CN
Search Within
135-19-3
应用筛选条件
关键词:'135-19-3'
显示 1-30 共 37 条结果 关于 "135-19-3" 范围 论文
Øyvind Halskau et al.
The Journal of biological chemistry, 284(47), 32758-32769 (2009-10-06)
Tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines, is activated by phosphorylation-dependent binding to 14-3-3 proteins. The N-terminal domain of TH is also involved in interaction with lipid membranes. We investigated the binding of the N-terminal domain
Raul S Gonzalez et al.
Human pathology, 44(6), 1065-1070 (2012-12-26)
Expression of GATA-3 in female breast cancers has been linked to estrogen receptor (ER) expression and, in turn, to improved outcomes. However, GATA-3 has not been studied in male breast cancers. Nineteen male breast carcinomas (average age: 63 years) and
Maike Monzel et al.
FEBS letters, 588(18), 3469-3474 (2014-08-17)
The degradation and biological role of the cyclic pyrimidine nucleotide cCMP is largely elusive. We investigated nucleoside 3',5'-cyclic monophosphate (cNMP) specificity of six different recombinant phosphodiesterases (PDEs) by using a highly-sensitive HPLC-MS/MS detection method. PDE7A1 was the only enzyme that
Deepa Gandhi et al.
Pesticide biochemistry and physiology, 125, 8-16 (2015-11-29)
Present study reports the identification of genomic and proteomic signatures of endosulfan exposure in hepatocellular carcinoma cells (HepG2). HepG2 cells were exposed to sublethal concentration (15μM) of endosulfan for 24h. DNA microarray and MALDI-TOF-MS analyses revealed that endosulfan induced significant
Sondas Alsharidah et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 103, 439-446 (2020-12-08)
To study the effectiveness of COVID-19 convalescent plasma (CCP) therapy for patients with moderate and severe COVID-19 disease. This non-randomized prospective cohort study was conducted from May 21 to June 30, 2020, at four major tertiary hospitals in Kuwait. CCP
Glenn A Doyle et al.
Gene, 395(1-2), 98-107 (2007-04-03)
The mouse mu-opioid receptor gene, Oprm1, currently contains 18 recognized alternatively spliced exons [Doyle, G.A., Sheng, X.R., Lin, S.S.J., Press, D.M., Grice, D.E., Buono, R.J., Ferraro, T.N., Berrettini, W.H., 2007. Identification of three mouse mu-opioid receptor (MOR) gene (Oprm1) splice
Peppi Koivunen et al.
The Journal of biological chemistry, 281(39), 28712-28720 (2006-08-04)
Three hypoxia-inducible factor prolyl 4-hydroxylases (HIF-P4Hs) regulate the HIFs by hydroxylating prolines at two separate sites in the oxygen-dependent degradation domain (ODDD) of their alpha subunits. We compared in vitro hydroxylation by purified recombinant human HIF-P4Hs of 19-20- and 35-residue
Shuen-Iu Hung et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(11), 4134-4139 (2005-03-04)
Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity syndrome, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The adverse events are unpredictable and carry significant morbidity
Pu Dai et al.
Journal of translational medicine, 6, 74-74 (2008-12-02)
The molecular etiology of hearing impairment in Chinese has not been thoroughly investigated. Study of GJB2 gene revealed that 30.4% of the patients with hearing loss in Inner Mongolia carried GJB2 mutations. The SLC26A4 gene mutations and relevant phenotype are
A Wissner et al.
Journal of medicinal chemistry, 35(9), 1650-1662 (1992-05-01)
A series of aryl phosphoglyceride (3, 19-61) and bis-aryl phosphate (67-135) antagonists of platelet activating factor (PAF) were prepared. A group of four bifunctional phosphorus reagents (5a-c and 7) were developed that allowed the preparation of these aryl phosphates in
L G Melo et al.
The American journal of physiology, 274(1 Pt 2), R255-R261 (1998-02-12)
Atrial natriuretic peptide (ANP), a peptide hormone produced by the heart, exerts a chronic hypotensive effect. Knockout mice with a homozygous disruption of the pro-ANP gene (-/-) are incapable of producing ANP and are hypertensive relative to their wild-type (+/+)
Donald F Smee et al.
Antiviral research, 131, 61-65 (2016-04-12)
Compounds were evaluated for antiviral activity in rhabdomyosarcoma (RD) cells against a recent 2014 clinical isolate of enterovirus D68 (EV-D68), a 1962 strain of EV-68D, rhinovirus 87 (RV-87, serologically the same as EV-D68), and enterovirus 71 (EV-71). Test substances included
Amit V Khera et al.
The American journal of cardiology, 115(2), 178-182 (2014-11-30)
Recent trials demonstrated substantial improvement in lipid parameters with inhibition of proprotein convertase subtilisin-like/kexin type 9 (PCSK9). Although statins and fibrates have been reported to increase plasma PCSK9 levels, the effect of niacin on PCSK9 is unknown. We investigated the
M Kawase et al.
Journal of medicinal chemistry, 33(8), 2204-2211 (1990-08-01)
The 5,6-dihydroxytryptamine (5,6-DHT) derivatives 4-fluoro- and 7-fluoro-5,6-DHTs (26a,b) and 4,7-difluoro-5,6-DHT (26c) were synthesized from 3-fluoroanisole (1) and 1,4-difluoro-2,3-dimethoxybenzene (13), respectively. Efficient methods were developed for the conversion of 1 to 4-fluoro- and 7-fluoro-5,6-bis(benzyloxy)indoles (12a,b, respectively), and 13 to 4,7-difluoro-5,6-[( diphenylmethylene)dioxy]indole
Elin Kindberg et al.
