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L A Clarke et al.
Genomics, 24(2), 311-316 (1994-11-15)
As an initial step toward the generation of a murine model for mucopolysaccharidosis type I, we have identified and characterized a full-length murine alpha-L-iduronidase cDNA. Expression of the murine cDNA in COS-1 cells results in the production of alpha-L-iduronidase enzyme
Sabrina Danilin et al.
Carcinogenesis, 30(3), 387-396 (2008-12-06)
We have shown that parathyroid hormone-related protein (PTHrP) is a survival factor for human renal cell carcinoma (RCC) and that its expression is negatively regulated by the von Hippel-Lindau (VHL) tumor suppressor gene at the level of messenger RNA (mRNA)
Patrick T Fueger et al.
The Journal of physiology, 566(Pt 2), 533-541 (2005-05-10)
Hexokinase (HK) II content is elevated in fatigue resistant muscle fibres and exercise trained muscle. The aim of this study was to determine if exercise capacity is dependent on muscle HK protein content. C57Bl/6 mice with a 50% HK knockout
Jozsef Czimmer et al.
Current pharmaceutical design, 19(1), 11-16 (2012-09-07)
Cytokines are known to play a key role in regulation of gastric functions. Interferon-alpha (IFN-α) has been published to impair gastric motility. Aims of this study were to clarify effect of IFN-α on gastric acid secretion (GAS) and determine role
Olivier Boucher et al.
Neurotoxicology, 35, 162-168 (2013-02-05)
Chlordecone is a persistent organochlorine pesticide that was used in the French West Indies until the early 1990s for banana weevil borer control. Human exposure to this chemical in this area still occurs nowadays due to consumption of contaminated food.
Hyunjung Kim et al.
Platelets, 26(2), 148-153 (2014-03-13)
The purpose of this study was to evaluate associations between INNOVANCE PFA P2Y (PFA P2Y) test results and CYP2C19 genotypes and provide baseline data for PFA P2Y testing to establish a therapeutic monitoring strategy for clopidogrel. A total of 75
Qian Chen et al.
Mutation research, 638(1-2), 11-16 (2007-09-28)
Carbadox, a quinoxaline 1,4-dioxide derivative, is a known mutagen with its functional mechanism yet to be well defined. In the present study we used a shuttle vector assay in vitro to uncover the functional details of carbadox-induced mutagenesis in mammalian
N A Johnson et al.
The Journal of biological chemistry, 264(11), 6220-6229 (1989-04-15)
The leukocyte common antigen is a family of glycoproteins uniquely expressed by cells of hemopoietic origin. The family is generated by alternative splicing of 3 exons, and individual members are expressed in a cell type-specific fashion. The glycoprotein consists of
Maria S França-Silva et al.
Autonomic neuroscience : basic & clinical, 171(1-2), 28-35 (2012-11-13)
Previously, we found that the nitrate synthesized from glycerin, 2-nitrate-1,3-dibuthoxypropan (NDBP), increased NO levels in rat aortic smooth muscle cells, inducing vasorelaxation in mesenteric artery. However, its effects on blood pressure and heart rate as well as on autonomic function
T Y Nelson et al.
The Journal of biological chemistry, 262(6), 2608-2612 (1987-02-25)
The mechanisms by which glyburide and tolbutamide signal insulin secretion were examined using a beta cell line (Hamster insulin-secreting tumor (HIT) cells). Insulin secretion was measured in static incubations, free cytosolic Ca2+ concentration ([Ca2+]i) was monitored in quin 2-loaded cells
Adi Broyde et al.
American journal of hematology, 84(6), 338-343 (2009-04-23)
Expression of Ki-67, a nuclear antigen protein present in all cycling cells, is used to determine the growth fraction of tumors. The aim of this study was to evaluate the role and prognostic significance of the Ki-67 proliferation index (PI)
S Y Lin-Shiau et al.
European journal of pharmacology, 382(2), 75-80 (1999-10-21)
Clinically available chemical antagonists of snake neurotoxins still await to be identified. In this study, we demonstrate that an anti-trypanosomiasis agent, suramin, is an effective inhibitor of beta-bungarotoxin isolated from the venom of Formosan Krait snake. Following intraperitoneal injection (12
Martin F Crook et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22(1), 225-235 (2007-08-30)
The cyclin-dependent kinase inhibitor p27(Kip1) arrests cell cycle progression through G1/S phases and is regulated by phosphorylation of serine/threonine residues. Recently, we identified the serine/threonine kinase, KIS, which phosphorylates p27(Kip1) on serine 10 leading to nuclear export of p27(Kip1) and
Krishan Sharma
Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur, 66(2), 211-224 (2008-08-21)
Quantitative genetic studies revealed that not all of the phenotypic variance in PTC taste perception is heritable. To study quantitative variations in PTC tasting ability in twins and to estimate heritability of PTC taste perception on the taste of twin
N U Haase et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(8), 1230-1238 (2012-07-13)
Heated plant foods may contain compounds with adverse health effects (e.g. acrylamide). On the other hand, health-promoting compounds (e.g. antioxidants) have also been identified in such foods. Therefore, a baking experiment with biscuits was carried out to study the potential
Vivaldo Gomes da Costa et al.
PloS one, 14(5), e0217594-e0217594 (2019-05-30)
Canine morbillivirus (canine distemper virus, CDV) persists as a serious threat to the health of domestic dogs and wildlife. Although studies have been conducted on the frequency and risk factors associated with CDV infection, there are no comprehensive data on
Hyeon-Kyu Go et al.
Nutrients, 7(10), 8532-8544 (2015-10-27)
The objective of this study was to investigate the therapeutic efficacies of crude yam (Dioscorea batatas) powder (PY), water extract of yam (EY), and allantoin (the active constituent of yam) in streptozotocin (STZ)-induced diabetic rats with respect to glucose, insulin
Joachim Greiner et al.
Frontiers in physiology, 9, 239-239 (2018-04-20)
Computational modeling is an important tool to advance our knowledge on cardiac diseases and their underlying mechanisms. Computational models of conduction in cardiac tissues require identification of parameters. Our knowledge on these parameters is limited, especially for diseased tissues. Here
Nancy M Bauman et al.
JAMA otolaryngology-- head & neck surgery, 140(4), 323-330 (2014-02-15)
While propranolol is touted as superior to prednisolone for treating infantile hemangiomas (IH), a randomized clinical trial (RCT) comparing the outcome and tolerability of these medications for symptomatic, proliferating IH has not been reported. To determine if oral propranolol is
Steven S Shen et al.
Cancer, 106(12), 2610-2616 (2006-05-16)
Estrogen receptors (ERs) are known to mediate important physiologic responses as well as the growth of some tumors in response to estradiol stimulation. In a previous study the selective ER modulator raloxifene was shown to induce apoptosis in an ERbeta-positive
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