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George S Brush
BMC research notes, 8, 275-275 (2015-07-01)
Histone H1, referred to as the linker histone, associates with the nucleosome core particle. While there is indication that the budding yeast version of histone H1 (Hho1) contributes to regulation of chromatin structure and certain chromatin-related processes, such as DNA
Qi Li et al.
Macromolecular rapid communications, 34(2), 185-189 (2012-11-10)
A novel fabrication method of polymer tubes with simple operation process and high yield is presented. N,N'-methylene bisacrylamide (MBA) polymer microtubes are fabricated via reversible addition-fragmentation chain transfer (RAFT) polymerization using MBA self-assembled fibers as both the template and monomer
Ikram Ullah Khan et al.
International journal of pharmaceutics, 493(1-2), 7-15 (2015-06-28)
In this study, we report on a novel method for the synthesis of poly(acrylamide) Trojan microparticles containing ketoprofen loaded poly(ethyl acrylate) or poly(methyl acrylate) nanoparticles. To develop these composite particles, a polymerizable nanoemulsion was used as a template. This nanoemulsion
Edwin Makhado et al.
International journal of biological macromolecules, 119, 255-269 (2018-07-23)
In the present study, facile and efficient method was adopted for the synthesis of graft copolymer hydrogel by graft copolymerization of acrylic acid (AA) onto xanthan gum (XG) biopolymer in the presence of N,N'-Methylenebisacrylamide (MBA), and ammonium persulfate (APS) as
Amol D Jadhav et al.
Biomicrofluidics, 9(3), 034114-034114 (2015-07-17)
Microvalves with different actuation methods offer great integrability and flexibility in operation of lab-on-chip devices. In this work, we demonstrate a hydrogel-based and optically controlled modular microvalve that can be easily integrated within a microfluidic device and actuated by an
Martin Soehle et al.
European journal of anaesthesiology, 32(8), 527-534 (2015-03-17)
Anaesthesia for awake craniotomy aims for an unconscious patient at the beginning and end of surgery but a rapidly awakening and responsive patient during the awake period. Therefore, an accurate pharmacokinetic/pharmacodynamic (PK/PD) model for propofol is required to tailor depth
Patricia Alvarez-Sieiro et al.
Food chemistry, 168, 439-444 (2014-08-31)
For patients with celiac disease, gliadin detoxification via the use of gliadinases may provide an alternative to a gluten-free diet. A culture medium, in which gliadins were the sole source of nitrogen, was developed for screening for microorganisms with gliadinase
Damla Keskin et al.
Biomacromolecules, 20(1), 243-253 (2018-12-05)
Bacterial infection is a severe problem especially when associated with biomedical applications. This study effectively demonstrates that poly- N-isopropylmethacrylamide based microgel coatings prevent bacterial adhesion. The coating preparation via a spraying approach proved to be simple and both cost and
Hyunwoo Yuk et al.
Nature communications, 7, 12028-12028 (2016-06-28)
Inspired by mammalian skins, soft hybrids integrating the merits of elastomers and hydrogels have potential applications in diverse areas including stretchable and bio-integrated electronics, microfluidics, tissue engineering, soft robotics and biomedical devices. However, existing hydrogel-elastomer hybrids have limitations such as
Joshua L Gowin et al.
Drug and alcohol dependence, 152, 93-101 (2015-05-16)
Nearly half of individuals with substance use disorders relapse in the year after treatment. A diagnostic tool to help clinicians make decisions regarding treatment does not exist for psychiatric conditions. Identifying individuals with high risk for relapse to substance use
Yan Huang et al.
Molecules (Basel, Switzerland), 19(10), 16158-16178 (2014-10-11)
This study investigated genome-wide gene expressions and the cardioprotective effects of electro-acupuncture pretreatment at the PC6 Neiguan acupoint on myocardial ischemia reperfusion (I/R) injury. Male SD rats were randomly divided into four groups: sham operation (SO), I/R, electro-acupuncture at the
Cristina Antunes Garagarza et al.
Hemodialysis international. International Symposium on Home Hemodialysis, 19(3), 412-418 (2015-01-07)
Monitoring nutritional parameters is an integral part of hemodialysis (HD) patient treatment program. The purpose of this study was to evaluate the impact of the personalized nutritional counseling (PNC) on calcium-phosphorus metabolism, potassium, albumin, protein intake, interdialytic weight gain (IDWG)
Christine Chiasson-MacKenzie et al.
The Journal of cell biology, 211(2), 391-405 (2015-10-21)
The proliferation of normal cells is inhibited at confluence, but the molecular basis of this phenomenon, known as contact-dependent inhibition of proliferation, is unclear. We previously identified the neurofibromatosis type 2 (NF2) tumor suppressor Merlin as a critical mediator of
Bin Huang et al.
Medical oncology (Northwood, London, England), 32(1), 408-408 (2014-12-10)
The aim of present investigation is to explore the molecular mechanisms of vasculogenic mimicry (VM) induced by hypoxia. Hepatocellular carcinoma cell lines were treated with CoCl2, and the VM-related parameters were assayed by real-time qPCR, Western blotting and immunofluorescence. Matrigel
Nima A Jalili et al.
Nanoscale, 9(40), 15379-15389 (2017-10-05)
"Smart" hydrogels are an emerging class of biomaterials that respond to external stimuli and have been investigated for a range of biomedical applications, including therapeutic delivery and regenerative engineering. Stimuli-responsive nanogels constructed of thermoresponsive polymers such as poly(N-isopropylacrylamide-co-acrylamide) (poly(NIPAM-co-AM)) and
Jiji Chen et al.
