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Maria B Goncalves et al.
The European journal of neuroscience, 37(7), 1182-1192 (2013-02-06)
The retinoic acid receptor (RAR) α system plays a key role in the adult brain, participating in the homeostatic control of synaptic plasticity, essential for memory function. Here we show that RARα signalling is down-regulated by amyloid beta (Aβ), which
Stephen Moss et al.
FEBS letters, 594(2), 327-336 (2019-09-13)
Neprilysin (NEP) is a promiscuous zinc metalloprotease with broad substrate specificity and cleaves a remarkable diversity of substrates through endopeptidase action. Two of these - amyloid-β and natriuretic peptides - implicate the enzyme in both Alzheimer's disease and cardiovascular disease
Raquel Pastrello Hirata et al.
Sleep & breathing = Schlaf & Atmung, 21(3), 631-638 (2017-01-09)
Negative expiratory pressure (NEP) is a simple technique for the evaluation of upper airway collapsibility in patients with obstructive sleep apnea (OSA). Most studies evaluated NEP using a mouthpiece that may exclude the cephalic portion of the upper airway. We
Wendel Wohlleben et al.
Nanoscale, 11(38), 17637-17654 (2019-09-21)
The project nanoGRAVUR (BMBF, 2015-2018) developed a framework for grouping of nanomaterials. Different groups may result for each of the three distinct perspectives of occupational, consumer and environmental safety. The properties, methods and descriptors are harmonised between the three perspectives
Stephen M Davis et al.
Harm reduction journal, 16(1), 23-23 (2019-04-04)
Using a new needle for every injection can reduce the spread of infectious disease among people who inject drugs (PWID). No previous study has examined new needle use barriers among PWIDs residing in the rural Appalachian part of the United
K F Standeven et al.
International journal of obesity (2005), 35(8), 1031-1040 (2010-11-03)
Neprilysin (NEP), a zinc metalloendopeptidase, has a role in blood pressure control and lipid metabolism. The present study tested the hypothesis that NEP is associated with insulin resistance and features of the metabolic syndrome (MetS) in a study of 318
Peng Hu et al.
Journal of receptor and signal transduction research, 37(1), 71-83 (2016-06-10)
The initiation and progression of renal interstitial fibrosis (RIF) is a complicated process in which many factors may play an activate role. Among these factors, C-type natriuretic peptide (CNP) is an endothelium-derived hormone and acts in a local, paracrine fashion
Paulo Ruiz-Grosso et al.
PloS one, 7(10), e45413-e45413 (2012-10-12)
Depressive disorders are leading contributors to burden of disease in developing countries. Research aiming to improve their diagnosis and treatment is fundamental in these settings, and psychometric tools are widely used instruments to support mental health research. Our aim is
Létitia Jean et al.
PloS one, 2(7), e652-e652 (2007-07-27)
Neurodegenerative diseases associated with abnormal protein folding and ordered aggregation require an initial trigger which may be infectious, inherited, post-inflammatory or idiopathic. Proteolytic cleavage to generate vulnerable precursors, such as amyloid-beta peptide (Abeta) production via beta and gamma secretases in
Björn Maul et al.
PloS one, 7(11), e50187-e50187 (2012-11-28)
Both acquired and inherited genetic factors contribute to excessive alcohol consumption and the corresponding development of addiction. Here we show that the genetic deficiency in neprilysin [NEP] did not change the kinetics of alcohol degradation but led to an increase
Salvatore T Scali et al.
Journal of vascular surgery, 68(1), 24-35 (2018-02-06)
The ideal stent combination for chimney endovascular aneurysm repair remains undetermined. Therefore, we sought to identify optimal aortic and chimney stent combinations that are associated with the best outcomes by analyzing the worldwide collected experience in the PERformance of chImney
Nathalie Esser et al.
Islets, 10(5), 175-180 (2018-08-25)
Neprilysin, a widely expressed peptidase upregulated in type 2 diabetes, is capable of cleaving and inactivating the insulinotropic glucagon-like peptide-1 (GLP-1). Like dipeptidyl peptidase-4 (DPP-4), inhibition of neprilysin activity under diabetic conditions is associated with increased active GLP-1 levels and
Christian Klein et al.
Acta neuropathologica communications, 6(1), 136-136 (2018-12-13)
Serotoninergic activation which decreases brain Aβ peptides is considered beneficial in mouse models for Alzheimer's disease (AD), but the mechanisms involved remain unclear. Because growing evidence suggested that the stimulation of proteases digesting Aβ, especially the endopeptidase neprilysin (NEP) may
Helen Landmann et al.
Cognition & emotion, 33(7), 1387-1409 (2019-01-25)
People can be moved and overwhelmed, a phenomenon typically accompanied by goose-bumps and tears. We argue that these feelings of being moved are not limited to situations that are appraised as pro-social but elicited when someone surpasses an internal standard.
Stephen Moss et al.
