CN
Search Within
15523
应用筛选条件
关键词:'15523'
显示 1-30 共 1986 条结果 关于 "15523" 范围 论文
L Carim et al.
Cytogenetics and cell genetics, 88(3-4), 330-332 (2000-06-01)
We have isolated C15orf3, a novel human gene that lacks homology to any known gene family. The C15orf3 gene encodes a transcript of 1676 nt with an ORF of 187 amino acids and a predicted protein product size of 20.8
Matthias B Stope et al.
Oncology reports, 32(6), 2380-2386 (2014-09-19)
Drug resistance minimizes the effects of prostate cancer (PC) chemotherapy with docetaxel and is generally considered to be associated with the expression of heat shock protein (HSP) 27 including various cytoprotective pathways. In the present study, we investigated the effects
J Y Huh et al.
International journal of obesity (2005), 38(12), 1538-1544 (2014-03-13)
Irisin is a recently identified exercise-induced myokine suggested to induce browning of white adipocytes. Deficiency of myostatin, and thus stimulation of muscle growth, has also been reported to induce irisin and its precursor FNDC5 expression in muscle and drive the
Johanna Bertrand et al.
European journal of pharmacology, 765, 337-345 (2015-08-13)
TRPC6 plays important human physiological functions, notably in artery and arterioles constriction, in regulation of vascular volume and in bronchial muscle constriction. It is implicated in pulmonary hypertension, cardiovascular disease, and focal segmental glomerulosclerosis and seems to play a role
Hong-Bo Wang et al.
Nature communications, 6, 6240-6240 (2015-02-12)
Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein for infection of both
Jinjin Wu et al.
Environmental research, 138, 67-73 (2015-02-24)
Silver nanoparticles (Ag-NPs) are among the most commonly used nanomaterials and may be exposed to human and ecosystem. Prior in vitro study showed that Ag-NPs compromised neurodevelopment of PC12 cells. This study aims to investigate the effect of prenatal exposure
Jennifer C Bailey et al.
Immunology, 143(4), 679-691 (2014-07-06)
CD1d-mediated lipid antigen presentation activates a subset of innate immune lymphocytes called invariant natural killer T (NKT) cells that, by virtue of their potent cytokine production, bridge the innate and adaptive immune systems. Transforming growth factor (TGF-β) is a known
Myrna Virreira et al.
The international journal of biochemistry & cell biology, 43(1), 10-13 (2010-11-09)
Pancreatic β-cells originate from gut endoderm during development. Pancreatic endocrine cells represent about 10% of the mature pancreatic cells, and β-cells represent the majority of endocrine cells. β-cells secrete insulin in response to elevation of nutrient concentrations. Insulin maintains glucose
K O Tokarchuk et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 25-31 (2013-05-30)
We investigated the changes in the forms of plasma iron and participation of aldehydes in the development of oxidative stress under glycerol-induced rhabdomyolysis in rats. Rhabdomyolysis was caused by intramuscular injection of 50% glycerol in the dose 10 ml/kg. We
Young-Chan Kim et al.
Nature communications, 6, 8520-8520 (2015-10-16)
The primary functions of the proteasome are driven by a highly allosteric ATPase complex. ATP binding to only two subunits in this hexameric complex triggers substrate binding, ATPase-20S association and 20S gate opening. However, it is unclear how ATP binding
Moonhee Lee et al.
Neurobiology of aging, 36(1), 42-52 (2014-08-30)
Neuroinflammation is hypothesized to be a major driving force behind Alzheimer's disease (AD) pathogenesis. This hypothesis predicts that activated microglial cells can stimulate neurons to produce excessive amounts of β-amyloid protein (Aβ₁₋₄₂) and tau. The excess Aβ₁₋₄₂ forms extracellular deposits
Brandon S Brown et al.
Cancer biology & therapy, 15(7), 851-861 (2014-04-24)
Systemic chemotherapeutics remain the standard of care for most malignancies even though they frequently suffer from narrow therapeutic index, poor serum solubility, and off-target effects. In this study, we have encapsulated etoposide, a topoisomerase inhibitor effective against a wide range
Diana F Lázaro et al.
PLoS genetics, 10(11), e1004741-e1004741 (2014-11-14)
Aggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. Furthermore, mutations in the gene encoding for ASYN are associated with familial and sporadic forms of PD, suggesting
David W Greening et al.
Oncotarget, 6(35), 38166-38180 (2015-10-31)
Angiogenesis and epidermal growth factor receptor (EGFR) inhibition has been shown to have anti-tumour efficacy, and enhance the therapeutic effects of cytotoxic chemotherapy in metastatic colorectal cancer. The interplay of signalling alterations and changes in metabolism and hypoxia in tumours
Nguyen H Tran et al.
Chemical Society reviews, 42(24), 9454-9479 (2013-09-18)
Presently there is a glut of glycerol as the by-product of biofuel production and it will grow as production increases. The conundrum is how we can consume this material and convert it into a more useful product. One potential route
Wen Qin et al.
