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Jacob Levitt
Journal of the American Academy of Dermatology, 57(5), 854-872 (2007-05-01)
Recently, the US Food and Drug Administration proposed a ban on over-the-counter hydroquinone mainly on the basis of high absorption, reports of exogenous ochronosis in humans, and murine hepatic adenomas, renal adenomas, and leukemia with large doses over extended time
Dusan Sladić et al.
Molecules (Basel, Switzerland), 11(1), 1-33 (2007-10-27)
A review of results of bioactivity and reactivity examinations of marine sesquiterpene (hydro)quinones is presented. The article is focused mostly on friedo- rearranged drimane structural types, isolated from sponges of the order Dictyoceratida. Examples of structural correlations are outlined. Available
Ren-Qi Wang et al.
Analytica chimica acta, 853, 608-616 (2014-12-04)
A hydrophilic interaction liquid chromatography (HILIC) method was developed to measure the composition of humic substances from river, reservoir, and treated wastewater based on their physicochemical properties. The current method fractionates the humic substances into four well-defined groups based on
Chi-Feng Hung et al.
International journal of pharmaceutics, 471(1-2), 135-145 (2014-05-27)
Intrinsic aging and photoaging modify skin structure and components, which subsequently change percutaneous absorption of topically applied permeants. The purpose of this study was to systematically evaluate drug/sunscreen permeation via young and senescent skin irradiated by ultraviolet (UV) light. Both
Richard T Penson et al.
The Lancet. Oncology, 16(3), 301-311 (2015-02-02)
GOG 240 was a practice-changing randomised phase 3 trial that concluded that chemotherapy plus bevacizumab for advanced cervical cancer significantly improves overall and progression-free survival, and the proportion of patients achieving an overall objective response, compared with chemotherapy alone. In
Mekhala Chandra et al.
Acta dermato-venereologica, 92(3), 232-235 (2011-10-18)
Post-inflammatory hyperpigmentation after acne can be as troublesome as the acne itself. Hydroquinone, a tyrosinase inhibitor, in a 4% cream can be used safely twice daily for up to 6 months to treat post-inflammatory hyperpigmentation. The efficacy of this treatment
Fanny Ramel et al.
PloS one, 10(4), e0123455-e0123455 (2015-04-04)
Although obligate anaerobe, the sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough (DvH) exhibits high aerotolerance that involves several enzymatic systems, including two membrane-bound oxygen reductases, a bd-quinol oxidase and a cc(b/o)o3 cytochrome oxidase. Effect of constant low oxygen concentration on growth and
M Yokono et al.
Nature communications, 6, 6675-6675 (2015-03-27)
Throughout the history of oxygen evolution, two types of photosystem reaction centres (PSI and PSII) have worked in a coordinated manner. The oxygen evolving centre is an integral part of PSII, and extracts an electron from water. PSI accepts the
Ayman M Atta et al.
Molecules (Basel, Switzerland), 19(5), 6246-6262 (2014-05-21)
A facile method was developed to synthesize in high yield dispersed silver nanoparticles (AgNPs) with small particle sizes of less than 10 nm. Silver nitrate was reduced to silver nanoparticles by p-chloroaniline in the presence of polyoxyethylene maleate 4-nonyl-2-propylene-phenol (NMA)
Jiyeon Yang et al.
Environmental geochemistry and health, 37(2), 321-332 (2014-09-27)
The objective of this study is to find the Cd levels in agricultural crops compared to soil, to evaluate the relationship between daily intake dose through the multimedia/multi-pathway of human exposure and biomarker levels of the residents in mine vicinity
M P Goldman
Journal of cutaneous laser therapy, 2(2), 73-77 (2001-05-22)
One complication of laser resurfacing that is especially common in people with skin types III-VI is hyperpigmentation. This may last for several months after the laser resurfacing procedure. To review the literature and detail the author's use of various techniques
G Karanikolopoulos et al.
Food chemistry, 177, 197-203 (2015-02-11)
Reliable methods for quantification of synthetic water-soluble colors in complex food matrices are currently not available. The present work describes the development and validation of an improved protocol for the analysis of synthetic food colorants in complex food matrices presenting
Y-A Bae et al.
Parasitology, 142(6), 807-815 (2015-01-27)
Trematode tyrosinases (TYRs) play a major role in the tanning process during eggshell formation. We investigated the molecular and biochemical features of Paragonimus westermani TYR (PwTYR). The PwTYR cDNA was composed of 1568-bp encompassing a 1422-bp-long open reading frame (474-amino
Athanasia Tourlaki et al.
The Journal of dermatological treatment, 25(3), 218-222 (2012-03-06)
Melasma is a common melanosis often difficult to treat. The aim of this paper was to report on the safety and efficacy of non-ablative fractional photothermolysis combined with the use of triple-combination cream (TCC) on a large population with melasma
Hydroquinone.
IARC monographs on the evaluation of carcinogenic risks to humans, 71 Pt 2, 691-719 (1999-09-07)
Jie Meng et al.
