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A Nezu et al.
Archives of oral biology, 79, 35-41 (2017-03-13)
Although the pathogeneses of Alzheimer's disease (AD) and periodontal diseases have overlapping features, including ageing and chronic inflammation, the association between AD and periodontitis remains unclear. To explore the pathogenesis of periodontitis, a comprehensive gene expression/transcriptome analysis in periodontitis-affected gingival
Yang Chen et al.
Journal of molecular and cellular cardiology, 130, 140-150 (2019-04-08)
The native particulate guanylyl cyclase B receptor (pGC-B) activator, C-type natriuretic peptide (CNP), induces anti-remodeling actions in the heart and kidney through the generation of the second messenger 3', 5' cyclic guanosine monophosphate (cGMP). Indeed fibrotic remodeling, particularly in cardiorenal
Erming Wang et al.
Nucleic acids research, 35(12), 4164-4178 (2007-06-15)
Alternative splicing of competing 5' splice sites is regulated by enhancers and silencers in the spliced exon. We have characterized sequences and splicing factors that regulate alternative splicing of PLP and DM20, myelin proteins produced by oligodendrocytes (OLs) by selection
Takuya Kobayashi et al.
Neuroscience letters, 698, 180-185 (2019-01-15)
Although the effects of neprilysin (NEP), also called CD10, on the clearance of Alzheimer's disease (AD)-associated amyloid-β (Aβ) have been reported, NEP is not made in the brain, and the mechanism for the transport of NEP to the brain has
Ping He et al.
The Journal of cell biology, 178(5), 829-841 (2007-08-29)
The tumor necrosis factor type 1 death receptor (TNFR1) contributes to apoptosis. TNFR1, a subgroup of the TNFR superfamily, contains a cytoplasmic death domain. We recently demonstrated that the TNFR1 cascade is required for amyloid beta protein (Abeta)-induced neuronal death.
Caroline W Gitonga et al.
Malaria journal, 9, 306-306 (2010-11-03)
To design and implement surveys of malaria infection and coverage of malaria control interventions among school children in Kenya in order to contribute towards a nationwide assessment of malaria. The country was stratified into distinct malaria transmission zones based on
Brian Spencer et al.
BMC neuroscience, 9, 109-109 (2008-11-19)
Proteolytic degradation has emerged as a key pathway involved in controlling levels of the Alzheimer's disease (AD)-associated amyloid-beta (Abeta) peptide in the brain. The endopeptidase, neprilysin, has been implicated as a major Abeta degrading enzyme in mice and humans. Previous
Min Sung Gee et al.
Alzheimer's research & therapy, 12(1), 45-45 (2020-04-23)
Chronic neuroinflammation, aggressive amyloid beta (Aβ) deposition, neuronal cell loss, and cognitive impairment are pathological presentations of Alzheimer's disease (AD). Therefore, resolution of neuroinflammation and inhibition of Aβ-driven pathology have been suggested to be important strategies for AD therapy. Previous
Jing Du et al.
PloS one, 4(5), e5530-e5530 (2009-05-14)
Metabolites of neural cells, is known to have a significant effect on the normal physiology and function of neurons in brain. However, whether they play a role in pathogenesis of neurodegenerative diseases is unknown. Here, we show that metabolites of
Travis Sexton et al.
PloS one, 7(2), e32343-e32343 (2012-03-03)
Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides. We have generated a series of neprilysin variants containing mutations at either one of
Miguel Chin-Chan et al.
Toxicological sciences : an official journal of the Society of Toxicology, 145(1), 128-137 (2015-02-13)
Levels of amyloid beta (Aβ) in the central nervous system are regulated by the balance between its synthesis and degradation. Neprilysin (NEP) is associated with Alzheimer's disease (AD) by its ability to degrade Aβ. Some studies have involved the exposure
Yicong Chen et al.
Stroke, 48(12), 3366-3374 (2017-11-18)
Focal cortical infarction causes neuronal apoptosis in the ipsilateral nonischemic thalamus and hippocampus, which is potentially associated with poststroke cognitive deficits. TSPO (translocator protein) is critical in regulating mitochondrial apoptosis pathways. We examined the effects of the novel TSPO ligand
Marília Prada et al.
Appetite, 114, 175-186 (2017-03-28)
The "organic" claim explicitly informs consumers about the food production method. Yet, based on this claim, people often infer unrelated food attributes. The current research examined whether the perceived advantage of organic over conventional food generalizes across different organic food
Youna Xie et al.
Chinese medicine, 15, 29-29 (2020-04-08)
Alzheimer's disease (AD) is ranked as the most prevalent neurodegenerative disease. However, the exact molecular mechanisms underlying pathophysiological alterations in AD remain unclear, especially at the prodromal stage. The decreased proteolytic degradation of Aβ, blood-brain barrier (BBB) disruption, and neuroinflammation
Vibeke Miller Breinholt et al.
The Journal of pharmacology and experimental therapeutics, 370(3), 459-471 (2019-06-27)
TransCon CNP is a C-type natriuretic peptide (CNP-38) conjugated via a cleavable linker to a polyethylene glycol carrier molecule, designed to provide sustained systemic CNP levels upon weekly subcutaneous administration. TransCon CNP is in clinical development for the treatment of
Anna Patrikidou et al.
