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Mohamed A Ghonim et al.
The Journal of allergy and clinical immunology, 135(2), 425-440 (2014-12-03)
We reported that DNA-dependent protein kinase (DNA-PK) is critical for the expression of nuclear factor κB-dependent genes in TNF-α-treated glioblastoma cells, suggesting an involvement in inflammatory diseases. We sought to investigate the role of DNA-PK in asthma. Cell culture and
Aurelie Vivares et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(1), 29-44 (2014-07-30)
1. The quantitative prediction of the pharmacokinetic parameters of a drug from data obtained using human in vitro systems remains a significant challenge i.e. prediction of metabolic clearance in humans and estimation of the relative contribution of enzymes involved in
Seungmi Ryu et al.
ACS nano, 9(10), 10186-10202 (2015-09-13)
Coculturing stem cells with the desired cell type is an effective method to promote the differentiation of stem cells. The features of the membrane used for coculturing are crucial to achieving the best outcome. Not only should the membrane act
Athina Bakopoulou et al.
Stem cells and development, 24(21), 2496-2512 (2015-07-24)
Stem cells from the apical papilla (SCAP) of human adult teeth are considered an accessible source of cells with angiogenic properties. The aims of this study were to investigate the endothelial transdifferentiation of SCAP, the secretion of pro- and antiangiogenic
Yimao Zhang et al.
Neoplasia (New York, N.Y.), 11(1), 96-101 (2008-12-25)
HhAntag691 (GDC-0449), a low-molecular weight inhibitor of the tumor-promoting hedgehog (Hh) signaling pathway, has been used to treat medulloblastoma in animal models and has recently entered clinical trials for a variety of solid tumors. Here, we show that HhAntag691 inhibits
Rui-Li Zhang et al.
PloS one, 9(12), e115134-e115134 (2014-12-17)
The recombinant Treponema pallidum protein Tp0965 (rTp0965), one of the many proteins derived from the genome of T. pallidum subsp. pallidum, shows strong immunogenicity and immunoreactivity. In this study, we investigated the effects of rTp0965 on the endothelial barrier. Treatment
Chian-Jiun Liou et al.
Allergy, asthma & immunology research, 6(6), 548-557 (2014-11-07)
Lovastatin is an effective inhibitor of cholesterol synthesis. A previous study demonstrated that lovastatin can also suppress airway hyperresponsiveness (AHR) in murine model of asthma. We aimed to investigate the effect of lovastatin on mucus secretion and inflammation-associated gene expression
Tomohiro Kawahara et al.
Microbiology and immunology, 59(1), 1-12 (2014-11-18)
Bifidobacterium, one of the major components of intestinal microflora, shows anti-influenza virus (IFV) potential as a probiotic, partly through enhancement of innate immunity by modulation of the intestinal immune system. Bifidobacterium longum MM-2 (MM-2), a very safe bacterium in humans
Nuno Jorge Lamas et al.
PloS one, 9(10), e110324-e110324 (2014-10-23)
Human motor neurons derived from embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are a potentially important tool for studying motor neuron survival and pathological cell death. However, their basic survival requirements remain poorly characterized. Here, we sought to
Hoda Elkhenany et al.
Journal of applied toxicology : JAT, 35(4), 367-374 (2014-09-16)
Current treatments for bone loss injuries involve autologous and allogenic bone grafts, metal alloys and ceramics. Although these therapies have proved useful, they suffer from inherent challenges, and hence, an adequate bone replacement therapy has not yet been found. We
Mesenchymal stem cells induce PD-L1 expression through the secretion of CCL5 in breast cancer cells.
Hamidreza Aboulkheyr Es et al.
Journal of cellular physiology, 236(5), 3918-3928 (2020-11-05)
Various factors in the tumor microenvironment (TME) regulate the expression of PD-L1 in cancer cells. In TME, mesenchymal stem cells (MSCs) play a crucial role in tumor progression, metastasis, and drug resistance. Emerging evidence suggests that MSCs can modulate the
Favián Treulen et al.
Human reproduction (Oxford, England), 30(4), 767-776 (2015-02-11)
Does mitochondrial permeability transition (MPT) induced by calcium overload cause reactive oxygen species (ROS) production and DNA fragmentation in human spermatozoa? Studies conducted in vitro suggest that in human spermatozoa, MPT occurs in response to intracellular calcium increase and is
G M Silva et al.
Zygote (Cambridge, England), 23(4), 475-484 (2014-03-29)
The aim of this study was to evaluate the influence of two-dimensional (2D) and three-dimensional (3D) alginate culture systems on in vitro development of pre-antral caprine follicles. In addition, the influence of the reproductive age of the ovary donor on
Stephanie Hirn et al.
Beilstein journal of nanotechnology, 5, 2440-2449 (2015-02-12)
Precision-cut lung slices (PCLS) are an established ex vivo alternative to in vivo experiments in pharmacotoxicology. The aim of this study was to evaluate the potential of PCLS as a tool in nanotoxicology studies. Silver (Ag-NPs) and zinc oxide (ZnO-NPs)
Ling-Wei Hu et al.
