130-15-4

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CC chemokine receptor 5 delta32 and CC chemokine receptor 2 64I polymorphisms do not influence the virologic and immunologic response to antiretroviral combination therapy in human immunodeficiency virus type 1-infected patients.

Ferdinand W N M Wit et al.

The Journal of infectious diseases, 186(12), 1726-1732 (2002-11-26)

To investigate the influence of the CC chemokine receptor 2 64I and CC chemokine receptor 5 delta32 polymorphisms on the virologic and immunologic response of human immunodeficiency virus type 1 (HIV-1)-infected patients to highly active antiretroviral therapy, data from 4

A phase 1 dose escalation study of BI 831266, an inhibitor of Aurora kinase B, in patients with advanced solid tumors.

Christian Dittrich et al.

Investigational new drugs, 33(2), 409-422 (2014-12-23)

Purpose BI 831266 is a potent, selective, low-molecular-weight inhibitor of Aurora kinase B. This trial aimed to determine the maximum tolerated dose (MTD) of BI 831266 in patients with advanced solid tumors (NCT00756223; EudraCT 2008-001631-36; 1257.1). Methods BI 831266 (4-130

Purification and characterization of a beta-D-mannosidase from the marine anaspidean Aplysia fasciata.

Giuseppina Andreotti et al.

Journal of biotechnology, 119(1), 26-35 (2005-07-21)

A beta-D-mannosidase was purified to homogeneity from visceral mass extract of Aplysia fasciata a mollusc belonging to the order Anaspidea. The purified enzyme is a homodimer with a subunit mass of 130 kDa. Temperature and pH optima of this enzyme

[The association between polymorphism of the serotonin 2A, 2C receptor genes and obstructive sleep apnea-hypopnea syndrome in Han population].

Jian-Yong Zhu et al.

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 30(12), 912-917 (2008-03-14)

To investigate the association between polymorphisms of the serotonin 2A, 2C receptor genes and obstructive sleep apnea-hypopnea syndrome (OSAHS), and therefore to explore the genotypes related to OSAHS. The T102C and A1438G polymorphisms of the serotonin 2A receptor genes and

Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).

R Hedderich et al.

European journal of biochemistry, 193(1), 255-261 (1990-10-05)

The reduction of the heterodisulfide of coenzyme M (H-S-CoM) and 7-mercaptoheptanoyl-L-threonine phosphate (H-S-HTP) is a key reaction in the metabolism of methanogenic bacteria. The heterodisulfide reductase catalyzing this step was purified 80-fold to apparent homogeneity from Methanobacterium thermoautotrophicum. The native

Studies on trimethylsilyl derivatives of 1-alkyl-2-acylglycerols by gas-liquid chromatography mass spectrometry.

K Satouchi et al.

Biomedical mass spectrometry, 3(3), 122-126 (1976-06-01)

Trimethylsilyl derivatives of 1-hexadecyl-2-decanoyl-, -hexadecanoyl- and -octadecenoyglycerols and 1-octadecyl-2-decanoyl-, hexadecanoyl- and -octadecenoylglycerols as well as 1,2-dihexadecanoylglycerol were analysed by a gas chromatography mass spectrometer system. The following points are characteristic of the fragmentation pattern of these 1-alkyl-2-acyl derivatives: (1) in

Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial.

Lesly A Pearce et al.

The Lancet. Neurology, 13(12), 1177-1185 (2014-12-03)

The primary outcome results for the SPS3 trial suggested that a lower systolic target blood pressure (<130 mm Hg) might be beneficial for reducing the risk of recurrent stroke compared with a higher target (130-149 mm Hg), but that the

Glyceryl monooleyl ether-based liquid crystalline nanoparticles as a transdermal delivery system of flurbiprofen: characterization and in vitro transport.

Tomonobu Uchino et al.

Chemical & pharmaceutical bulletin, 63(5), 334-340 (2015-05-08)

Liquid crystalline nanoparticles (LCNs) were prepared using glyceryl monooleyl ether (GME) by the modified film rehydration method. Hydrogenated lecithin (HL), 1,3-butylene glycol (1,3-BG), and Poloxamer 407 were used as additives. The prepared LCN formulations were evaluated based on particle size

Frontline treatment with gemcitabine, oxaliplatin and erlotinib for the treatment of advanced or metastatic pancreatic cancer: a multicenter phase II study of the Hellenic Oncology Research Group (HORG).

O Katopodis et al.

Cancer chemotherapy and pharmacology, 74(2), 333-340 (2014-06-16)

Intravenous gemcitabine is the standard of care for patients with metastatic cancer of the pancreas. Gemcitabine-based chemotherapy combinations, either doublets or triplets, have been tested in the past but have offered a small advantage (Brodoefel et al. in Eur J

Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus.

C Pupilli et al.

