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Cancan Xu et al.
ACS applied materials & interfaces, 10(12), 9969-9979 (2018-02-17)
Cell printing is becoming a common technique to fabricate cellularized printed scaffold for biomedical application. There are still significant challenges in soft tissue bioprinting using hydrogels, which requires live cells inside the hydrogels. Moreover, the resilient mechanical properties from hydrogels
Xuanyi Ma et al.
Biomaterials, 185, 310-321 (2018-09-29)
Hepatocellular carcinoma (HCC), as the fifth most common malignant cancer, develops and progresses mostly in a cirrhotic liver where stiff nodules are separated by fibrous bands. Scaffolds that can provide a 3D cirrhotic mechanical environment with complex native composition and
Y Shanjani et al.
Biofabrication, 7(4), 045008-045008 (2015-12-20)
Three dimensional (3D) bioprinting is a promising approach to form tissue engineering constructs (TECs) via positioning biomaterials, growth factors, and cells with controlled spatial distribution due to its layer-by-layer manufacturing nature. Hybrid TECs composed of relatively rigid porous scaffolds for
T Srinivasa Reddy et al.
Dalton transactions (Cambridge, England : 2003), 47(43), 15312-15323 (2018-09-07)
A series of gold(i), gold(iii) and cationic gold(i) complexes of tris(4-methoxyphenyl)phosphine and tris(2,6-dimethoxyphenyl)phosphine were synthesised and fully characterised by spectroscopic methods. The molecular structures of selected complexes were also determined by X-ray diffraction analysis. The prepared complexes [AuX{P(C6H4-4-OMe)3}] [X =
Zhongliang Jiang et al.
Biofabrication, 12(3), 035006-035006 (2020-03-12)
Hydrogels formed via free radical-mediated thiol-ene step-growth photopolymerization have been developed for a broad range of tissue engineering and regenerative medicine applications. While the crosslinking mechanism of thiol-ene hydrogels has been well-described, there has been only limited work exploring the
Kai Sun et al.
Stem cells translational medicine, 9(12), 1631-1642 (2020-08-14)
Tissue engineering using adult human mesenchymal stem cells (MSCs) seeded within biomaterial scaffolds has shown the potential to enhance bone healing. Recently, we have developed an injectable, biodegradable methacrylated gelatin-based hydrogel, which was especially effective in producing scaffolds in situ
A sequential 3D bioprinting and orthogonal bioconjugation approach for precision tissue engineering.
Claire Yu et al.
Biomaterials, 258, 120294-120294 (2020-08-18)
Recent advances in 3D bioprinting have transformed the tissue engineering landscape by enabling the controlled placement of cells, biomaterials, and bioactive agents for the biofabrication of living tissues and organs. However, the application of 3D bioprinting is limited by the
Bhushan P Mahadik et al.
Biomaterials, 67, 297-307 (2015-08-04)
Hematopoietic stem cells (HSCs) are a rare stem cell population found primarily in the bone marrow and responsible for the production of the body's full complement of blood and immune cells. Used clinically to treat a range of hematopoietic disorders
Xuanyi Ma et al.
Acta biomaterialia, 95, 319-327 (2018-12-24)
Human induced pluripotent stem cell - derived cardiomyocytes (iPSC-CMs) are regarded as a promising cell source for establishing in-vitro personalized cardiac tissue models and developing therapeutics. However, analyzing cardiac force and drug response using mature human iPSC-CMs in a high-throughput
Hang Lin et al.
Scientific reports, 7(1), 11327-11327 (2017-09-14)
Currently, sustained in vivo delivery of active bone morphogenetic protein-2 (BMP-2) protein to responsive target cells, such as bone marrow-derived mesenchymal stem cells (BMSCs), remains challenging. Ex vivo gene transfer method, while efficient, requires additional operation for cell culture and
Rujing Zhang et al.
Lab on a chip, 17(24), 4273-4282 (2017-11-09)
Three-dimensional (3D) in vitro models capturing both the structural and dynamic complexity of the in vivo situation are in great demand as an alternative to animal models. Despite tremendous progress in engineering complex tissue/organ models in the past decade, approaches
Adele Faralli et al.
Advanced healthcare materials, 5(2), 244-254 (2015-12-01)
Stable and low-cost multiplexed drug sensitivity assays using small volumes of cells or tissue are in demand for personalized medicine, including patient-specific combination chemotherapy. Spatially defined projected light photopolymerization of hydrogels with embedded active compounds is introduced as a flexible
Daniel Wangpraseurt et al.
