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Gustavo H C Varca et al.
Drug development and industrial pharmacy, 41(3), 430-435 (2014-01-15)
The performance of the standardized extrusion-spheronization technique, operational conditions, formulation parameters and storage of the final product over the bioactivity of papain containing pellets has been evaluated to obtain an insight into the potential of the technique for the manufacture
Feyza Savcioglu et al.
Toxicology mechanisms and methods, 21(6), 479-486 (2011-04-06)
This study aimed to investigate the effects of hypercholesterolemia on visual evoked potentials (VEPs) and sulfite additional effects. Rats were assigned as follows: control (C), sulfite (S), hypercholesterolemia (H), vitamin E (E), sulfite + vitamin E (SE), hypercholesterolemia + sulfite
Acquisition of MDMA self-administration: pharmacokinetic factors and MDMA-induced serotonin release.
Sarah Bradbury et al.
Addiction biology, 19(5), 874-884 (2013-06-15)
The current study aimed to elucidate the role of pharmacokinetic (PK) parameters and neurotransmitter efflux in explaining variability in (±) 3, 4-methylenedioxymethamphetamine (MDMA) self-administration in rats. PK profiles of MDMA and its major metabolites were determined after the administration of
Hadis Honarvar et al.
International journal of oncology, 46(2), 513-520 (2014-12-02)
Carbonic anhydrase IX (CAIX) is a transmembrane enzyme involved in regulation of tissue pH balance. In cancer, CAIX expression is associated with tumor hypoxia. CAIX is also overexpressed in renal cell carcinoma and is a molecular target for the therapeutic
Ioan Bicu et al.
Bioresource technology, 102(21), 10013-10019 (2011-09-07)
Orange peel (OP) was used as raw material for cellulose extraction. Two different pulping reagents were used, sodium sulfite and sodium metabisulfite. The effect of the main process parameters, sulfite agent dosage and reaction duration, on cellulose yield was investigated.
Kharla A Segovia-Bravo et al.
Journal of food science, 77(5), S194-S201 (2012-04-12)
Subjecting bruised olives to a nitrogen atmosphere during the postharvest period prevented the oxidation of phenols and subsequent browning. However, a rapid phenol oxidation and browning occurred when fruits were re-exposed to air. Based on models deduced from the effects
Ping Chu et al.
PLoS pathogens, 10(10), e1004439-e1004439 (2014-10-24)
Francisella tularensis causes the disease tularemia. Human pulmonary exposure to the most virulent form, F. tularensis subsp. tularensis (Ftt), leads to high morbidity and mortality, resulting in this bacterium being classified as a potential biothreat agent. However, a closely-related species
Evelien Wynendaele et al.
PloS one, 10(11), e0142071-e0142071 (2015-11-05)
Bacteria communicate with each other by the use of signaling molecules, a process called 'quorum sensing'. One group of quorum sensing molecules includes the oligopeptides, which are mainly produced by Gram-positive bacteria. Recently, these quorum sensing peptides were found to
Thomas Oliphant et al.
Contact dermatitis, 66(3), 128-130 (2012-02-11)
Sulfites are in widespread use as preservatives/antioxidants. There is increasing recognition of allergic contact dermatitis caused by sodium metabisulfite; however, contact allergy to sodium sulfite is less well recognized. We sought to establish the prevalence of positive patch test reactions
Nihal Ozturk et al.
Neurotoxicology and teratology, 33(2), 244-254 (2010-09-30)
The aim of this study was to clarify the dose-dependent effect of sulfite (SO₃²⁻) ingestion on brain and retina by means of electrophysiological and biochemical parameters. Fifty two male Wistar rats, aged 3 months, were randomized into four experimental groups
Dhaval R Kalaria et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(1), 56-63 (2014-02-15)
The objective of the study was to investigate the anodal iontophoretic delivery of pramipexole (PRAM), a dopamine agonist used for the treatment of Parkinson's disease, in order to determine whether therapeutic amounts of the drug could be delivered across the
Orlando B S Galli et al.
Bulletin of environmental contamination and toxicology, 89(2), 274-280 (2012-05-31)
Sodium metabisulphite (SMB) is used in marine shrimp aquaculture to prevent the occurrence of black spot. The release SMB into the estuarine environment from shrimp farm pond effluents has been reported. This study evaluated the susceptibility of larvae and post-larvae
Sven Dänicke et al.
Mycotoxin research, 28(4), 199-218 (2013-04-23)
Both hydrothermal treatment and wet preservation of mainly deoxynivalenol (DON)-containing, Fusarium toxin (FUS)-contaminated cereal grains with sodium metabisulfite (Na2S2O5 [SBS]) were successfully demonstrated to reduce the DON contamination through formation of the sulfonated derivative of DON, termed as DON sulfonate
Patrizia Marchetti et al.
Scientific reports, 5, 17353-17353 (2015-12-03)
Thin film composite membranes were prepared through a facile single-step wire-wound rod coating procedure in which internally crosslinked poly(styrene-co-butadiene) polymer nanoparticles self-assembled to form a thin film on a hydrophilic ultrafiltration support. This nanoparticle film provided a defect-free separation layer
W Wright et al.
The American review of respiratory disease, 141(6), 1400-1404 (1990-06-01)
Sodium metabisulfite (MBS) is used as a preservative in food and wine and frequently triggers attacks of asthma. To determine the characteristics of responses to inhaled MBS, 30 asthmatic subjects and 16 nonasthmatic subjects inhaled MBS, in concentrations of 6.2
Microextraction by packed sorbent (MEPS) to analyze catecholamines in innovative biological samples.
