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关键词:'130-22-3'
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Richard V Macri et al.
Bioorganic & medicinal chemistry, 17(8), 3162-3168 (2009-03-25)
Three series of homologous dendritic amphiphiles--RCONHC(CH(2)CH(2)COOH)(3), 1(n); ROCONHC(CH(2)CH(2)COOH)(3), 2(n); RNHCONHC(CH(2)CH(2)COOH)(3), 3(n), where R = n-C(n)H(2n+1) and n = 13-22 carbon atoms--were assayed for their potential to serve as antimicrobial components in a topical vaginal formulation. Comparing epithelial cytotoxicities to the
German Zafra et al.
Microbes and infection, 9(9), 1049-1052 (2007-07-24)
The aim of this study was to investigate the possible influence of a 3' untranslated region (3' UTR) polymorphism of the IL12B gene in susceptibility to Trypanosoma cruzi infection or in the development to cardiomyopathy in Chagas' disease (CD). We
C M Nutting et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 20(7), 1275-1279 (2009-02-28)
Treatment options for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) are limited with response rates to cytotoxic chemotherapy of approximately 30% and median survival of 6 months. In a multicentre phase II study, 32 patients with recurrent
H Zou et al.
Cell, 90(3), 405-413 (1997-08-08)
We report here the purification and cDNA cloning of Apaf-1, a novel 130 kd protein from HeLa cell cytosol that participates in the cytochrome c-dependent activation of caspase-3. The NH2-terminal 85 amino acids of Apaf-1 show 21% identity and 53%
N Heisterkamp et al.
Nucleic acids research, 16(21), 10069-10081 (1988-11-11)
The hallmark of chronic myelogenous leukemia (CML) is a translocation between chromosomes 9 and 22 - the Philadelphia (Ph') translocation. The translocation is also found in acute lymphocytic leukemia (ALL) albeit in a lower percentage of patients. The breakpoint on
P W Hammond et al.
Molecular and cellular biology, 17(1), 296-308 (1997-01-01)
Telomerase is a ribonucleoprotein enzyme that adds telomeric sequence repeats to the ends of linear chromosomes. In vitro, telomerase has been observed to add repeats to a DNA oligonucleotide primer in a processive manner, leading to the postulation of a
Sarah Egert et al.
The British journal of nutrition, 107(4), 539-546 (2011-07-22)
The flavonol quercetin, is one of the major flavonoids found in edible plants. The bioavailability of quercetin in humans may be influenced by the food matrix in which it is consumed as well as by its chemical and physical form.
Laura Todaro et al.
Journal of neuro-oncology, 83(2), 135-144 (2007-01-12)
The neural cell adhesion molecule (NCAM) is involved in the intercellular junctions of neurons and glial cells. We investigated its relevance as a biomarker in gliomas which main characteristic is their high invasiveness. We studied by Western blot the pattern
Francesco De Seta et al.
American journal of obstetrics and gynecology, 197(6), 613-613 (2007-08-07)
The objective of the study was to examine mannose-binding lectin gene (MBL2) polymorphisms in women with recurrent episodes of bacterial vaginosis (BV). Seventy-one women with at least 4 episodes of BV in the last 12 months and 130 healthy controls
J B Richards et al.
Theriogenology, 52(6), 1055-1066 (2000-03-29)
Sixteen ram lambs (5 m.o. old, 45 +/- 1.5 kg) received a control diet (50% concentrate, no locoweed, n = 4), locoweed (20% locoweed for 21 d, n = 4), MUSE (2 mL i.m. of MUSE containing 5 mg selenium
Liang Cao et al.
Journal of colloid and interface science, 361(2), 472-476 (2011-06-28)
Highly ordered mesoporous SBA-15 silica with large pore diameter of 18 nm (nominal BJH pore diameter ~22 nm) and short pore length (~500 nm) was synthesized using a micelle expander 1,3,5-triisopropylbenzene in the absence of ammonium fluoride by employing short
G Senaldi et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(20), 11458-11463 (1999-09-29)
We have identified a cytokine of the IL-6 family and named it novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3). NNT-1/BSF-3 cDNA was cloned from activated Jurkat human T cell lymphoma cells. Its sequence predicts a 225-aa protein with a 27-aa signal peptide
Darrell R Borger et al.
The oncologist, 17(1), 72-79 (2011-12-20)
Cancers of origin in the gallbladder and bile ducts are rarely curable with current modalities of cancer treatment. Our clinical application of broad-based mutational profiling for patients diagnosed with a gastrointestinal malignancy has led to the novel discovery of mutations
Birger Wenge et al.
Naunyn-Schmiedeberg's archives of pharmacology, 383(2), 203-208 (2011-01-08)
The muscarinic antagonists oxybutynin and trospium are used as spasmolytic agents for the treatment of overactive urinary bladder disease. Recently, it has been shown that trospium, but not oxybutynin, is a substrate of the multidrug efflux carrier P-glycoprotein, but carrier-mediated
M Inzinger et al.
The British journal of dermatology, 165(3), 640-645 (2011-05-14)
Few studies have directly compared the clinical efficacy of psoralen plus ultraviolet A (PUVA) vs. biologics in the treatment of psoriasis. To compare the clinical efficacy of PUVA and biologic therapies for psoriasis under daily life conditions. Data from a
Keith G McMillan et al.
