搜索范围
137030
应用筛选条件
关键词:'137030'
显示 1-30 #N/A 159 条结果 关于 "137030" 范围 论文
Lowela Siarot et al.
Biochemical and biophysical research communications, 503(4), 2970-2976 (2018-08-22)
The interaction between viral protein Gag and cellular protein tumor susceptibility gene 101 (TSG101) is a crucial step in the HIV-1 replication cycle. This interaction initiates the viral assembly/budding via the cellular endosomal sorting complexes required for transport (ESCRT) pathway
Zhong-Jian Shen et al.
Insect biochemistry and molecular biology, 122, 103391-103391 (2020-05-04)
Insect metamorphosis is a complex process involving many metabolic pathways, such as juvenile hormones and molting hormones, bioamines, microRNAs (miRNAs), etc. However, relatively little is known about the biogenic amines and their miRNAs to regulate cotton bollworm metamorphosis. Here we
Isabel Cristina Céspedes et al.
Psychiatry research, 295, 113563-113563 (2020-11-18)
The development of alcohol use disorder (AUD) is influenced by genetic, psychological, and social factors. However, the identification of the load of each of these factors and the association between them is still debatable. This study aimed to explore the
Wim Schelstraete et al.
Scientific reports, 9(1), 9233-9233 (2019-06-27)
Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism. Porcine CYP450 has been demonstrated to convert typical
Jinhang Zhang et al.
Hepatology (Baltimore, Md.), 73(3), 1140-1157 (2020-06-15)
Activation of hepatic stellate cells (HSCs) is a central driver of fibrosis. This study aimed to elucidate the role of the deacetylase sirtuin 6 (Sirt6) in HSC activation and liver fibrosis. Gain-of-function and loss-of-function models were used to study the
Liping Huang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 94, 666-678 (2017-08-09)
Levodopa (L-dopa) is the key component in Parkinson's disease (PD) treatment. Recently, we demonstrated that β-asarone improves the motor behavior of rats with unilateral striatal 6-hydroxydopamine lesion. Striatal level of dopamine (DA) and L-dopa increased after β-asarone and L-dopa co-administered
Vikas Gupta et al.
Gastroenterology, 159(2), 624-638 (2020-04-15)
In response to tissue injury, stromal cells secrete extracellular matrix (ECM) components that remodel the tissue and lead to fibrosis. Parenchymal stellate cells are the primary contributors to fibrosis in models of hepatocellular and cholestatic injury. The liver comprises different
Ho-Fung Chan et al.
Magnetic resonance in medicine, 81(5), 2959-2971 (2018-12-06)
To compare in vivo lung morphometry parameters derived from theoretical gas diffusion models, the cylinder model and stretched exponential model, in a range of acinar microstructural length scales encountered in healthy and diseased lungs with 3 He and 129 Xe
Alexandre Sarre et al.
Free radical biology & medicine, 52(1), 142-150 (2011-11-09)
Excess reactive oxygen species (ROS) production is thought to play a key role in the loss of pancreatic β-cell number and/or function, in response to high glucose and/or fatty acids. However, contradictory findings have been reported showing that in pancreatic
Effects of BMS-986094, a Guanosine Nucleotide Analogue, on Mitochondrial DNA Synthesis and Function.
Bethany R Baumgart et al.
Toxicological sciences : an official journal of the Society of Toxicology, 153(2), 396-408 (2016-07-29)
BMS-986094, the prodrug of a guanosine nucleotide analogue (2'-C-methylguanosine), was withdrawn from clinical trials due to serious safety issues. Nonclinical investigative studies were conducted as a follow up to evaluate the potential for BMS-986094-related mitochondrial-toxicity. In vitro, BMS-986094 was applied
Yi Ma et al.
Neurobiology of disease, 44(3), 270-276 (2011-08-10)
Mitochondrial dysfunction plays an important role in mediating ischemic brain damage. Immp2l is an inner mitochondrial membrane peptidase that processes mitochondrial protein cytochrome c1 (Cyc1). Homozygous mutation of Immp2l (Immp2l(Tg(Tyr)979Ove) or Immp2l(-/-)) elevates mitochondrial membrane potential, increases superoxide (O(2)(-)) production
Alessio Strano et al.
Cell reports, 31(10), 107732-107732 (2020-06-11)
Directed differentiation of human pluripotent stem cells varies in specificity and efficiency. Stochastic, genetic, intracellular, and environmental factors affect maintenance of pluripotency and differentiation into early embryonic lineages. However, factors affecting variation in in vitro differentiation to defined cell types are
Zhen Chen et al.
Plant physiology and biochemistry : PPB, 111, 179-192 (2016-12-13)
Soil mercury (Hg) contamination is a major factor that affects agricultural yield and food security. Hydrogen sulfide (H
Lu Li et al.
International journal of oncology, 50(5), 1832-1838 (2017-03-25)
Although vitamin K2 (VK2) exhibits inhibitory effects on the viability of hepatoma cells, hepatoma cells are insensitive to VK2. Therefore, this investigation is an attempt to enhance the sensitivity of hepatoma cells to VK2. Our results showed that VK2 acted
Mohamed Wehbe et al.
