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Lysandro P Borges et al.
Chemico-biological interactions, 160(2), 99-107 (2006-02-01)
The effect of post-treatment with diphenyl diselenide on liver damage induced by 2-nitropropane (2-NP) was examined in male rats. Rats were pre-treated with a single dose of 2-NP (100 mg/kg body weight dissolved in canola oil). Afterward, the animals were
Diane C Cabelof et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 61(5), 427-434 (2006-05-25)
Young (4- to 6-month-old) and aged (24- to 28-month-old) mice were exposed to 2-nitropropane (2-NP), a DNA oxidizing agent, and the ability to induce DNA polymerase beta (beta-pol) and AP endonuclease (APE) was determined. In contrast to the inducibility of
Karla Yadira Cervantes Quintero et al.
Applied microbiology and biotechnology, 104(7), 2987-2997 (2020-02-16)
Metarhizium species are the most abundant fungi that can be isolated from soil, with a well-known biopesticide capacity. Metarhizium recognizes their hosts when the conidium interacts with insects, where the fungi are in contact with the hydrocarbons of the outermost
2-Nitropropane.
IARC monographs on the evaluation of carcinogenic risks to humans, 71 Pt 3, 1079-1094 (1999-09-07)
Reversal of enantioselectivity by tuning the conformational flexibility of phase-transfer catalysts.
Ming-Qing Hua et al.
Angewandte Chemie (International ed. in English), 49(15), 2772-2776 (2010-03-17)
Kevin Francis et al.
The Journal of biological chemistry, 280(7), 5195-5204 (2004-12-08)
2-Nitropropane dioxygenase (EC 1.13.11.32) catalyzes the oxidation of nitroalkanes into their corresponding carbonyl compounds and nitrite. In this study, the ncd-2 gene encoding for the enzyme in Neurospora crassa was cloned, expressed in Escherichia coli, and the resulting enzyme was
Jun Yong Ha et al.
The Journal of biological chemistry, 281(27), 18660-18667 (2006-05-10)
Nitroalkane compounds are widely used in chemical industry and are also produced by microorganisms and plants. Some nitroalkanes have been demonstrated to be carcinogenic, and enzymatic oxidation of nitroalkanes is of considerable interest. 2-Nitropropane dioxygenases from Neurospora crassa and Williopsis
Mohammad Ibrahim et al.
Cell biochemistry and function, 28(4), 258-265 (2010-06-03)
Organoselenides have been documented as promising pharmacological agents against a number of diseases associated with oxidative stress. Here we have investigated, for the first time, the potential antioxidant activity of binaphthyl diselenide ((NapSe)(2); 50 mg kg(-1), p.o.) against the 2-nitropropane
Fabian Leinisch et al.
Molecules (Basel, Switzerland), 16(10), 8428-8436 (2011-10-12)
5,5-Dimethylpyrroline N-oxide (15N) and 5,5-di(trideuteromethyl)pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special
Kirk Simon et al.
Mechanisms of ageing and development, 130(9), 637-647 (2009-08-15)
The p53 DNA damage response attenuated with age and we have evaluated downstream factors in the DNA damage response. In old animals p21 protein accumulates in the whole cell fraction but significantly declines in the nucleus, which may alter cell
Yesol Bak et al.
Journal of microbiology and biotechnology, 28(4), 645-651 (2018-03-16)
The carcinogenicity of chemicals in the environment is a major concern. Recently, numerous studies have attempted to develop methods for predicting carcinogenicity, including rodent and cell-based approaches. However, rodent carcinogenicity tests for evaluating the carcinogenic potential of a chemical to
Gamal H El-Sokkary
Neuro endocrinology letters, 23(4), 335-340 (2002-08-27)
2-Nitropropane (2-NP) is mutagenic in a number of short-term mutagenicity assays in vitro and in vivo, and is a potent hepatocarcinogen in rats. Many studies have determined that differences in the metabolism and disposition of the chemicals that produce mutagenicity
Laura Dill Morton et al.
Toxicologic pathology, 30(5), 559-564 (2002-10-10)
This study examined the response of the Eker rat to nephrotoxic compounds and to genotoxic nonrenal carcinogens. Groups of male Eker rats received either no treatment; a vehicle treatment; treatment with a noncarcinogenic nephrotoxin (aluminum nitrilotriacetate, 2 mg/kg/day of aluminum
2-Nitropropane.
Report on carcinogens : carcinogen profiles, 12, 300-302 (2011-08-24)
Bente Riis et al.
DNA repair, 1(9), 709-717 (2003-01-02)
This study was set up to investigate the relationships between the formation and removal of DNA damage in form of 8-oxodeoxyguanosine (8-oxodG) in neonatal (day 16 of gestation) as compared to adult rats. The hypothesis addressed was whether the rapidly
Diane C Cabelof et al.
