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Allison Bakovic et al.
Viruses, 12(9) (2020-09-17)
Venezuelan equine encephalitis virus (VEEV), a mosquito transmitted alphavirus of the Togaviridae family, can cause a highly inflammatory and encephalitic disease upon infection. Although a category B select agent, no FDA-approved vaccines or therapeutics against VEEV currently exist. We previously
Dustin E Starkey et al.
Journal of AOAC International, 96(5), 1082-1085 (2013-11-29)
Data from a previously published study in J. AOAC Int. 91,130-142 (2008) was presented to the Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN) during the AOAC Annual Meeting held in Las Vegas, NV, from September 30 to October
Giovanni Carlo Del Vecchio et al.
Immunopharmacology and immunotoxicology, 30(4), 679-686 (2008-08-08)
We evaluated the capacity of peripheral CD4+ T helper cells in four Common Variable Immunodeficiency (CVI) patients to secrete interleukin-4 (IL-4) and IL-5. While in control CD4+ T cells, stimulated via CD3 and cultured in presence of IL-2 or IL-15
B Saitta et al.
The Journal of biological chemistry, 267(9), 6188-6196 (1992-03-25)
Cosmid clones containing the 5' region of the human alpha 2(VI) collagen gene have been isolated and characterized. DNA sequencing indicates that the signal peptide and the amino-globular domain are encoded by four exons of 142, 596, 21, and 66
Ioannis Papageorgiou et al.
Biochemical pharmacology, 146, 199-213 (2017-10-01)
Posttranscriptional repression of UDP-glucuronosyltransferase (UGT) 2B7 and 2B15 expression by microRNAs (miRNAs) may be an important mechanism underlying inter-individual variability in drug glucuronidation. Furthermore, the UGT2B15 3'-UTR contains a common SNP (rs3100) that could influence miRNA binding. The aim of
Yoong-Ling Oon et al.
Bioresource technology, 203, 190-197 (2016-01-03)
This study demonstrated a successful operation of up-flow constructed wetland-microbial fuel cell (UFCW-MFC) in wastewater treatment and energy recovery. The goals of this study were to investigate the effect of circuit connection, organic loading rates, and electrode spacing on the
Thomas P Gunnarsson et al.
American journal of physiology. Cell physiology, 318(6), C1252-C1263 (2020-04-09)
Essential hypertension is associated with impairments in vascular function and sympathetic nerve hyperactivity; however, the extent to which the lower limbs are affected remains unclear. We examined the leg vascular responsiveness to infusion of acetylcholine (ACh), sodium nitroprusside (SNP), and
Aman U Buzdar et al.
The Lancet. Oncology, 14(13), 1317-1325 (2013-11-19)
Neoadjuvant chemotherapy with trastuzumab for patients with HER2-positive breast cancer can produce a pathological complete response in the breast in 30-65% of patients. We investigated the effect of the timing of trastuzumab administration with anthracycline and taxane neoadjuvant chemotherapy. This
Stéphane Flamant et al.
Haematologica, 95(8), 1325-1333 (2010-05-13)
Micro-RNAs (miRNAs) control gene expression by destabilizing targeted transcripts and inhibiting their translation. Aberrant expression of miRNAs has been described in many human cancers, including chronic myeloid leukemia. Current first-line therapy for newly diagnosed chronic myeloid leukemia is imatinib mesylate
Zhi-Dong Ge et al.
Cardiovascular research, 91(2), 340-349 (2011-03-23)
Hyperglycaemia (HG) decreases intracellular tetrahydrobiopterin (BH(4)) concentrations, and this action may contribute to injury during myocardial ischaemia and reperfusion. We investigated whether increased BH(4) by cardiomyocyte-specific overexpression of the GTP cyclohydrolase (GTPCH) 1 gene rescues myocardial and mitochondrial protection by
X Zhao et al.
Epidemiology and infection, 145(3), 545-552 (2016-11-04)
Epidemic surveillance is an effective means to determine the characteristics of acute diarrhoea and the benefits of disease control and prevention. The epidemiological, clinical, and aetiological data of adult (aged ⩾15 years) acute diarrhoea in a general hospital in Shanghai
Francisco J Morales et al.
Nutrients, 12(5) (2020-05-20)
Nutritional composition and neo-formed contaminant content in ultra-processed foods, amongst other factors, may contribute to increasing overall risk of non-communicable diseases and cancer. Commercial breakfast cereals (n = 53) were classified according to the NOVA approach as un-/minimally processed (NOVA-1
Angie Paola Lagos-Carvajal et al.
Life sciences, 139, 139-144 (2015-09-01)
The pulmonary vasodilation induced by adrenomedullin may be beneficial in the acute pulmonary embolism (APE) setting. This study examined effects of adrenomedullin in sheep with microsphere-induced APE. Twenty four anesthetized, mechanically ventilated sheep were randomly assigned into 3 groups (n=8
V Bachanova et al.
Bone marrow transplantation, 50(2), 197-203 (2014-11-18)
Alternative donor transplantation is increasingly used for high-risk lymphoma patients. We analyzed 1593 transplant recipients (2000-2010) and compared transplant outcomes in recipients of 8/8 allele HLA-A, -B, -C and DRB1 matched unrelated donors (MUDs; n=1176), 7/8 allele HLA mismatched unrelated
Eugene R Viscusi et al.
Current medical research and opinion, 28(8), 1323-1335 (2012-06-29)
To evaluate the effects of two different doses of etoricoxib delivered perioperatively compared with placebo and standard pain management on pain at rest, pain with mobilization, and use of additional morphine/opioids postoperatively. In this double-blind, placebo-controlled, randomized clinical trial, we
Paul R Gigante et al.
