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Sandhya Xavier et al.
Biochimica et biophysica acta, 1573(2), 109-120 (2002-10-26)
Modulation of radiation- and metal ion-catalyzed oxidative-induced damage using plasmid DNA, genomic DNA, and cell survival, by three nitroxides and their corresponding hydroxylamines, were examined. The antioxidant property of each compound was independently determined by reacting supercoiled DNA with copper
C Kroll et al.
Free radical biology & medicine, 26(7-8), 850-857 (1999-05-08)
Metabolism of different nitroxides with piperidine structure used as spin labels in electron spin resonance (ESR) studies in vitro and in vivo was investigated in human keratinocytes of the cell line HaCaT by GC and GC-MS technique combined with S-band
Jesus Vazquez et al.
Journal of medicinal chemistry, 50(9), 2137-2143 (2007-03-31)
We report on the design, synthesis, and evaluation of a series of furanyl-salicyl-nitroxide derivatives as effective chemical probes for second-site screening against phosphotyrosine phosphatases (PTPs) using NMR-based techniques. The compounds have been tested against a panel of PTPs to assess
Md Amran Hossain et al.
Journal of drug targeting, 22(7), 638-647 (2014-06-24)
Silica nanoparticles were synthesized via a sol-gel method in which tetraethyl orthosilicate was hydrolyzed by the alkaline core of the nitroxide radical-containing nanoparticle (RNP). The silica nanoparticles were successively captured in the RNP core to obtain silica/RNP nanocomposite (siRNP). Alternatively
Spin-Labeled Dendrimers in EPR Imaging with Low Molecular Weight Nitroxides.
Alexander T. Yordanov et al.
Angewandte Chemie (International ed. in English), 40(14), 2690-2692 (2001-07-18)
Agnieszka Marczak et al.
Cell biology international, 30(2), 127-132 (2005-11-08)
Doxorubicin (DOX) and idarubicin (IDA) are anthracycline antibiotics, widely used in human cancer treatment. The present study addressed the effects of these two drugs on lipid bilayer fluidity, protein conformation and microviscosity in erythrocytes from acute myeloid leukaemia patients, using
Natalia Pieńkowska et al.
Aging, 12(2), 1910-1927 (2020-01-22)
The study was aimed at evaluation of the role of secondary oxidative stress in the stress-induced premature senescence (SIPS) of human fibroblasts induced by H2O2. Two fibroblast lines were used: lung MRC-5 and ear H8F2p25LM fibroblasts. The lines differed considerably
Pablo Kizelsztein et al.
Journal of neuroimmunology, 213(1-2), 20-25 (2009-07-01)
Reactive oxygen species are involved in the pathogenesis of multiple sclerosis (MS), Parkinson's disease and neurodegenerative diseases. Here we report that Tempamine (TMN), a stable radical with antioxidant and proapoptotic activities, when encapsulated in the intraliposome aqueous phase of pegylated
H Dragutan et al.
Bioorganic & medicinal chemistry, 4(10), 1577-1583 (1996-10-01)
Stable free mono- and diradicals containing reactive primary or secondary amino groups in the side-chain have been synthesized by transesterification of amino-substituted esters with paramagnetic alcohols or from spin-labeled acid derivatives and amines. In the second approach the new radical
A O Salman et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 134(1), 1-6 (1998-09-19)
A weak field DNP study of 4-hydroxy-2,2,6, 6-tetramethyl-1-piperidinyloxy (4-hydroxy-TEMPO), 4-amino-2,2,6, 6-tetramethyl-1-piperidinyloxy (4-amino-TEMPO), and 2, 2-Di(4-tert-octylphenyl)-1-picrylhydrazyl (DPPH) free radicals invarious solvents was performed at 1.53 mT using a doubleresonance spectrometer. pi transitions, in which the RF fieldhas a component perpendicular to
Tareq Taha Jubeh et al.
Journal of drug targeting, 14(3), 155-163 (2006-06-07)
Superoxide dismutase (SOD), 4-amino tempol (tempamine, denoted as TMN) and catalase were encapsulated into negatively charged liposomes. The activity of the antioxidants against dinitrobenzenesulfonic acid (DNBS) induced colitis was tested in the rat and compared to the anti-inflammatory activity of
M C Krishna et al.
Free radical biology & medicine, 17(5), 379-388 (1994-11-01)
Nitroxides are cell-permeable, stable radicals that react readily with paramagnetic species such as transition metals or short-lived free radicals, though not generally with diamagnetic molecules. Nitroxides can undergo one-electron selective redox reactions and thereby potentially modify the activity of cytotoxic
Keren Turjeman et al.
PloS one, 10(7), e0130442-e0130442 (2015-07-07)
The present study shows the advantages of liposome-based nano-drugs as a novel strategy of delivering active pharmaceutical ingredients for treatment of neurodegenerative diseases that involve neuroinflammation. We used the most common animal model for multiple sclerosis (MS), mice experimental autoimmune
Darja Jaušovec et al.
Carbohydrate polymers, 116, 74-85 (2014-12-03)
The chemo-enzymatic modification of cellulose nanofibers (CNFs) using laccase as biocatalysts and TEMPO or 4-Amino-TEMPO as mediators under mild aqueous conditions (pH 5, 30 °C) has been investigated to introduce surface active aldehyde groups. 4-Amino TEMPO turned out to be
Robert Lyzeń et al.