Chembiochem : a European journal of chemical biology, 15(18), 2747-2753 (2014-10-30)
Macrolactins (MLNs) have unique structural patterns containing a 24-membered ring lactone and diverse bioactivities. The MLN skeleton is biosynthesized via a trans-acyl transferase (AT) type I polyketide synthase (PKS) pathway, but the tailoring steps are still unknown. Herein, we report
Shweta Mishra et al.
PloS one, 10(1), e0116611-e0116611 (2015-01-31)
New Delhi metallo β-lactamases are one of the most significant emerging resistance determinants towards carbapenem drugs. Their persistence and adaptability often depends on their genetic environment and linkage. This study reports a unique and novel arrangement of blaNDM-1 gene within
Trung Thanh Thach et al.
Biochemistry, 54(12), 2136-2148 (2015-03-11)
Rad18 is a key factor in double-strand break DNA damage response (DDR) pathways via its association with K63-linked polyubiquitylated chromatin proteins through its bipartite ubiquitin-binding domains UBZ and LRM with extra residues between them. Rad18 binds K63-linked polyubiquitin chains as
Patrick Osei-Owusu et al.
Infection and immunity, 83(4), 1507-1522 (2015-02-04)
The type III secretion system is employed by many pathogens, including the genera Yersinia, Shigella, Pseudomonas, and Salmonella, to deliver effector proteins into eukaryotic cells. The injectisome needle is formed by the polymerization of a single protein, e.g., YscF (Yersinia
Laura J Kingsley et al.
Pharmaceutical research, 32(3), 986-1001 (2014-09-12)
Predicting atoms in a potential drug compound that are susceptible to oxidation by cytochrome P450 (CYP) enzymes is of great interest to the pharmaceutical community. We aimed to develop a computational approach combining ligand- and structure-based design principles to accurately
Peter Draxler et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 12015-12028 (2014-09-05)
Sensory nerve fibers differ not only with respect to their sensory modalities and conduction velocities, but also in their relative roles for pain hypersensitivity. It is presently largely unknown which types of sensory afferents contribute to various forms of neuropathic
Yunhui Peng et al.
International journal of molecular sciences, 16(11), 27270-27287 (2015-11-19)
Mutations in KDM5C gene are linked to X-linked mental retardation, the syndromic Claes-Jensen-type disease. This study focuses on non-synonymous mutations in the KDM5C ARID domain and evaluates the effects of two disease-associated missense mutations (A77T and D87G) and three not-yet-classified
Vineela Chukkapalli et al.
Virology, 476, 168-179 (2014-12-30)
Combinations of direct-acting antivirals (DAAs) against the hepatitis C virus (HCV) have the potential to revolutionize the HCV therapeutic regime. An integral component of DAA combination therapies is HCV NS5A inhibitors. It has previously been proposed that NS5A DAAs inhibit
Jinbo Liu et al.
Biochemical and biophysical research communications, 467(2), 197-203 (2015-10-11)
Mitochondrial dysfunction is a direct target of hypoxic/ischemic stress in astrocytes, which results in the increased production of reactive oxygen species (ROS). Previous reports showed that ROS can activate NF-kB in spinal cord astrocytes, which occurs as a secondary injury
Urea cycle disorder drug approved.
Malini Guha
Nature biotechnology, 31(4), 274-274 (2013-04-09)
Eytan R Barnea et al.
PloS one, 9(7), e100263-e100263 (2014-07-02)
Endogenous PIF, upon which embryo development is dependent, is secreted only by viable mammalian embryos, and absent in non-viable ones. Synthetic PIF (sPIF) administration promotes singly cultured embryos development and protects against their demise caused by embryo-toxic serum. To identify
Cayo Almeida et al.
Pain, 156(3), 504-513 (2015-02-18)
Treatment of neuropathic pain is a clinical challenge likely because of the time-dependent changes in many neurotransmitter systems, growth factors, ionic channels, membrane receptors, transcription factors, and recruitment of different cell types. Conversely, an increasing number of reports have shown
Volodymyr Petrenko et al.
Experimental neurology, 273, 126-137 (2015-08-21)
Apoptotic cell death is the leading cause of neuronal loss after neonatal brain injury. Little is known about the intrinsic capacity of the immature cerebral cortex for replacing dead cells. Here we test the hypothesis that neuronal apoptosis is able
Sang Youn Hwang et al.
International journal of molecular sciences, 16(2), 3323-3334 (2015-02-06)
Chronic intermittent hypoxia, a characteristic of obstructive sleep apnea (OSA), is associated with the progression of simple hepatic steatosis to necroinflammatory hepatitis. We determined whether inhibition of a hypoxia-induced signaling pathway could attenuate hypoxia-exacerbated lipoapoptosis in human hepatocytes. The human
Sylvie Maubant et al.
PloS one, 10(4), e0122333-e0122333 (2015-04-08)
The canonical Wnt/β-catenin pathway is activated in triple-negative breast cancer (TNBC). The activation of this pathway leads to the expression of specific target genes depending on the cell/tissue context. Here, we analyzed the transcriptome of two different TNBC cell lines
1/67