PloS one, 9(5), e97880-e97880 (2014-05-23)
The neurotoxin 6-hydroxydopamine (6-OHDA), which causes transcriptional changes associated with oxidative and proteotoxic stress, has been widely used to generate an experimental model of Parkinson's disease. The food-derived compound luteolin has multi-target actions including antioxidant, anti-inflammatory and neurotrophic activities. The
Aihua Song et al.
Antiviral research, 111, 60-68 (2014-09-15)
Influenza virus is a global health concern due to its unpredictable pandemic potential. Frequent mutations of surface molecules, hemagglutinin (HA) and neuraminidase (NA), contribute to low efficacy of the annual flu vaccine and therapeutic resistance to standard antiviral agents. The
James R Connor et al.
PloS one, 10(5), e0125272-e0125272 (2015-05-15)
There is a significant clinical need for effective treatment of iron deficiency. A number of compounds that can be administered intravenously have been developed. This study examines how the compounds are handled by macrophages and their relative potential to provoke
Po-Hsun Huang et al.
Lab on a chip, 15(15), 3125-3131 (2015-06-18)
We demonstrate the first microfluidic-based on-chip liquefaction device for human sputum samples. Our device is based on an acoustofluidic micromixer using oscillating sharp edges. This acoustofluidic sputum liquefier can effectively and uniformly liquefy sputum samples at a throughput of 30
Namita Kumari et al.
Drug design, development and therapy, 9, 5051-5060 (2015-09-15)
Despite the remarkable success of combination antiretroviral therapy at curtailing HIV progression, emergence of drug-resistant viruses, chronic low-grade inflammation, and adverse effects of combination antiretroviral therapy treatments, including metabolic disorders collectively present the impetus for development of newer and safer
Alak Manna et al.
Anti-cancer agents in medicinal chemistry, 15(9), 1156-1163 (2015-06-03)
Multidrug resistance (MDR) refers to cross-resistance to a range of structurally and functionally unrelated compounds, and is accompanied by an elevated expression of ATP driven cell-membrane transporters. The cytotoxicity of Malabaricone-A (MAL-A), a diarylnonanoid derived from Myristica malabarica was demonstrated
Yiwei Li et al.
Lab on a chip, 15(15), 3203-3210 (2015-07-02)
Active control over the cell gradient is essential for understanding biological systems and the reconstitution of the functionality of many types of tissues, particularly for organ-on-a-chip. Here, we propose a three-dimensional (3D) microfluidic strategy for generating controllable cell gradients. In
Anusha Jayaraman et al.
Endocrinology, 155(4), 1398-1406 (2014-01-17)
The decline in testosterone levels in men during normal aging increases risks of dysfunction and disease in androgen-responsive tissues, including brain. The use of testosterone therapy has the potential to increase the risks for developing prostate cancer and or accelerating
Samantha C W Chan et al.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 24(11), 2402-2410 (2015-07-29)
Mechanical loading is an important parameter that alters the homeostasis of the intervertebral disc (IVD). Studies have demonstrated the role of compression in altering the cellular metabolism, anabolic and catabolic events of the disc, but little is known how complex
Nae Tanpradit et al.
Theriogenology, 83(9), 1553-1561 (2015-03-10)
The objectives of the study were to (1) examine and optimize the impact of sucrose during slow freezing and (2) compare the results of two freezing methods (slow freezing and vitrification) on cellular viability (germinal and stromal cells), follicle morphology
Karina H Nakayama et al.
ACS nano, 9(7), 6900-6908 (2015-06-11)
The objective of this study was to enhance the angiogenic capacity of endothelial cells (ECs) using nanoscale signaling cues from aligned nanofibrillar scaffolds in the setting of tissue ischemia. Thread-like nanofibrillar scaffolds with porous structure were fabricated from aligned-braided membranes
Julie A Rytlewski et al.
Microvascular research, 99, 26-35 (2015-02-26)
Stem cell-based therapies are a promising new avenue for treating ischemic disease and chronic wounds. Mesenchymal stem cells (MSCs) have a proven ability to augment the neovascularization processes necessary for wound healing and are widely popular as an autologous source
Michael J Mitchell et al.
American journal of physiology. Cell physiology, 309(11), C736-C746 (2015-10-09)
Metastasis contributes to over 90% of cancer-related deaths and is initiated when cancer cells detach from the primary tumor, invade the basement membrane, and enter the circulation as circulating tumor cells (CTCs). While metastasis is viewed as an inefficient process
Yusheng Shen et al.
Scientific reports, 5, 9293-9293 (2015-03-20)
The extracellular matrix (ECM) exhibits tissue-specific topography and composition and plays a crucial role in initiating the biochemical and biomechanical signaling required for organizing cells into distinct tissues during development. How single cells assemble into structures featuring specific shapes in
Miaomiao Shi et al.
Journal of bacteriology, 197(13), 2179-2189 (2015-04-22)
Oxidative stresses triggered by reactive oxygen species (ROS) that damage various cellular components are unavoidable for virtually all living organisms. In defense, microorganisms have evolved sophisticated mechanisms to sense, respond to, and battle against ROS. Shewanella oneidensis, an important research
Anja R Scholze et al.
PloS one, 9(10), e110668-e110668 (2014-10-21)
Astrocytes constitute a major cell population in the brain with a myriad of essential functions, yet we know remarkably little about the signaling pathways and mechanisms that direct astrocyte maturation. To explore the signals regulating astrocyte development, we prospectively purified
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