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14370
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Yujiao Fu et al.
Molecular pharmacology, 88(1), 161-170 (2015-02-27)
The timely resolution of inflammation prevents continued tissue damage after an initial insult. In the brain, the death of activated microglia by apoptosis has been proposed as one mechanism to resolve brain inflammation. How microglial death is regulated after activation
Maja Surbatovic et al.
Scientific reports, 5, 11355-11355 (2015-06-17)
Sepsis is a principal cause of death in critical care units worldwide and consumes considerable healthcare resources. The aim of our study was to determine whether the early cytokine profile can discriminate between Gram-positive and Gram-negative bacteraemia (GPB and GNB
Bilirubin levels and redox status in a young healthy population.
Carina Rodrigues et al.
Acta haematologica, 130(1), 57-60 (2013-03-15)
S S Sheen et al.
Journal of clinical pharmacy and therapeutics, 40(1), 48-54 (2014-10-21)
Angiotensin receptor blockers (ARBs) are medications commonly used for treating conditions such as hypertension. However, ARBs are frequently associated with hyperkalemia, a potentially critical adverse event, in high-risk patients. Although both the liver and the kidney are major elimination routes
C Pérez de Ciriza et al.
Clinical biochemistry, 47(13-14), 1279-1285 (2014-05-23)
Osteoprotegerin (OPG), an osteoclastogenesis inhibitor implicated in bone remodelling, has emerged as a potential biomarker for cardiovascular disease. In order to implement OPG determination in the clinical laboratory, it is crucial to identify the most appropriate specimen type, preparation and
Tinsay A Woreta et al.
The Medical clinics of North America, 98(1), 1-16 (2013-11-26)
The routine use of serum biochemical tests allows for the detection of acute and chronic liver injury before the onset of symptoms. These tests consist of markers of hepatocellular injury (aminotransferases and APs); tests of liver metabolism (total bilirubin); and
H Perazzo et al.
Alimentary pharmacology & therapeutics, 40(9), 1081-1093 (2014-09-05)
In cardiometabolic disorders, non-alcoholic fatty liver disease is frequent and presumably associated with increased mortality and cardiovascular risk. To evaluate the prognostic value of non-invasive biomarkers of liver fibrosis (FibroTest) and steatosis (SteatoTest) in patients with type-2 diabetes and/or dyslipidaemia.
N Talaat et al.
Journal of viral hepatitis, 22(5), 481-488 (2014-10-15)
With the approval of 2 direct-acting antivirals (DAAs) in 2011 and anticipation of interferon (IFN)-free regimens, more hepatitis C virus (HCV) chronically infected patients are now seeking treatment. To describe the characteristics of newly referred HCV patients in 2011-2012 (Era-2)
Somenath Datta et al.
PloS one, 9(10), e110012-e110012 (2014-10-22)
The contribution of chronic hepatitis B virus (HBV) infection in the pathogenesis of hepatocellular carcinoma (HCC) through progressive stages of liver fibrosis is exacerbated by the acquisition of naturally occurring mutations in its genome. This study has investigated the prevalence
U Warttinger et al.
Analytical and bioanalytical chemistry, 408(28), 8241-8251 (2016-10-22)
Heparins are widely used anticoagulant drugs. The current monitoring practice for heparin in plasma, such as the chromogenic anti-factor Xa assay, relies on heparin-triggered activation of antithrombin, an inhibitor of coagulation proteases. Such assays are not applicable to the detection
Shahnaz Sali et al.
Diagnostic microbiology and infectious disease, 82(2), 114-119 (2015-04-13)
Hepatitis B envelope antigen (HBeAg)-negative hepatitis B virus (HBV) infection exerts both inactive carrier (IC) state and chronic hepatitis B (CHB), which are sometimes difficult to be differentiated. We aimed to assess the role of hepatitis B surface antigen (HBsAg)
Amy N Schnelle et al.
Veterinary clinical pathology, 44(2), 275-286 (2015-04-14)
Oxidative stress inhibits albumin's ability to complex with cobalt. Feline serum-cobalt binding has not been described. The objective was to develop a cobalt binding test for use with feline serum, and correlate the results with other biochemical and cellular constituents
Meiyan Dai et al.
Journal of cellular physiology, 230(9), 2108-2119 (2015-01-30)
Macrophages, owning tremendous phenotypic plasticity and diverse functions, were becoming the target cells in various inflammatory, metabolic and immune diseases. Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to form epoxyeicosatrienoic acids (EETs), which possess various beneficial effects on cardiovascular
Alban Zarzavadjian Le Bian et al.
World journal of gastroenterology, 20(39), 14455-14462 (2014-10-24)
To investigate the mechanism leading to perioperative mortality in patients undergoing major liver resection and presenting with metabolic disorders. The link between Metabolic Syndrome and non-alcoholic fatty liver disease is currently demonstrated. Various metabolic disorders and the Metabolic Syndrome (the
Christine Mölzer et al.