Journal of pediatric endocrinology & metabolism : JPEM, 18(12), 1417-1423 (2006-02-08)

To test for anti-CD38 autoimmunity in children with newly-diagnosed type 1 diabetes mellitus (DM1). Serum anti-CD38 autoantibodies were detected by Western blot in 270 children (130 girls, 140 boys, mean age 8 +/- 4 years) with newly-diagnosed DM1 and 179

Determination of total iodine in infant formula and nutritional products by inductively coupled plasma/mass spectrometry: single-laboratory validation.

Lawrence H Pacquette et al.

Journal of AOAC International, 95(1), 169-176 (2012-04-04)

A single-laboratory validation by inductively coupled plasma-mass spectrometry was developed for the determination total iodine (m/z 127) in infant formula and adult nutritional products. All samples were digested in nitric acid using a closed vessel microwave oven system; Te (m/z

Interaction of clonidine and clonidine analogues with alpha-adrenergic receptors of neuroblastoma X glioma hybrid cells and rat brain: comparison of ligand binding with inhibition of adenylate cyclase.

D Atlas et al.

European journal of biochemistry, 113(3), 521-529 (1981-01-01)

Clonidine and several analogues of clonidine are shown to be useful probes for alpha 2-adrenergic receptors in a comparative study of ligand binding and inhibition of adenylate cyclase. The alpha-adrenergic properties of a new potential probe, N-(4-hydroxyphenacetyl)-4-aminoclonidine hydrochloride, are described.

Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.

Digna R Velez et al.

American journal of obstetrics and gynecology, 200(2), 209-209 (2008-11-21)

The objective of the study was to study the genetic risk factors of spontaneous preterm birth (PTB) in African Americans. Case-control analyses were performed using maternal and fetal deoxyribonucleic acid from 279 African American birth events (82 PTB and 197

A simple extraction and LC-MS/MS approach for the screening and identification of over 100 analytes in eight different matrices.

Deborah Montenarh et al.

Drug testing and analysis, 7(3), 214-240 (2014-04-23)

In the present study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) multi-analyte approach using one single work-up approach in whole blood, plasma, serum, post-mortem blood, liver tissue, gastric content, hair, and urine was developed for fast target screening and reliable identification

Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.

X Lin et al.

Nature, 402(6763), 761-768 (2000-01-05)

Arabidopsis thaliana (Arabidopsis) is unique among plant model organisms in having a small genome (130-140 Mb), excellent physical and genetic maps, and little repetitive DNA. Here we report the sequence of chromosome 2 from the Columbia ecotype in two gap-free

NAD(P)H oxidase/nitric oxide interactions in peroxisome proliferator activated receptor (PPAR)alpha-mediated cardiovascular effects.

Mohammad Newaz et al.

Mutation research, 579(1-2), 163-171 (2005-08-02)

Activation of peroxisome proliferator activated receptor (PPAR)alpha and its protective role in cardiovascular function has been reported but the exact mechanism(s) involved is not clear. As we have shown that PPARalpha ligands increased nitric oxide (NO) production and cardiovascular function

Fluorouracil, epirubicin, and cyclophosphamide (FEC-75) followed by paclitaxel plus trastuzumab versus paclitaxel plus trastuzumab followed by FEC-75 plus trastuzumab as neoadjuvant treatment for patients with HER2-positive breast cancer (Z1041): a randomised, controlled, phase 3 trial.

Aman U Buzdar et al.

The Lancet. Oncology, 14(13), 1317-1325 (2013-11-19)

Neoadjuvant chemotherapy with trastuzumab for patients with HER2-positive breast cancer can produce a pathological complete response in the breast in 30-65% of patients. We investigated the effect of the timing of trastuzumab administration with anthracycline and taxane neoadjuvant chemotherapy. This

Effect of sorbic acid feeding on peroxisomes and sorboyl-CoA metabolizing enzymes in mouse liver. Selective induction of 2,4-dienoyl-CoA hydratase.

T Nishimaki-Mogami et al.

Biochemical pharmacology, 42(2), 239-246 (1991-07-05)

On the basis of the finding that sorbic acid (SA)-induced hepatoma was correlated with the depletion of reduced glutathione (GSH) in mouse liver (Tsuchiya et al., Mutation Res 130: 267-262, 1984), the possible conversion of SA to a metabolite which

Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy.

M Ernberg et al.

Mediators of inflammation, 2018, 3985154-3985154 (2018-06-01)

The aims of this study were to compare circulating cytokines between FM and healthy controls and to investigate the effect on cytokine levels by 15 weeks of progressive resistance exercise or relaxation therapy in FM. Baseline plasma cytokine levels and

Facilitated skin permeation of oregonin by elastic liposomal formulations and suppression of atopic dermatitis in NC/Nga mice.

Myung Joo Kang et al.