DNA repair, 2(3), 295-307 (2003-01-28)
Caloric restriction is a potent experimental manipulation that extends mean and maximum life span and delays the onset and progression of tumors in laboratory rodents. While caloric restriction (CR) clearly protects the genome from deleterious damage, the mechanism by which
Hamid Mirzaei et al.
Analytical chemistry, 77(8), 2386-2392 (2005-04-15)
It has been shown that oxidatively modified forms of proteins accumulate during oxidative stress, aging, and in some age-related diseases. One of the unique features of a wide variety of routes by which proteins are oxidized is the generation of
Ethel A Wilhelm et al.
Fundamental & clinical pharmacology, 25(1), 80-90 (2010-02-10)
The in vitro effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole (BPD) was evaluated through iron/EDTA-induced thiobarbituric acid reactive species (TBARS) and reactive species (RS) determinations as well as of the scavenging 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical quantification. BPD at the concentrations of 10 and 50 μΜ
2-Nitropropane.
Report on carcinogens : carcinogen profiles, 10, 174-175 (2004-08-26)
Ethel Antunes Wilhelm et al.
Cell biology and toxicology, 26(6), 569-577 (2010-04-17)
The aim of this study was to investigate the protective effect of 3-alkynyl selenophene (3-ASP) on acute liver injury induced by carbon tetrachloride (CCl(4)) and 2-nitropropane (2-NP) in rats. On the first day of treatment, the animals received 3-ASP (25 mg/kg
Ethel A Wilhelm et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 61(3), 197-203 (2008-09-27)
This study was undertaken to investigate if the introduction of trifluoromethyl (F(3)C) group into diphenyl diselenide (PhSe)(2) molecule causes acute toxicity in rats. It was further examined if the presence of F(3)C group in (PhSe)(2) molecule alters the protective effect
Anton de Groot et al.
Contact dermatitis, 62(1), 18-31 (2010-02-09)
This is the second part of an article on formaldehyde-releasers in cosmetics. The patch test relationship between the releasers in cosmetics to formaldehyde contact allergy is reviewed and it is assessed whether products preserved with formaldehyde-releasers may contain enough free
Archana Unnikrishnan et al.
Free radical biology & medicine, 46(11), 1488-1499 (2009-03-10)
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is the redox regulator of multiple stress-inducible transcription factors, such as NF-kappaB, and the major 5'-endonuclease in base excision repair (BER). We utilized mice containing a heterozygous gene-targeted deletion of APE1/Ref-1 (Apex(+/-)) to determine the
Lysandro P Borges et al.
Toxicology, 210(1), 1-8 (2005-04-05)
The effect of diphenyl diselenide, (PhSe)2, administration on 2-nitropropane (2-NP)-induced hepatic damage was examined in male rats. Rats were pre-treated with a single dose of diphenyl diselenide (10, 50 or 100 micromol/kg). Afterward, they received only one dose of 2-NP
Xiaoyu Wang et al.
Journal of chromatography. A, 1424, 118-126 (2015-11-26)
In this paper, heart-cutting two-dimensional GC/MS (GC-GC/MS) method in combination with a simple sample collection procedure was developed for the determination of 6 nitroalkanes in mainstream cigarette smoke. The method could remove large amounts of impurities on-line in the first
Cédric Gobin et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60(1-2), 329-336 (2003-12-13)
New experimental results are reported on molecular interactions in the n-ethylamines and 2-nitropropane (2-NP)/n-ethylamine mixtures studied by Raman spectroscopy under pressure in a diamond anvil cell (0-50 GPa) and, at ambient pressure, by infrared spectroscopy. Modifications of the infrared spectra
Yuko Doi et al.
Journal of toxicologic pathology, 24(4), 207-213 (2012-02-10)
This study was conducted to determine the concordance of results for a pair of structural isomers, 2-nitropropane (2-NP) and 1-nitropropane (1-NP), using the rat medium-term liver carcinogenesis bioassay (Ito test) and previously published long-term carcinogenicity tests. Male F344 rats were
2-Nitropropane.
Report on carcinogens : carcinogen profiles, 11, III194-III196 (2004-01-01)
Yu Song et al.
The Journal of chemical physics, 142(22), 224306-224306 (2015-06-15)
Ultraviolet (UV) photodissociation dynamics of jet-cooled n-propyl (n-C3H7) radical via the 3s Rydberg state and i-propyl (i-C3H7) radical via the 3p Rydberg states are studied in the photolysis wavelength region of 230-260 nm using high-n Rydberg atom time-of-flight and resonance
Hong Deng et al.
Mutation research, 726(1), 84-87 (2011-09-10)
V79-hCYP2E1-hSULT1A1, a V79-derived cell line co-expressing both human CYP2E1 and SULT1A1, has been constructed and efficiently used in detection of the mutagenic activities of a number of promutagens. 2-Nitropropane (2-NP) and N-nitrosodimethylamine (NDMA), both being hepatocarcinogenic to animals but inactive
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