Nature communications, 11(1), 1748-1748 (2020-04-11)
Corals have evolved as optimized photon augmentation systems, leading to space-efficient microalgal growth and outstanding photosynthetic quantum efficiencies. Light attenuation due to algal self-shading is a key limiting factor for the upscaling of microalgal cultivation. Coral-inspired light management systems could
Dai Xue et al.
ACS applied materials & interfaces, 10(23), 19428-19435 (2018-05-22)
To fully actualize artificial, cell-laden biological models in tissue engineering, such as 3D organoids and organs-on-a-chip systems, cells need to be patterned such that they can precisely mimic natural microenvironments in vitro. Despite increasing interest in this area, patterning cells
Steven R Caliari et al.
Scientific reports, 6, 21387-21387 (2016-02-26)
Tissue fibrosis contributes to nearly half of all deaths in the developed world and is characterized by progressive matrix stiffening. Despite this, nearly all in vitro disease models are mechanically static. Here, we used visible light-mediated stiffening hydrogels to investigate
Shida Lyu et al.
Soft matter, 16(5), 1270-1278 (2020-01-09)
Morphing materials, also known as smart materials are attracting increasing attention as sensors, actuators and in soft robotic applications. In this work bilayered morphing composites were created by exploiting the thiol-ene photoclick reaction via maskless digital light processing (DLP). This
Zhongliang Jiang et al.
Journal of materials chemistry. B, 5(1), 173-180 (2017-01-10)
Cell encapsulation within photopolymerized polyethylene glycol (PEG)-based hydrogel scaffolds has been demonstrated as a robust strategy for cell delivery, tissue engineering, regenerative medicine, and developing in vitro platforms to study cellular behavior and fate. Strategies to achieve spatial and temporal
Matthew S Rehmann et al.
Biomacromolecules, 18(10), 3131-3142 (2017-08-30)
Hydrogel-based depots are of growing interest for release of biopharmaceuticals; however, a priori selection of hydrogel compositions that will retain proteins of interest and provide desired release profiles remains elusive. Toward addressing this, in this work, we have established a
Yuwen Chen et al.
Science advances, 6(23), eaba7406-eaba7406 (2020-06-17)
Three-dimensional (3D) printing technology has great potential in advancing clinical medicine. Currently, the in vivo application strategies for 3D-printed macroscale products are limited to surgical implantation or in situ 3D printing at the exposed trauma, both requiring exposure of the
Pengrui Wang et al.
Advanced healthcare materials, 9(15), e1900977-e1900977 (2019-11-08)
Growth factors (GFs) are critical components in governing cell fate during tissue regeneration. Their controlled delivery is challenging due to rapid turnover rates in vivo. Functionalized hydrogels, such as heparin-based hydrogels, have demonstrated great potential in regulating GF release. While
Shruti Krishna Davey et al.
Tissue engineering. Part C, Methods, 21(11), 1188-1196 (2015-07-15)
Techniques that can create three-dimensional (3D) structures to provide architectural support for cells have a significant impact in generating complex and hierarchically organized tissues/organs. In recent times, a number of technologies, including photopatterning, have been developed to create such intricate
Zachary K Zander et al.
Biomaterials, 178, 339-350 (2018-05-23)
The use of catheters is ubiquitous in medicine and the incidence of infection remains unacceptably high despite numerous advances in functional surfaces and drug elution. Herein we report the use of a thermoplastic polyurethane containing an allyl ether side-chain functionality
Zheng Zhong et al.
Biomaterials, 267, 120462-120462 (2020-11-01)
Ocular surface diseases including conjunctival disorders are multifactorial progressive conditions that can severely affect vision and quality of life. In recent years, stem cell therapies based on conjunctival stem cells (CjSCs) have become a potential solution for treating ocular surface
Claire Yu et al.
Biomaterials, 194, 1-13 (2018-12-19)
Decellularized extracellular matrices (dECMs) have demonstrated excellent utility as bioscaffolds in recapitulating the complex biochemical microenvironment, however, their use as bioinks in 3D bioprinting to generate functional biomimetic tissues has been limited by their printability and lack of tunable physical
Scott C Grindy et al.
Soft matter, 13(22), 4057-4065 (2017-05-24)
Control over the viscoelastic mechanical properties of hydrogels intended for use as biomedical materials has long been a goal of soft matter scientists. Recent research has shown that materials made from polymers with reversibly associating transient crosslinks are a promising
Hiroshi Sasaki et al.
The American journal of sports medicine, 46(10), 2402-2413 (2018-07-13)
Radial tears of the meniscus are a common knee injury, frequently resulting in osteoarthritis. To date, there are no established, effective treatments for radial tears. Adipose-derived stem cells (ASCs) may be an attractive cell source for meniscal regeneration because they
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