Journal of neurology, neurosurgery, and psychiatry, 82(3), 247-253 (2010-09-16)
Up to 28% of patients undergoing carotid endarterectomy (CEA) are estimated to experience neurocognitive dysfunction following surgery. The complement cascade plays a central role in ischaemia-reperfusion injury. The authors investigated the effect of common polymorphisms in the complement component 3
Bo-an Zheng et al.
Zhonghua zhong liu za zhi [Chinese journal of oncology], 32(2), 111-116 (2010-04-21)
To study the E-CD and Snail expressions in colorectal cancer and their relationship with colorectal cancer invasion, metastasis and prognosis. Immunohistochemical staining (EnVision) was used to detect the E-CD and Snail expressions in 30 normal colorectal mucosa, 30 colorectal adenoma
P J Venta et al.
The Journal of biological chemistry, 260(22), 12130-12135 (1985-10-05)
We have isolated a cosmid clone containing the entire mouse (YBR strain) carbonic anhydrase (CA) II gene in 38 kilobase pairs of genomic DNA. The gene was found to be composed of seven exons and six introns. A TATA box
Jennifer Dien et al.
The American journal of pathology, 169(2), 633-642 (2006-08-01)
Signal transducers and activators of transcription (STAT)-3 is an oncogenic protein that is constitutively activated in many human cancers, including 30 to 60% of primary breast cancer. The biological significance of STAT3 activation in breast cancer is not fully understood.
Christine C Pemberton et al.
The journal of physical chemistry. A, 119(33), 8832-8845 (2015-07-21)
All stages of the electrocyclic ring-opening of 1,3-cyclohexadiene (CHD) were observed by time-resolved photoionization-photoelectron spectroscopy. Spectra of the 1B state, previously unobserved using time-resolved methods, were obtained upon optical excitation using ultrashort laser pulses at 4.60 or 4.65 eV, followed
Jian-Jun Zhao et al.
Blood, 115(13), 2630-2639 (2010-01-21)
Mantle cell lymphoma (MCL) is one of the most aggressive B-cell lymphomas. Although several protein-coding genes are altered, expression signature and importance of microRNA (miRNA) have not been well documented in this malignancy. Here, we performed miRNA expression profile in
Ariane Söling et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 11(1), 249-258 (2005-01-27)
The identification of new molecular markers in astrocytic tumors may help to understand the biology of these tumors in more detail. Informative tumor markers may represent prognostic factors for response to therapy and outcome as well as potential targets for
Laura Paesano et al.
Journal of hazardous materials, 393, 122430-122430 (2020-03-11)
Cadmium is toxic to humans, although Cd-based quantum dots exerts less toxicity. Human hepatocellular carcinoma cells (HepG2) and macrophages (THP-1) were exposed to ionic Cd, Cd(II), and cadmium sulfide quantum dots (CdS QDs), and cell viability, cell integrity, Cd accumulation
U Fuhr et al.
International journal of clinical pharmacology and therapeutics, 43(7), 327-334 (2005-07-23)
Triamterene (TA), a potassium-sparing diuretic, is extensively metabolized by hydroxylation in 4'-position and subsequent conjugation by cytosolic sulfotransferases. To identify the cytochrome P450 enzyme(s) catalyzing hydroxylation of triamterene (the rate-limiting step in the formation of the sulfate ester (STA)), in
Maura Arosio et al.
The Journal of clinical endocrinology and metabolism, 89(10), 5101-5104 (2004-10-09)
The mechanisms involved in the preprandial rise and postprandial fall of circulating ghrelin levels are as yet unknown. Many hormonal and metabolic responses to nutrient intake begin during the cephalic or preabsorptive phase and are mostly mediated by the autonomous
Hyo-Jin Jeong et al.
Molecular pain, 4, 54-54 (2008-11-19)
There is evidence to suggest that the midbrain periaqueductal grey (PAG) has a role in migraine and the actions of the anti-migraine drug sumatriptan. In the present study we examined the serotonergic modulation of GABAergic and glutamatergic synaptic transmission in
Miry Blich et al.
The Journal of invasive cardiology, 22(10), 461-464 (2010-10-15)
Traditionally, stent thrombosis (STH) has been regarded as a complication of percutaneous coronary interventions during the first 30 post-procedural days. However, delayed endothelialization associated with the implantation of drug-eluting stents (DES) may extend the risk of thrombosis beyond 30 days.
Adam S Wu et al.
Journal of neurosurgery, 118(4), 873-883 (2013-02-12)
Seizures are a potentially devastating complication of resection of brain tumors. Consequently, many neurosurgeons administer prophylactic antiepileptic drugs (AEDs) in the perioperative period. However, it is currently unclear whether perioperative AEDs should be routinely administered to patients with brain tumors
S Munnangi et al.
Placenta, 35(11), 900-906 (2014-08-27)
In an effort to improve prenatal screening for Trisomy 21, we evaluated pregnancy associated plasma protein-A2 (PAPP-A2) as a potential novel second trimester biomarker for Trisomy 21. Trisomy 21 and normal control mid-trimester placental samples were subjected to quantitative rt
Andreas Teufel et al.
World journal of gastroenterology, 12(34), 5513-5516 (2006-09-29)
To report on our large German collective and updated data of 142 patients with autoimmune hepatitis (AIH) type 1. Key investigations performed were liver biopsy, serum autoantibodies as well as serum markers such as IgG and elevated transaminases. Antinuclear antigen
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