Carbohydrate research, 341(1), 41-48 (2005-11-03)
5-(1,2,3,4-tetra-O-acetyl-alpha-D-xylopyranos-5S-C-yl)-1,3,4-oxathiazol-2-one (8) has been prepared from glucuronamide in two steps and 73% overall yield by conversion to the tetra-O-acetyl derivative 7 followed by reaction with chlorocarbonylsulfenyl chloride. 5-(2,3,4-Tri-O-acetyl-beta-D-xylopyranosyl)-1,3,4-oxathiazol-2-one (12) was synthesised from D-xylose by a four-step sequence involving conversion to
H C Peters et al.
Neurogenetics, 2(1), 47-54 (1999-05-18)
Neurophysiological and pharmacological studies suggest a major role of the GABAB receptor in the epileptogenesis of absence seizures. The gene encoding the human GABABR1 receptor (GABABR1) has recently been mapped to human chromosome 6p21.3 by in situ hybridization, a region
Adelaide E Clark et al.
Chemosphere, 137, 33-44 (2015-05-20)
An analytical method has been developed for the pressurized liquid extraction (PLE) of a wide range of semi-volatile organic compounds (SVOCs) from atmospheric particulate matter. Approximately 130 SVOCs from eight compound classes were selected as molecular markers of (1) agricultural
Françoise Blondé-Cynober et al.
Annales de biologie clinique, 68(5), 569-575 (2010-09-28)
Diagnosis of iron deficiency is not easily performed in inflammatory situation as usually encountered in elderly hospitalized patients (>70 years old). At first, we determined serum soluble receptor transferrin (RsTf), RsTf/serum ferritin ratio (RsTf-F index) and biochemical and haematological values
Cornelis M van Tilburg et al.
Clinical epigenetics, 11(1), 188-188 (2019-12-12)
Until today, adult and pediatric clinical trials investigating single-agent or combinatorial HDAC inhibitors including vorinostat in solid tumors have largely failed to demonstrate efficacy. These results may in part be explained by data from preclinical models showing significant activity only
Y Yanagisawa et al.
Nihon eiseigaku zasshi. Japanese journal of hygiene, 48(3), 698-706 (1993-08-01)
Leukotriene B4 (LTB4), an arachidonic acid metabolite released by neutrophils, is involved in the regulation of the host immune response to antigenic stimulation. Furthermore, LTB4 affects the chemokinesis, aggregation, and enzyme release of neutrophils and stimulates activity of cytotoxic T
Mairéad A Carroll et al.
American journal of physiology. Renal physiology, 291(1), F155-F161 (2006-02-16)
Dilation of rat preglomerular microvessels (PGMV) by activation of adenosine A2A receptors (A2AR) is coupled to epoxyeicosatrienoic acid (EET) release. We have investigated the commonality of this signal transduction pathway, i.e., sequential inhibition of G(salpha), adenylyl cyclase, PKA, and Ca2+-activated
Sayon Roy et al.
Diabetes, 52(5), 1229-1234 (2003-04-30)
Overexpression of extracellular matrix (ECM) components is closely associated with the development of vascular basement membrane (BM) thickening, a histological hallmark of diabetic microangiopathy. To determine whether BM thickening of retinal capillaries could be prevented by down regulating synthesis of
C Marzolini et al.
AIDS (London, England), 15(1), 71-75 (2001-02-24)
Limited information exists on the clinical usefulness of drug level monitoring for efavirenz, a once-daily non-nucleoside reverse transcriptase inhibitor (NNRTI). The aim of this study was to determine whether efavirenz plasma concentration monitoring could predict treatment failure and central nervous
J D Nkrumah et al.
Journal of animal science, 85(12), 3170-3181 (2007-08-22)
Feed intake and feed efficiency of beef cattle are economically relevant traits. The study was conducted to identify QTL for feed intake and feed efficiency of beef cattle by using genotype information from 100 microsatellite markers and 355 SNP genotyped
Arun Ghosh et al.
Biomacromolecules, 10(7), 1681-1688 (2009-05-14)
The development of advanced materials from biorenewable protein biopolymers requires the generation of more exogenous bonds to maintain the microstructure and durability in the final products. Casein is the main protein of milk, representing about 80% of the total protein.
Mercedes Roldán-Pijuán et al.
Analytical and bioanalytical chemistry, 407(10), 2811-2819 (2015-02-16)
The new sample preparation concept "Parallel artificial liquid membrane extraction (PALME)" was evaluated for extraction of the acidic drugs ketoprofen, fenoprofen, diclofenac, flurbiprofen, ibuprofen, and gemfibrozil from human plasma samples. Plasma samples (250 μL) were loaded into individual wells in
Irene Lurkin et al.
PloS one, 5(1), e8802-e8802 (2010-01-26)
Recently a number of randomized trials have shown that patients with advanced colorectal cancer do not benefit from therapies targeting the epidermal growth factor receptor when their tumors harbor mutations in the KRAS, BRAF and PIK3CA genes. We developed two
T M Haqqi et al.
The Journal of experimental medicine, 169(6), 1903-1909 (1989-06-01)
We have identified an inbred strain of mouse, RIII S/J (H-2r), that has the largest known deletion of the TCR V beta genes by screening with mAb and TCR V beta specific probes. Upon screening of PBL with mAb F23.1
Rute A Tomaz et al.
Clinical endocrinology, 77(6), 926-933 (2012-08-14)
FOXE1 is a transcription factor required for thyroid differentiation and function. FOXE1 locus polymorphisms (chromosome 9q22.33) were recently associated with increased sporadic thyroid cancer risk. In this study, we aimed to investigate the association of FOXE1 variants with nonmedullary thyroid
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