160644

应用筛选条件

关键词:'160644'

显示 1-11 共 11 条结果关于 "160644" 范围论文

Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer.

Katherine M Aird et al.

Cell cycle (Georgetown, Tex.), 13(2), 199-207 (2013-11-10)

Epithelial ovarian cancer (EOC) is the leading cause of gynecological-related cancer deaths in the United States. There is, therefore, an urgent need to develop novel therapeutic strategies for this devastating disease. Cellular senescence is a state of stable cell growth

Trypanotoxic activity of thiosemicarbazone iron chelators.

Samuel Ellis et al.

Experimental parasitology, 150, 7-12 (2015-01-18)

Only a few drugs are available for treating sleeping sickness and nagana disease; parasitic infections caused by protozoans of the genus Trypanosoma in sub-Saharan Africa. There is an urgent need for the development of new medicines for chemotherapy of these

Adenosine cyclic 3',5',-monophosphate phosphodiesterasr inhibitors. 2.3-Substituted 5,7-dialkylpyrazolo [1,5-a]pyrimidines.

T Novinson et al.

Journal of medicinal chemistry, 18(5), 460-464 (1975-05-01)

A number of 3-bromo-, 3-nitro-, and 3-ethoxycarbonyl-5,7-dialkylpyrazolo[1,5-a]pyrimidines were synthesized and screened as in vitro cAMP phosphodiesterase inhibitors. The condensation of 3-aminopyrazole with symmetrical beta-diketones (acetylacetone, heptane-3,5-dione, etc.) afforded symmetrical dialkylpyrazolo[1,5-a]pyrimidines (5). The reaction of 3-aminopyrazole with unsymmetrical beta-diketones (hexane-2,4-dione, heptane-3,5-dione

Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer.

Lina S Schneider et al.

Cancer research, 75(14), 2863-2874 (2015-05-29)

Generalized strategies to improve breast cancer treatment remain of interest to develop. In this study, we offer preclinical evidence of an important metabolic mechanism underlying the antitumor activity of inhibitors of the vacuolar-type ATPase (V-ATPase), a heteromultimeric proton pump. Specifically

Trends Heterocycl. Chem., 2, 97-97 (1991)

Tetrahedron Letters, 47, 2611-2611 (2006)

The interaction of ferrocenoyl peptides with 3-aminopyrazole.

Saweczko P and Kraatz H-B.

Coordination Chemistry Reviews, 190, 185-198 (1999)

Multiple Defects Sensitize p53-Deficient Head and Neck Cancer Cells to the WEE1 Kinase Inhibition.

Ahmed Diab et al.

Molecular cancer research : MCR, 17(5), 1115-1128 (2019-01-27)

The p53 gene is the most commonly mutated gene in solid tumors, but leveraging p53 status in therapy remains a challenge. Previously, we determined that p53 deficiency sensitizes head and neck cancer cells to AZD1775, a WEE1 kinase inhibitor, and

Analysis of gait in rats with olivocerebellar lesions and ability of the nicotinic acetylcholine receptor agonist varenicline to attenuate impairments.

C S Lambert et al.

Behavioural brain research, 291, 342-350 (2015-06-07)

Studies have demonstrated that administration of the neuronal nicotinic receptor agonist varenicline to rats with olivocerebellar lesions attenuates balance deficits on a rotorod and balance beam, but the effects of this drug on gait deficits have not been investigated. To

Synthesis and structure of some 3, 4-annelated coumarin systems.

Govori S, et al.

Heterocyclic Communications, 8(2), 129-134 (2002)

Simultaneous determination of liensinine, isoliensinine and neferine in rat plasma by UPLC-MS/MS and application of the technique to pharmacokinetic studies.

Guoxin Hu et al.

Journal of ethnopharmacology, 163, 94-98 (2015-02-01)

The in vivo effects of traditional herbal medicines are generally mediated by multiple bioactive components. The main constituents of Lotus Plumule are alkaloids such as liensinine, isoliensinine and neferine. In this study, a simple, sensitive, and robust analytical method based

1/1