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Amal Alachkar et al.
Journal of molecular neuroscience : MN, 46(1), 145-152 (2011-05-13)
The changes in the mRNA levels of α(2A) and α(2C) adrenoceptors were investigated in unilateral 6-OHDA-lesioned rat model of Parkinson's disease and L: -DOPA-induced dyskinesia using in situ hybridization. In the untreated 6-OHDA-lesioned rats, α(2A) expression was elevated in the
Aman U Buzdar et al.
The Lancet. Oncology, 14(13), 1317-1325 (2013-11-19)
Neoadjuvant chemotherapy with trastuzumab for patients with HER2-positive breast cancer can produce a pathological complete response in the breast in 30-65% of patients. We investigated the effect of the timing of trastuzumab administration with anthracycline and taxane neoadjuvant chemotherapy. This
Pálma Benedek et al.
Orvosi hetilap, 155(18), 703-707 (2014-04-30)
Treatment of pediatric obstructive sleep apnea syndrome is surgical. The incidence of postoperative respiratory complications in this population is 5-25%. The aim of the authors was to present the preoperative evaluation and monitoring procedure elaborated in Heim Pál Children Hospital
Niloofar Moghadas-Sharif et al.
Drug development and industrial pharmacy, 41(3), 445-450 (2014-01-11)
The aim of the present study was to assess the in vitro antimicrobial activities of nanoliposomal formulations loaded with vancomycin or/and rifampin against the biofilm formed by Staphylococcus epidermidis at 37 °C under aerobic condition. Liposomal formulations were prepared by dehydration-rehydration
P Gomes et al.
European journal of pharmacology, 332(2), 219-225 (1997-08-06)
The present study aimed to determine the kinetics of L-3,4-dihydroxyphenylalanine (L-DOPA) uptake in Opossum kidney (OK) cells and to define the type of inhibition produced by L-5-hydroxytryptophan (L-5-HTP), cyanine 863 and 3,3'-diethyloxacarbocyanine (3,3'-DOC). Non-linear analysis of the saturation curves revealed
Shuichi Tsuruoka et al.
Internal medicine (Tokyo, Japan), 52(3), 303-308 (2013-02-02)
Some angiotensin receptor blockers (ARBs), including irbesartan, increase the peroxisome proliferator-activated receptor (PPAR)-g activity in vitro. The aim of this study was to evaluate the interactions between obesity and the effects of irbesartan on inflammatory cytokines in chronic glomerulonephritis patients
Bruno Coudert et al.
The Lancet. Oncology, 15(13), 1493-1502 (2014-12-03)
An effective and well tolerated treatment is needed for patients with early HER2-positive breast cancer who do not achieve a pathological complete response after neoadjuvant therapy. The AVATAXHER trial aimed to predict pathological complete response early with the use of
Konstantinos J Dabos et al.
Liver international : official journal of the International Association for the Study of the Liver, 31(5), 707-711 (2011-04-05)
Little is known about the metabolism of acetoacetate and β-hydroxybutyrate in patients with cirrhosis and encephalopathy. We investigated the fate of ketone bodies in these conditions. We studied 18 cirrhotic patients with encephalopathy and 17 cirrhotics without. At the time
Andreas Wolf et al.
Human mutation, 30(2), 239-247 (2008-09-19)
To assess the evolutionary importance of nonallelic (or interlocus) gene conversion for the highly polymorphic human growth hormone (GH1) gene promoter, sequence variation in this region was studied in four different ethnic groups. For 14 SNPs in the proximal GH1
Cheng-Hsu Chen et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 23(10), 3166-3173 (2008-05-23)
Idiopathic membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in adults, and 25% of MN patients proceed to end-stage renal disease. Plasminogen activator inhibitor type 1 (PAI-1) activity plays an important role in renal fibrosis.
Danny Christiansen et al.
Acta physiologica (Oxford, England), 231(3), e13580-e13580 (2020-11-23)
To assess how blood-flow-restricted (BFR) interval-training affects the capacity of the leg muscles for pH regulation during dynamic exercise in physically trained men. Ten men (age: 25 ± 4y; V˙O2max : 50 ± 5 mL∙kg-1 ∙min-1 ) completed a 6-wk interval-cycling intervention (INT) with one
R Cimaz et al.
