1711202

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Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models.

Yasuo Uchida et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1719-1726 (2014-07-26)

The purpose of this study was to demonstrate experimentally that alterations of in vivo transporter function at the blood-brain barrier (BBB) in disease and during pharmacotherapy can be reconstructed from in vitro data based on our established pharmacoproteomic concept of

Tacrine sinusoidal uptake and biliary excretion in sandwich-cultured primary rat hepatocytes.

Loqman A Mohamed et al.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(3), 427-438 (2014-09-17)

PURPOSE. The knowledge of hepatic disposition kinetics of tacrine, a first cholinesterase inhibitor was approved by FDA for the treatment of Alzheimer's disease (AD), would help to understand its hepatotoxicity, its therapeutic effect, and improve the management of patients with

Remote laser ablation electrospray ionization mass spectrometry for non-proximate analysis of biological tissues.

Laine R Compton et al.

Rapid communications in mass spectrometry : RCM, 29(1), 67-73 (2014-12-03)

We introduce remote laser ablation electrospray ionization (LAESI), a novel, non-proximate ambient sampling technique. Remote LAESI allows additional analytical instrumentation to be incorporated during sample analysis. This work demonstrates the utility of remote LAESI and, when combined with optical microscopy

Sex differences in liver toxicity-do female and male human primary hepatocytes react differently to toxicants in vitro?

Milena Mennecozzi et al.

PloS one, 10(4), e0122786-e0122786 (2015-04-08)

There is increasing amount of evidence for sex variation in drug efficiency and toxicity profiles. Women are more susceptible than men to acute liver injury from xenobiotics. In general, this is attributed to sex differences at a physiological level as

L-type calcium channel modulates cystic kidney phenotype.

Xingjian Jin et al.

Biochimica et biophysica acta, 1842(9), 1518-1526 (2014-06-14)

In polycystic kidney disease (PKD), abnormal proliferation and genomic instability of renal epithelia have been associated with cyst formation and kidney enlargement. We recently showed that L-type calcium channel (CaV1.2) is localized to primary cilia of epithelial cells. Previous studies

Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease.

Jeong-A Lim et al.

Autophagy, 11(2), 385-402 (2015-03-12)

Mitochondria-induced oxidative stress and flawed autophagy are common features of neurodegenerative and lysosomal storage diseases (LSDs). Although defective autophagy is particularly prominent in Pompe disease, mitochondrial function has escaped examination in this typical LSD. We have found multiple mitochondrial defects

Re-evaluation of cytostatic therapies for meningiomas in vitro.

Annette Wilisch-Neumann et al.

Journal of cancer research and clinical oncology, 140(8), 1343-1352 (2014-05-13)

The purpose was to re-evaluate in cell culture models the therapeutic usefulness of some discussed chemotherapies or targeted therapies for meningiomas with a special emphasis on the role of the neurofibromatosis type 2 (NF2) tumor suppressor, which had been neglected

Round window membrane vibration may increase the effect of intratympanic dexamethasone injection.

Soon Hyung Park et al.

The Laryngoscope, 124(6), 1444-1451 (2013-10-25)

We investigated whether the round window membrane (RWM) vibration can facilitate dexamethasone perfusion via the RWM in patients with sudden hearing loss. Prospective study. We first performed an in vitro study using a semipermeable membrane. In the subsequent in vivo

Tarka® (trandolapril/verapamil hydrochloride extended-release) overdose.

Victor Cohen et al.

The Journal of emergency medicine, 40(3), 291-295 (2009-03-03)

Patients with fixed-dose combination product overdoses involving verapamil and trandolapril may present differently than sole calcium channel blocker (CCB) or angiotensin-converting enzyme inhibitor (ACE-I) overdose alone, and may have implications for the toxicological management. The ACE-I component may confound the

Pharmacology and pathophysiology of mutated KCNJ5 found in adrenal aldosterone-producing adenomas.

P Tauber et al.

Endocrinology, 155(4), 1353-1362 (2014-02-11)

Somatic mutations of the potassium channel KCNJ5 are found in 40% of aldosterone producing adenomas (APAs). APA-related mutations of KCNJ5 lead to a pathological Na(+) permeability and a rise in cytosolic Ca(2+), the latter presumably by depolarizing the membrane and

Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates.

Yoko Nagaya et al.

Drug metabolism and pharmacokinetics, 29(5), 419-426 (2014-05-09)

In central nervous system drug discovery, cerebrospinal fluid (CSF) drug concentration (C(CSF)) has been widely used as a surrogate for unbound brain concentrations (C(u,brain)). However, previous rodent studies demonstrated that when drugs undergo active efflux by transporters, such as P-glycoprotein

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