIPV) that may function in direct defence by repelling herbivores or reducing their growth. Emission of HIPV may also contribute to indirect defence by attracting natural enemies of the herbivore. Here
Monika Frey et al.
Phytochemistry, 65(8), 1047-1055 (2004-04-28)
The indole-3-glycerol phosphate lyase Igl is the structural gene of volatile indole biosynthesis in the tritrophic interaction in maize. The gene is activated on transcriptional level with the same kinetics and to the same level by the fatty acid-amino acid
J C Bedick et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 130(1), 107-117 (2001-09-07)
Nodulation is the first, and qualitatively predominant, cellular defense reaction to bacterial infections in insects. We tested the hypothesis that eicosanoids also mediate nodulation reactions to bacterial challenge in adults of a social insect, the honey bee, Apis mellifera. Treating
Zhengyi Li et al.
Neuroscience letters, 445(1), 1-6 (2008-09-02)
Anti-inflammatory drugs such as ibuprofen appear to prevent the development of Parkinson's disease (PD); however, long-term use has undesirable side-effects. A new strategy for anti-inflammatory drug therapy is using a dual inhibitor of COX and lipooxygenase (LOX). Here, we compared
Maaike Bruinsma et al.
Oecologia, 162(2), 393-404 (2009-10-07)
Herbivore-induced plant defences influence the behaviour of insects associated with the plant. For biting-chewing herbivores the octadecanoid signal-transduction pathway has been suggested to play a key role in induced plant defence. To test this hypothesis in our plant-herbivore-parasitoid tritrophic system
H Fujita et al.
Atherosclerosis, 147(1), 69-75 (1999-10-19)
Our aim was to assess the potential role of lipoxygenase (LO) products in neointimal formation following vascular injury. We investigated the effect of LO pathway inhibition, by phenidone, on the concentration of 12- and 5-hydroxyeicosatetraenoic acid (12- and 5-HETE) in
Joonyup Kim et al.
FEBS letters, 587(2), 226-230 (2012-12-12)
It has previously been shown that jasmonic acid affects the ethylene signaling pathway. EIN2 is a central component of ethylene signaling that is downstream of the receptors. EIN2 has previously been shown to be required for ethylene responses. We found
Dong Duan et al.
Journal of experimental botany, 67(6), 1795-1804 (2016-02-05)
Stilbene synthase is a key enzyme for the production of the phytoalexin resveratrol. Some clones of Vitis sylvestris, a wild European grapevine species which is almost extinct, have been shown to accumulate more resveratrol in response to different forms of
P Rebuffat et al.
International journal of molecular medicine, 7(3), 301-305 (2001-02-17)
Endothelins (ETs) are a family of 21-amino acid hypertensive peptides, which together with their receptors ETA and ETB are expressed in human adrenal cortex. Evidence has been provided that ETs exert a potent secretagogue effect on human adrenocortical cells, acting
Ender Büyükgüzel et al.
Journal of insect physiology, 57(4), 501-507 (2011-02-10)
Eicosanoids are oxygenated metabolites of three C20 polyunsaturated fatty acids, mainly arachidonic acid (AA; 20:4n-6), but also 20:3n-6 and 20:5n-3. Aside from their importance in biomedicine, eicosanoids act in invertebrate biology. Prostaglandins (PGs) influence salt and water transport physiology in
F Stanke-Labesque et al.
Cardiovascular research, 47(2), 376-383 (2000-08-18)
This study investigated, in isolated human internal mammary artery, the involvement of the cyclooxygenase and the lipoxygenase pathways of arachidonic acid metabolism in the contraction induced by angiotensin II. Rings of human internal mammary arteries were suspended in organ baths
Claudia Cusan et al.
Farmaco (Societa chimica italiana : 1989), 60(1), 7-13 (2005-01-18)
A new series of potential human 5-LOX inhibitors structurally related to the 1-phenyl-3-pyrazolidinone (phenidone, 2) has been synthesized and the activity against COX-1, COX-2, and human 5-LOX enzymes has been evaluated. In contrast with literature data, we observed that phenidone
Yangyang Luo et al.
Planta, 249(6), 1889-1902 (2019-03-14)
MYB15 promoter of Vitis quinquangularis has potential as a target for disease resistance breeding, and its involvement in PTI is associated with a range of defense mechanisms. China is a center of origin for Vitis and is home to diverse
R Kumarathasan et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 78(2), 87-91 (2000-06-30)
Lipoxygenases catalyze peroxidation of polyunsaturated fatty acids containing the 1-cis, 4-cis pentadiene structure. Linoleic (18:2), linolenic (18:3), and arachidonic (20:4) acids are the predominant substrates for this class of enzymes. Effects of 15-lipoxygenase on the hydrolysis of adenosine 5'-triphosphate were
Ender Büyükgüzel et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 204, 121-128 (2016-11-27)
We posed the hypothesis that inhibition of eicosanoid biosynthesis leads to increased lipid peroxidation in insects. Here we report that rearing the greater wax moth, Galleria mellonella, on media supplemented with selected inhibitors of eicosanoid biosynthesis throughout the larval, pupal
A Wakatsuki et al.
Biology of the neonate, 76(2), 84-91 (1999-07-08)
To determine whether ischemia followed by subsequent reperfusion can induce fetal cerebral oxidative damage, we created a model of fetal ischemia/reperfusion using rats at day 19 of pregnancy. Fetal ischemia was induced by unilateral occlusion of the utero-ovarian artery for
H C Kim et al.
Brain research, 874(1), 15-23 (2000-08-11)
Acculmulating evidence indicates that a marked generation of oxygen free radicals derived from the metabolism of arachidonic acid causes neurodegeneration. Recently, we have demonstrated that the novel antioxidant actions mediated by phenidone, a dual inhibitor of cyclooxygenase/lipoxygenase pathways, may play
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