Investigational new drugs, 35(6), 682-690 (2017-07-25)
Insensitivity to platinum, either through inherent or acquired resistance, is a major clinical problem in the treatment of many solid tumors. Here, we explored the therapeutic potential of diethyldithiocarbamate (DDC), pyrithione (Pyr), plumbagin (Plum), 8-hydroxyquinoline (8-HQ), clioquinol (CQ) copper complexes
Liu Qian et al.
Aging, 10(12), 3713-3735 (2018-12-05)
Aged liver is usually impaired in response to hepatic injury. Tissue-specific stem cells participate in the repair of tissue injury. However, how oval cells (OCs) respond to injury and how the process is regulated by tissue microenvironment in aged mice
Bernhard Zatloukal et al.
PloS one, 9(5), e96690-e96690 (2014-05-07)
The in situ proximity ligation assay (isPLA) is an increasingly used technology for in situ detection of protein interactions, post-translational modifications, and spatial relationships of antigens in cells and tissues, in general. In order to test its performance we compared
S W French et al.
Experimental and molecular pathology, 93(3), 309-314 (2012-09-18)
Mallory-Denk bodies (MDBs) are aggresomes composed of undigested ubiqutinated short lived proteins which have accumulated because of a decrease in the rate of their degradation by the 26s proteasome. The decrease in the activity of the proteasome is due to
Larry P Lehnen et al.
The Journal of eukaryotic microbiology, 66(3), 404-412 (2018-08-14)
Zoospores of the oomycete Saprolegnia ferax release adhesive material from K-bodies at the onset of attachment to substrates. To understand more fully how K-bodies function in adhesion, enzyme activity was investigated cytochemically in secondary zoospores. Presence of catalase, a marker
M E Solovieva et al.
Redox biology, 20, 28-37 (2018-10-06)
It is known that some metals (Cu, Zn, Cd, Au) markedly increase the toxic effect of thiocarbamates. It was shown in the present study that hydroxycobalamin (a form of vitamin B12, HOCbl), which incorporates cobalt, significantly enhances the cytotoxicity of
Vikash Pandey et al.
PloS one, 9(10), e111006-e111006 (2014-10-28)
Non-alcoholic fatty liver disease (NAFLD) has a broad spectrum of disease states ranging from mild steatosis characterized by an abnormal retention of lipids within liver cells to steatohepatitis (NASH) showing fat accumulation, inflammation, ballooning and degradation of hepatocytes, and fibrosis.
Frédérick D'Aragon et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 67(8), 992-1004 (2020-05-10)
Canadian donor management practices have not been reported. Our aim was to inform clinicians and other stakeholders about the range of current practices. This prospective observational cohort study enrolled consecutive, newly consented organ donors from August 1 2015 to July
Magdalena Pawlak et al.
Acta biochimica Polonica, 62(2), 287-296 (2015-04-23)
The Grainyhead-like 1 (GRHL1) transcription factor is tissue-specific and is very highly expressed in the kidney. In humans the GRHL1 gene is located at the chromosomal position 2p25. A locus conferring increased susceptibility to essential hypertension has been mapped to
Carmen Prieto et al.
PloS one, 10(11), e0141207-e0141207 (2015-11-07)
Our possibility to appropriately detect, interpret and respond to climate-driven phenological changes depends on our ability to model and predict the changes. This ability may be hampered by non-linearity in climate-phenological relations, and by spatiotemporal variability and scale mismatches of
Kota Kaneko et al.
Hepatology (Baltimore, Md.), 61(6), 2056-2066 (2015-01-13)
Serving as the center for metabolism and detoxification, the liver is inherently susceptible to a wide variety of damage imposed by toxins or chemicals. Induction of cell populations with biliary epithelial phenotypes, which include progenitor-like cells and are referred to
Francisco Aguirre et al.
International journal of molecular sciences, 21(11) (2020-06-04)
Sarcopenia associated with chronic liver disease (CLD) is one of the more common extrahepatic features in patients with these pathologies. Among the cellular alterations observed in the muscle tissue under CLD is the decline in the muscle strength and function
Keiichi Hiramoto et al.
Photodermatology, photoimmunology & photomedicine, 31(3), 124-128 (2014-10-28)
It is known that the levels of hormones secreted from the pituitary gland are increased by ultraviolet B (UVB) eye irradiation. The ovaries are affected by the hormones secreted from the pituitary gland. Therefore, we observed the influence of UVB
Jing Zhang et al.
Cancer research, 75(9), 1859-1867 (2015-03-15)
miR-21 is upregulated in hepatocellular carcinoma and intrahepatic cholangiocarcinoma, where it is associated with poor prognosis. Here, we offer preclinical evidence that miR-21 offers a therapeutic and chemopreventive target in these liver cancers. In mice with hepatic deletion of Pten
Shuhei Yoshida et al.
Gastroenterology, 147(6), 1378-1392 (2014-09-01)
Platelet-derived growth factor-β (PDGFB) is a mitogen for hepatic stellate cells (HSCs). We studied the cellular sources of PDGFB and the effects of a high-affinity monoclonal antibody against PDGFB (MOR8457) in mouse models of biliary fibrosis. Cellular sources of PDGFB
Konstantinos Grintzalis et al.
Free radical research, 43(9), 803-808 (2009-06-24)
The time-related alterations of superoxide radical measured in vivo by employing an ultrasensitive fluorescent assay in the liver, intestine, kidney and brain of rats with experimentally induced obstructive jaundice was investigated. Eighteen rats were randomly divided into Group A, rats
1/6