Epilepsia, 43(1), 52-59 (2002-03-07)
To measure anti-cardiolipin (aCL), anti-beta2 glycoprotein I (anti-beta2GPI), and anti-prothrombin (aPT) antibodies in young patients with epilepsy, and to correlate their presence with demographic data, clinical diagnoses, laboratory and neuroradiologic findings, and antiepileptic drugs (AEDs). Sera from one hundred forty-two
Bankole A Johnson et al.
JAMA psychiatry, 70(12), 1338-1346 (2013-10-18)
No medication has been established as an efficacious treatment for cocaine dependence. We hypothesized that dual modulation of the mesocorticolimbic dopamine system by topiramate-a glutamate receptor antagonist and γ-aminobutyric acid receptor agonist-would result in efficacious treatment for cocaine dependence compared
Fredrik Lindmark et al.
Journal of the National Cancer Institute, 96(16), 1248-1254 (2004-08-19)
Accumulating epidemiologic and molecular evidence suggest that inflammation is an important component in the etiology of prostate cancer. Macrophage-inhibitory cytokine-1 (MIC-1), a member of the transforming growth factor beta superfamily, is thought to play an important role in inflammation by
Shay-Whey M Koh et al.
Investigative ophthalmology & visual science, 52(8), 5632-5640 (2011-04-13)
To demonstrate corneal endothelial (CE) integrity enhanced during eye banking by a brief treatment of human donor corneoscleral explant (explant) with CE autocrine trophic factor vasoactive intestinal peptide (VIP). Paired explants were used as control versus VIP (10 nM)-treated before
Xuejie Guo et al.
BMC plant biology, 17(1), 48-48 (2017-02-23)
Oil in the form of triacylglycerols (TAGs) is quantitatively the most important storage form of energy for eukaryotic cells. Diacylglycerol acyltransferase (DGAT) is considered the rate-limiting enzyme for TAG accumulation. Chlorella, a unicellular eukaryotic green alga, has attracted much attention
Mohammad Bagher Oghazian et al.
Pharmacotherapy, 35(2), 148-157 (2015-02-18)
To compare the effectiveness and safety of two glycemic control regimens in stable critical care patients receiving parenteral nutrition (PN). Prospective, randomized open-label clinical trial. Eligible postoperative critical care patients in the ICU began PN on the first to the
Kerstin Boengler et al.
Current pharmaceutical design, 19(39), 6890-6895 (2013-04-18)
The signal transducer and activator of transcription 3 (STAT3) transduces stress signals from the plasma membrane to the nucleus but has recently also been identified in mitochondria. Inhibition of cardiomyocyte mitochondrial STAT3 with the STAT3-specific inhibitor Stattic decreases ADP-stimulated respiration
Elizabeth M Grainger et al.
The British journal of nutrition, 114(4), 596-607 (2015-07-24)
Tomato product consumption and estimated lycopene intake are hypothesised to reduce the risk of prostate cancer. To define the impact of typical servings of commercially available tomato products on resultant plasma and prostate lycopene concentrations, men scheduled to undergo prostatectomy
Lingmin He et al.
JAMA ophthalmology, 133(1), 51-59 (2014-10-17)
Wavefront-guided (WFG) and wavefront-optimized (WFO) platforms for refractive surgery are designed for improved visual outcomes. It is unclear which treatment profile is superior for patients undergoing photorefractive keratectomy (PRK). To compare the safety, efficacy, predictability, stability, and higher-order aberrations in
Claudia Asenjo Lobos et al.
The Cochrane database of systematic reviews, (11)(11), CD006633-CD006633 (2010-11-12)
Clozapine is an atypical antipsychotic demonstrated to be superior in the treatment of refractory schizophrenia which causes fewer movement disorders. Clozapine, however, entails a significant risk of serious blood disorders such as agranulocytosis which could be potentially fatal. Currently there
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