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Daniel J T Kyle et al.
Biomaterials, 52, 88-102 (2015-03-31)
Reproducing extracellular matrix topographical cues, such as those present within acellular dermal matrix (ADM), in synthetic implant surfaces, may augment cellular responses, independent of surface chemistry. This could lead to enhanced implant integration and performance while reducing complications. In this
Dan Li et al.
PloS one, 10(3), e0118284-e0118284 (2015-03-05)
Mammary gland development is controlled by several genes. Although miRNAs have been implicated in mammary gland function, the mechanism by which miR-486 regulates mammary gland development and lactation remains unclear. We investigated miR-486 expression in cow mammary gland using qRT-PCR
Elin Möllerström et al.
Neurochemical research, 40(2), 336-352 (2014-09-25)
Brain tumors are heterogeneous with respect to genetic and histological properties of cells within the tumor tissue. To study subpopulations of cells, we developed a protocol for obtaining viable single cells from freshly isolated human brain tissue for single cell
Alice Cheng et al.
Biofabrication, 6(4), 045007-045007 (2014-10-08)
Additive manufacturing by laser sintering is able to produce high resolution metal constructs for orthopedic and dental implants. In this study, we used a human trabecular bone template to design and manufacture Ti-6Al-4V constructs with varying porosity via laser sintering.
J.T.Watson and B.J.Sweetman
Org. Mass Spectrom., 9, 39-39 (1974)
Luis J Cruz et al.
Molecular pharmaceutics, 11(12), 4299-4313 (2014-10-08)
Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs), involved in the induction of immunity and currently exploited for antitumor immunotherapies. An optimized noninvasive imaging modality capable of determining and quantifying DC-targeted nanoparticle (NP) trajectories could provide valuable information
Marina Zieger et al.
PloS one, 9(9), e106562-e106562 (2014-09-06)
We aimed to investigate fractalkine (CX3CL1) protein expression in wild type (wt) retina and its alterations during retinal degeneration in mouse model (rd10) of retinitis pigmentosa. Forms of retinal protein CX3CL1, total protein and mRNA levels of CX3CL1 were analyzed
Roland M Huber et al.
Oncotarget, 6(4), 2134-2147 (2015-01-13)
Though metastatic cancers often initially respond to genotoxic therapeutics, acquired resistance is common. In addition to cytotoxic effects on tumor cells, DNA damaging agents such as ionizing radiation and chemotherapy induce injury in benign cells of the tumor microenvironment resulting
Friederike S Rossmann et al.
PLoS pathogens, 11(2), e1004653-e1004653 (2015-02-24)
The microbiome and the phage meta-genome within the human gut are influenced by antibiotic treatments. Identifying a novel mechanism, here we demonstrate that bacteria use the universal communication molecule AI-2 to induce virulence genes and transfer them via phage release.
A novel regioselective desulfation of polysaccharide sulfates: Specific 6-O-desulfation with N,O-bis(trimethylsilyl)acetamide.
M Matsuo et al.
Carbohydrate research, 241, 209-215 (1993-03-17)
Ghazal Fadaeian et al.
Iranian journal of pharmaceutical research : IJPR, 14(2), 395-405 (2015-04-23)
Herein, 1F2, an anti-HER2 monoclonal antibody (mAb), was covalently coupled to the surface of 5-Fluorouracil (5-FU) loaded bovine serum albumin (BSA) nanoparticles. Concerning two different crosslinkers for conjugation of 1F2, Maleimide-poly (ethylene glycol)-Succinimidyl carbonate (Mal-PEG5000-NHS) was selected due to its
Mohammad Saraji et al.
Journal of chromatography. A, 1098(1-2), 30-36 (2005-11-30)
Trace analysis of phenolic compounds in water was performed by coupling single-drop microextraction (SDME) with in-syringe derivatization of the analytes and GC-MS analysis. The analytes were extracted from a 3ml sample solution using 2.5microl of hexyl acetate. After extraction, derivatization
Shweta Pasi et al.
Biomaterials, 42, 121-133 (2014-12-30)
Protein therapeutics targeting inflammatory mediators have shown great promise for the treatment of autoimmunities such as rheumatoid arthritis (RA). However, a significant challenge in this area has been their low in vivo stability and consequently their severely compromised therapeutic efficacy.
Miguel Quintela-Fandino et al.
Molecular oncology, 8(8), 1719-1728 (2014-08-12)
Given our preclinical data showing synergy between dovitinib and paclitaxel in preclinical models we conducted this phase I trial aiming to define the recommended phase II-dose (RP2D) on the basis of toxicity and pharmacodynamic criteria while searching for genetic variants
Cytoxicity and apoptotic mechanism of ruthenium(II) amino acid complexes in sarcoma-180 tumor cells.
Aliny Pereira Lima et al.
