CN
Search Within
137030
应用筛选条件
关键词:'137030'
显示 1-30 共 159 条结果 关于 "137030" 范围 论文
Rui Yang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 120, 253-260 (2018-07-17)
Cholestasis is characterized by the obstruction of bile duct, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). The complicated etiology and injury mechanism greatly limits the development of new drugs for its treatment. To better understand the mechanism
Efseveia Frakolaki et al.
Cells, 8(8) (2019-08-08)
l-dopa decarboxylase (DDC) that catalyzes the biosynthesis of bioactive amines, such as dopamine and serotonin, is expressed in the nervous system and peripheral tissues, including the liver, where its physiological role remains unknown. Recently, we reported a physical and functional
Benoist Chibaudel et al.
BMC cancer, 15, 496-496 (2015-07-05)
The management of unresectable metastatic colorectal cancer (mCRC) is a comprehensive treatment strategy involving several lines of therapy, maintenance, salvage surgery, and treatment-free intervals. Besides chemotherapy (fluoropyrimidine, oxaliplatin, irinotecan), molecular-targeted agents such as anti-angiogenic agents (bevacizumab, aflibercept, regorafenib) and anti-epidermal
Edward R Kastenhuber et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(50), 13076-13084 (2017-11-23)
A segmental deletion resulting in
Stephan W Anderson et al.
Journal of magnetic resonance imaging : JMRI, 35(1), 140-146 (2011-10-13)
To evaluate the effects of hepatic fibrosis on ADC and T(2) values of ex vivo murine liver specimens imaged using 11.7 Tesla (T) MRI. This animal study was IACUC approved. Seventeen male, C57BL/6 mice were divided into control (n =
Lingmei Sun et al.
PloS one, 12(2), e0172228-e0172228 (2017-02-14)
To investigate the effects of honokiol on induction of reactive oxygen species (ROS), antioxidant defense systems, mitochondrial dysfunction, and apoptosis in Candida albicans. To measure ROS accumulation, 2',7'-dichlorofluorescein diacetate fluorescence was used. Lipid peroxidation was assessed using both fluorescence staining
So Yeon Kim et al.
American journal of physiology. Gastrointestinal and liver physiology, 318(3), G531-G541 (2020-01-22)
Cirrhotic cardiomyopathy is a clinical syndrome in patients with liver cirrhosis characterized by blunted cardiac contractile responses to stress and/or heart rate-corrected QT (QTc) interval prolongation. Caveolin-3 (Cav-3) plays a critical role in cardiac protection and is an emerging therapeutic
Meng Lin et al.
European radiology, 27(6), 2400-2410 (2016-09-30)
To investigate the potential of various metrics derived from mono-exponential model (MEM), bi-exponential model (BEM) and stretched exponential model (SEM)-based diffusion-weighted imaging (DWI) in diagnosing and differentiating the pathological subtypes and grades of uterine cervical carcinoma. 71 newly diagnosed patients
Tomonori Matsumoto et al.
Cancer research, 77(22), 6131-6143 (2017-09-28)
Hepatocellular carcinoma (HCC) originates from regenerating liver cells with genetic alterations in chronically inflamed liver. Ductal cells and hepatocytes proliferate for liver regeneration, and proliferating ductal cells (PDC) derived from bile ductules have long been considered putative liver stem/progenitor cells
Diana M Toivola et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 5081-5089 (2015-09-25)
Human mutations in keratin 8 (K8) and keratin 18 (K18), the intermediate filament proteins of hepatocytes, predispose to several liver diseases. K8-null mice develop chronic liver injury and fragile hepatocytes, dysfunctional mitochondria, and Th2-type colitis. We tested the hypothesis that
Fangyi Gu et al.
International journal of cancer, 141(9), 1794-1802 (2017-07-13)
Circadian disruption has been linked to carcinogenesis in animal models, but the evidence in humans is inconclusive. Genetic variation in circadian rhythm genes provides a tool to investigate such associations. We examined associations of genetic variation in nine core circadian
Beata Orman-Ligeza et al.
Development (Cambridge, England), 143(18), 3328-3339 (2016-07-13)
Lateral root (LR) emergence represents a highly coordinated process in which the plant hormone auxin plays a central role. Reactive oxygen species (ROS) have been proposed to function as important signals during auxin-regulated LR formation; however, their mode of action
Zhen Chen et al.
Plant physiology and biochemistry : PPB, 111, 179-192 (2016-12-13)
Soil mercury (Hg) contamination is a major factor that affects agricultural yield and food security. Hydrogen sulfide (H
Bernhard Zatloukal et al.
PloS one, 9(5), e96690-e96690 (2014-05-07)
The in situ proximity ligation assay (isPLA) is an increasingly used technology for in situ detection of protein interactions, post-translational modifications, and spatial relationships of antigens in cells and tissues, in general. In order to test its performance we compared
Shihong Zheng et al.
Food & function, 12(5), 2323-2334 (2021-02-24)
Cholestasis can induce liver fibrosis and cirrhosis. Apigenin has anti-oxidant and anti-inflammatory effects. Herein, we determined whether apigenin can protect mice against cholestasis. In vitro, apigenin protected TFK-1 cells (a human bile duct cancer cell line) against H2O2-induced ROS generation
Lu Li et al.
