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Yi Lu et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 71, 139-145 (2015-05-12)
Anaesthetic agents were confirmed to play a role on the tumor angiogenesis. The effect of sevoflurane on tongue squamous cell carcinoma (TSCC) cell has not been investigated. SCC-4 cells were exposed to sevoflurane after simulating hypoxia. Then, both the mRNA
Courtney Sobieski et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(31), 11105-11117 (2015-08-08)
Neuron-astrocyte interactions are critical for proper CNS development and function. Astrocytes secrete factors that are pivotal for synaptic development and function, neuronal metabolism, and neuronal survival. Our understanding of this relationship, however, remains incomplete due to technical hurdles that have
Diana G Soares et al.
Archives of oral biology, 60(9), 1428-1436 (2015-07-15)
To evaluate the effect of a 17.5% H2O2 gel on the odontoblastic differentiation capability of human dental pulp cells (HDPCs). The bleaching gel was applied for 45, 15 or 5min to enamel/dentine discs adapted to transwells, positioned over previously cultured
F Treumer et al.
Experimental eye research, 97(1), 63-72 (2012-03-06)
The purpose of this study was to investigate release of matrix metalloproteinases (MMP) 2 and 9 during retinal pigment epithelium (RPE) wound healing after Selective Retina Therapy (SRT) with laser energy levels below and above the threshold of RPE cell
Jun Wang et al.
Scientific reports, 5, 10729-10729 (2015-06-04)
Lactoferrin (Lf) can bind to lactoferrin receptor (LfR), leading to iron transport through the plasma membrane. Besides iron transportation, Lf also has antioxidant and anti-inflammatory properties. In the brain, Lf is only synthesized by activated microglia. LfR is present in
James Keane et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 40(2), 105-115 (2014-12-23)
This study investigated whether the putative physiological benefits induced by growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are countered at supra-physiological concentrations because of an augmentation in the production of mitochondrial-derived free radicals with a subsequent increase in oxidative
Patricia L Musolino et al.
Brain : a journal of neurology, 138(Pt 11), 3206-3220 (2015-09-18)
See Aubourg (doi:10.1093/awv271) for a scientific commentary on this article.X-linked adrenoleukodystrophy is caused by mutations in the ABCD1 gene leading to accumulation of very long chain fatty acids. Its most severe neurological manifestation is cerebral adrenoleukodystrophy. Here we demonstrate that
Hye Yeon Seo et al.
PloS one, 9(11), e113477-e113477 (2014-11-25)
The surface topography and chemistry of titanium implants are important factors for successful osseointegration. However, chemical modification of an implant surface using currently available methods often results in the disruption of topographical features and the loss of beneficial effects during
Griffin J Jardine et al.
Cornea, 34(7), 838-843 (2015-05-02)
The aim of this study was to investigate the use of a femtosecond laser (FL) in the eye bank preparation of corneas for Descemet membrane (DM) automated endothelial keratoplasty (fDMAEK) and to compare endothelial cell death in graft preparations between
Gianmaria Miolo et al.
BMC cancer, 14, 954-954 (2014-12-17)
Neoadjuvant Chemotherapy (NC) including trastuzumab induces a high rate of pathological Complete Responses (pCR) in patients with locally advanced HER2-overexpressing Breast Cancer (BC), but is penalized by a severe cardiotoxicity when combined with anthracyclines. A phase II study was designed
Chien-Hui Hong et al.
Chemico-biological interactions, 227, 96-103 (2015-01-07)
Arsenic remains an important environmental hazard that causes several human cancers. Arsenic-induced Bowen's disease (As-BD), a skin carcinoma in situ, is the most common arsenical cancer. While great strides have been made in our understanding of arsenic carcinogenesis, how host
Prayag J Amin et al.
Life sciences, 126, 19-27 (2015-02-28)
The goal of this study is to investigate the tumor cytotoxic effects of sulforaphane (SFN) and ionizing radiation (IR) as well as their ability to up-regulate natural killer group 2, member D (NKG2D) ligands and modulate the susceptibility of tumor
Elizabeth Carmen Pastrana Alta et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 27(6), 1351-1360 (2014-10-01)
Desferrioxamine (DFO) is a potent iron chelator used in the treatment of iron overload (IO) disorders. However, due to its low cell permeability and fast clearance, DFO administration is usually prolonged and of limited use for the treatment of IO
Juliane F C Viana et al.
Nanoscale, 7(14), 6238-6246 (2015-03-18)
Candida albicans is a common human-pathogenic fungal species with the ability to cause several diseases including surface infections. Despite the clear difficulties of Candida control, antimicrobial peptides (AMPs) have emerged as an alternative strategy for fungal control. In this report
Jana Lišková et al.
Carbohydrate polymers, 129, 135-142 (2015-06-09)
Injectable hydrogels for bone regeneration consisting of chitosan, sodium beta-glycerophosphate (Na-β-GP) and alkaline phosphatase (ALP) were enriched with the polyphenols phloroglucinol (PG) and gallic acid (GA) and characterized physicochemically and biologically with respect to properties relevant for applications in bone
Jie Shen et al.
Scientific reports, 5, 8651-8651 (2015-03-04)
It is technically challenging to investigate the function of secreted protein in real time by supply of conditioned medium that contains secreted protein of interest. The internalization of anthrax toxin is facilitated by a secreted protein Dickkopf-1 (DKK1) and its
Bożena Bukowska et al.