PloS one, 9(10), e105865-e105865 (2014-10-21)
Over the past several decades, much attention has been focused on ruthenium complexes in antitumor therapy. Ruthenium is a transition metal that possesses several advantages for rational antitumor drug design and biological applications. In the present study, five ruthenium complexes
Matthew J Fogarty et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 643-647 (2015-01-16)
Motor cortex layer V pyramidal neurons (LVPNs) regulate voluntary control of motor output and selectively degenerate (along with lower motor neurons) in amyotrophic lateral sclerosis. Using dye-filling and whole-cell patch clamping in brain slices, together with high-resolution spinning disk confocal
Houben-Weyl Methods of Molecular Transformations. Heteroatom Analogues of Aldehydes and Ketones.
Aggarwal VK
Science of Synthesis Knowledge Updates, 27, 593-594 (2014)
Michael John Robert Previte et al.
Nature communications, 6, 5936-5936 (2015-01-24)
Next-generation sequencing (NGS) has transformed genomic research by decreasing the cost of sequencing. However, whole-genome sequencing is still costly and complex for diagnostics purposes. In the clinical space, targeted sequencing has the advantage of allowing researchers to focus on specific
Migaku Kawaguchi et al.
Analytical and bioanalytical chemistry, 388(2), 391-398 (2007-03-16)
A novel method, stir-bar-sorptive extraction (SBSE), with in-situ deconjugation and thermal desorption (TD) with in-tube silylation, followed by gas chromatography-mass spectrometry (GC-MS), for determination of trace amounts of 4-nonylphenol glucuronide (NP-G) and 4-tert-octylphenol glucuronide (OP-G) in human urine, is described.
Abdelbasset Amara et al.
Iranian journal of public health, 44(3), 396-403 (2015-04-24)
HNF4A-p.I463Vvariant, reported previously in two distinct families suspected of MODY-1, is assessed in this report to determine whether it is a mutation or a polymorphism (frequency >1%). 200 Tunisian healthy people were screened for the presence of HNF4A-p.I463V variant, using
Lauren K Woolley et al.
Vaccine, 32(34), 4333-4341 (2014-06-17)
Pig responses to recombinant subunit vaccines containing fragments of eight multifunctional adhesins of the Mycoplasma hyopneumoniae (Mhp) P97/P102 paralog family formulated with Alhydrogel(®) or Montanide™ Gel01 were compared with a commercial bacterin following experimental challenge. Pigs, vaccinated intramuscularly at 9
Sheng Shen et al.
Journal of virology, 89(10), 5288-5297 (2015-02-27)
Herpesvirus nascent capsids, after assembly in the nucleus, must acquire a variety of tegument proteins during maturation. However, little is known about the identity of the tegument proteins that are associated with capsids in the nucleus or the molecular mechanisms
Use of bis-trimethylsilylacetamide in the preparation of derivatives for the gas-liquid chromatography of certain adrenocortical steroids.
W J VandenHeuvel et al.
Biochimica et biophysica acta, 144(3), 691-694 (1967-12-05)
Björn Heindryckx et al.
Mitochondrion, 18, 12-17 (2014-08-28)
To investigate the applicability of preimplantation genetic diagnosis (PGD), we used trophectoderm (TE) biopsy to determine the mutation load in a 35-year-old female with mitochondrial encephalopathy, lactic acidosis and stroke-like syndrome (MELAS). Transfer of a mutation-free blastocyst gave birth to
19-Hydroxylated E prostaglandins as the major prostaglandins of human semen.
P L Taylor et al.
Nature, 250(5468), 665-667 (1974-08-23)
Masaki Edamatsu
Biochemical and biophysical research communications, 453(3), 595-599 (2014-10-07)
Axonemal dynein plays an essential role in ciliary motility, and impaired ciliary motility causes human diseases such as primary ciliary dyskinesia (PCD). The motor domain of axonemal dynein powers ciliary motility and its function is regulated by several accessary proteins
J.A.F.Wickramasinghe and R.S.Shaw
Journal of Biochemistry, 141, 179-179 (1974)
A Etxebarria et al.
Atherosclerosis, 238(2), 304-312 (2014-12-30)
The LDL receptor (LDLR) is a Class I transmembrane protein critical for the clearance of cholesterol-containing lipoprotein particles. The N-terminal domain of the LDLR harbours the ligand-binding domain consisting of seven cysteine-rich repeats of approximately 40 amino acids each. Mutations
Jia-mou Li et al.
PloS one, 9(9), e106598-e106598 (2014-09-06)
Ossification of the posterior longitudinal ligament of the cervical spine (OPLL) is characterized by the replacement of ligament tissues with ectopic bone formation, and this result is strongly affected by genetic and local factors. Two single nucleotide polymorphisms (SNPs) of
Marcia Shu-Wei Su et al.
Microbiology (Reading, England), 160(Pt 4), 795-806 (2014-02-11)
This study characterized the two-component regulatory systems encoded by bfrKRT and cemAKR, and assessed their influence on biofilm formation by Lactobacillus reuteri 100-23. A method for deletion of multiple genes was employed to disrupt the genetic loci of two-component systems.
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