Cancer cell international, 11(1), 13-13 (2011-05-17)
Castration-resistance in prostate cancer (PC) is a critical event hallmarking a switch to a more aggressive phenotype. Neuroendocrine differentiation and upregulation of NFκB transcriptional activity are two mechanisms that have been independently linked to this process. We investigated these two
Marina Vivarelli et al.
Kidney international, 87(3), 602-609 (2015-01-08)
Alloimmune antenatal membranous nephropathy (MN) during pregnancy results from antibodies produced by a neutral endopeptidase (NEP)-deficient mother. Here we report two recent cases that provide clues to the severity of renal disease. Mothers of the two children had circulating antibodies
Chen Hou et al.
Free radical research, 52(11-12), 1311-1322 (2018-04-24)
Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be
Francisco M Pinto et al.
Reproductive biology and endocrinology : RB&E, 8, 104-104 (2010-08-28)
We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa. Freshly ejaculated semen was collected from forty-eight normozoospermic human donors. We analyzed the expression of substance P, neurokinin A, neurokinin
Gayane Hrachia Buniatian et al.
Cells, 9(2) (2020-02-25)
The function and regulation of amyloid-beta (Aβ) in healthy and diseased liver remains unexplored. Because Aβ reduces the integrity of the blood-brain barrier we have examined its potential role in regulating the sinusoidal permeability of normal and cirrhotic liver. Aβ
Jin-Zhong Huang et al.
Molecular medicine reports, 13(1), 491-496 (2015-11-05)
Alzheimer's disease (AD) is the most common form of dementia and there currently are no effective treatment strategies available. Catalpol is an iridoid glucoside, and large quantities can be isolated from the genus Rehmannia (Orobanchaceae). The present study assessed whether
Ah Young Lee et al.
Journal of agricultural and food chemistry, 66(19), 4853-4861 (2018-04-19)
Therapeutic approaches for neurodegeneration, such as Alzheimer's disease (AD), have been widely studied. One of the critical hallmarks of AD is accumulation of amyloid beta (Aβ). Aβ induces neurotoxicity and releases inflammatory mediators or cytokines through activation of glial cell
Seung-Il Choi et al.
Experimental eye research, 182, 167-174 (2019-04-02)
Alzheimer's disease (AD) primarily affects the brain and is the most common form of dementia worldwide. Despite more than a century of research, there are still no early biomarkers for AD. It has been reported that AD affects the eye
Qi Wang et al.
Disease models & mechanisms, 7(12), 1385-1395 (2014-12-07)
The complex pathogenesis of Alzheimer's disease (AD) involves multiple contributing factors, including amyloid β (Aβ) peptide accumulation, inflammation and oxidative stress. Effective therapeutic strategies for AD are still urgently needed. Triptolide is the major active compound extracted from Tripterygium wilfordii
Xiaolei Zhu et al.
Aging cell, 16(5), 1073-1082 (2017-08-05)
The accumulation and deposition of beta-amyloid (Aβ) is a key neuropathological hallmark of Alzheimer's disease (AD). Histone deacetylases (HDACs) are promising therapeutic targets for the treatment of AD, while the specific HDAC isoforms associated with cognitive improvement are poorly understood.
Ah Young Lee et al.
Journal of agricultural and food chemistry, 65(49), 10719-10729 (2017-11-03)
Alzheimer's disease (AD) is characterized by progressive cognitive and memory impairment. The major pathological hallmark of AD is the accumulation of amyloid beta (Aβ), which is produced from the amyloid precursor protein (APP) through cleavage of β- and γ-secretase. Recently
Stephen Moss et al.
FEBS letters, 594(2), 327-336 (2019-09-13)
Neprilysin (NEP) is a promiscuous zinc metalloprotease with broad substrate specificity and cleaves a remarkable diversity of substrates through endopeptidase action. Two of these - amyloid-β and natriuretic peptides - implicate the enzyme in both Alzheimer's disease and cardiovascular disease
Jie Zhang et al.
Environmental science and pollution research international, 26(22), 22160-22172 (2019-05-31)
The variations of vegetation carbon sequestration have become a gauge for evaluating the ecological effect of vegetation restoration. In this study, the spatiotemporal patterns of the net ecosystem production (NEP) were simulated using an improved CASA model and GSMSR model.
Vanessa Colombaro et al.
Acta histochemica, 117(1), 83-91 (2014-12-04)
Hyaluronidase 1 (HYAL1) and hyaluronidase 2 (HYAL2) are the major hyaluronidases acting synergistically to degrade hyaluronan (HA). In the kidney, HA is distributed heterogeneously. Our goal was to determine the consequences of a lack of either HYAL1 or HYAL2 (using
Jonathan Gilkerson et al.
BMC plant biology, 12, 102-102 (2012-07-10)
Transcription of plastid-encoded genes requires two different DNA-dependent RNA polymerases, a nuclear-encoded polymerase (NEP) and plastid-encoded polymerase (PEP). Recent studies identified two related pfkB-type carbohydrate kinases, named FRUCTOKINASE-LIKE PROTEIN (FLN1 and FLN2), as components of the thylakoid bound PEP complex
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