Molecular cancer therapeutics, 13(12), 3107-3122 (2014-10-04)
This study was conducted to examine the effects of doxycycline on the survival time and proliferation of hepatocellular carcinoma (HCC) in vivo and on the biologic functions of HCC in vitro. This study was also designed to evaluate the effects
Anna Gulkowska et al.
Chemosphere, 107, 366-372 (2014-01-28)
Soil incubation experiments using (14)C-labelled sulfamethazine were carried out to assess the factors governing its nonextractable residue (NER) formation via nucleophilic addition reactions. Circumstantial evidence on possible mechanisms of NER formation was derived from a selective manipulation of soil samples.
Shaik Mohammad Naushad et al.
Molecular and cellular biochemistry, 392(1-2), 273-280 (2014-03-29)
Obesity, genetic polymorphisms of xenobiotic metabolic pathway, hypermethylation of tumor suppressor genes, and hypomethylation of proapoptotic genes are known to be independent risk factors for breast cancer. The objective of this study is to evaluate the combined effect of these
Filomena Aste Silveira et al.
Experimental and molecular pathology, 98(2), 308-311 (2015-01-13)
DNA methylation is the most important epigenetic change involved in the control of gene expression in human cells. Methylation of the p16(INK4a) gene occurs early in the development of cervical cancer. Low-grade squamous intraepithelial lesions (LSILs) are prevalent, and their
Zoe Diana Draelos
Dermatologic therapy, 20(5), 308-313 (2007-11-30)
Skin lightening preparations are widely used in dermatology by persons of all Fitzpatrick skin types. Fitzpatrick skin types I-III require local pigment lightening for the treatment of hormonally induced melasma and postinflammatory hyperpigmentation caused by acne and trauma. Fitzpatrick skin
Carlo Foresta et al.
Human reproduction (Oxford, England), 29(6), 1134-1145 (2014-04-29)
What are the dynamics of zinc (Zn) trafficking in sperm, at the testicular, epididymal and ejaculate levels? Zn transporters are peculiarly expressed in the cells of the germ line and Zn uptake is maximal at the post-epididymal phase, where Zn
Liming Zhang et al.
Journal of biomedical nanotechnology, 10(8), 1440-1449 (2014-07-16)
Although gold nanorods (GNRs) have been investigated extensively for optical hyperthermia therapies, the synthesis of rods is far from ideal. In this report, we optimized the synthesis of gold nanorods using hydroquinone as a reducing agent. Compared with the GNRs
J J Nordlund et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 20(7), 781-787 (2006-08-11)
Hydroquinone is one of the most effective molecules for the treatment of hyperpigmentary disorders, with over 40 years of efficacy and safety data. Concerns over its safety have been raised because of the fact that it is a derivative of
Hydroquinone-induced exogenous ochronosis in Chinese--two case reports and a review.
Siak-Kim Tan et al.
International journal of dermatology, 47(6), 639-640 (2008-05-15)
Susana Garcia de Arriba et al.
International journal of toxicology, 32(6), 442-453 (2013-12-04)
Uva-ursi folium (bearberry leaf) has been traditionally used to treat symptoms of lower urinary tract infections. The most representative constituent of this herbal drug is arbutin that is rapidly absorbed in the small intestine and undergoes hepatic conjugation to form
Yan-Fang Tao et al.
Journal of experimental & clinical cancer research : CR, 34, 4-4 (2015-01-23)
Pediatric acute myeloid leukemia (AML) comprises up to 20% of all childhood leukemia. Recent research shows that aberrant DNA methylation patterning may play a role in leukemogenesis. The epigenetic silencing of the EBF3 locus is very frequent in glioblastoma. However
Ludovic Peyre et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(8), 1507-1520 (2014-07-06)
Pesticides as well as many other environmental pollutants are considered as risk factors for the initiation and the progression of cancer. In order to evaluate the in vitro effects of chemicals present in the diet, we began by combining viability
E Roemer et al.
Regulatory toxicology and pharmacology : RTP, 70 Suppl 1, S2-14 (2014-12-17)
This publication introduces a series of six other publications describing the toxicological assessment of kretek cigarettes, i.e., cigarettes characterized primarily by the use of a significant amount of cloves as an ingredient added to the tobacco. This paper presents background
Xiuxing Wang et al.
Biochemical and biophysical research communications, 457(4), 514-519 (2015-01-15)
MILI, a member of the PIWI/AGO gene family, has been well documented to maintain genome integrity by transposon silencing in animal germ cells. It has been reported to be selectively expressed in precancerous stem cells (pCSCs), tumor cell lines and
Felix W Friedrich et al.
Basic research in cardiology, 109(6), 451-451 (2014-11-02)
Based on evidence that FHL2 (four and a half LIM domains protein 2) negatively regulates cardiac hypertrophy we tested whether FHL2 altered expression or variants could be associated with hypertrophic cardiomyopathy (HCM). HCM is a myocardial disease characterized by left
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