Archives of microbiology, 183(3), 203-208 (2005-02-18)
Recent studies indicated that bioluminescence of the marine bacterium Vibrio harveyi may both stimulate DNA repair and contribute to detoxification of deleterious oxygen derivatives. Therefore, it was also proposed that these reactions can be considered biological roles of bacterial luminescence
Gabriela Ionita et al.
Soft matter, 11(46), 8968-8974 (2015-09-25)
The formation of alginate gel from low molecular weight alginate and very low molecular weight alginate in the presence of divalent cations was investigated using Electron Paramagnetic Resonance (EPR) spectroscopy. The transition from sol to gel in the presence of
R Zhang et al.
Archives of biochemistry and biophysics, 312(2), 385-391 (1994-08-01)
Nitroxides stable radicals are unreactive toward most diamagnetic molecules, but readily undergo one-electron redox reactions with paramagnetic species such as free radicals and transition metals, thus serving as cell-permeable antioxidants. The cytotoxicity of juglone (5-hydroxy-1,4-naphthoquinone), like that of other naphthoquinones
Alisa Leavesley et al.
Physical chemistry chemical physics : PCCP, 19(5), 3596-3605 (2017-01-18)
Here, we present an integrated experimental and theoretical study of
SEC-MALS analysis of cellouronic acid prepared from regenerated cellulose by TEMPO-mediated oxidation.
Shibata I, et al.
Cellulose, 13(1), 73-80 (2006)
C Mathieu et al.
Free radical research, 27(2), 165-171 (1997-08-01)
The synproportionation reaction between ferryl leghemoglobin and oxyleghemoglobin does not occur, at least under conditions where this process could be clearly demonstrated with myoglobin and hemoglobin. In contrast, a cross synproportionation can occur between oxyleghemoglobin and ferryl myoglobin or between
Journal of Colloid and Interface Science, 165, 236-236 (1994)
Gabriela Ionita et al.
Physical chemistry chemical physics : PCCP, 22(21), 12154-12165 (2020-05-23)
Electron paramagnetic resonance (EPR) spectroscopy is the main tool for evidencing the formation of inclusion complexes of cyclodextrins with paramagnetic guests, based on changes in the EPR parameters. In-depth information on complexation can only be obtained by a combination of
J Czepas et al.
Cell biology and toxicology, 24(1), 101-112 (2007-07-05)
The piperidine nitroxides Tempamine and Tempace have been studied for their effect on doxorubicin (DOX) and hydrogen peroxide (H(2)O(2)) cytotoxicity in immortalized B14 cells, a model for neoplastic phenotype. The significance for nitroxide performance of the substituent in position 4
Veronica Wasserman et al.
Langmuir : the ACS journal of surfaces and colloids, 23(4), 1937-1947 (2007-02-07)
The piperidine nitroxide tempamine (TMN) is a cell-permeable, stable radical having antioxidant, anticancer, and proapoptotic and/or pronecrotic activities, as was demonstrated by us in cell cultures. We also demonstrated synergism between TMN and doxorubicin in doxorubicin-sensitive and doxorubicin-resistant cell lines.
Carlos A Macias et al.
Annals of surgery, 245(2), 305-314 (2007-01-25)
We sought to develop a therapeutic agent that would permit prolongation of survival in rats subjected to lethal hemorrhagic shock (HS), even in the absence of resuscitation with asanguinous fluids or blood. We synthesized a series of compounds that consist
K A Schnorr et al.
Journal of biomolecular NMR, 68(1), 53-63 (2017-05-14)
Paramagnetic relaxation enhancement (PRE) is a versatile tool for NMR spectroscopic structural and kinetic studies in biological macromolecules. Here, we compare the quality of PRE data derived from two spin labels with markedly different dynamic properties for large RNAs using
N Naber et al.
Biochemistry, 33(13), 3855-3861 (1994-04-05)
Each actin molecule contains a nucleotide, tightly bound in a deep cleft that divides the molecule. To probe conformational changes within this region of the molecule, we have incorporated two spin label analogues of ATP into actin. In both analogs
Hanna Szpilewska et al.
Current microbiology, 47(5), 379-382 (2003-12-13)
The origin and function of bioluminescence was considered a problematic question of the Charles Darwin theory. Early evolution of bacterial luminescence and its current physiological importance seem to be especially mysterious. Recently, it was proposed that stimulation of DNA repair
Boris V Trubitsin et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 163(2), 257-269 (2003-08-14)
We present a method for measuring the transmembrane pH difference (deltapH=pHin-pHout) in chloroplasts with a spin label TEMPAMINE (4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl) accumulating inside the thylakoids in response to generation of deltapH. Experiments with chloroplasts suspended in the media of different osmolarity demonstrated
Tareq Taha Jubeh et al.
Molecular pharmaceutics, 2(1), 2-11 (2005-04-05)
The purpose of the present study was to investigate whether the local prevention of luminal superoxide-mediated biological damage in the rat jejunal mucosa could be achieved by liposomal superoxide dismutase (SOD) and the SOD mimic tempamine (TMN). Cationic liposomes loaded
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