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Sang Jin Kim et al.
ChemSusChem, 8(22), 3783-3792 (2015-10-21)
Herein, we report a high performance polymer membrane with simultaneously large improvements in the CO2 permeability and CO2/N2 selectivity. These improvements are obtained by incorporation of a multi-functional amphiphilic comb copolymer micelle, that is, poly(dimethylsiloxane)-g-poly(oxyethylene methacrylate) (PDMS-g-POEM), into a poly(amide-b-ethylene
Yi Zhu et al.
Journal of translational medicine, 12, 309-309 (2014-11-05)
MUC4 plays important roles in the malignant progression of human pancreatic cancer. But the huge length of MUC4 gene fragment restricts its functional and mechanism research. As one of its splice variants, MUC4/Y with coding sequence is most similar to
Norika Chiba et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3840-3851 (2015-03-11)
Mast cells are known as central players in allergy and anaphylaxis, and they play a pivotal role in host defense against certain pathogens. Chlamydia pneumoniae is an important human pathogen, but it is unclear what role mast cells play during
Li Wang et al.
The Journal of biological chemistry, 289(52), 35731-35742 (2014-11-08)
Our previous study demonstrated that the NGX6b gene acts as a suppressor in the invasion and migration of nasopharyngeal carcinoma (NPC). Recently, we identified the novel isoform NGX6a, which is longer than NGX6b. In this study, we first found that
Chang-Ning Liu et al.
Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 116-125 (2014-10-19)
Crizotinib (Xalkori) is a tyrosine kinase inhibitor of both anaplastic lymphoma kinase (ALK) and mesenchymal-epithelial transition factor (c-Met). Though not predicted from standard nonclinical toxicological evaluation, visual disturbance became a frequently observed adverse event in humans. To understand the possible
Hulda R Jonsdottir et al.
Laboratory investigation; a journal of technical methods and pathology, 95(12), 1418-1428 (2015-09-22)
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with high morbidity and mortality. The cellular source of the fibrotic process is currently under debate with one suggested mechanism being epithelial-to-mesenchymal transition (EMT) in the alveolar region. In this
Clemens Tscheka et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 95(Pt A), 151-155 (2015-03-18)
Cylindrical particles offer the opportunity to develop controlled and sustained release systems for the respiratory tract. One reason is that macrophages can phagocyte such particles only from either of the two ends. We investigated the uptake behaviour of murine alveolar
Muzaffar Iqbal et al.
Talanta, 132, 29-36 (2014-12-06)
Canagliflozin is the first sodium-glucose co-transporter-2 inhibitor, approved by the US Food and Drug Administration for the treatment of type 2 diabetes mellitus. In this study, a sensitive UHPLC-MS/MS assay for rapid determination of canagliflozin in rat plasma was developed
Elizabeth Delorme-Axford et al.
mBio, 5(6), e02147-e02147 (2014-12-11)
Enteroviruses require autophagy to facilitate the formation of autophagosome (AP)-like double-membrane vesicles that provide the scaffolding for RNA replication. Here, we identify bactericidal/permeability-increasing protein (BPI) fold-containing family B, member 3 (BPIFB3) as a gene whose silencing greatly enhances coxsackievirus B
Giusy Lofrano et al.
Ecotoxicology and environmental safety, 123, 65-71 (2015-08-11)
Chloramphenicol sodium succinate (CAP, C15H15Cl2N2 Na2O8) is a broad-spectrum antibiotic exhibiting activity against both Gram-positive and Gram-negative bacteria as well as other groups of microorganisms only partially removed by conventional activated sludge wastewater treatment plants. Thus, CAP and its metabolites
Jun Jiang et al.
Drug testing and analysis, 7(4), 309-319 (2014-06-18)
The isomers, although of similarly chemical structures, have different pharmacological activities due to their metabolic processes in vivo. Central-icaritin (c-IT) and icaritin (IT) are isomers and major bioactive aglycones of the Herba Epimedii. In this study, we found that the
Charan Singh et al.
International journal of pharmaceutics, 495(2), 627-632 (2015-09-24)
The aim of the present study was to establish the potential of rifampicin loaded phospholipid lipospheres carrier for pulmonary application. Lipospheres were prepared with rifampicin and phospholipid in the ratio of 1:1 using spray drying method. Further, lipospheres were evaluated
Haibo Wang et al.
Journal of chromatography. A, 1392, 20-27 (2015-03-24)
Lipase is the key enzyme for catalyzing triglyceride hydrolysis in vivo, and lipase inhibitors have been used in the management of obesity. We present the first report on the use of lipase-adsorbed halloysite nanotubes as an efficient medium for the
Caio Maximino et al.
Pharmacology, biochemistry, and behavior, 124, 425-433 (2014-07-16)
Alarm reactions to a substance secreted by the damaged skin of conspecifics and closely-related species are increasingly being recognized as fear-like responses in fish. The neurochemical underpinnings of these effects are so far unknown; however, given the role of the
Steven Pham et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt B, 436-444 (2014-09-10)
Castration resistant prostate cancer (CRPC) is often lethal and inevitably develops after androgen ablation therapy. However, in the majority of cases it remains androgen dependent. CRPC tumors have the ability to synthesize their own androgens from cholesterol by engaging in
Milena R Simic et al.