Journal of structural biology, 204(1), 19-25 (2018-06-16)
Neprilysin is a transmembrane M13 zinc metalloprotease responsible for the degradation of several biologically active peptides including insulin, enkephalin, substance P, bradykinin, endothelin-1, neurotensin and amyloid-β. The protein has received attention for its role in modulating blood pressure responses with
Johannes J Kovarik et al.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 36(3), 355-365 (2016-10-25)
Angiotensin-converting enzyme (ACE) inhibitors (ACEis) are beneficial in patients with heart failure, yet their role after heart transplantation (HTx) remains ambiguous. Particularly, the effects of ACEis on plasma and cardiac metabolites of the "classical" and "alternative" renin-angiotensin system (RAS) in
Benjamin R Riegger et al.
Carbohydrate polymers, 201, 172-181 (2018-09-23)
Glutaraldehyde-crosslinked chitosan nanoparticles (Chi-NPs) were prepared reproducibly via miniemulsion crosslinking for effective adsorption of the active pharmaceutical ingredient (API) Diclofenac (DCL). Three different molecular weights (MWs) of highly deacetylated (>90%) chitosans (low, medium and high MW) were used to vary
A Fernández-Atucha et al.
Biology of sex differences, 8, 5-5 (2017-02-09)
Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of the renin-angiotensin system (RAS). Dysregulation of these enzymes has been associated with hypertension and cardiovascular risk.
Jie Zhang et al.
Environmental science and pollution research international, 26(22), 22160-22172 (2019-05-31)
The variations of vegetation carbon sequestration have become a gauge for evaluating the ecological effect of vegetation restoration. In this study, the spatiotemporal patterns of the net ecosystem production (NEP) were simulated using an improved CASA model and GSMSR model.
Anne K Dettmar et al.
Pediatric nephrology (Berlin, Germany), 33(3), 463-472 (2017-10-17)
Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults, but is less frequent in children. Antibodies against four antigens leading to MN have been described in children: phospholipase A Twelve children with MN were included in this
Ermelindo C Leal et al.
The American journal of pathology, 185(6), 1638-1648 (2015-04-15)
Diabetic foot ulceration is a major complication of diabetes. Substance P (SP) is involved in wound healing, but its effect in diabetic skin wounds is unclear. We examined the effect of exogenous SP delivery on diabetic mouse and rabbit wounds.
Hugo Bernelin et al.
Clinical cardiology, 42(1), 32-38 (2018-10-05)
Several preliminary analyses suggested an association between neprilysin (NEP) levels and myocardial infarction. The objective was to assess whether NEP plasma levels following reperfusion might be a surrogate for infarct size (IS) or predict adverse outcomes in acute ST-segment elevation
Joseph A Davis et al.
Indian journal of pharmacology, 44(6), 759-764 (2012-12-19)
Dipeptidyl peptidase IV (DPP-IV) inhibition to modulate the incretin effect is a proven strategy to treat type 2 diabetes mellitus. The present study describes the pharmacological profile of a novel DPP-IV inhibitor RBx-0128, as an antidiabetic agent. DPP-IV assay was
Wenting Zhang et al.
Virology journal, 14(1), 30-30 (2017-02-17)
Infectious salmon anemia virus (ISAV) is an important fish pathogen that causes high mortality in farmed Atlantic salmon. The ISAV genome consists of eight single-stranded, negative-sense RNA segments. The six largest segments contain one open reading frame (ORF) each, and
Michel Wehrhold et al.
Nanoscale, 11(31), 14742-14756 (2019-07-28)
Electrochemical devices based on a single graphene monolayer are often realized on a solid support such as silicon oxide, glassy carbon or a metal film. Here, we show that, with graphene on insulating substrates, the kinetics of the electron transfer
Ah Young Lee et al.
Journal of agricultural and food chemistry, 66(19), 4853-4861 (2018-04-19)
Therapeutic approaches for neurodegeneration, such as Alzheimer's disease (AD), have been widely studied. One of the critical hallmarks of AD is accumulation of amyloid beta (Aβ). Aβ induces neurotoxicity and releases inflammatory mediators or cytokines through activation of glial cell
Qi Wang et al.
Disease models & mechanisms, 7(12), 1385-1395 (2014-12-07)
The complex pathogenesis of Alzheimer's disease (AD) involves multiple contributing factors, including amyloid β (Aβ) peptide accumulation, inflammation and oxidative stress. Effective therapeutic strategies for AD are still urgently needed. Triptolide is the major active compound extracted from Tripterygium wilfordii
Seung-Il Choi et al.
Experimental eye research, 182, 167-174 (2019-04-02)
Alzheimer's disease (AD) primarily affects the brain and is the most common form of dementia worldwide. Despite more than a century of research, there are still no early biomarkers for AD. It has been reported that AD affects the eye
Fatma Ayhan et al.
The EMBO journal, 37(19) (2018-09-13)
Spinocerebellar ataxia type 8 (SCA8) is caused by a bidirectionally transcribed CTG·CAG expansion that results in the in vivo accumulation of CUG RNA foci, an ATG-initiated polyGln and a polyAla protein expressed by repeat-associated non-ATG (RAN) translation. Although RAN proteins have
Chen Hou et al.
Free radical research, 52(11-12), 1311-1322 (2018-04-24)
Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be
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