Journal of natural products, 76(10), 1958-1965 (2013-10-26)
Bilirubin exhibits antioxidant and antimutagenic effects in vitro. Additional tetrapyrroles that are naturally abundant were tested for antigenotoxicity in Salmonella. Un-/conjugated bilirubin (1 and 2), biliverdin (4), bilirubin and biliverdin dimethyl esters (3 and 5), stercobilin (6), urobilin (7), and
Robert Ollinger et al.
Cell cycle (Georgetown, Tex.), 6(1), 39-43 (2007-01-25)
We have recently shown that the natural bile pigment bilirubin has antiproliferative effects on vascular smooth muscle cells (VSMCs). Bilirubin is the end product of heme catabolism mediated by heme oxygenases and has for decades been considered a toxic waste
Rohit Loomba et al.
Hepatology (Baltimore, Md.), 60(6), 1920-1928 (2014-08-12)
Retrospective studies have shown that two-dimensional magnetic resonance elastography (2D-MRE), a novel MR method for assessment of liver stiffness, correlates with advanced fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Prospective data on diagnostic accuracy of 2D-MRE in the
Syed Muhammad Shahid et al.
Pakistan journal of pharmaceutical sciences, 26(5), 853-857 (2013-09-17)
Angiotensin converting enzyme (ACE) is a key player of Renin Angiotensin System (RAS), involved in conversion of active product, angiotensin-II. Alterations in RAS have been implicated in the pathophysiology of various diseases involving heart, kidney, lung and liver. This study
Raphael A Seidel et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 974, 83-89 (2014-12-03)
Bilirubin oxidation end products (BOXes) appear upon endogenous heme degradation and can be found in the cerebrospinal fluid after hemorrhagic stroke. BOXes are assumed to contribute to delayed cerebral vasospasm and secondary loss of brain tissue. Here, we present a
Mohammad Mahdi Moein et al.
Journal of chromatography. A, 1366, 15-23 (2014-10-01)
In the present work, a needle trap utilizing a molecularly imprinted sol-gel xerogel was prepared for the on-line microextraction of bilirubin from plasma and urine samples. Each prepared needle could be used for approximately one hundred extractions before it was
Ryan J Butts et al.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 33(12), 1282-1287 (2014-08-17)
A higher degree of human leukocyte antigen (HLA) matching at the A, B, and DR loci has been associated with improved long-term survival after pediatric heart transplantation in multiple International Society for Heart and Lung Transplantation registry reports. The aim
K M Burghardt et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(6), 1674-1681 (2015-03-27)
Current listing indications used for intestinal transplantation (IT) were proposed in 2001. We undertook the present single center study to see if these criteria are still valid. The 2001 criteria (advanced cholestasis, loss of >50% central venous catheter (CVC) sites
Joong Gyu Ha et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(12), 1530-1538 (2015-06-05)
Abnormal spiral artery remodeling during early pregnancy leads to preeclampsia. The proliferation and invasion of trophoblasts in pregnancy are important for spiral artery remodeling. This study examined whether heme oxygenase (HO) by-products (carbon monoxide biliverdin, and iron) play roles in
Jun Hyuk Son et al.
American journal of surgery, 206(1), 40-46 (2013-05-28)
Despite routine preoperative biliary drainage (PBD) with periampullary cancer, its optimal duration has not been established. The objective of this study was to investigate PBD in severely jaundiced patients. A total of 120 patients with periampullary tumors who underwent surgery with
Azza A G Tantawy et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 26(4), 419-425 (2015-02-24)
Endothelial nitric oxide synthase (eNOS), an enzyme that generates nitric oxide, is a major determinant of endothelial function. Several eNOS gene polymorphisms have been reported as 'susceptibility genes' in various human diseases states, including cardiovascular, pulmonary and renal diseases. We
Eltrombopag and serum of a different hue.
David Cardamone et al.
Archives of pathology & laboratory medicine, 137(9), 1175-1175 (2013-09-03)
José Altamirano et al.
Gastroenterology, 146(5), 1231-1239 (2014-01-21)
There is no histologic classification system to determine prognoses of patients with alcoholic hepatitis (AH). We identified histologic features associated with disease severity and created a histologic scoring system to predict short-term (90-day) mortality. We analyzed data from 121 patients
Juan-Ni Gong et al.
Chinese medical journal, 128(23), 3125-3131 (2015-11-28)
Inoperable chronic thromboembolic pulmonary hypertension (CTEPH) is a severe clinical syndrome characterized by right cardiac failure and possibly subsequent liver dysfunction. However, whether serum markers of liver dysfunction can predict prognosis in inoperable CTEPH patients has not been determined. Our
S Nadalin et al.
Pediatric transplantation, 19(4), 358-365 (2015-04-17)
Biliary complications remain a major challenge for long-term success after LT, as it is, as a rule, the most common technical - early and late - complication that occurs, and because these complications contribute to a significant number of late
Emmanuel Milot et al.
Mechanisms of ageing and development, 141-142, 56-63 (2014-12-03)
Mechanistic and evolutionary perspectives both agree that aging involves multiple integrated biochemical networks in the organism. In particular, the homeostatic physiological dysregulation (PD) hypothesis contends that aging is caused by the progressive breakdown of key regulatory processes. However, nothing is
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