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Qian Gong et al.
DNA and cell biology, 30(6), 347-354 (2011-02-25)
Hepatitis B Virus (HBV) covalently closed circular DNA (cccDNA) is the main replicative intermediate of HBV and is organized into minichromosomes by the interaction with histone and nonhistone proteins. The remodeling of HBV minichromosomes such as post-translational modifications of histone
Amit Kumar Jaiswal et al.
Scientific reports, 11(1), 13158-13158 (2021-06-25)
Post-transcriptional gene regulation, including that by RNA binding proteins (RBPs), has recently been described as an important mechanism in cancer. We had previously identified a set of RBPs that were highly dysregulated in B-cell acute lymphoblastic leukemia (B-ALL) with MLL
Hong-Ren Yu et al.
Immunology, 143(4), 651-660 (2014-06-26)
Glucocorticoid (GC) is often given when preterm delivery is expected. This treatment is successful in stimulating the development of the fetal lung. However, reports and related research regarding the prolonged effects of prenatal GC on the development of immunity are
Yelena Gulchina et al.
Journal of neurochemistry, 143(3), 320-333 (2017-06-20)
Schizophrenia (SCZ) is characterized not only by psychosis, but also by working memory and executive functioning deficiencies, processes that rely on the prefrontal cortex (PFC). Because these cognitive impairments emerge prior to psychosis onset, we investigated synaptic function during development
De-Qiang Li et al.
Neoplasma (2022-02-22)
Gallbladder cancer is a malignant tumor with a high mortality rate. Accumulating evidence supports that lncRNA MEG3 may halt the progression of gallbladder cancer, while the downstream mechanism is rarely studied. Thus, we aim to investigate the molecular basis of
Keren Martínez-Aguilar et al.
Frontiers in plant science, 7, 653-653 (2016-06-01)
To survive in adverse conditions, plants have evolved complex mechanisms that "prime" their defense system to respond and adapt to stresses. Their competence to respond to such stresses fundamentally depends on its capacity to modulate the transcriptome rapidly and specifically.
Yao Yu et al.
Scientific reports, 6, 31752-31752 (2016-08-20)
Heterochromatin formation in fission yeast depends on RNAi machinery and histone-modifying enzymes. One of the key histone-modifying complexes is Clr4-Rik1-Cul4 methyltransferase complex (CLRC), which mediates histone H3K9 methylation, a hallmark for heterochromatin. CLRC is composed of the Clr4 histone methyltransferase
Lijun Shu et al.
Frontiers in cell and developmental biology, 10, 837000-837000 (2022-08-27)
Preeclampsia (PE) is the predominant medical condition leading to maternal and fetal mortality, and the lack of effective treatment increases its risk to the public health. Among the numerous predisposing factors, the ineffectual remodeling of the uterine spiral arteries, which
Cheng Zhang et al.
Cell death & disease, 10(7), 477-477 (2019-06-19)
Caveolin-1 (Cav-1) is an important structural protein of caveolae and plays an oncogene-like role by influencing protein glycosylation in hepatocellular carcinoma (HCC) cells. However, the mechanism by which Cav-1 promotes invasion and metastasis capacity has not been completely clarified. In
Alessia Angelin et al.
Cell metabolism, 25(6), 1282-1293 (2017-04-19)
Immune cells function in diverse metabolic environments. Tissues with low glucose and high lactate concentrations, such as the intestinal tract or ischemic tissues, frequently require immune responses to be more pro-tolerant, avoiding unwanted reactions against self-antigens or commensal bacteria. T-regulatory cells
Natasha Vafadar-Isfahani et al.
Epigenetics, 12(6), 465-475 (2017-03-17)
Hypomethylation of LINE-1 repeats in cancer has been proposed as the main mechanism behind their activation; this assumption, however, was based on findings from early studies that were biased toward young and transpositionally active elements. Here, we investigate the relationship
Jianing Xu et al.
The Journal of international medical research, 49(5), 3000605211004414-3000605211004414 (2021-05-14)
To examine the role of the long noncoding RNA LINC01296 in colorectal carcinoma (CRC) and to explore the underlying mechanism. We detected LINC01296 expression levels in a cohort of 51 paired CRC and normal tissues. We also assessed the effects
Ting Xu et al.
Cellular oncology (Dordrecht), 43(2), 297-310 (2019-12-31)
Long non-coding RNAs (lncRNAs) are known to be frequently dysregulated in many types of human cancer. As yet, however, their roles in colon carcinogenesis have not been fully elucidated. In the current study, we assessed whether lncRNA LINC00858 may be
The use of chromatin immunoprecipitation assays in genome-wide analyses of histone modifications.
Bernstein, Bradley E, et al.
Test, 376, 349-360 (2004)
Javier R Revollo et al.
Science signaling, 6(304), ra103-ra103 (2013-12-05)
Hairy and enhancer of split-1 (HES1) is a basic helix-loop-helix transcription factor that is a key regulator of development and organogenesis. However, little is known about the role of HES1 after birth. Glucocorticoids, primary stress hormones that are essential for
Yujie Liu et al.
