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L Carim et al.
Cytogenetics and cell genetics, 88(3-4), 330-332 (2000-06-01)
We have isolated C15orf3, a novel human gene that lacks homology to any known gene family. The C15orf3 gene encodes a transcript of 1676 nt with an ORF of 187 amino acids and a predicted protein product size of 20.8
Annika B M Åstrand et al.
American journal of physiology. Lung cellular and molecular physiology, 308(1), L22-L32 (2014-11-02)
Airway dehydration causes mucus stasis and bacterial overgrowth in cystic fibrosis and chronic bronchitis (CB). Rehydration by hypertonic saline is efficacious but suffers from a short duration of action. We tested whether epithelial sodium channel (ENaC) inhibition would rehydrate normal
Simon Piet van Rosendal et al.
Sports medicine (Auckland, N.Z.), 40(2), 113-129 (2010-01-23)
Dehydration in athletes alters cardiovascular and thermoregulatory function and may inhibit endurance exercise capacity if fluid loss exceeds 2% of bodyweight (BW). If this level of dehydration cannot be prevented when starting from a state of euhydration, then athletes may
Han-Jun Wang et al.
American journal of physiology. Heart and circulatory physiology, 308(5), H447-H455 (2014-12-17)
Excitatory amino acids (e.g., glutamate) released by contraction-activated skeletal muscle afferents into the dorsal horn of the spinal cord initiate the central component of the exercise pressor reflex (EPR) in physiological conditions. However, the role of glutamate and glutamate receptors
Anja K K Rahn et al.
Food chemistry, 166, 301-308 (2014-07-24)
Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indicated that the reaction mixture should contain an amino acid and it should
César Pedroza-Roldán et al.
Folia microbiologica, 60(1), 21-31 (2014-07-21)
All organisms have the capacity to sense and respond to environmental changes. These signals often involve the use of second messengers such as cyclic adenosine monophosphate (cAMP). This second messenger is widely distributed among organisms and coordinates gene expression related
Janet K Horton et al.
Radiation research, 184(5), 456-469 (2015-10-22)
Although a standardized approach to radiotherapy has been used to treat breast cancer, regardless of subtype (e.g., luminal, basal), recent clinical data suggest that radiation response may vary significantly among subtypes. We hypothesized that this clinical variability may be due
Myrna Virreira et al.
The international journal of biochemistry & cell biology, 43(1), 10-13 (2010-11-09)
Pancreatic β-cells originate from gut endoderm during development. Pancreatic endocrine cells represent about 10% of the mature pancreatic cells, and β-cells represent the majority of endocrine cells. β-cells secrete insulin in response to elevation of nutrient concentrations. Insulin maintains glucose
J Y Huh et al.
International journal of obesity (2005), 38(12), 1538-1544 (2014-03-13)
Irisin is a recently identified exercise-induced myokine suggested to induce browning of white adipocytes. Deficiency of myostatin, and thus stimulation of muscle growth, has also been reported to induce irisin and its precursor FNDC5 expression in muscle and drive the
Kenta Masuda et al.
PloS one, 10(2), e0118662-e0118662 (2015-02-28)
In budding yeast, the Mitotic Exit Network (MEN) regulates anaphase promoting complex/cyclosome (APC/C) via the Dbf2-Cdc14 signaling cascade. Dbf2 kinase phosphorylates and activates Cdc14 phosphatase, which removes the inhibitory phosphorylation of the APC/C cofactor Cdh1. Although each component of the
Jennifer C Bailey et al.
Immunology, 143(4), 679-691 (2014-07-06)
CD1d-mediated lipid antigen presentation activates a subset of innate immune lymphocytes called invariant natural killer T (NKT) cells that, by virtue of their potent cytokine production, bridge the innate and adaptive immune systems. Transforming growth factor (TGF-β) is a known
C Yilmaz et al.
Acta physiologica (Oxford, England), 213(4), 933-946 (2014-11-05)
Obese diabetic (ZDF fa/fa) rats with genetic leptin resistance suffer chronic lipotoxicity associated with age-related lung restriction and abnormal alveolar ultrastructure. We hypothesized that these abnormalities impair adaptation to ambient hypoxia. Male fa/fa and lean (+/+) ZDF rats (4-months old)
Laura J Kingsley et al.
Pharmaceutical research, 32(3), 986-1001 (2014-09-12)
Predicting atoms in a potential drug compound that are susceptible to oxidation by cytochrome P450 (CYP) enzymes is of great interest to the pharmaceutical community. We aimed to develop a computational approach combining ligand- and structure-based design principles to accurately
Sofia I A Pereira et al.
Journal of basic microbiology, 55(10), 1179-1190 (2015-06-11)
This study aimed at the isolation and characterization of metal(loid)-tolerant bacteria from the rhizosphere of Phragmites australis and Juncus effusus plants growing in two long-term contaminated sites in Northern Portugal. Site 1 had higher contamination than Site 3. Bacteria were
Hongxia Chen et al.
BMC cancer, 15, 103-103 (2015-04-18)
Lymphangiogenesis plays a significant role in metastasis and recurrence of gastric cancer. There is no report yet focusing on the modulation of VEGF pathway and lymphangiogenesis of gastric cancer by targeting Akt/mTOR pathway. This study aims to demonstrate the relationship
Ryuichiro Sekiya et al.