Nature methods, 18(6), 678-687 (2021-06-02)
We demonstrate residual channel attention networks (RCAN) for the restoration and enhancement of volumetric time-lapse (four-dimensional) fluorescence microscopy data. First we modify RCAN to handle image volumes, showing that our network enables denoising competitive with three other state-of-the-art neural networks.
Shaheen Jeeawoody et al.
Analytical chemistry, 92(4), 3180-3188 (2020-01-28)
Immunoprobed isoelectric focusing (IEF) resolves proteins based on differences in isoelectric point (pI) and then identifies protein targets through immunoprobing of IEF-separated proteins that have been immobilized onto a gel scaffold. During the IEF stage, the gel functions as an
Shaoting Lin et al.
Advanced materials (Deerfield Beach, Fla.), 28(22), 4497-4505 (2015-12-08)
Stretchable hydrogel electronics and devices are designed by integrating stretchable conductors, functional chips, drug-delivery channels, and reservoirs into stretchable, robust, and biocompatible hydrogel matrices. Novel applications include a smart wound dressing capable of sensing the temperatures of various locations on
Mark William Lopes et al.
Neurochemistry international, 87, 22-33 (2015-05-20)
Disturbances in glutamatergic transmission and signaling pathways have been associated with temporal lobe epilepsy (TLE) in humans. However, the profile of these alterations within specific regions of the hippocampus and cerebral cortex has not yet been examined. The pilocarpine model
Anping Peng et al.
Scientific reports, 5, 12173-12173 (2015-07-18)
This is the first investigation of the diversity and distribution of 16S rRNA and phenol monooxygenase (PHE) genes in endophytic and rhizosphere bacteria of plants at sites contaminated with different levels of PAHs. Ten PAHs at concentrations from 34.22 to
Yong Cui et al.
Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 29(2), 300-311 (2015-01-27)
Nicotine dependence has been suggested to be related to reinforcement sensitivity, which encompasses behavioral predispositions either to avoid aversive (behavioral inhibition) or to approach appetitive (behavioral activation) stimuli. Reinforcement sensitivity may shape motives for nicotine use and offer potential targets
Shinji Urata et al.
eLife, 8 (2019-01-19)
The highly organized spatial arrangement of sensory hair cells in the organ of Corti is essential for inner ear function. Here, we report a new analytical pipeline, based on optical clearing of tissue, for the construction of a single-cell resolution
Hari B Krishnan et al.
Journal of agricultural and food chemistry, 63(11), 2862-2869 (2015-03-11)
Soybean is an important protein source for both humans and animals. However, soybean proteins are relatively poor in the sulfur-containing amino acids, cysteine and methionine. Improving the content of endogenous proteins rich in sulfur-containing amino acids could enhance the nutritive
I-Chien Liao et al.
Advanced functional materials, 23(47), 5833-5839 (2014-03-01)
The development of synthetic biomaterials that possess mechanical properties that mimic those of native tissues remains an important challenge to the field of materials. In particular, articular cartilage is a complex nonlinear, viscoelastic, and anisotropic material that exhibits a very
Hao Meng et al.
Acta biomaterialia, 17, 160-169 (2015-02-14)
To decouple the extracellular oxidative toxicity of catechol adhesive moiety from its intracellular non-oxidative toxicity, dopamine was chemically bound to a non-degradable polyacrylamide hydrogel through photo-initiated polymerization of dopamine methacrylamide (DMA) with acrylamide monomers. Network-bound dopamine released cytotoxic levels of
Mayrut Urióstegui-Acosta et al.
Toxicology and applied pharmacology, 279(3), 391-400 (2014-07-08)
Methamidophos (MET) is a highly toxic organophosphate (OP) pesticide that is widely used in developing countries. MET has male reproductive effects, including decreased fertility. We evaluated MET effects on sperm quality, fertilization and DNA integrity, exploring the sensitivity of different
Timothy Olding et al.
Journal of medical physics, 36(1), 3-14 (2011-03-25)
This paper explores the combination of cone beam optical computed tomography with an N-isopropylacrylamide (NIPAM)-based polymer gel dosimeter for three-dimensional dose imaging of small field deliveries. Initial investigations indicate that cone beam optical imaging of polymer gels is complicated by
Mohamed Elsherif et al.
Biosensors & bioelectronics, 137, 25-32 (2019-05-12)
Continuous glucose monitoring facilitates the stringent control of blood glucose concentration in diabetic and intensive care patients. Optical fibers have emerged as an attractive platform; however, their practical applications are hindered due to lack of biocompatible fiber materials, complex and
Han Gao et al.
Macromolecular rapid communications, 34(1), 63-68 (2012-10-20)
Traditional pH-sensitive hydrogels inevitably suffer strength deterioration while the responsive weak acid or base groups are in the ionized state. In this study, we report on a facile approach to fabricate a novel pH-sensitive high-strength hydrogel from copolymerization of two
Carrie P Earthman
JPEN. Journal of parenteral and enteral nutrition, 39(7), 787-822 (2015-08-20)
Because of the key role played by the body's lean tissue reserves (of which skeletal muscle is a major component) in the response to injury and illness, its maintenance is of central importance to nutrition status. With the recent development
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