International journal of oncology, 50(5), 1832-1838 (2017-03-25)
Although vitamin K2 (VK2) exhibits inhibitory effects on the viability of hepatoma cells, hepatoma cells are insensitive to VK2. Therefore, this investigation is an attempt to enhance the sensitivity of hepatoma cells to VK2. Our results showed that VK2 acted
Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells.
Gorbatchev Ambroise et al.
Oncotarget, 6(35), 38181-38194 (2015-10-03)
The BH3-only protein PUMA (p53-upregulated modulator of apoptosis) is a major regulator of apoptosis. It belongs to the Bcl-2 family of proteins responsible for maintaining mitochondrial outer membrane integrity by controlling the intrinsic (mitochondrial) apoptotic pathway. We describe here a
Meng Xu et al.
Cell, 178(6), 1478-1492 (2019-09-03)
Liver fibrosis is a very common condition seen in millions of patients with various liver diseases, and yet no effective treatments are available owing to poorly characterized molecular pathogenesis. Here, we show that leukocyte cell-derived chemotaxin 2 (LECT2) is a
Harrie A Verhoeven et al.
Journal of bioenergetics and biomembranes, 44(1), 91-99 (2012-02-10)
Two human leukemia cells K562 and THP-1, the breast cancer lines MCF-7 and ZR-75-1, and the melanoma line MDA-MB-435S were compared by flowcytometry for their behaviour at increasing levels of 3BP. K562 and THP-1 responded to 3BP by membrane depolarization
Zhen Tian et al.
Medical physics, 42(6), 2841-2852 (2015-07-02)
Volumetric modulated arc therapy (VMAT) optimization is a computationally challenging problem due to its large data size, high degrees of freedom, and many hardware constraints. High-performance graphics processing units (GPUs) have been used to speed up the computations. However, GPU's
Shengda Lin et al.
Nature, 556(7700), 244-248 (2018-04-06)
Hepatocytes are replenished gradually during homeostasis and robustly after liver injury1, 2. In adults, new hepatocytes originate from the existing hepatocyte pool3-8, but the cellular source of renewing hepatocytes remains unclear. Telomerase is expressed in many stem cell populations, and
Jan Walach et al.
Journal of chemometrics, 34(1), e3182-e3182 (2020-03-20)
Data outliers can carry very valuable information and might be most informative for the interpretation. Nevertheless, they are often neglected. An algorithm called cellwise outlier diagnostics using robust pairwise log ratios (cell-rPLR) for the identification of outliers in single cell
Lingjuan He et al.
Nature medicine, 23(12), 1488-1498 (2017-11-14)
The Cre-loxP recombination system is the most widely used technology for in vivo tracing of stem or progenitor cell lineages. The precision of this genetic system largely depends on the specificity of Cre recombinase expression in targeted stem or progenitor
Tohru Itoh et al.
FEBS letters, 583(4), 777-781 (2009-01-29)
In injured livers where hepatocyte growth is severely limited, facultative hepatic stem/progenitor cells, termed oval cells in rodents, are known to emerge and contribute to the regeneration process. Here, we investigated a possible involvement of Wnt signaling during mouse oval
Magdalena Pawlak et al.
Acta biochimica Polonica, 62(2), 287-296 (2015-04-23)
The Grainyhead-like 1 (GRHL1) transcription factor is tissue-specific and is very highly expressed in the kidney. In humans the GRHL1 gene is located at the chromosomal position 2p25. A locus conferring increased susceptibility to essential hypertension has been mapped to
Vikash Pandey et al.
PloS one, 9(10), e111006-e111006 (2014-10-28)
Non-alcoholic fatty liver disease (NAFLD) has a broad spectrum of disease states ranging from mild steatosis characterized by an abnormal retention of lipids within liver cells to steatohepatitis (NASH) showing fat accumulation, inflammation, ballooning and degradation of hepatocytes, and fibrosis.
Liu Qian et al.
Aging, 10(12), 3713-3735 (2018-12-05)
Aged liver is usually impaired in response to hepatic injury. Tissue-specific stem cells participate in the repair of tissue injury. However, how oval cells (OCs) respond to injury and how the process is regulated by tissue microenvironment in aged mice
Larry P Lehnen et al.
The Journal of eukaryotic microbiology, 66(3), 404-412 (2018-08-14)
Zoospores of the oomycete Saprolegnia ferax release adhesive material from K-bodies at the onset of attachment to substrates. To understand more fully how K-bodies function in adhesion, enzyme activity was investigated cytochemically in secondary zoospores. Presence of catalase, a marker
M E Solovieva et al.
Redox biology, 20, 28-37 (2018-10-06)
It is known that some metals (Cu, Zn, Cd, Au) markedly increase the toxic effect of thiocarbamates. It was shown in the present study that hydroxycobalamin (a form of vitamin B12, HOCbl), which incorporates cobalt, significantly enhances the cytotoxicity of
Shuhei Yoshida et al.
Gastroenterology, 147(6), 1378-1392 (2014-09-01)
Platelet-derived growth factor-β (PDGFB) is a mitogen for hepatic stellate cells (HSCs). We studied the cellular sources of PDGFB and the effects of a high-affinity monoclonal antibody against PDGFB (MOR8457) in mouse models of biliary fibrosis. Cellular sources of PDGFB
1/6