Carcinogenesis, 35(9), 1993-2001 (2014-03-29)
Pleomorphic adenoma gene like-2 (PLAGL2), a member of the PLAG gene family, is a C2H2 zinc finger transcriptional factor that is involved in cellular transformation and apoptosis. In this report, we show that PLAGL2 is associated with the organization of
B C Sweatman et al.
Journal of pharmaceutical and biomedical analysis, 11(8), 651-664 (1993-08-01)
Extensive assignments of resonances in the 600 MHz 1H-NMR spectra of cerebrospinal fluid are reported. These have been achieved by the measurement of a combination of two-dimensional experiments comprising homonuclear J-resolved, COSY45, and double-quantum filtered COSY (DQCOSY) spectra. By these
Suniti Misra et al.
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 23(8), 3836-3851 (2014-07-12)
Inflammatory pathway plays an important role in tumor cell progression of colorectal cancers. Although colon cancer is considered as one of the leading causes of death worldwide, very few drugs are available for its effective treatment. Many studies have examined
Chris J Malajczuk et al.
Biochimica et biophysica acta, 1828(9), 2041-2055 (2013-05-28)
Molecular dynamics (MD) simulations have been used to investigate the interactions of a variety of hydroxylated cryosolvents (glycerol, propylene glycol and ethylene glycol), methanol and dimethyl sulfoxide (DMSO) in aqueous solution with a 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) bilayer in its fluid phase
Jahwarhar Izuan Abd Rashid et al.
Pakistan journal of biological sciences : PJBS, 16(18), 933-938 (2014-02-08)
Microbial mannanases have become biotechnologically important in industry but their application is limited due to high production cost. In presents study, the extraction of mannanase from fermented Palm Kernel Cake (PKC) in the Solid State Fermentation (SSF) was optimized. Local
K J Yi et al.
Journal of neuroendocrinology, 27(5), 335-342 (2015-02-24)
Although it has been reported that oxytocin stimulates lipolysis in adipocytes, changes in the expression of oxytocin receptor (OTR) mRNA in adipogenesis are still unknown. The present study aimed to investigate the expression of OTR mRNA during adipocyte differentiation and
Iman Chouikha et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(52), 18709-18714 (2014-12-03)
The arthropod-borne transmission route of Yersinia pestis, the bacterial agent of plague, is a recent evolutionary adaptation. Yersinia pseudotuberculosis, the closely related food-and water-borne enteric species from which Y. pestis diverged less than 6,400 y ago, exhibits significant oral toxicity
Vinko Besic et al.
PloS one, 10(3), e0119270-e0119270 (2015-03-06)
Type 2 diabetes mellitus (T2DM) results from a combination of progressive insulin resistance and loss of pancreatic beta cell function and/or mass. Insulin signalling occurs through the insulin receptor, (INSR) which is alternatively spliced into two isoforms: INSRA (-exon 11)
Kyung-Hyo Kim et al.
Journal of Korean medical science, 30(2), 145-150 (2015-02-06)
Differentiated HL-60 is an effector cell widely used for the opsonophagocytic-killing assay (OPKA) to measure efficacy of pneumococcal vaccines. We investigated the correlation between phenotypic expression of immunoreceptors and phagocytic ability of HL-60 cells differentiated with N,N-dimethylformamide (DMF), all-trans retinoic
Konrad Kowalski et al.
Chembiochem : a European journal of chemical biology, 16(3), 424-431 (2015-01-16)
Two complementary methods, "in solution" and "in solid state", for the synthesis of lysozyme modified with metallacarborane (cobalt bis(dicarbollide), Co(C2 B9 H11 )2 (2-) ) were developed. As metallacarborane donors, oxonium adducts of cobalt bis(dicarbollide) and 1,4-dioxane or tetrahydropyran were
Frank Cichocki et al.
The Journal of experimental medicine, 211(6), 1079-1091 (2014-05-21)
Autosomal recessive mutations in UNC13D, the gene that encodes Munc13-4, are associated with familial hemophagocytic lymphohistiocytosis type 3 (FHL3). Munc13-4 expression is obligatory for exocytosis of lytic granules, facilitating cytotoxicity by T cells and natural killer (NK) cells. The mechanisms
Joanna L Workman et al.
Hippocampus, 25(3), 329-344 (2014-10-02)
Chronic stress or chronically high glucocorticoids attenuate adult hippocampal neurogenesis by reducing cell proliferation, survival, and differentiation in male rodents. Neurons are still produced in the dentate gyrus during chronically high glucocorticoids, but it is not known whether these new
Milena Georgieva et al.
The international journal of biochemistry & cell biology, 59, 182-192 (2014-12-30)
Chromatin structure promotes important epigenetic mechanisms that regulate cellular fate by organizing, preserving and controlling the way by which the genetic information works. Our understanding of chromatin and its functions is sparse and not yet well defined. The uncertainty comes
Peng Yi et al.
Molecular biology of the cell, 26(1), 29-42 (2014-11-08)
The Cdo-p38MAPK (p38 mitogen-activated protein kinase) signaling pathway plays important roles in regulating skeletal myogenesis. During myogenic differentiation, the cell surface receptor Cdo bridges scaffold proteins BNIP-2 and JLP and activates p38MAPK, but the spatial-temporal regulation of this process is
Cheng-Yen Kao et al.
Helicobacter, 19(6), 443-454 (2014-08-12)
Motility mediated by the flagella of Helicobacter pylori has been shown to be required for normal colonization and is thought to be important for the bacteria to move toward the gastric mucus in niches adjacent to the epithelium. Barnard et
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