Maria Addolorata Saracino et al.
Journal of pharmaceutical and biomedical analysis, 104, 122-129 (2014-12-17)
A new microextraction by packed sorbent (MEPS) procedure coupled to a high-performance liquid chromatographic method has been developed for quantitation of catecholamines (i.e. norepinephrine, epinephrine and dopamine) in innovative biological samples, namely dried plasma and urine spots. Analyses were carried
Maria A Vlasova et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 96-102 (2014-06-26)
Intravenously administered nanocarriers are widely studied to improve the delivery of various therapeutic agents. However, recent in vivo studies have demonstrated that intravenously administered nanocarriers that do not contain any drug may affect cardiovascular function. Here we provide an example
S Dänicke et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 27(11), 1558-1565 (2010-08-03)
The Fusarium toxin deoxynivalenol (DON) is of outstanding importance in pig nutrition because of its frequent occurrence in cereal grains at levels high enough to cause adverse effects such as a decrease in feed intake and impairment of the immune
Robert Schlegl et al.
Vaccine, 33(44), 5989-5996 (2015-06-23)
Aluminum hydroxide is a critical raw material in the production of many vaccines. It is used as an adjuvant in the formulation of the final bulk vaccine, and for this it must meet the specifications of the European Pharmacopeia Monograph.
Ilgaz Akdogan et al.
Toxicology and industrial health, 27(9), 771-778 (2011-04-23)
Sulfite, which is continuously formed in the body during metabolism of sulfur-containing amino acids, is commonly used in preservatives. It has been shown that there are toxic effects of sulfite on many cellular components. The aim of this study was
Prakash Tiwari et al.
Toxicology and applied pharmacology, 278(2), 148-158 (2014-05-06)
We investigated the chemopreventive effects of naturally occurring compounds like butyric acid (BA), nicotinamide (NA) and calcium glucarate (CAG) individually or in combination in 7, 12-dimethylbenz [a] anthracene (DMBA) treated mouse skin at 4 and 16 weeks, the time before
Yan-Fang Tao et al.
Journal of experimental & clinical cancer research : CR, 34, 4-4 (2015-01-23)
Pediatric acute myeloid leukemia (AML) comprises up to 20% of all childhood leukemia. Recent research shows that aberrant DNA methylation patterning may play a role in leukemogenesis. The epigenetic silencing of the EBF3 locus is very frequent in glioblastoma. However
Natalia Mosconi et al.
ChemMedChem, 9(6), 1211-1220 (2014-05-09)
We report the synthesis, characterization, antibacterial and antifungal activities, phytotoxicity, and genotoxicity of two new complexes of silver(I) with sulfachloropyridazine (SCP), one of which is heteroleptic with SCP and SCN(-) ligands (Ag-SCP-SCN), the other of which is homoleptic (Ag-SCP); furthermore
David W Roberts et al.
Contact dermatitis, 66(3), 123-127 (2012-02-11)
Skin-sensitizing chemicals that cause allergic contact dermatitis do so by reacting with self-proteins such that the modified structure becomes antigenic. The reaction chemistry involved is well characterized, but there are exceptions, such as the occasional allergen sodium metabisulfite. To identify
Jiafu Feng et al.
Drug development and industrial pharmacy, 38(3), 264-270 (2011-08-05)
The objective of this paper is to calculate the shelf life of ascorbic acid solution under given conditions by using a mathematical model. An antioxidant, sodium metabisulfite, was added to the ascorbic acid solution. The kinetic parameters of the degradation
Zhiliang Cheng et al.
Langmuir : the ACS journal of surfaces and colloids, 24(15), 8169-8173 (2008-06-24)
The ability of chelated Gd to serve as an effective magnetic resonance (MR) contrast agent largely depends on fast exchange rates between the Gd-bound water molecules and the surrounding bulk water. Because water diffuses slowly across lipid bilayers, liposomes with
Ozlem Ozsoy et al.
Environmental toxicology, 27(8), 453-460 (2010-10-01)
The purpose of this study was to investigate the effects of hypercholesterolemia and sulphite on active avoidance learning. Male Wistar rats were divided into eight groups as follows: Control (C), Sulphite (S), Vitamin E (E), Sulphite + Vitamin E (SE)
Neal Luther et al.
Neuro-oncology, 16(6), 800-806 (2014-02-15)
Reasons for failure in prior human glioma convection-enhanced delivery (CED) clinical trials remain unclear. Concentration-dependent volume of distribution (Vd) measurement of CED-infused agents in the human brain is challenging and highlights a potential technical shortcoming. Activity of iodine isotope 124
Carole Laffont et al.
PloS one, 10(1), e0116819-e0116819 (2015-01-07)
Cytokinins are phytohormones that regulate many developmental and environmental responses. The Medicago truncatula cytokinin receptor MtCRE1 (Cytokinin Response 1) is required for the nitrogen-fixing symbiosis with rhizobia. As several cytokinin signaling genes are modulated in roots depending on different biotic
Marzena Podolska et al.
Acta poloniae pharmaceutica, 68(5), 637-644 (2011-09-21)
Sulfurous compounds: sodium sulfite Na2SO3 (E 221), sodium bisulfite NaHSO, (E 222), and sodium metabisulfite Na2S2O5 (E 223) are largely used as antioxidants in many pharmaceutical formulations. A method for determination of sodium metabisulfite in parenteral formulations containing tartrate ions
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