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Dopamine receptor and Gα(olf) expression in DYT1 dystonia mouse models during postnatal development.
Lin Zhang et al.
PloS one, 10(4), e0123104-e0123104 (2015-04-11)
DYT1 dystonia is a heritable, early-onset generalized movement disorder caused by a GAG deletion (ΔGAG) in the DYT1 gene. Neuroimaging studies and studies using mouse models suggest that DYT1 dystonia is associated with dopamine imbalance. However, whether dopamine imbalance is
Aline R Schindler et al.
Clinical chemistry and laboratory medicine, 53(5), 801-808 (2014-10-03)
The parallelization of clinically relevant antigens in a microarray format is of growing importance due to the ability to measure multiple antigen-antibody interactions. With the development of a microarray for the detection of antiphospholipid antibodies we focussed on one important
Sofia Lourenco et al.
Journal of immunology (Baltimore, Md. : 1950), 194(7), 3463-3474 (2015-02-26)
Mesenchymal stromal cells (MSCs) are inherently tumor homing and can be isolated, expanded, and transduced, making them viable candidates for cell therapy. This tumor tropism has been used to deliver anticancer therapies to various tumor models. In this study, we
Robert Farkaš et al.
PloS one, 9(4), e94383-e94383 (2014-04-16)
In contrast to the well defined mechanism of merocrine exocytosis, the mechanism of apocrine secretion, which was first described over 180 years ago, remains relatively uncharacterized. We identified apocrine secretory activity in the late prepupal salivary glands of Drosophila melanogaster
Björn Heindryckx et al.
Mitochondrion, 18, 12-17 (2014-08-28)
To investigate the applicability of preimplantation genetic diagnosis (PGD), we used trophectoderm (TE) biopsy to determine the mutation load in a 35-year-old female with mitochondrial encephalopathy, lactic acidosis and stroke-like syndrome (MELAS). Transfer of a mutation-free blastocyst gave birth to
19-Hydroxylated E prostaglandins as the major prostaglandins of human semen.
P L Taylor et al.
Nature, 250(5468), 665-667 (1974-08-23)
A Etxebarria et al.
Atherosclerosis, 238(2), 304-312 (2014-12-30)
The LDL receptor (LDLR) is a Class I transmembrane protein critical for the clearance of cholesterol-containing lipoprotein particles. The N-terminal domain of the LDLR harbours the ligand-binding domain consisting of seven cysteine-rich repeats of approximately 40 amino acids each. Mutations
J.A.F.Wickramasinghe and R.S.Shaw
Journal of Biochemistry, 141, 179-179 (1974)
Masaki Edamatsu
Biochemical and biophysical research communications, 453(3), 595-599 (2014-10-07)
Axonemal dynein plays an essential role in ciliary motility, and impaired ciliary motility causes human diseases such as primary ciliary dyskinesia (PCD). The motor domain of axonemal dynein powers ciliary motility and its function is regulated by several accessary proteins
Lauren K Woolley et al.
Vaccine, 32(34), 4333-4341 (2014-06-17)
Pig responses to recombinant subunit vaccines containing fragments of eight multifunctional adhesins of the Mycoplasma hyopneumoniae (Mhp) P97/P102 paralog family formulated with Alhydrogel(®) or Montanide™ Gel01 were compared with a commercial bacterin following experimental challenge. Pigs, vaccinated intramuscularly at 9
Migaku Kawaguchi et al.
Analytical and bioanalytical chemistry, 388(2), 391-398 (2007-03-16)
A novel method, stir-bar-sorptive extraction (SBSE), with in-situ deconjugation and thermal desorption (TD) with in-tube silylation, followed by gas chromatography-mass spectrometry (GC-MS), for determination of trace amounts of 4-nonylphenol glucuronide (NP-G) and 4-tert-octylphenol glucuronide (OP-G) in human urine, is described.
Chad J Roy et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(12), 3782-3787 (2015-03-17)
Ricin toxin (RT) is the second most lethal toxin known; it has been designated by the CDC as a select agent. RT is made by the castor bean plant; an estimated 50,000 tons of RT are produced annually as a
Naeem Khan et al.
Clinical and vaccine immunology : CVI, 22(1), 99-107 (2014-11-21)
The shortcomings of the licensed polysaccharide-based pneumococcal vaccine are driving efforts toward development of a protein-based vaccine that is serotype independent and effective in all age groups. An opsonophagocytic killing assay (OPKA) is used to evaluate the antibody response against
Sabrina Valente et al.
Ultrastructural pathology, 39(2), 88-94 (2014-10-01)
Cells use several mechanisms to transfer information to other cells. In this study, we describe micro/nanotubular connections and exosome-like tubule fragments in multipotent mesenchymal stem cells (MSCs) from human arteries. Scanning and transmission electron microscopy allowed characterization of sinusoidal microtubular
Anna Hjelm et al.
