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Spyridon Katsanos et al.
Orthopedics, 40(3), e417-e424 (2017-01-12)
This prospective study included 152 elderly patients (mean age, 80 years; range, 72-88 years) with a hip fracture treated surgically. Comorbidities were evaluated, and B-type natriuretic peptide was measured at baseline and at postoperative days 4 and 5 in addition
Jais R Bjelke et al.
The Journal of biological chemistry, 283(38), 25863-25870 (2008-07-22)
The intrinsic activity of coagulation factor VIIa (FVIIa) is dependent on Ca(2+) binding to a loop (residues 210-220) in the protease domain. Structural analysis revealed that Ca(2+) may enhance the activity by attenuating electrostatic repulsion of Glu(296) and/or by facilitating
David S Rosero et al.
The British journal of nutrition, 114(12), 1985-1992 (2015-10-07)
The objective of this study was to investigate the effect of increasing degrees of lipid peroxidation on structure and function of the small intestine of nursery pigs. A total of 216 pigs (mean body weight was 6·5 kg) were randomly
Walter Bonfig et al.
The Journal of pediatrics, 198, 260-264 (2018-04-17)
To analyze first-year treatment growth response and growth hormone (GH) dosage in prepubertal patients with the combination of type 1 diabetes mellitus (T1DM) and growth hormone deficiency (GHD). A total of 69 patients with T1DM and GHD treated with GH
Techawaree Ueatrongchit et al.
Bioscience, biotechnology, and biochemistry, 72(6), 1513-1522 (2008-06-10)
A hydroxynitrile lyase was isolated and purified to homogeneity from seeds of Eriobotrya japonica (loquat). The final yield, of 36% with 49-fold purification, was obtained by 30-80% (NH(4))(2)SO(4) fractionation and column chromatography on DEAE-Toyopearl and Concanavalin A Sepharose 4B, which
O A Mojiminiyi et al.
Diabetic medicine : a journal of the British Diabetic Association, 23(8), 839-844 (2006-08-17)
Low plasma erythropoietin (EPO) is a key causal factor in the anaemia of diabetic patients. The aim of this study was to investigate the prevalence of anaemia in relation to EPO in patients with Type 2 diabetes. In a clinic-based
Hagen S Bachmann et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 13(19), 5790-5797 (2007-10-03)
Expression of the antiapoptotic and antiproliferative protein Bcl-2 has been repeatedly shown to be associated with better clinical outcome in breast cancer. We recently showed a novel regulatory (-938C>A) single-nucleotide polymorphism (SNP) in the inhibitory P2 BCL2 gene promoter generating
B Attali et al.
The Journal of biological chemistry, 267(12), 8650-8657 (1992-04-25)
Low stringency screening of a Jurkat cDNA library with a rat brain K+ channel (RCK1) probe has resulted in the isolation of HLK3, a voltage-gated K+ channel. In Xenopus oocytes, the HLK3 clone directs the expression of a rapidly activating
Paul D DiMusto et al.
American journal of physiology. Heart and circulatory physiology, 302(7), H1378-H1386 (2012-02-07)
The serine proteases, along with their inhibitor plasmin activator inhibitor-1 (PAI-1), have been shown to play a role in abdominal aortic aneurysm (AAA) formation. The aim of this study is to determine if PAI-1 may be a protective factor for
Genetic polymorphism of cytochrome P450 2C19 in Mexican Americans: a cross-ethnic comparative study.
Huai-Rong Luo et al.
Clinical pharmacology and therapeutics, 80(1), 33-40 (2006-07-04)
Our objectives were to investigate cytochrome P450 (CYP) 2C19 polymorphism in Mexican Americans and compare the findings with those in 4 other ethnic groups. The CYP2C19 genotype (n = 346) and S-mephenytoin hydroxylation phenotype (n = 220) were studied in
Anthony J White et al.
Cardiovascular research, 75(4), 813-820 (2007-06-05)
Matrix metalloproteinases (MMPs) are plausible candidates for prediction of unstable coronary syndromes. We hypothesised that the MMP-3 polymorphism (- 1171, 5A/6A) would relate to coronary plaque characteristics and unstable clinical presentation. Forty patients with de novo presentation of coronary artery
Lin Wang et al.
Pacing and clinical electrophysiology : PACE, 39(12), 1388-1393 (2016-10-13)
We investigated computed tomography (CT) angiography (CTA) in assessment of left atrial appendage (LAA) stasis and thrombus in preprocedural evaluation for atrial fibrillation (AF) ablation in a large community cohort. We reviewed CTA and transesophageal echocardiographic images obtained in 861
Gustav V B Sørensen et al.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 25(4), 376-380 (2015-03-17)
Patients with end-stage renal disease (ESRD) have a high risk of cardiovascular disease. Small dense low-density lipoprotein (sdLDL) particles are particularly atherogenic. Marine n-3 polyunsaturated fatty acids (PUFA) may have a beneficial effect on numbers of sdLDL particles, and the
D Nicholas Bateman et al.
