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Michael F Neerman et al.
International journal of pharmaceutics, 281(1-2), 129-132 (2004-08-04)
Cell-based and acute and subchronic in vivo toxicity profiles of a dendrimer based on melamine reveal that this class of molecules warrants additional study as vehicles for drug delivery. In cell culture, a substantial decrease in viability was observed at
H D Heck et al.
Regulatory toxicology and pharmacology : RTP, 5(3), 294-313 (1985-09-01)
Terephthalic acid (TPA), dimethyl terephthalate (DMT), and melamine (MA) induced calculi and transitional cell hyperplasia in urinary bladders of rats. A high incidence of calculi was induced in weanling rats, but the incidence was much lower in adult rats ingesting
S A Tittlemier
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 27(2), 129-145 (2010-01-06)
In recent years, two adulteration incidents concerning the addition of melamine (MEL) and related compounds to dairy products and vegetable proteins have occurred in China. These episodes prompted numerous governmental and private laboratories to develop or implement methods for the
Yuejiao Wei et al.
Toxicology and industrial health, 28(7), 579-582 (2011-10-12)
In September 2008, in China, tens of thousands of children were hospitalized, several even died, as a result of infant-formula milk adulterated with a synthetic chemical compound, melamine, and in the next few months, this crisis became the focus of
T Porenta et al.
Scientific reports, 4, 7337-7337 (2014-12-06)
Metastable configurations formed by defects, inclusions, elastic deformations and topological solitons in liquid crystals are a promising choice for building photonic crystals and metamaterials with a potential for new optical applications. Local optical modification of the director or introduction of
Jean Lou Dorne et al.
Toxicology and applied pharmacology, 270(3), 218-229 (2012-02-07)
Melamine can be present at low levels in food and feed mostly from its legal use as a food contact material in laminates and plastics, as a trace contaminant in nitrogen supplements used in animal feeds, and as a metabolite
Yu-Chang Tyan et al.
Analytical and bioanalytical chemistry, 395(3), 729-735 (2009-08-12)
In the summer of 2008, serious illnesses and deaths of babies in China were linked to melamine-tainted powdered infant formula. Melamine contains several metabolites, such as ammeline, ammelide, and cyanuric acid, and has been used for the adulteration of foods
Man Wang et al.
Talanta, 132, 922-928 (2014-12-06)
An easy preparation of g-C3N4/Fe3O4 nanocomposites by chemical co-precipitation has been demonstrated. The as-prepared materials were characterized by X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy and thermogravimetric analysis. The high affinity of g-C3N4 toward polycyclic aromatic hydrocarbons and
Ghee Hwan Kim et al.
Journal of toxicology and environmental health. Part A, 77(22-24), 1346-1358 (2014-10-25)
To investigate the nephrotoxic potential of melamine (MEL) and cyanuric acid (CA) in male Sprague-Dawley rats, 7-d repeated-dose studies were performed. The experimental groups of MEL100 and CA100 were orally administered with MEL and CA at 100 mg/kg/d for 7
Jon Draher et al.
Journal of chromatography. A, 1373, 106-113 (2014-12-02)
A method for the rapid quantification of 9 potential nitrogen-rich economic adulterants (dicyandiamide, urea, biuret, cyromazine, amidinourea, ammeline, amidinourea, melamine, and cyanuric acid) in five milk and soy derived nutritional ingredients, i.e. whole milk powder, nonfat dry milk, milk protein
Rong H Yin et al.
Research in veterinary science, 97(3), 505-513 (2014-12-03)
Melamine is an organic nitrogenous compound whose acute toxicity was generally thought to be low in animals. In the present work, we investigated the potential cytotoxic effects of melamine on spleen lymphocytes in mice. In the treated group, morphological changes
Hui Yang et al.
Nano letters, 15(3), 1730-1735 (2015-02-11)
We detect by optical microscopy Au and fluorescent nanoparticles (NPs) during their motion in water-based medium, using an array of dielectric microspheres that are patterned in a microwell array template. The microspheres act as lenses focusing the light originating from
Jie Cheng et al.
PloS one, 9(9), e107770-e107770 (2014-09-23)
A rapid, selective, and sensitive method to determine the melamine content in animal feeds was developed using surface-enhanced Raman scattering spectroscopy on aggregated 55 nm Au nanoparticles with liquid-liquid extraction sample preparation. Butyl alcohol was used as the initial extraction
Yuan Liu et al.
Journal of Zhejiang University. Science. B, 13(7), 525-532 (2012-07-05)
In recent years, there were two reported outbreaks of food borne illness associated with melamine. The presence of melamine and its related compounds in milk, feed, and other foods has resulted in the need for reliable methods for the detection
Carl G Skinner et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 6(1), 50-55 (2010-03-03)
Melamine contamination of infant formula in China and its health effects highlight the safety of the global food supply especially as it relates to formula-fed infants. Melamine is a widely used industrial chemical not considered acutely toxic with a high
D Frösch et al.
Electron microscopy reviews, 2(2), 231-255 (1989-01-01)
Melamine resins are derived from the heterocyclic compound triaminotriazine, C3H6N6. Similar to proteins in structure and reactivity, water-soluble melamine resins can be used as water-embedding media for electron microscopy (Bachhuber and Frösch, 1983). The idea behind this approach was to
Rishikesh P Dalal et al.
