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Samuel Ellis et al.
Experimental parasitology, 150, 7-12 (2015-01-18)
Only a few drugs are available for treating sleeping sickness and nagana disease; parasitic infections caused by protozoans of the genus Trypanosoma in sub-Saharan Africa. There is an urgent need for the development of new medicines for chemotherapy of these
Katherine M Aird et al.
Cell cycle (Georgetown, Tex.), 13(2), 199-207 (2013-11-10)
Epithelial ovarian cancer (EOC) is the leading cause of gynecological-related cancer deaths in the United States. There is, therefore, an urgent need to develop novel therapeutic strategies for this devastating disease. Cellular senescence is a state of stable cell growth
Lina S Schneider et al.
Cancer research, 75(14), 2863-2874 (2015-05-29)
Generalized strategies to improve breast cancer treatment remain of interest to develop. In this study, we offer preclinical evidence of an important metabolic mechanism underlying the antitumor activity of inhibitors of the vacuolar-type ATPase (V-ATPase), a heteromultimeric proton pump. Specifically
T Novinson et al.
Journal of medicinal chemistry, 18(5), 460-464 (1975-05-01)
A number of 3-bromo-, 3-nitro-, and 3-ethoxycarbonyl-5,7-dialkylpyrazolo[1,5-a]pyrimidines were synthesized and screened as in vitro cAMP phosphodiesterase inhibitors. The condensation of 3-aminopyrazole with symmetrical beta-diketones (acetylacetone, heptane-3,5-dione, etc.) afforded symmetrical dialkylpyrazolo[1,5-a]pyrimidines (5). The reaction of 3-aminopyrazole with unsymmetrical beta-diketones (hexane-2,4-dione, heptane-3,5-dione
Tetrahedron Letters, 47, 2611-2611 (2006)
Trends Heterocycl. Chem., 2, 97-97 (1991)
Ahmed Diab et al.
Molecular cancer research : MCR, 17(5), 1115-1128 (2019-01-27)
The p53 gene is the most commonly mutated gene in solid tumors, but leveraging p53 status in therapy remains a challenge. Previously, we determined that p53 deficiency sensitizes head and neck cancer cells to AZD1775, a WEE1 kinase inhibitor, and
The interaction of ferrocenoyl peptides with 3-aminopyrazole.
Saweczko P and Kraatz H-B.
Coordination Chemistry Reviews, 190, 185-198 (1999)
Synthesis and structure of some 3, 4-annelated coumarin systems.
Govori S, et al.
Heterocyclic Communications, 8(2), 129-134 (2002)
C S Lambert et al.
Behavioural brain research, 291, 342-350 (2015-06-07)
Studies have demonstrated that administration of the neuronal nicotinic receptor agonist varenicline to rats with olivocerebellar lesions attenuates balance deficits on a rotorod and balance beam, but the effects of this drug on gait deficits have not been investigated. To
Guoxin Hu et al.
Journal of ethnopharmacology, 163, 94-98 (2015-02-01)
The in vivo effects of traditional herbal medicines are generally mediated by multiple bioactive components. The main constituents of Lotus Plumule are alkaloids such as liensinine, isoliensinine and neferine. In this study, a simple, sensitive, and robust analytical method based
Erika Plazas et al.
Pharmacological research, 177, 106126-106126 (2022-02-14)
Complex diseases such as neurodegenerative disorders and cancer constitute a growing public health problem due to the rising incidence and lack in effective therapies. Since pharmacotherapy based on a single target has been insufficient for drug development in complex diseases
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