Archiv der Pharmazie, 348(2), 100-112 (2015-02-11)
Cytoprotective compounds such as amifostine play an important role in chemo- and radiotherapy due to their ability to reduce the side effects of these treatments. Our work was initiated with the intention to design, synthesise and test a new class
Zhoulin Yao et al.
Analytical and bioanalytical chemistry, 407(29), 8849-8859 (2015-09-30)
A novel, sensitive, and efficient enantioselective method for the determination of triadimefon and its metabolite triadimenol in edible vegetable oil, was developed by gel permeation chromatography and ultraperformance convergence chromatography/tandem triple quadrupole mass spectrometry. After the vegetable oil samples were
Cheng-Shi Xu et al.
Journal of translational medicine, 12, 148-148 (2014-06-03)
Anti-angiogenic therapy inhibits tumor growth and is considered as a potential clinical therapy for malignant glioma. However, inevitable recurrences and unexpected tumor resistance, particularly increased invasion ability of glioma cell, were observed after anti-angiogenic treatment. The underlying mechanism remains undetermined.
Giacomo Gianotti et al.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 78(3), 207-213 (2014-07-02)
The objective of this study was to determine if prior measurement of the minimum alveolar concentration (MAC) of isoflurane influences the effect of ketamine on the MAC of isoflurane in dogs. Eight mixed-breed dogs were studied on 2 occasions. Anesthesia
Kristin Derlig et al.
Cell and tissue research, 362(2), 281-294 (2015-05-28)
Chromatin organization and the management of transcription and splicing are fundamental to the correct functioning of every cell but, in particular, for highly active cells such as photoreceptors, the sensory neurons of the retina. Rod photoreceptor cells of nocturnal animals
Kate L Lee et al.
Endocrinology, 156(3), 1194-1199 (2014-12-30)
The search for an islet β-cell growth factor has been a key objective in recent diabetes research, because the ability to regenerate and/or protect the functioning β-cell population in patients could result in a great advancement for diabetes treatment. IGF-I
J Justin Milner et al.
PloS one, 9(5), e97238-e97238 (2014-05-23)
Obese individuals are at greater risk for death from influenza virus infection. Paralleling human evidence, obese mice are also more susceptible to influenza infection mortality. However, the underlying mechanisms driving greater influenza severity in the obese remain unclear. Metabolic profiling
Linlin Zhao et al.
Evidence-based complementary and alternative medicine : eCAM, 2014, 385102-385102 (2014-08-21)
A metabonomics approach based on liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS) was utilized to obtain potential biomarkers of coronary heart disease (CHD) patients and investigate the ZHENG types differentiation in CHD patients. The plasma samples of 20 CHD patients with
Angela M A Anthony Jalin et al.
Biomolecules & therapeutics, 23(6), 531-538 (2015-11-05)
Preceding infection or inflammation such as bacterial meningitis has been associated with poor outcomes after stroke. Previously, we reported that intracorpus callosum microinjection of lipopolysaccharides (LPS) strongly accelerated the ischemia/reperfusion-evoked brain tissue damage via recruiting inflammatory cells into the ischemic
Alexander Hellqvist et al.
Biomedical chromatography : BMC, 29(4), 504-513 (2014-08-12)
Renal function can be monitored by estimation of the glomerular filtration rate (GFR), for example, through measurement of the plasma clearance of a marker that is freely filtrated through the kidney without reabsorption. It has been proposed that iohexol is
Lilac Amirav et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(2), 353-359 (2014-11-29)
A spray-based technique, originally developed for the production of semiconductor nanocrystals, is utilized for the preparation of high-quality nanocrystalline thin films, as demonstrated with manganese sulfide. The films are formed by the use of pneumatic-assisted thermospray or pneumatic nebulizers. Our
José Robles-Molina et al.
Journal of chromatography. A, 1350, 30-43 (2014-06-04)
This article describes the development and validation of a liquid chromatography high-resolution mass spectrometry method for the simultaneous determination of over 400 multi-class priority and emerging pollutants with different physicochemical properties in environmental waters (surface water and wastewater). The proposed
Handan Uysal et al.
Toxicology and industrial health, 31(1), 44-51 (2012-12-12)
In this study, potential genotoxic effects of ethyl methanesulfonate (EMS) that caused mutagenicity in a variety of organisms were tried to resolve by the methanol and chloroform extract of Echium amoenum (EAmet and EAchl) Fisch. & C.A. Mey. from the
Xiao-Hong Wang et al.
Pediatric research, 76(4), 347-354 (2014-07-17)
Bronchopulmonary dysplasia (BPD) is a multifactor chronic lung disease that mainly affects premature infants. In this study, we investigate the preventive effects of Astragalus polysaccharides (APS) on BPD, and explore its potential molecular mechanisms. Lung tissues of newborn Sprague-Dawley rats
Emilie Degagné et al.
The Journal of clinical investigation, 124(12), 5368-5384 (2014-10-28)
Growing evidence supports a link between inflammation and cancer; however, mediators of the transition between inflammation and carcinogenesis remain incompletely understood. Sphingosine-1-phosphate (S1P) lyase (SPL) irreversibly degrades the bioactive sphingolipid S1P and is highly expressed in enterocytes but downregulated in
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