Nature reviews. Nephrology, 7(5), 267-274 (2011-03-23)
Several well-documented outbreaks of melamine poisoning have occurred in both animals and humans during the past 7 years, which led to the identification of melamine and cyanuric acid as nephrotoxins. This Review provides an overview of the known experimental and
Ida Arvidsson et al.
Journal of immunology (Baltimore, Md. : 1950), 194(5), 2309-2318 (2015-02-01)
Shiga toxin (Stx)-producing Escherichia coli (STEC) cause hemolytic uremic syndrome (HUS). This study investigated whether Stx2 induces hemolysis and whether complement is involved in the hemolytic process. RBCs and/or RBC-derived microvesicles from patients with STEC-HUS (n = 25) were investigated
Vivek Bhalla et al.
Kidney international, 75(8), 774-779 (2009-02-13)
Recent outbreaks of nephrolithiasis and acute kidney injury among children in China have been linked to ingestion of milk-based infant formula contaminated with melamine. These cases provide evidence in humans for the nephrotoxicity of melamine, which previously had been described
Honggang Tu et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 777, 62-67 (2015-03-03)
The genotoxicity of melamine was evaluated with the combined Pig-a mutation/micronucleus assay, the bacterial reverse mutation assay, and the in vitro cytokinesis-block micronucleus assay (CBMN). Five groups of six- to eight-week-old male Sprague-Dawley (SD) rats were given three daily doses
Jun Feng Wang et al.
PloS one, 9(6), e97976-e97976 (2014-06-03)
A new high-performance surface-enhanced Raman scattering (SERS) substrate with extremely high SERS activity was produced. This SERS substrate combines the advantages of Au film over nanosphere (AuFON) substrate and Ag nanoparticles (AgNPs). A three order enhancement of SERS was observed
Carl A Osborne et al.
The Veterinary clinics of North America. Small animal practice, 39(1), 1-14 (2008-11-29)
This article discusses the 2007 recall of canned pet food because of concerns about adverse effects on kidney function of cats and dogs. The discovery of melamine and cyanuric acid in the foods is detailed. Case studies, including clinical, pathology
Jia-Jia Yang et al.
Sheng li xue bao : [Acta physiologica Sinica], 64(2), 238-244 (2012-04-20)
In recent years there have been more widely and deeply studies in investigating melamine toxicity. Generally, it is believed that the main target of melamine is the urinary system. However, previous studies revealed that it also had additional biological actions.
Anthony Kai-ching Hau et al.
Journal of the American Society of Nephrology : JASN, 20(2), 245-250 (2009-02-06)
The toxicity of melamine caught the attention of physicians as a result of a recent spate of renal injury after exposure to melamine-tainted milk in China. Melamine is an organic nitrogenous compound used in the production of plastics, dyes, fertilizers
Yaxi Hu et al.
Food chemistry, 176, 123-129 (2015-01-28)
A novel biosensor combining molecularly imprinted polymers and surface-enhanced Raman spectroscopy (MIPs-SERS) determines melamine in whole milk. MIPs were synthesized by bulk polymerization of melamine (template), methacrylic acid (functional monomer), ethylene glycol dimethacrylate (cross-linking agent) and 2,2'-azobisisobutyronitrile (initiator). Static and
Yongning Wu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 56, 325-335 (2013-03-06)
This review summarizes the most recent scientific literature and regulations regarding analytical chemistry, toxicology, epidemiology, exposure, and risk assessment of melamine in infant formula. For analyses, enzyme-linked immunosorbent assay, high-performance liquid chromatography, capillary electrophoresis, gas chromatography coupled with mass spectrometry
Yueming Zhou et al.
The Analyst, 139(21), 5387-5392 (2014-08-26)
Better sensitivity and interface of ambient sampling/ionization mass spectrometry remain a challenge. Herein, a novel, plasma-based, ambient sampling/ionization/transmission (PASIT) integrated source in a pin-to-funnel configuration was developed for the sensitive analysis of complex samples. With the funnel sleeve directly affected
Pei-Xin Wang et al.
BioMed research international, 2013, 868202-868202 (2013-08-31)
Studies have reported inconsistent results regarding clinical feature and the prognosis status of the affected children in China melamine-contamination event. We summarized available literatures by performing a review and meta-analysis. Statistical pooling was performed using random-effects model; the sources of
M Vara Messler et al.
Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, 30(2), 174-187 (2012-06-14)
Urinary tract tumors are tenth in frequency, and many environmental carcinogens are excreted by urine. Interplay between chronic inflammatory urolithiasis and urothelial carcinogenesis is not well understood. Experimental evidences show that dietary melamine induce these events even at low concentrations.
Jie Ding
Kidney international, 75(8), 780-782 (2009-02-27)
Through screening, diagnosing, and treating childhood urinary stones induced by melamine-tainted formula, Chinese doctors obtained more experience with the clinical as well as the imaging features of the stones, although there still are many questions regarding melamine-associated stones. By reviewing
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