Lancet (London, England), 383(9918), 697-704 (2013-12-03)
Paracetamol poisoning is common worldwide. It is treated with intravenous acetylcysteine, but the standard regimen is complex and associated with frequent adverse effects related to concentration, which can cause treatment interruption. We aimed to ascertain whether adverse effects could be
Marika Rudler et al.
Journal of hepatology, 62(4), 816-821 (2014-12-03)
All trials on severe alcoholic hepatitis (AH) have included patients with "pure" AH, i.e., without concomitant gastrointestinal bleeding (GIB). Severe AH is often suspected in cirrhotic patients with GIB. We aimed at (1) assessing the prevalence of AH in patients
Vincenzo Panuccio et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 50(6), 1001-1008 (2007-11-27)
In mice, neuropeptide Y (NPY) decreases bone turnover by means of a parathyroid hormone-independent effect on osteoblast activity. Cross-sectional study. We studied the relationship between levels of NPY and biomarkers of osteoblast activity in 161 nondiabetic patients with end-stage renal
Pao-Chen Kuo et al.
The Journal of biological chemistry, 279(53), 55875-55885 (2004-10-01)
Quercetin, a ubiquitous bioactive plant flavonoid, has been shown to inhibit the proliferation of cancer cells. However, the regulation of survivin and p53 on the quercetin-induced cell growth inhibition and apoptosis in cancer cells remains unclear. In this study, we
P Menè et al.
Journal of the American Society of Nephrology : JASN, 7(7), 983-990 (1996-07-01)
Sustained Ca2+ influx follows discharge of intracellularly stored Ca2+ in a variety of cell types previously equilibrated in Ca(2+)-free media, including cultured human mesangial cells. This Ca2+ influx pathway has been referred to as capacitative Ca2+ entry or Ca2+ release-activated
Amer Mahmood et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 25(6), 1216-1233 (2010-03-05)
Directing differentiation of human embryonic stem cells (hESCs) into specific cell types using an easy and reproducible protocol is a prerequisite for the clinical use of hESCs in regenerative-medicine procedures. Here, we report a protocol for directing the differentiation of
Maryam Bibi Rumaney et al.
PloS one, 9(6), e100516-e100516 (2014-07-01)
Co-inheritance of α-thalassemia was reported to be associated with a delayed age of disease onset among Cameroonian Sickle Cell Anemia (SCA) patients. The present study aimed to explore the correlation between α-thalassemia, hematological indices, and clinical events in these patients.
Fernando Holguin et al.
JCI insight, 4(24) (2019-11-13)
BACKGROUNDThe airways of obese asthmatics have been shown to be NO deficient, and this contributes to airway dysfunction and reduced response to inhaled corticosteroids. In cultured airway epithelial cells, L-citrulline, a precursor of L-arginine recycling and NO formation, has been
Sergio Manzano-Fernández et al.
The American journal of cardiology, 103(12), 1753-1759 (2009-06-23)
The aims of this study were to compare the prognostic value of cystatin C over creatinine and the Modification of Diet in Renal Disease (MDRD) equation and to evaluate whether it provides complementary information to cardiac biomarkers in the risk
Hugo E R Ford et al.
The Lancet. Oncology, 15(1), 78-86 (2013-12-18)
Second-line chemotherapy for patients with oesophagogastric adenocarcinoma refractory to platinum and fluoropyrimidines has not shown benefits in health-related quality of life (HRQoL). We assessed whether the addition of docetaxel to active symptom control alone can improve survival and HRQoL for
Jae-Won Jang et al.
International journal of clinical pharmacology and therapeutics, 51(2), 152-160 (2013-01-29)
Levodropropizine is an oral non-opioid anti-tussive drug used in treatment of cough. A new generic 60 mg capsule formulation of levodropropizine has recently been developed. The aim of this study was to assess the pharmacokinetics and bioequivalence of the test
Patrina Hy Caldwell et al.
The Cochrane database of systematic reviews, 5, CD002911-CD002911 (2020-05-05)
Enuresis (bedwetting) affects up to 20% of five-year-olds and can have considerable social, emotional and psychological effects. Treatments include alarms (activated by urination), behavioural interventions and drugs. To assess the effects of enuresis alarms for treating enuresis in children. We
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