142-91-6

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The influence of G-protein beta3-subunit gene and endothelial nitric oxide synthase gene in exon 7 polymorphisms on progression of autosomal dominant polycystic kidney disease.

J Reiterová et al.

Renal failure, 26(2), 119-125 (2004-08-04)

A significant phenotypical variability is observed in autosomal dominant polycystic kidney disease (ADPKD). The variability cannot be fully explained by the genetic heterogeneity of the disease. We examined the influence of G-protein beta3-subunit C825T polymorphism and endothelial nitric oxide synthase

Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma.

A G Rossi et al.

The Journal of clinical investigation, 101(12), 2869-2874 (1998-06-24)

Macrophage migration inhibitory factor (MIF) is a potent proinflammatory mediator that has been shown to potentiate lethal endotoxemia and to play a potentially important regulatory role in human acute respiratory distress syndrome (ARDS). We have investigated whether eosinophils are an

Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance.

Oliver Zolk et al.

Circulation, 106(12), 1442-1446 (2002-09-18)

Cardiotrophin-1 (CT-1), a member of the interleukin-6 superfamily, is a potent inducer of cardiomyocyte hypertrophy that prolongs myocyte survival. Although cardiac CT-1 gene expression is known to be upregulated in some animal models of congestive heart failure, the activation state

Metabolism and disposition of bupropion in pregnant baboons (Papio cynocephalus).

Erik Rytting et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1773-1779 (2014-08-07)

Recent in vitro data obtained in our laboratory revealed similarities between baboons and humans in the biotransformation of bupropion (BUP) by both hepatic and placental microsomes. These data supported the use of baboons to study BUP biotransformation during pregnancy. The

Solution structure of rat apo-S100B(beta beta) as determined by NMR spectroscopy.

A C Drohat et al.

Biochemistry, 35(36), 11577-11588 (1996-09-10)

S100B(beta beta), a member of the S100 protein family, is a Ca(2+)-binding protein with noncovalent interactions at its dimer interface. Each apo-S100 beta subunit (91 residues) has four alpha-helices and a small antiparallel beta-sheet, consistent with two predicted helix-loop-helix Ca(2+)-binding

U-73122, an aminosteroid phospholipase C antagonist, noncompetitively inhibits thyrotropin-releasing hormone effects in GH3 rat pituitary cells.

R C Smallridge et al.

Endocrinology, 131(4), 1883-1888 (1992-10-01)

TRH increases cytosolic-free calcium ([Ca2+]i) by activating phospholipase C(PL-C), which induces phosphoinositol hydrolysis, leading to Ca2+ mobilization from inositol trisphosphate (IP3) sensitive stores, and by increasing Ca2+ influx. Increases in [Ca2+]i stimulate PRL secretion. We investigated the effects of U-73122

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