The Journal of infectious diseases, 203(4), 523-528 (2011-01-11)
Tick-borne encephalitis virus (TBEV) infections may be asymptomatic or cause severe symptoms in the central nervous system. A mutation in the chemokine receptor 5 gene has been associated with increased risk of TBE but explains only a limited number of
D R Broom et al.
Journal of applied physiology (Bethesda, Md. : 1985), 102(6), 2165-2171 (2007-03-10)
Ghrelin is an orexigenic hormone secreted from endocrine cells in the stomach and other tissues. Acylation of ghrelin is essential for appetite regulation. Vigorous exercise induces appetite suppression, but this does not appear to be related to suppressed concentrations of
Rong Jiang et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 38(8), 539-544 (2015-03-20)
The in-hospital mortality of severe pulmonary hypertension (PH) with right heart failure (RHF) is high despite the use of vasoactive and PH-specific therapies. We conducted a prospective analysis evaluating the safety and outcomes of fasudil hydrochloride (Chuan Wei) therapy in
Jian-Jun Li et al.
Clinica chimica acta; international journal of clinical chemistry, 352(1-2), 127-133 (2005-01-18)
Previous studies showed that monocytes from patients with unstable coronary disease exhibit a greatly enhanced production of interleukin-6 (IL-6) in response to lipopolysaccharide and artery injury. Moreover, accumulating evidence suggest that C-reactive protein (CRP) may have direct proinflammatory effects on
J Sommer et al.
Biochemistry, 26(20), 6407-6410 (1987-10-06)
Rat glial cells release a neurite-promoting factor with serine protease inhibitory activity. By using a rat glioma cDNA clone as a probe, it was possible to isolate rat cDNAs containing the entire sequence coding for this neurite-promoting factor. The largest
Terzah M Horton et al.
British journal of haematology, 186(2), 274-285 (2019-04-09)
While survival in paediatric acute lymphoblastic leukaemia (ALL) is excellent, survival following relapse is poor. Previous studies suggest proteasome inhibition with chemotherapy improves relapse ALL response rates. This phase 2 Children's Oncology Group study tested the hypothesis that adding the
T Nikawa et al.
European journal of biochemistry, 204(1), 381-393 (1992-02-15)
Cathepsin J has been partially purified [Liao, J. C. R. & Lenney, J. F. (1984) Biochem. Biophys. Res. Commun. 124, 909-916], but its detailed properties are still unknown. In this study, we have purified cathepsin J completely and characterized it.
Beata J Mossakowska et al.
International journal of molecular sciences, 23(5) (2022-03-11)
Corticotroph pituitary adenomas commonly cause Cushing's disease (CD), but some of them are clinically silent. The reason why they do not cause endocrinological symptoms remains unclear. We used data from small RNA sequencing in adenomas causing CD (n = 28)
Alan K Kelly et al.
Journal of animal science, 98(10) (2020-09-22)
This study examined the effect of plane of nutrition on the endocrinological regulation of the hypothalamic-pituitary-ovarian (HPO) axis in beef heifer calves during a critical sexual developmental window early in calf hood. Forty Holstein-Friesian × Angus heifers (mean age 19
Aleksandra Rojek et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(15), 6037-6042 (2006-04-04)
Aquaporin-2 (AQP2) is the predominant vasopressin-regulated water channel in kidney connecting tubule (CNT) and collecting duct (CD) and is essential for renal regulation of body water balance. However, the relative role of AQP2 to urinary concentration in the CNT and
Bart Pennings et al.
The American journal of clinical nutrition, 98(1), 121-128 (2013-05-03)
Older individuals generally experience a reduced food-chewing efficiency. As a consequence, food texture may represent an important factor that modulates dietary protein digestion and absorption kinetics and the subsequent postprandial protein balance. We assessed the effect of meat texture on
Olivier Lortholary et al.
Lancet (London, England), 389(10069), 612-620 (2017-01-11)
Indolent systemic mastocytosis, including the subvariant of smouldering systemic mastocytosis, is a lifelong condition associated with reduced quality of life. Masitinib inhibits KIT and LYN kinases that are involved in indolent systemic mastocytosis pathogenesis. We aimed to assess safety and
Igor V Peshenko et al.
Biochemistry, 50(25), 5590-5600 (2011-05-24)
Mouse photoreceptor function and survival critically depend on Ca(2+)-regulated retinal membrane guanylyl cyclase (RetGC), comprised of two isozymes, RetGC1 and RetGC2. We characterized the content, catalytic constants, and regulation of native RetGC1 and RetGC2 isozymes using mice lacking guanylyl cyclase
Kenneth V I Rolston et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 22(1), 7-14 (2013-08-27)
The goal of this study was to describe the outcomes associated with daptomycin treatment of documented gram-positive infections in patients with neutropenia. All patients with neutropenia (≤500 cells/m(3)) and at least one documented gram-positive culture from 2006-2009 were identified from
H J van de Velde et al.
Journal of cell science, 107 ( Pt 9), 2403-2416 (1994-09-01)
The novel NSP gene was previously shown to encode, among a variety of neuroendocrine cell types, two 3'-overlapping transcripts, a 3.4 kb one for NSP-A (776 amino acids) and a 1.8 kb one for NSP-C (208 amino acids). The deduced
T R Kumar et al.
Molecular endocrinology (Baltimore, Md.), 7(7), 898-906 (1993-07-01)
Transgenic mice that express a 10-kilobase human FSH beta (hFSH beta) gene exclusively in pituitary gonadotropes were used to study the regulation of hFSH beta gene expression by gonadal steroids. For comparison, the mouse FSH beta (mFSH beta) gene was
1/2