Applied and environmental microbiology, 81(2), 726-735 (2014-11-16)
Bacterial ghosts are empty cell envelopes of Gram-negative bacteria that can be used as vehicles for antigen delivery. Ghosts are generated by releasing the bacterial cytoplasmic contents through a channel in the cell envelope that is created by the controlled
Yuzhen Guo et al.
Lab on a chip, 15(7), 1759-1764 (2015-02-17)
A simple method to fabricate microchannels is demonstrated based on an inkjet printing liquid template. The morphology of the liquid template can be well controlled by using ink with viscosity sensitive to temperature. The as-prepared Y-shape microchannel is used as
Mathilde Couteaudier et al.
Stem cell research, 14(2), 224-237 (2015-02-24)
A common challenge in avian cell biology is the generation of differentiated cell-lines, especially in the keratinocyte lineage. Only a few avian cell-lines are available and very few of them show an interesting differentiation profile. During the last decade, mammalian
Elena Pascual et al.
Journal of virology, 89(5), 2563-2574 (2014-12-19)
Bioengineering of viruses and virus-like particles (VLPs) is a well-established approach in the development of new and improved vaccines against viral and bacterial pathogens. We report here that the capsid of a major avian pathogen, infectious bursal disease virus (IBDV)
Maria Q Gaunsbaek et al.
ORL; journal for oto-rhino-laryngology and its related specialties, 76(5), 288-301 (2014-12-17)
To investigate the presence of surfactant protein (SP) A, B, C and D in nasal airways and to determine whether the proteins exert their main functions in nasal secretions or in the deeper layers of the nasal mucosa. Volunteers were
Clara Sciorati et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(3), 809-822 (2014-12-17)
Muscle regeneration is a hallmark of the idiopathic inflammatory myopathies (IIMs), a group of autoimmune disorders that are characterized by leukocyte infiltration and dysfunction of the skeletal muscle. Despite detailed studies describing the clinical and histopathologic features of IIMs, the
Jia-mou Li et al.
PloS one, 9(9), e106598-e106598 (2014-09-06)
Ossification of the posterior longitudinal ligament of the cervical spine (OPLL) is characterized by the replacement of ligament tissues with ectopic bone formation, and this result is strongly affected by genetic and local factors. Two single nucleotide polymorphisms (SNPs) of
Marcia Shu-Wei Su et al.
Microbiology (Reading, England), 160(Pt 4), 795-806 (2014-02-11)
This study characterized the two-component regulatory systems encoded by bfrKRT and cemAKR, and assessed their influence on biofilm formation by Lactobacillus reuteri 100-23. A method for deletion of multiple genes was employed to disrupt the genetic loci of two-component systems.
U Henriksen
Nucleosides, nucleotides & nucleic acids, 19(7), 1093-1100 (2000-09-22)
N-(1-alkenyl) derivatives of 2,4-pyrimidinediones (6-9) were prepared in a one pot synthesis from aldehydes and the nucleobases using trimethylsilyl trifluoromethanesulfonate (TfOTMS) as coupling reagent. Presilylation of the above nucleobases, and N6-benzoyladenine, with excess N,O-bis(trimethylsilyl)acetamide (BSA) followed by addition of one
Abdelbasset Amara et al.
Iranian journal of public health, 44(3), 396-403 (2015-04-24)
HNF4A-p.I463Vvariant, reported previously in two distinct families suspected of MODY-1, is assessed in this report to determine whether it is a mutation or a polymorphism (frequency >1%). 200 Tunisian healthy people were screened for the presence of HNF4A-p.I463V variant, using
Analysis of the prostaglandins E by glass capillary gas chromatography with electron capture detection.
M Korteweg et al.
Prostaglandins, 13(6), 1221-1223 (1977-06-01)
Gerald B W Wertheim et al.
Clinical chemistry, 61(1), 249-258 (2014-10-29)
Epigenetic dysregulation involving alterations in DNA methylation is a hallmark of various types of cancer, including acute myeloid leukemia (AML). Although specific cancer types and clinical aggressiveness of tumors can be determined by DNA methylation status, the assessment of DNA
Karkkainen and R. Vihko
Carbohydrate Research, 10, 113-113 (1969)
Houben-Weyl Methods of Molecular Transformations. Heteroatom Analogues of Aldehydes and Ketones.
Aggarwal VK
Science of Synthesis Knowledge Updates, 27, 593-594 (2014)
Michael John Robert Previte et al.
Nature communications, 6, 5936-5936 (2015-01-24)
Next-generation sequencing (NGS) has transformed genomic research by decreasing the cost of sequencing. However, whole-genome sequencing is still costly and complex for diagnostics purposes. In the clinical space, targeted sequencing has the advantage of allowing researchers to focus on specific
Doory Kim et al.
PloS one, 10(4), e0124581-e0124581 (2015-04-16)
Correlative fluorescence light microscopy and electron microscopy allows the imaging of spatial distributions of specific biomolecules in the context of cellular ultrastructure. Recent development of super-resolution fluorescence microscopy allows the location of molecules to be determined with nanometer-scale spatial resolution.
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