Biological & pharmaceutical bulletin, 33(1), 100-106 (2010-01-05)

To develop an external preparation of oregonin (ORG) for the treatment of atopic dermatitis (AD), conventional creams (CC) and elastic liposomes (EL) containing ORG have been formulated and examined for their in vitro skin permeation properties and in vivo therapeutic

Electrophysiological studies of the GABAA receptor ligand, 4-PIOL, on cultured hippocampal neurones.

U Kristiansen et al.

British journal of pharmacology, 104(1), 85-90 (1991-09-01)

1. Whole-cell, patch-clamp recordings from cultured hippocampal neurones have been used to characterize the action of the GABAA ligand, 5-(4-piperidyl)isoxazol-3-ol (4-PIOL). The action of 4-PIOL was compared with that of the established GABAA agonist, isoguvacine. 2. With a symmetrical Cl-

Facile hydrolysis of mebeverine in vitro and in vivo: negligible circulating concentrations of the drug after oral administration.

R G Dickinson et al.

Journal of pharmaceutical sciences, 80(10), 952-957 (1991-10-01)

The HPLC methods for the determination of plasma concentrations of the antispasmodic agent mebeverine (0.01-10 micrograms/mL) and its hydrolysis product veratric acid (0.1-50 micrograms/mL) are presented. Mebeverine was demonstrated to hydrolyze readily in fresh unbuffered human and rat plasma samples

The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy.

Jochen Springer et al.

International journal of cardiology, 168(4), 3527-3531 (2013-06-12)

Cachexia is a common complication of cancer and may be responsible for 22% of all cancer-related deaths. The exact cause of death in cancer cachexia patients is unknown. Recently, atrophy of the heart has been described in cancer cachexia animal

Fast liquid chromatographic-tandem mass spectrometric method using mixed-mode phase chromatography and solid phase extraction for the determination of 12 mono-hydroxylated brominated diphenyl ethers in human serum.

Syrago-Styliani E Petropoulou et al.

Journal of chromatography. A, 1356, 138-147 (2014-07-09)

Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are formed from the oxidative metabolism of polybrominated diphenyl ethers (PBDEs) in humans, rats and mice, but their quantitation in human blood and other matrices with liquid chromatography-mass spectrometric techniques has been a challenge. In

Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia.

T C Liu et al.

American journal of hematology, 63(4), 170-175 (2000-03-08)

Recently, a putative tumor suppressor gene, PTEN/MMAC1, has been identified at chromosome 10q23.3, which encodes a 403 amino acid dual-specificity phosphatase containing a region of homology to tensin and auxillin. Somatic mutations of the PTEN/MMAC1 gene have been identified in

Minimal residual disease as biomarker for optimal biologic dosing of ARA-C in patients with acute myeloid leukemia.

Luca Maurillo et al.

American journal of hematology, 90(2), 125-131 (2014-11-08)

We assessed by flow cytometry minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) given standard-dose (SDAC) and high-dose ARA-C (HDAC) regimens. Of 163 patients enrolled, 130 (median age, 45 years; range, 18-59 years) qualified for analysis, all

Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran.

Mohammad R Akbari et al.

Cancer research, 69(20), 7994-8000 (2009-10-15)

There is a region with a high risk for esophageal squamous cell carcinoma (ESCC) in the northeast of Iran. Previous studies suggest that hereditary factors play a role in the high incidence of cancer in the region. We selected 22

Viral dynamics of persistent hepatitis C virus infection in high-sensitive reporter cells resemble patient's viremia.

Peiju Tsai et al.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 51(4), 446-455 (2017-07-13)

Hepatitis C virus (HCV) infection has a high persistence rate in patients. Although immune cells play a central role in determining the outcomes of HCV infection, the liver is crucial in controlling HCV activity from acute to chronic stages. This

Co-expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) in thyroid nodules is associated with co-expression of CD30 ligand/CD30 receptor.

R M Ruggeri et al.

Journal of endocrinological investigation, 25(11), 959-966 (2003-01-30)

Data on the expression of interleukin 6 (IL-6)/interleukin 6 receptor (IL-6R) in thyroid nodules is scarce. Based on our recent data of CD30 ligand (CD30L)/CD30 receptor (CD30) in these nodules and on the knowledge that this signal stimulates IL-6 production

Effects of hypertonic saline infusion on the adrenocortical response to thiopental-halothane anesthesia in sheep after premedication with acepromazine.

P M Taylor

Veterinary surgery : VS, 28(1), 77-82 (1999-02-20)

To investigate whether hypertonic saline infusion would prevent hypotension and pituitary-adrenocortical axis activation during halothane anesthesia after acepromazine premedication and thiopental induction in sheep. Randomized crossover study. Six Welsh Mountain ewes weighing 40+/-2 kg and aged 2 to 3 years.

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