Molecular and cellular biology, 34(21), 3993-4007 (2014-08-27)
T-regulatory (Treg) cells are important to immune homeostasis, and Treg cell deficiency or dysfunction leads to autoimmune disease. A histone/protein acetyltransferase (HAT), p300, was recently found to be important for Treg function and stability, but further insights into the mechanisms
Yingchi Zhang et al.
Nucleic acids research, 45(2), 657-671 (2017-01-27)
The first intronic mutations in the intron 1 GATA site (int-1-GATA) of 5-aminolevulinate synthase 2 (ALAS2) have been identified in X-linked sideroblastic anemia (XLSA) pedigrees, strongly suggesting it could be causal mutations of XLSA. However, the function of this int-1-GATA
Jin-Xuan Zhao et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 39(4), 1010428317697546-1010428317697546 (2017-04-07)
hMLH1 is one of the mismatch genes closely related to the occurrence of gastric cancer. Epigenetic regulation may play more important roles than gene mutations in DNA damage repair genes to drive carcinogenesis. In this article, we discuss the role
Chong-Kuei Lii et al.
Oncotarget, 7(18), 25162-25179 (2016-04-02)
Fascin-1, an actin-bundling protein, plays an important role in cancer cell migration and invasion; however, the underlying mechanism remains unclear. On the basis of a 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cell migration model, it was shown that TPA increased fascin-1 mRNA and
Xiaolong Deng et al.
Scientific reports, 5, 14707-14707 (2015-10-08)
RNA interference (RNAi) is a widespread gene-silencing mechanism and is required for heterochromatin assembly in a variety of organisms. The RNA-induced transcriptional silencing complex (RITS), composed of Ago1, Tas3 and Chp1, is a key component of RNAi machinery in fission
Syamantak Majumder et al.
The Journal of clinical investigation, 128(1), 483-499 (2017-12-12)
Histone protein modifications control fate determination during normal development and dedifferentiation during disease. Here, we set out to determine the extent to which dynamic changes to histones affect the differentiated phenotype of ordinarily quiescent adult glomerular podocytes. To do this
Minghui Ou et al.
EBioMedicine, 55, 102694-102694 (2020-04-27)
Atherosclerosis involves a slow process of plaque formation on the walls of arteries, and comprises a leading cause of cardiovascular disease. Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of atherosclerosis. In this study, we aim to explore
Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism.
Intlekofer, KA; Berchtold, NC; Malvaez, M; Carlos, AJ; McQuown, SC; Cunningham, MJ; Wood et al.
Neuropsychopharmacology null
Ming-Yi Chou et al.
The Tohoku journal of experimental medicine, 241(3), 225-237 (2017-03-28)
Prenatal glucocorticoid therapy is indicated in preterm delivery to prevent respiratory distress. This study was designed to evaluate the age-dependent effects of prenatal dexamethasone (DEX) therapy on the immune system using a rat model. Pregnant Sprague-Dawley rats received an intraperitoneal
Fan Yang et al.
International journal of cancer, 141(5), 986-997 (2017-05-17)
Cr (VI) is mutagenic and carcinogenic, but the mechanism is unclear. In this study, the involvement of high mobility group A2 (HMGA2) in Cr (VI)-induced autophagy was investigated. Cr (VI) treatment induced formation of autophagosomes, increased expression of LC3II, Atg12-Atg5
Siqi Chen et al.
Biochimica et biophysica acta, 1830(10), 4769-4777 (2013-06-19)
Guanine-rich sequence of c-myc nuclease hypersensitive element (NHE) III1 is known to fold in G-quadruplex and subsequently serves as a transcriptional silencer. Cellular nucleic-acid-binding protein (CNBP), a highly conserved zinc-finger protein with multiple biological functions, could bind to c-myc NHE
Jing Xu et al.
EBioMedicine, 46, 54-65 (2019-07-22)
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies with poor prognosis. Cancer-testis genes (CTGs) have been vigorously pursued as targets for cancer immunotherapy, but the expressive patterns and functional roles of CTGs remain unclear in ESCC.
Lei Zhang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2), 2703-2714 (2020-01-10)
Diabetic nephropathy (DN) is a frequently occurred microvascular complication associated with type I and type II diabetes mellitus. The participation of long noncoding RNAs (lncRNAs) in diabetes-related microvascular complications has been reported extensively. We attempted to unveil the possible regulatory
Cheng Wu et al.
Developmental neuroscience, 44(3), 121-130 (2021-12-23)
Spinal cord ischemia/reperfusion injury (SCIRI) is usually caused by spinal surgery or aortic aneurysm surgery and can eventually lead to paralysis or paraplegia and neurological dysfunction. Exosomes are considered as one of the most promising therapeutic strategies for SCIRI as
l-Glutamine supplementation promotes an improved energetic balance in Walker-256 tumor-bearing rats.
Heber Amilcar Martins et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 39(3), 1010428317695960-1010428317695960 (2017-03-28)
We evaluated the effects of supplementation with oral l-glutamine in Walker-256 tumor-bearing rats. A total of 32 male Wistar rats aged 54 days were randomly divided into four groups: rats without Walker-256 tumor, that is, control rats (C group); control
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