Environmental toxicology and pharmacology, 39(1), 187-193 (2014-12-22)
Catechol also known as pyrocatechol or 1,2-dihydroxybenzene is formed endogenously in the organism from neurotransmitters including adrenaline, noradrenaline, and dopamine. It is also a metabolite of many drugs like DOPA, isoproterenol or aspirin and it is also formed in the
Xin Wang et al.
ACS nano, 8(12), 12151-12166 (2014-12-02)
Chemoresistance is a primary cause of treatment failure in cancer and a common property of tumor-initiating cancer stem cells. Overcoming mechanisms of chemoresistance, particularly in cancer stem cells, can markedly enhance cancer therapy and prevent recurrence and metastasis. This study
Jason Spina et al.
Veterinary surgery : VS, 43(6), 750-760 (2014-03-13)
To determine the in vitro effects of differing growth factor treatments on the fibrochondrogenic potential of fibroblast-like synoviocytes from cruciate ligament deficient femorotibial joints of dogs. In vitro study. Synoviocytes from dogs (n = 8) with naturally occurring cruciate ligament insufficiency. Synoviocytes
M Bosnjak et al.
Gene therapy, 22(7), 578-590 (2015-03-18)
Gene therapy with Plasmid AMEP (antiangiogenic metargidin peptide) has recently been studied as a potential targeted therapy for melanoma. This plasmid is designed to downregulate α5β1 and αvβ3 integrins. In our study, electroporation was used as a nonviral delivery system.
Juliane Meyer et al.
Aesthetic surgery journal, 35(8), 1030-1039 (2015-05-27)
In recent years the therapeutic application of extracted adipose tissue for autologous fat grafting and the application of adipose tissue-derived mesenchymal stem cells (adMSC) isolated thereof has progressed. Water-jet assisted liposuction (WAL) is 1 procedure for harvesting adipose tissue and
Yuan Zhang et al.
Scientific reports, 5, 12563-12563 (2015-07-29)
Previous work has shown that gap junction intercellular communication (GJIC) enhances cisplatin (Pt) toxicity in testicular tumor cells but decreases it in non-tumor testicular cells. In this study, these different GJIC-propagated effects were demonstrated in tumor versus non-tumor cells from
Mohamed F Mohamed et al.
Antimicrobial agents and chemotherapy, 58(7), 4113-4122 (2014-05-07)
The seriousness of microbial resistance combined with the lack of new antimicrobials has increased interest in the development of antimicrobial peptides (AMPs) as novel therapeutics. In this study, we evaluated the antimicrobial activities of two short synthetic peptides, namely, RRIKA
Karina H Nakayama et al.
ACS nano, 9(7), 6900-6908 (2015-06-11)
The objective of this study was to enhance the angiogenic capacity of endothelial cells (ECs) using nanoscale signaling cues from aligned nanofibrillar scaffolds in the setting of tissue ischemia. Thread-like nanofibrillar scaffolds with porous structure were fabricated from aligned-braided membranes
Yusheng Shen et al.
Scientific reports, 5, 9293-9293 (2015-03-20)
The extracellular matrix (ECM) exhibits tissue-specific topography and composition and plays a crucial role in initiating the biochemical and biomechanical signaling required for organizing cells into distinct tissues during development. How single cells assemble into structures featuring specific shapes in
Urszula Posadowska et al.
International journal of pharmaceutics, 485(1-2), 31-40 (2015-03-10)
Systemic administration of bisphosphonates, e.g. sodium alendronate (Aln) is characterized by extremely low bioavailability and high toxicity. To omit aforementioned drawbacks an injectable system for the intra-bone delivery of Aln based on Aln-loaded nanoparticles (NPs-Aln) suspended in a hydrogel matrix
A M Pabst et al.
Clinical oral investigations, 19(7), 1625-1633 (2015-01-16)
Geranylgeraniol (GGOH) has been reported as a potential treatment option for bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ). The aim of this study was to analyze the effects of GGOH on endothelial progenitor cells (EPC) after bisphosphonate treatment in vitro. EPC
Nikola Sladojevic et al.
Neurobiology of disease, 67, 57-70 (2014-03-25)
Proinflammatory mediators trigger intensive postischemic inflammatory remodeling of the blood-brain barrier (BBB) including extensive brain endothelial cell surface and junctional complex changes. Junctional adhesion molecule-A (JAM-A) is a component of the brain endothelial junctional complex with dual roles: paracellular route
Tomoko Smyth et al.
Molecular cancer therapeutics, 13(12), 2793-2804 (2014-10-29)
Emergence of clinical resistance to BRAF inhibitors, alone or in combination with MEK inhibitors, limits clinical responses in melanoma. Inhibiting HSP90 offers an approach to simultaneously interfere with multiple resistance mechanisms. Using the HSP90 inhibitor AT13387, which is currently in
Yimao Zhang et al.
Neoplasia (New York, N.Y.), 11(1), 96-101 (2008-12-25)
HhAntag691 (GDC-0449), a low-molecular weight inhibitor of the tumor-promoting hedgehog (Hh) signaling pathway, has been used to treat medulloblastoma in animal models and has recently entered clinical trials for a variety of solid tumors. Here, we show that HhAntag691 inhibits
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